scholarly journals Study of microalbuminuria as early risk marker of nephropathy in type 2 diabetic subjects

2017 ◽  
Vol 5 (7) ◽  
pp. 3161 ◽  
Author(s):  
Manish K. Verma ◽  
Pradeep Kumar ◽  
Preeti Sharma ◽  
V. K. Singh ◽  
Shashi Prabha Singh
Keyword(s):  
Diabetes Mellitus ◽  
Diabetic Nephropathy ◽  
Glycated Hemoglobin ◽  
Early Stage ◽  
Fasting Blood Glucose ◽  
Ion Exchange Resin ◽  
Risk Marker ◽  
Uncontrolled Diabetes ◽  
Type 2 Diabetic

 Background: Diabetic nephropathy (DN) is a common complication of diabetes mellitus that lead to end-stage of kidney disease (ESKD). Detection of early-stage can slow loss of kidney function and improve patient outcomes with use of diagnostic biomarker detection of DN. Aims and objectives of this study is to evaluate the possible association between glycated hemoglobin and urinary microalbumin as a predictor of diabetic nephropathy in type 2 diabetic patients.Methods: Total 162 subjects were included in this study comprises uncontrolled diabetes 54 cases, controlled diabetes 54 cases and healthy controlled 54 controls. Micro albumin was measured by urinary microalbumin (turbidimetric immunoassay), glycated hemoglobin (HbA1c) measured by ion exchange resin method and fasting blood glucose estimated by GOD-POD method. The inclusion of age group was between 35 to 74 years. Statistical analysis was done by using SPSS, version 16.0. p values were calculated by ANOVA unpaired t-test. The p<0.05 was considered a statistically significant.Results: Urinary microalbumin levels were statistically significant increase in type 2 diabetes mellitus with nephropathy in comparison to uncontrolled diabetes mellitus and controlled diabetes mellitus (138.9±13.7 mg/l vs 67.7±14.1 mg/l and p<0.005**).  HbA1c, which acts as a biomarker of diabetes was significant higher diabetic nephropathy, in comparison to uncontrolled diabetes mellitus, controlled diabetes mellitus and healthy control (8.0±1.1% vs 7.1±0.9% and 5.7±0.4%).Conclusions: The present study was demonstrated impaired glycaemic control is associated with elevations in urinary micro albumin levels and it may be considered as risk marker of diabetic nephropathy.

scholarly journals Correlation between fasting blood glucose, postprandial blood glucose and glycated hemoglobin in non-insulin treated type 2 diabetic subjects

2013 ◽  
Vol 1 (1) ◽  
pp. 18-21 ◽  
Author(s):  
L Shrestha ◽  
B Jha ◽  
B Yadav ◽  
S Sharma
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Glycated Hemoglobin ◽  
Fasting Blood Glucose ◽  
University Teaching ◽  
Postprandial Blood Glucose ◽  
Diabetic Patients ◽  
Type 2 Diabetic ◽  
Better Than

Background: Diabetes mellitus (DM) comprises a group of common metabolic disorders that share phenotype of hyperglycemia. Objectives: This study was conducted to determine the correlation between glucose monitoring by fasting blood glucose or two hours postprandial blood glucose with glycated hemoglobin (HbA1c) in type 2 diabetic patients. Method: A cross sectional study was conducted over a period of six month in the Department of Biochemistry. Institute of Medical, Tribhuvan University Teaching Hospital. Sixty inpatients with Diabetes mellitus type 2 were assessed for daily fasting and postprandial blood sugar for 15 consecutive days. HbA1c was measured on the 15th day. Result: Both postprandial blood glucose and fasting blood glucose significantly correlated with HbA1c. Postprandial blood glucose showed better correlation to HbA1c than fasting blood glucose (r = 0.630, P <0.001 vs. r =0.452, P = 0.05). Conclusion: These results show that postprandial blood glucose correlated better than fasting blood glucose to HbA1c. Thus, postprandial blood glucose predicted overall glycemic control better than fasting blood glucose. This finding has potential implications for treatment and monitoring of metabolic control in type-2 diabetes. DOI: http://dx.doi.org/10.3126/stcj.v1i1.8654 Sunsari Technical College Journal Vol.1(1) 2012 18-21

