An attempt to establish mathematical models of the equilibrium existing among serum protein fractions (albumin(alb) .GAMMA.-globulin(.GAMMA.-glb)) and total protein(T.P.), and their relationship with liver function tests.

Abstract 1. Thirty-two patients with Mediterranean anemia were studied in Thailand. The diagnotic criteria are presented. All cases fulfilled these requirements. 2. In addition to the classical blood findings, the following observations are presented: (a) fetal hemoglobin, (b) erythrocytic inclusion bodies, (c) liver function tests. 3. Eighty-four per cent of the patients studied were found to have abnormally high amounts of fetal hemoglobin. 4. The inclusion bodies observed in four cases (case histories included) are presented and discussed. 5. Tests for liver function, plasma protein fractions, cephalin cholesterol flocculation, bromsulfalein retention, and bilirubin are reported for twenty patients. 6. A consideration of the effects of splenectomy on the clinical and hematologic status in Mediterranena anemia is presented.

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COMPARISON OF LIVER FUNCTION TESTS OF NORMALAND PRE-ECLAMPTIC PREGNANT FEMALES: A HOSPITAL BASED STUDY

10.36106/ijsr/5203593 ◽

2020 ◽

pp. 8-9

Author(s):

Shayista Gull

Keyword(s):

Liver Function ◽

Liver Function Test ◽

Total Protein ◽

Serum Bilirubin ◽

Complete Blood Count ◽

Liver Function Tests ◽

Unknown Etiology ◽

Serum Total Protein ◽

Function Tests ◽

Function Test

Background: Pre-eclampsia is a multi-system disorder of unknown etiology involving almost every organ of body including kidney, liver, brain, heart, stomach and adrenals. In liver periportal hemorrhagic necrosis, ischemic lesions and fibrin deposition occurs due to thrombosis of arterioles. Objective: To compare the liver function tests in normal pregnancy and preeclampsia Methodology: This study was conducted in the Department of Obstetrics and Gynaecology, SKIMS, Soura, Kashmir for 18 months. Participants were divided into two groups: Cases: Comprised of 200 patients with toxemia of pregnancy, Controls: comprised of 500 normal, healthy normotensive pregnant women. This group was studied to get the normal values of liver enzymes and served as controls. A complete blood count, microscopic examination of urine, liver function test, kidney function test , 24 hour urinary protein estimation was done on all participants. Results: Among the cases, 49(24.5%) patients while 76 (15.2%) controls had deranged serum bilirubin. Ninety-nine(49.5%) cases had deranged ALT while 16(3.2%) controls had so. Among the cases, 103(51.5%) had deranged AST level while it was deranged in 64(12.8%) controls. ALP and serum total protein followed similar pattern (more deranged in cases than controls). Conclusion: Liver function test impairment occurs in preeclampsia which is characterized by rise in mean level of serum transaminase levels and serum bilirubin level and fall in serum total protein and albumin level.

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The Serum Protein Pattern, Liver Function Tests and Hematological Findings in the Differential Diagnosis of Amebic Liver Abscess *

American Journal of Tropical Medicine and Hygiene ◽

10.4269/ajtmh.1959.8.337 ◽

1959 ◽

Vol 8 (3) ◽

pp. 337-341 ◽

Cited By ~ 4

Author(s):

S. J. Powell

Keyword(s):

Differential Diagnosis ◽

Liver Function ◽

Liver Abscess ◽

Serum Protein ◽

Protein Pattern ◽

Liver Function Tests ◽

Amebic Liver Abscess ◽

Function Tests

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Liver function tests in patients of pre-eclampsia in Bhilai, Chhattisgarh, India: a clinical study

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20184975 ◽

2018 ◽

Vol 7 (12) ◽

pp. 5102

Author(s):

Rashid Lodhi ◽

Navanil Roy

Keyword(s):

Blood Pressure ◽

Liver Function ◽

Pregnant Women ◽

Total Protein ◽

Liver Enzymes ◽

Serum Bilirubin ◽

Liver Function Tests ◽

Mean Value ◽

Function Tests ◽

The Mean

Background: Pre-eclampsia is a multisystem disorder, which occurs only in pregnant women during the second and third trimesters of pregnancy and is associated with raised blood pressure and proteinuria. Liver function Test (LFT) abnormalities occur in 3% of the pregnancies and probably the lesion that causes elevated serum liver enzymes. This study was conducted to compare the liver function tests in pre-eclampsia with normal pregnancy.Methods: This study was carried out on 60 pregnant women after 20 weeks of gestation admitted in Obstetrics and Gynaecology units of Shri Shankaracharya Institute of Medical Sciences, Bhilai, and Chhattisgarh. The subjects were divided into two groups. Group A comprised of 30 cases of pre-eclampsia having blood pressure ≥ 140/90mm Hg, proteinuria in 24 hours ≥ 300 mg and edema. Group B had 30 normal pregnant women after 20 weeks of gestation. The data including parity, period of gestation, blood pressure and presenting complaints of all subjects were recorded. Serum bilirubin, total protein, albumin and plasma levels of liver enzymes ALT and AST were measured.Results: The mean value of serum bilirubin in cases was 3.45 and in controls it was 0.50. The mean value of enzymes ALT in cases was 92.7 while in the controls it was 22.37. Mean serum AST in the cases was 85.43 and in the controls, it was 21.96. Total protein in cases was 7.77 and controls it was 7.26. Albumin level in cases was 4.62 and controls were 4.17.Conclusions: Increased concentrations of serum bilirubin, total protein, albumin and liver enzymes ALT, AST were found in pre-eclampsia cases.

