scholarly journals Liver function tests in patients of pre-eclampsia in Bhilai, Chhattisgarh, India: a clinical study

2018 ◽  
Vol 7 (12) ◽  
pp. 5102
Author(s):  
Rashid Lodhi ◽  
Navanil Roy
Keyword(s):  
Blood Pressure ◽  
Liver Function ◽  
Pregnant Women ◽  
Total Protein ◽  
Liver Enzymes ◽  
Serum Bilirubin ◽  
Liver Function Tests ◽  
Mean Value ◽  
Function Tests ◽  
The Mean

Background: Pre-eclampsia is a multisystem disorder, which occurs only in pregnant women during the second and third trimesters of pregnancy and is associated with raised blood pressure and proteinuria. Liver function Test (LFT) abnormalities occur in 3% of the pregnancies and probably the lesion that causes elevated serum liver enzymes. This study was conducted to compare the liver function tests in pre-eclampsia with normal pregnancy.Methods: This study was carried out on 60 pregnant women after 20 weeks of gestation admitted in Obstetrics and Gynaecology units of Shri Shankaracharya Institute of Medical Sciences, Bhilai, and Chhattisgarh. The subjects were divided into two groups. Group A comprised of 30 cases of pre-eclampsia having blood pressure ≥ 140/90mm Hg, proteinuria in 24 hours ≥ 300 mg and edema.  Group B had 30 normal pregnant women after 20 weeks of gestation. The data including parity, period of gestation, blood pressure and presenting complaints of all subjects were recorded. Serum bilirubin, total protein, albumin and plasma levels of liver enzymes ALT and AST were measured.Results: The mean value of serum bilirubin in cases was 3.45 and in controls it was 0.50. The mean value of enzymes ALT in cases was 92.7 while in the controls it was 22.37. Mean serum AST in the cases was 85.43 and in the controls,  it was 21.96. Total protein in cases was 7.77 and controls it was 7.26. Albumin level in cases was 4.62 and controls were 4.17.Conclusions: Increased concentrations of serum bilirubin, total protein, albumin and liver enzymes ALT, AST were found in pre-eclampsia cases.

Liver function tests and one year risperidone treatment in children and adolescents

2011 ◽  
Vol 26 (S2) ◽  
pp. 280-280
Author(s):  
A. Erdogan ◽  
N. Yurteri ◽  
A.E. Tufan ◽  
H. Ankarali ◽  
E. Demirci
Keyword(s):  
Liver Function ◽  
Children And Adolescents ◽  
Liver Enzymes ◽  
Antipsychotic Agent ◽  
Liver Function Tests ◽  
Function Tests ◽  
The Mean ◽  
One Year ◽  
Risperidone Treatment

ObjectiveRisperidone is an atypical antipsychotic agent, despite its many advantages and widespread use, there is increasing attention to the adverse effects associated with long-term exposure to this drug.We aimed to investigate the changes in the liver function tests (LFTs) associated with one year risperidone treatment in children and adolescents.MethodsOne hundred youths who treated with risperidone more than one year were included in the study. For this study, patients’ baseline and follow-up weight and hepatobiliary function tests including alanine aminotransferases(ALT) and aspartat aminotransferases (AST), gamma gluatamyl transerase (GGT), alkaline phosphatase (ALP) and serum bilirubin levels were measured baseline, after the treatment period of six months and one year.ResultsAsymptomatic liver function test abnormalities mostly ALP elevation was found in subjects treated with risperidone. The mean levels of liver enzymes and billuribin of the patients were significantly higher after one year of treatment than the baseline. Also the mean levels of liver enzymes and billuribin of the patients were significantly higher after one year of treatment than the six months. There was significant association between changes in weight, risperidone dose and liver enzymes and billuribin levels.ConclusionsThese findings suggest that risperidone treatment in the long term commonly leads to liver function changes however it rarely may induce a serious hepatic toxicity at therapeutic doses in children and adolescents.