Evaluation of urinary TNF-α and KIM-1 biomarkers in T2DM in Upper Egypt

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Magdy EL Sharkawy ◽  
Samir K Abdul-Hamid ◽  
Tarek T Elmelegy ◽  
Mohammed F Adawy
Keyword(s):  
Diabetic Nephropathy ◽  
Early Stage ◽  
Clinical Syndrome ◽  
Diabetic Patients ◽  
University Hospitals ◽  
Type 2 Diabetic Patients ◽  
Cross Sectional ◽  
Tnf Α ◽  
Type 2 Diabetic

Abstract Background Diabetes mellitus (DM) is the most frequent cause of chronic kidney failure in both developed and developing countries. Diabetic nephropathy, is a clinical syndrome characterized by albuminuria (&gt;300 mg/day) with permanent and irreversible decrease in glomerular filtration rate (GFR). Aim of the Work To study the role of urinary TNF-α and urine KIM-1 in type 2 diabetic patients as predictors of DN comparative with albuminuria. Patients and Methods This is a cross-sectional study which include 90 type-2 diabetic patients and 30 controls selected from the outpatient clinic of Assiut University hospitals. All patients gave an informed consent and approval for the study was obtained from the IRB committee of the Assiut Medical Faculty. The recruited patients were divided into three groups: Normo-albuminuria Group (A) (n = 30): UACR less than 30 mg/gm, Microalbuminuria Group (B) (n = 30): UACR between 30-299 mg/gm and Macro-albuminuria Group (C) (n = 30): UACR equal or more than 300 mg/gm. Assess Urinary TNF-α and urine KIM-1 in comparision with albuminuria. Results Urinary KIM-1 and urinary TNF-α are statically significant with albuminuria in patients in the early stage of diabetic nephropathy (eGFR _60 mL/min/1.73 m2).Also there are statically significance between patients with macroalbuminuria than microalbuminuria. Conclusion The results of this study recommend the use of KIM-1 and TNF-α as good predictors of early detection of development of diabetic nephropathy.

scholarly journals Glycemic Status, Lipid Profile and Proteinuria in Diabetic nephropathy

2010 ◽  
Vol 49 (178) ◽  
Author(s):  
P Jha ◽  
BKL Das ◽  
S Shrestha ◽  
S Majhi ◽  
L Chandra ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Diabetic Nephropathy ◽  
Lipid Profile ◽  
Glycated Hemoglobin ◽  
Fasting Blood Glucose ◽  
Diabetic Patients ◽  
Age Group ◽  
Arterial Blood ◽  
Cardiovascular Morbidity And Mortality ◽  
Glycated Hemoglobin Level

INTRODUCTION: Diabetic nephropathy is one of the major complications of Diabetes Mellitus characterized by persistent albuminuria, elevated arterial blood pressure, a relentless decline in glomerular filtration rate (GFR) and a high risk of cardiovascular morbidity and mortality. METHODS: In this study, urinary micro-albumin estimation was done in 177 diabetic patients. This study aims to ascertain association of glycemicstatus, lipid profile and proteinuria in Type 2 Diabetes Mellitus with nephropathy. RESULTS: Among 177 patients, 26 had frank proteinuria, 79 had micro-albuminuria and 72 were without proteinuria. Increased frequency ofproteinuria was seen in male than female. Micro-albuminuria and frank proteinuria was seen more in older age group. The multiple comparisons showed the significantly increased levels of urea, creatinine, fasting blood glucose in micro-albuminuria and overt proteinuria patients in comparison to without proteinuria. Glycated hemoglobin level was increased with the increasing age group particularly in overt proteinuric patients. CONCLUSIONS: The glycemic control, monitoring of lipid profile and early urinary protein estimation with better management may delay diabetic nephropathy or its further complications in diabetes mellitus.  KEYWORDS: diabetes mellitus, diabetic nephropathy, frank proteinuria, glycated hemoglobin, micro-albuminuria.