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Assessment of liver function test and associated factors among visceral leishmaniasis patients attending university of gondar leishmaniasis research and treatment center, Northwest Ethiopia

PLoS ONE ◽

10.1371/journal.pone.0260022 ◽

2021 ◽

Vol 16 (11) ◽

pp. e0260022

Author(s):

Hiwot Tezera Endale ◽

Tiget Ayelgn Mengstie ◽

Dilargachew Dessie Dawit ◽

Rezika Mohammed ◽

Gashaw Dessie ◽

...

Keyword(s):

Risk Factors ◽

Liver Function ◽

Total Protein ◽

Total Bilirubin ◽

Liver Function Tests ◽

The Other ◽

Treatment Center ◽

Function Tests ◽

Specialized Hospital ◽

Associated Risk Factors

Background Visceral leishmaniasis (VL) is one of the major public health burden, mainly distributed throughout tropical and subtropical regions of the world. Among the Sub-Saharan African countries, Ethiopia is the second most affected country with VL. An Alteration of liver function is a typical manifestation of the disease. Objective The purpose of conducting this study was to assess liver function tests and associated risk factors among VL patients at Leishmaniasis Research and Treatment Center of University of Gondar Comprehensive Specialized Hospital, North West Ethiopia. Method Hospital based comparative cross-sectional study design was conducted. A total of 102 study participants were involved in this study. Newly diagnosed VL patients who were attended at Leishmaniasis Research and Treatment Center of University of Gondar Comprehensive Specialized Hospital from 21st February 2020 to 30th September 2020 were included under case group category. On the other hand, age-sex matched apparently healthy study subjects were categorized as control group. Written consent was obtained willingness of patients to participate after ethical clearance was obtained from the Institutional Review Board of School of Medicine, University of Gondar. After overnight fasting, 5ml venous blood was drawn from both VL patients and controls to evaluate liver function tests, including AST, ALT, total bilirubin, albumin, and total protein. Thus, senior health professionals (laboratory technologist) investigate the results using Cobas Integra 400 Plus clinical chemistry analyzer. Data was entered into Epi-data version 4.6 and exported to STATA 14 for analysis of liver function tests and associated risk factors. Result The result of this study showed that significant mean difference was exhibited in aspartate aminotransferase (AST), alanine aminotransferase (ALT), total bilirubin, serum albumin, and total protein level among VL patients and controls. It showed that there was a statistically significant elevation in the level of AST, ALT, and total bilirubin among cases as compared to control. The serum AST level was significantly (p<0.001) elevated among cases as compared to controls. Serum ALT was significantly (p<0.001) elevated among cases compared to controls. Additionally, the total serum bilirubin level was significantly increased (P<0.001) among cases as compared to controls. There was a statistically significant (P<0.001) reduction of serum albumin level among VL patients as compared to controls. Similarly, serum total protein was significantly (P<0.001) reduced in VL patients than control groups. Conclusion There were significantly higher mean levels of serum AST, ALT, and total bilirubin among VL patients as compared to controls. On the other hand, VL patients showed significantly lowered level of albumin and total protein as compared to controls.

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Biochemical effects of Cigarettes Smoking on Liver functions of Sudanese diabetics smokers

Journal of The Faculty of Science and Technology ◽

10.52981/jfst.vi5.365 ◽

2018 ◽

pp. 41-53

Author(s):

Salah Ahmed Mohamed Ali , Abdelraouf Ahmed Abass

Keyword(s):

Liver Function ◽

Total Protein ◽

Liver Function Tests ◽

Cross Sectional Study ◽

Cross Sectional ◽

Diabetes Mellitus Type Ii ◽

Function Tests ◽

Significant Difference ◽

Liver Functions ◽

Proteins Metabolism

The present study was conducted in Khartoum state (Sudan) as a cross-sectional study in 200 participants (100 smokers and 100 non-smokers), to investigate the effects of Cigarettes Smoking on Liver functions of Sudanese smokers. The smokers were categorized into either current smokers (70 participants) or past smokers (30 Participants). Parameters were analyzed by using spectrophotometer. From the results, the levels of liver function tests (TB, Albumin and globulin) were significantly higher in non-smokers (6.0, 3.6 and 2.43 g/dl) as compared to current smokers (4.4, 2.4 and 1.98 g/dl) and past smokers (4.7, 2.7 and 1.93 g/dl). Meanwhile, ALT was significantly increased in current and past smokers as compared to non-smokers, where as AST was significantly higher in current smokers as compared to non-smokers, while there was no significant difference between current and past smokers as well as between past and non-smokers for this parameter. In addition, heavy and long duration of smoking were both associated with low total protein, albumin and AST levels .Also liver function tests were not significantly differing in current smoker's non-diabetics and non-smokers diabetics except total protein. From the results when, liver enzymes raised that may lead to increase proteins metabolism and increase blood glucose. These signs may place cigarettes smoking one of the top causes of hepatitis, pancreatitis, insulin resistance and finally diabetes mellitus type II. On the other hand, smoking cessation in diabetics lead to decrease the risk of hepatitis, Also regular physical activity and using medication regularly in diabetics lead to the same actions above; in addition diabetes complications were decreased.

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