scholarly journals Comparative study of anthropometric measurements, liver function tests, hemoglobin and plasma glucose levels between individuals with alcohol abuse and controls

2019 ◽  
Vol 6 (4) ◽  
pp. 1064
Author(s):  
P. C. Lalramenga ◽  
Honey Satish Savla ◽  
Naveen P.
Keyword(s):  
Alcohol Abuse ◽  
Liver Function ◽  
Plasma Glucose ◽  
Serum Bilirubin ◽  
Liver Function Tests ◽  
Anthropometric Measurements ◽  
Years Of Life Lost ◽  
Glucose Levels ◽  
Function Tests ◽  
The Mean

Background: Alcohol abuse is global burden to families as well as society. On the ‘years of life lost scale’, which is based on alcohol attributable years of life lost, India has been rated 4 on a scale of 1 to 5. This implies that the alcohol consuming population of our country loses most of the years of their life because of drinking and its consequences. The aim of this research is to compare anthropometric measurements, liver function tests, haemoglobin and plasma glucose levels in individuals with alcohol abuse and normal population.Methods: The study was conducted in the Department of General Medicine, Civil Hospital, Aizawl. 84 cases of individuals with alcohol abuse (as per DSM-IV criteria) within the age group of 18-70 years and 70 age, sex, height and weight matched lifetime abstainers, healthy individuals were taken as controls from medicine department. They underwent a detailed clinical examination, anthropometric measurements, liver function tests, haemoglobin and plasma glucose levels.Results: 15.5% of the individuals with alcohol abuse had hypertension. The mean post prandial glucose among the individuals with alcohol abuse was 116.8±12.3 mg/dl and among the controls was 121.1±11.0 mg/dl. Mean serum bilirubin 1.1 mg/dl, AST 79 IU/l & ALT was 79.6 in alcoholics. The mean serum bilirubin 0.8 mg/dl, AST 27.2 IU/l and ALT was 29.4 in non-alcoholics.Conclusions: The individuals with alcohol abuse have raised serum bilirubin, AST and ALT levels compared to the non-alcoholics. Prevalence of hypertension is higher in the individuals with alcohol abuse compared to normal population.

scholarly journals COMPARISON OF LIVER FUNCTION TESTS OF NORMALAND PRE-ECLAMPTIC PREGNANT FEMALES: A HOSPITAL BASED STUDY

2020 ◽  
pp. 8-9
Author(s):  
Shayista Gull
Keyword(s):  
Liver Function ◽  
Liver Function Test ◽  
Total Protein ◽  
Serum Bilirubin ◽  
Complete Blood Count ◽  
Liver Function Tests ◽  
Unknown Etiology ◽  
Serum Total Protein ◽  
Function Tests ◽  
Function Test

Background: Pre-eclampsia is a multi-system disorder of unknown etiology involving almost every organ of body including kidney, liver, brain, heart, stomach and adrenals. In liver periportal hemorrhagic necrosis, ischemic lesions and fibrin deposition occurs due to thrombosis of arterioles. Objective: To compare the liver function tests in normal pregnancy and preeclampsia Methodology: This study was conducted in the Department of Obstetrics and Gynaecology, SKIMS, Soura, Kashmir for 18 months. Participants were divided into two groups: Cases: Comprised of 200 patients with toxemia of pregnancy, Controls: comprised of 500 normal, healthy normotensive pregnant women. This group was studied to get the normal values of liver enzymes and served as controls. A complete blood count, microscopic examination of urine, liver function test, kidney function test , 24 hour urinary protein estimation was done on all participants. Results: Among the cases, 49(24.5%) patients while 76 (15.2%) controls had deranged serum bilirubin. Ninety-nine(49.5%) cases had deranged ALT while 16(3.2%) controls had so. Among the cases, 103(51.5%) had deranged AST level while it was deranged in 64(12.8%) controls. ALP and serum total protein followed similar pattern (more deranged in cases than controls). Conclusion: Liver function test impairment occurs in preeclampsia which is characterized by rise in mean level of serum transaminase levels and serum bilirubin level and fall in serum total protein and albumin level.