scholarly journals Association of ANGPTL8 and Resistin With Diabetic Nephropathy in Type 2 Diabetes Mellitus

2021 ◽  
Vol 12 ◽  
Author(s):  
Mengni Li ◽  
Rongping Fan ◽  
Xuemin Peng ◽  
Jiaojiao Huang ◽  
Huajie Zou ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Diabetic Nephropathy ◽  
Glycosylated Hemoglobin ◽  
Fasting Blood Glucose ◽  
Serum Levels ◽  
Hs Crp ◽  
The Relationship

BackgroundPrevious studies showed altered angiopoietin-like protein-8 (ANGPTL-8) and resistin circulating levels in type 2 diabetes mellitus (T2DM). Whether or not the alteration in ANGPTL-8 and resistin level can be a predictive maker for increased diabetic nephropathy risk remains unclear.AimTo Investigate the possible association of ANGPTL-8 and resistin with DN, and whether this association is affected by NAFLD status.MethodsA total of 278 T2DM patients were enrolled. Serum levels of ANGPTL8, resistin, BMI, blood pressure, duration of diabetes, glycosylated hemoglobin (HbA1c), fasting blood glucose (FPG), hypersensitive C-reactive protein (hs-CRP), lipid profile, liver, and kidney function tests were assessed. The relationship between DN with ANGPTL8 and resistin was analyzed in the unadjusted and multiple-adjusted regression models.ResultsSerum levels of ANGPTL8 and resistin were significantly higher in DN compared with T2DM subjects without DN (respectively; P &lt;0.001), especially in non-NAFLD populations. ANGPTL8 and resistin showed positive correlation with hs-CRP (respectively; P&lt;0.01), and negative correlation with estimated GFR (eGFR) (respectively; P=&lt;0.001) but no significant correlation to HOMA-IR(respectively; P&gt;0.05). Analysis showed ANGPTL8 levels were positively associated with resistin but only in T2DM patients with DN(r=0.1867; P&lt;0.05), and this significant correlation disappeared in T2DM patients without DN. After adjusting for confounding factors, both ANGPTL8(OR=2.095, 95%CI 1.253-3.502 P=0.005) and resistin (OR=2.499, 95%CI 1.484-4.208 P=0.001) were risk factors for DN. Data in non-NAFLD population increased the relationship between ANGPTL8 (OR=2.713, 95% CI 1.494-4.926 P=0.001), resistin (OR=4.248, 95% CI 2.260-7.987 P&lt;0.001)and DN. The area under the curve (AUC) on receiver operating characteristic (ROC) analysis of the combination of ANGPTL8 and resistin was 0.703, and the specificity was 70.4%. These data were also increased in non-NAFLD population, as the AUC (95%CI) was 0.756, and the specificity was 91.2%.ConclusionThis study highlights a close association between ANGPTL8, resistin and DN, especially in non-NAFLD populations. These results suggest that ANGPTL-8 and resistin may be risk predictors of DN.

Effect of pioglitazone on the early stage of type 2 diabetic nephropathy in KK/Ta mice

Metabolism ◽  
2004 ◽  
Vol 53 (11) ◽  
pp. 1473-1479 ◽  
Author(s):  
Mitsuo Tanimoto ◽  
Qiuling Fan ◽  
Tomohito Gohda ◽  
Toshihide Shike ◽  
Yuichiro Makita ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Early Stage ◽  
Type 2 Diabetic

Nonalbumin proteinuria is a simple and practical predictor of the progression of early-stage type 2 diabetic nephropathy

2017 ◽  
Vol 31 (2) ◽  
pp. 395-399 ◽  
Author(s):  
Jong Ho Kim ◽  
Sang Soo Kim ◽  
In Joo Kim ◽  
Min Jin Lee ◽  
Yun Kyung Jeon ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Early Stage ◽  
Type 2 Diabetic

scholarly journals Alterations in Serum Electrolyte Homeostasis in Type-2 Diabetes Mellitus Patients - A Cross-Sectional Study in VIMSAR, Burla

2020 ◽  
Vol 7 (52) ◽  
pp. 3148-3152
Author(s):  
Labanyabati Pattanaik ◽  
Madhusmita Acharya ◽  
Manoj Kumar Yadav ◽  
Prafulla Kumar Mishra ◽  
Madhab Nayak
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Blood Glucose ◽  
Fasting Blood Glucose ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Electrolyte Disturbances ◽  
Uncontrolled Diabetes ◽  
Diabetes Patients

BACKGROUND Type 2 diabetes mellitus is a widely prevalent lifestyle disease associated with high morbidity and mortality due to dead end complications like acute coronary syndrome, chronic kidney failure and acute stroke. Diabetes mellitus patients frequently develop problems of dyselectrolytemia which is common among hospitalised patients with decompensated diabetes. But there is little information on the prevalence of electrolyte disturbances among diabetes patients. Our aim is to find out the pattern of dyselectrolytemia among type 2 diabetes patients and to know if there is any association of blood glucose level with dyselectrolytemia. METHODS An analytical cross-sectional study was done among type 2 diabetes patients admitted in the department of medicine. Fasting blood glucose (FBG), glycosylated haemoglobin level (HbA1c), blood sodium (Na+), potassium (K+) and calcium (Ca2+) were analysed. Occurrence of dyselectrolytemia was compared between patients of very much controlled versus uncontrolled blood glucose levels. RESULTS Out of 199 patients included in the study, 112 (56 %) had uncontrolled diabetes mellitus (DM) with HbA1c level > / = 7.0 %. Occurrence of hyponatremia, hypokalaemia, hyperkalaemia, hypocalcaemia and hypercalcemia were 35 %, 13 %, 7 %, 16 % and 2 % respectively. In diabetes patients, hyponatremia was seen more commonly in patients with uncontrolled DM than those with very much controlled blood glucose (52.67 % versus 12.64 %, p < 0.001). The extent of patients with hypokalaemia or hyperkalaemia didn't vary between the two groups. Patients on insulin treatment were more likely to have hyponatremia than noninsulin patients (p < 0.001). CONCLUSIONS Type 2 DM patients specifically those who have uncontrolled diabetes mellitus have an increased chance to develop dyselectrolytemia. The most well-known electrolyte disturbances seen were hyponatremia followed by hypocalcaemia in our study and they were generally predominant among patients with uncontrolled DM. KEYWORDS Type 2 Diabetes, Dyselectrolytemia, Hyperglycaemia, Fasting Blood Glucose, Hyponatremia

scholarly journals 102 Jurnal Kesehatan Andalas. 2015; 4(1) Pola Komplikasi Kronis Penderita Diabetes Melitus Tipe 2 Rawat Inap di Bagian Penyakit Dalam RS. Dr. M. Djamil Padang Januari 2011 - Desember 2012

2015 ◽  
Vol 4 (1) ◽  
Author(s):  
Dwi Amelisa Edwina ◽  
Asman Manaf ◽  
Efrida Efrida
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Diabetic Nephropathy ◽  
Medical Record ◽  
Macrovascular Complications ◽  
Chronic Complications ◽  
Microvascular And Macrovascular Complications ◽  
Type 2 Diabetic ◽  
Diabetes Melitus