scholarly journals Cytomegalovirus may mimic the presentation of intrahepatic cholestasis and hemolysis, elevated liver enzymes and low platelets in immunosuppressed pregnant women

2016 ◽  
Vol 9 (3) ◽  
pp. 135-137 ◽  
Author(s):  
Gurleen Wander ◽  
Francesa Neuberger ◽  
Mandish K Dhanjal ◽  
Catherine Nelson-Piercy ◽  
May Ching Soh
Keyword(s):  
Liver Function ◽  
Pregnant Women ◽  
Intrahepatic Cholestasis ◽  
Congenital Abnormalities ◽  
Liver Enzymes ◽  
Liver Function Tests ◽  
Abnormal Liver Function ◽  
Function Tests ◽  
Elevated Liver Enzymes ◽  
Cholestasis Of Pregnancy

Most published cases of cytomegalovirus infection in pregnancy relate to congenital abnormalities in neonates infected in early pregnancy, while the mother remains asymptomatic. We describe a diagnostically challenging case of an immunosuppressed woman with scleroderma who developed deranged liver function tests attributed to intrahepatic cholestasis of pregnancy and haemolysis, elevated liver enzymes and low platelets syndrome but was ultimately found to have disseminated cytomegalovirus. Cytomegalovirus can present in a myriad of ways. Clinicians caring for immunocompromised pregnant women should consider cytomegalovirus as a possible differential diagnosis when reviewing abnormal liver function tests.

scholarly journals Reversal of Jaundice in Two Patients with Inoperable Cholangiocarcinoma Treated with Cisplatin and Gemcitabine Combination

2012 ◽  
Vol 2012 ◽  
pp. 1-3
Author(s):  
Maarten Criel ◽  
Filip Geurs ◽  
Siegfried Ponette ◽  
Katrien Bulte ◽  
Johan Ponette
Keyword(s):  
Liver Function ◽  
Combination Chemotherapy ◽  
Serum Bilirubin ◽  
Liver Function Tests ◽  
Normal Serum ◽  
Tumor Type ◽  
Chemotherapeutic Approach ◽  
Function Tests ◽  
Severe Jaundice

Two patients are presented with severe jaundice, due to inoperable cholangiocarcinoma. The chemotherapeutic approach in patients with severe jaundice is discussed. Many schedules of chemotherapy were developed in this tumor type with normal serum bilirubin. We report here the first successful use of cisplatin and gemcitabine combination chemotherapy in these patients. Tolerability was good and liver function tests gradually improved.

scholarly journals Vegan Diet Advice Might Benefit Liver Enzymes in Nonalcoholic Fatty Liver Disease: an Open Observational Pilot Study

2021 ◽  
Author(s):  
Giuseppe Chiarioni ◽  
Stefan Lucian Popa ◽  
Andrea Dalbeni ◽  
Carlo Senore ◽  
Daniel Corneliu Leucuta ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Body Weight ◽  
Liver Disease ◽  
Liver Function ◽  
Fatty Liver Disease ◽  
Liver Enzymes ◽  
Liver Function Tests ◽  
Vegan Diet ◽  
Nonalcoholic Fatty Liver ◽  
Function Tests