AbstrakDiabetes Melitus (DM) merupakan suatu kelompok penyakit metabolik dengan karakteristik hiperglikemia. DM tipe 2 adalah yang paling sering ditemukan. Komplikasi kronis DM tipe 2 yaitu mikrovaskular dan makrovaskular yang dapat menurunkan kualitas hidup penderita. Tujuan penelitian ini adalah untuk memperoleh gambaran tentang insidensi penderita DM tipe 2 dengan komplikasi kronis. Penelitian deskriptif ini dilakukan dengan mengambil data pada rekam medik penderita DM tipe 2 dengan komplikasi kronis yang dirawat inap di bagian Penyakit Dalam RS.Dr. M. Djamil, Padang Januari 2011-Desember 2012. Penelitian dilakukan dari Februari 2013-April 2013 di bagian rekam medik RS. Dr. M. Djamil Padang. Data didapatkan sebanyak 261 pasien, dari jumlah tersebut didapatkan 197 pasien memiliki komplikasi kronis DM tipe 2. Data dikategorikan berdasarkan jenis komplikasi makrovaskular dan mikrovaskular. Hasil penelitian menunjukkan bahwa penderita dengan komplikasi kronis makrovaskular (66,5%) dan mikrovaskular (81,7%). Terdapat perubahan insidensi dalam dua tahun yaitu dari tahun 2011 dengan 2012. Komplikasi kronis yang paling sering terjadi adalah nefropati diabetik (42,6%) pada perempuan <60 tahun.Kata kunci: diabetes melitus, komplikasi mikrovaskular, komplikasi makrovaskularAbstractDiabetes mellitus is a group of metabolic diseases with characterized by hyperglycemia. Type 2 diabetes is the most common disease in the world. Chronic complications of type 2 diabetes are microvascular and macrovascular complications that can reduce the quality of life of patients. The objective of this study was to obtain a picture of the incidence of type 2 diabetic chronic complications. This descriptive study was conducted by taking medical record data of hospitalized type 2 diabetic patients with chronic complications inInternal Medicine Department Dr. M. Djamil hospital, Padang on January 2011-December 2012. The study was conducted from February 2013-April 2013 at the hospital medical record Dr. M. Djamil, Padang. This study was conducted on 261 patients, from that number 197 patients have chronic complications of type 2 diabetes mellitus. Data were categorized by type of macrovascular and microvascular complications.The results showed that patients with chronic complications of macrovascular (66,5%) and microvascular (81,7%). There is a change in incidence from 2011 to 2012. The most common of chronic complications is diabetic nephropathy (42.6%). Chronic microvascular and macrovascular complications are different incidence in two years, the most common is diabetic nephropathy which often occurs in women <60 years.Keyword: diabetes mellitus, microvascular complication, macrovacular complication.

scholarly journals COMPARATIVE STUDY TO ASSESS THE HEARING LEVELS AMONG INDIVIDUALS WITH CONTROLLED AND UNCONTROLLED DIABETES MELLITUS

2017 ◽  
Vol 10 (8) ◽  
pp. 248
Author(s):  
Ranganatha Reddy ◽  
Vinod Kumar ◽  
Rakesh V ◽  
Mahitha B ◽  
Ashritha K ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Pure Tone ◽  
Glycated Hemoglobin ◽  
Complete Case ◽  
Pure Tone Average ◽  
Hearing Function ◽  
Uncontrolled Diabetes ◽  
Threshold Testing ◽  
Diabetic Care

Objective: The aim of the study is to assess and compare the hearing levels among individuals with controlled and uncontrolled diabetes mellitus (DM).Methods: Before conducting threshold testing, a complete case history was obtained and otoscopy completed. Blood samples were collected to assess glycated hemoglobin levels. Pure-tone average (PTA) was calculated from three frequencies (500 Hz, 1,000 Hz, and 2,000 Hz). PTA two was calculated from three frequencies (1,000 Hz, 2,000 Hz, and 4000 Hz). It is charted in the form of a graph called the “audiogram.”Results: Overall results showed that the PTA values were better for controlled DM patients when compared to uncontrolled DM which is statistically significant (p<0.05).Conclusion: Observations from the study conclude on the massive need for screening hearing function as routine in diabetic care from the very start with diagnosis. Aggressive control of hyperglycemia and timely checks are mandatory to arrest hearing loss in type 2 diabetes.

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