Background and Aims: The Western diet is rich in saturated fats, refined sugars and meat consistent with a high-energy load and secondary risk of increased metabolic diseases including nonalcoholic fatty liver disease (NAFLD). However, no data are available on potential benefit of vegan diets in NAFLD and/or nonalcoholic steatohepatitis (NASH). We aimed to study prospectively the effect of a vegan diet, excluding all animal products on liver chemistry in a group of consecutive NAFLD patients. Methods: This was a prospective, pilot study run on 40 consecutive patients affected by NAFLD. Eight subjects refused to join the study for poor diet palatability, leaving 32 patients (19 males, mean age 50 years), with abnormal measures of liver function who agreed to adhere to a vegan diet for six months. The caloric intake was tailored by the dietitian to obtain a weight loss ≥5% of body weight in overweight patients [body-mass index (BMI) ≥25] and ranged from 1500 Kcal to 1800 Kcal. Patients were contacted monthly by phone to reinforce diet and lifestyle advice and were seen at the gastrointestinal clinic when doubtful about diet advice. Results: At six-month follow-up, 6 subjects did not attend the clinic leaving only 26 patients for data analysis. Initial anthropometric values were mean weight 78 kg (range 52-95), mean body mass index (BMI) 26.8 Kg/m2 (range 20.3-31.2). Liver function tests showed mean ALT value 99 U/L (SD±45), mean AST value 54 U/L (SD±44), mean GGT value 160 U/L (SD±122), pre-treatment. After six months mean body weight was 73 Kg (range 52-87), mean BMI was 25.2 Kg/m2 (range 20.3-29.7) (p<0.001 compared to baseline for both parameters). Liver enzymes improved to a mean of ALT value 36 U/L (SD±21), AST value 27 U/L (SD±10) and GGT value 55 U/L (SD±57), respectively (p<0.001 compared to baseline for all enzymes). Normalization of liver function tests as a whole was observed in 20/26 patients (76.9%). A loss of ≥ 5% of body weight was observed in 12 patients (46.1%), but it did not correlate with the normalization of liver function tests (p=0.5). Conclusions: Our data provide preliminary evidence of improved liver enzymes in NAFLD patients with a strict vegan diet and although our study sample is limited, decreased body weight did not seem critical to the outcome.

Nuclear medicine liver-function tests for pregnant women and children

1985 ◽  
Vol 11-11 (2-3) ◽  
Author(s):  
P. Krumbiegel ◽  
K. Hirschberg ◽  
H. Faust ◽  
K. G�nther ◽  
G. Schneider
Keyword(s):  
Nuclear Medicine ◽  
Liver Function ◽  
Pregnant Women ◽  
Liver Function Tests ◽  
Function Tests ◽  
Women And Children

scholarly journals Comparison of Liver Function Tests in Normal Pregnancy with Non-pregnant Matched Controls

2020 ◽  
Vol 33 (1) ◽  
pp. 17-24
Author(s):  
M Rokeya Khatun ◽  
Amina Khatun ◽  
Md Nowshad Ali
Keyword(s):  
Liver Function ◽  
Serum Albumin ◽  
Pregnant Women ◽  
Liver Function Tests ◽  
Albumin Concentration ◽  
Third Trimester ◽  
Serum Globulin ◽  
College Hospital ◽  
Cross Sectional ◽  
Function Tests

Background: Change of liver biochemical profiles is normal during pregnancy. It is almost impossible to understand disease processes that can threaten women during pregnancy without understanding normal physiological change. Aim of this study is to evaluate changes in serum liver function tests in normal pregnant women in first, second and third trimester. Material and Methods: The cross-sectional comparative study was carried out in the Department of Obstetrics & Gynaecology of Rajshahi Medical College Hospital, Bangladesh in 2019. This study consists of 90 pregnant women and 90 matched control. Among the 90 pregnant women, 30 were in first trimester, 30 were in second trimester and 30 were in third trimester. Blood samples were taken for routine liver function and protein profiles Results: Serum total and direct bilirubin concentrations were significantly lower in second and third trimester. The mean ALP level was slightly increased in 2nd trimester and drastically increased in 3rd trimesters during pregnancy. Serum ALT and AST activity was significantly increased in third trimester. No significant change in serum total proteins concentration, but serum albumin concentration was significantly lower and serum globulin concentration was significantly higher in all three trimester. Serum albumin/globulin ratio was significantly reduced in second and third trimester. Conclusion: Relative values of various liver function tests during gestational trimesters appear to be the best guide to confirm the diagnosis and treatment strategies. Thus, gynecologists should routinely monitor liver function tests in all gestational trimesters to avoid the future complications to mother and offspring. TAJ 2020; 33(1): 17-24

Sign in / Sign up

Export Citation Format

Share Document