scholarly journals A study of urinary Bisphenol A levels in endocrine disorders

2018 ◽  
Vol 6 (2) ◽  
pp. 696 ◽  
Author(s):  
Anupam Kumar ◽  
Rajesh Verma ◽  
N. K. Agrawal
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Polycystic Ovarian Syndrome ◽  
Primary Hypothyroidism ◽  
Endocrine Disorders ◽  
Obstructive Azoospermia ◽  
Urinary Levels ◽  
Simple Obesity ◽  
Ovarian Syndrome

Background: Bisphenol A (BPA) is a very common endocrine disruptor. Traditionally high doses of BPA showed adverse effects with respect to organ failure and cancer. However, evidence now shows that doses well below the traditional toxicological threshold have metabolic effects. This observational study was aimed to measure the urinary levels of BPA among patients with endocrine disorders namely type 2 diabetes mellitus, hypothyroidism, non-obstructive azoospermia, polycystic ovarian syndrome (PCOS) and simple obesity, and to correlate urinary BPA levels with different clinical, biochemical and hormonal parameters. Methods: 30 newly diagnosed cases each of Type 2 diabetes mellitus, primary hypothyroidism, polycystic ovarian syndrome (PCOS), non-obstructive azoospermia and simple obesity were selected for study (single disorder in one patient). Age and sex matched healthy relatives of patients (n=30) were recruited as controls. All cases and controls were subjected to spot urinary BPA level estimation.Results: There were significant differences obtained in the median values of BPA in urine between cases of azoospermia, and simple obesity as compared to controls whereas no correlation was obtained between urinary BPA levels and BMI or waist hip ratio, in patients of type 2 DM and primary hypothyroidism. Urinary BPA was significantly lower than controls in cases of PCOS.Conclusions: Urinary levels of BPA are an indicator of its toxic effects especially in patients of non-obstructive azoospermia and simple obesity. The values of BPA in urine were widely distributed showing variability of exposure from the environment. 

Prevalence of type 2 diabetes mellitus compared between lean and overweight/obese patients with polycystic ovarian syndrome: a 5-year follow-up study

2020 ◽  
Vol 301 (3) ◽  
pp. 809-816 ◽  
Author(s):  
Panicha Chantrapanichkul ◽  
Suchada Indhavivadhana ◽  
Thanyarat Wongwananuruk ◽  
Kitirat Techatraisak ◽  
Chongdee Dangrat ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Polycystic Ovarian Syndrome ◽  
Obese Patients ◽  
Follow Up Study ◽  
Ovarian Syndrome

scholarly journals ANGKA BANDING KADAR ASAM URAT AIR KEMIH TERHADAP SERUM DI DIABETES MELITUS TIPE 2 (Ratio of Urinary Uric Acid Levels and Serum Uric Acid in Type 2 Diabetes Mellitus)

2018 ◽  
Vol 21 (1) ◽  
pp. 28
Author(s):  
Amarensi Milka Betaubun ◽  
Fitriani Mangarengi ◽  
Ruland DN Pakasi
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Uric Acid ◽  
Blood Glucose ◽  
Serum Uric Acid ◽  
Colorimetric Method ◽  
Urinary Levels ◽  
Urine Serum

Diabetes Mellitus (DM) belongs to the group of metabolic diseases. The long-term complications of diabetes such as: diabeticretinopathy, neuropathy, and nephropathy, can be prevented or reduced by controlling the blood glucose levels. Impaired glucose tolerance,hypertension and dyslipidemia can decrease the disappearance from proximal tubules resulting in an increase in serum uric acid. The aimof the study to know the ratio of uric acid urine/serum in DMT2 with controls. This research study used a cross sectional study was andconducted on 35 samples of type 2 diabetes mellitus and 35 control samples of In- and Out-patient Clinics at the Dr. Wahidin SudirohusodoHospital, Makassar. The blood glucose, uric acid levels and urine uric acid were examined by ABX Pentra 400 (colorimetric method). Thenumber of DMT2 male patients was higher than females. Most of their age were between 50−54 years. The ratio of the urinary levels ofurine/serum UA was positively correlated to: age, sex, urine UA in DMT2 and control. Their data were analyzed with unpaired t test (p =0.00). This research showed that the ratio of urine/serum UA in DMT2 was 1.5 times than the controls. The results of this study showedan increase in the ratio of urinary levels of serum uric acid as 1.5 times higher than the controls.

Polycystic Ovarian Syndrome (PCOS): A Significant Contributor to The Overall Burden of Type 2 Diabetes in Women

2007 ◽  
Vol 16 (2) ◽  
pp. 191-197 ◽  
Author(s):  
Evelyn O. Talbott ◽  
Jeanne V. Zborowski ◽  
Judith R. Rager ◽  
Kevin E. Kip ◽  
Xiaohui Xu ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Polycystic Ovarian Syndrome ◽  
Significant Contributor ◽  
Ovarian Syndrome

scholarly journals A study of prevalence of primary hypothyroidism in recently diagnosed type 2 diabetes mellitus in a tertiary care hospital

2015 ◽  
Vol 1 (2) ◽  
pp. 105 ◽  
Author(s):  
Sudeb Mukherjee ◽  
Suhana Datta ◽  
Pramathanath Datta ◽  
Apurba K. Mukherjee ◽  
Indira Maisnam
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Thyroid Dysfunction ◽  
Tertiary Care ◽  
Primary Hypothyroidism ◽  
Overt Hypothyroidism ◽  
Care Hospital ◽  
Thyroid Disorder

<p class="abstract"><strong><span lang="EN-US">Background: </span></strong>The association between thyroid dysfunction and DM has long been recognized, although the prevalence of thyroid dysfunction among diabetes population varies in different studies. This study destined to know the prevalence of thyroid dysfunction of recently diagnosed type 2 diabetes mellitus patients.  </p><p class="abstract"><strong><span lang="EN-US">Methods: </span></strong>Retrospective chart review of 60 patients with type 2 diabetes mellituswas done. Total 60 patients (male 51, female9) fulfillingdiagnostic criteria for diabetes mellitus according to ADA (American Diabetes Association) criteria were analysed by doing Thyroid Function Test (FT4,TSH).</p><p class="abstract"><strong><span lang="EN-US">Results:</span></strong><span lang="EN-US"> 75% of patients have the biochemical features of thyroid dysfunction. Subcategorically in descending order of frequency they are - Subclinical hypothyroidism (33.33%) (defined by no symptoms or clinical fetures of hypothyroidism but biochemically TSH level in the range of above 5 mIU/ml but below 10 mIU/ml with normal FT4 level), 15% of patients each for overt hypothyroidism (either clinical features or Biochemically TSH &gt;10 mIU/ml or FT4 below normal), and subclinical hyperthyroidism (only biochemical low level of TSH &lt;0.34 mIU/ml in this study) and 11.667% patients show the features of clinical hyperthyroidism (clinical or FT4 level well above normal range along with low TSH).</span></p><p class="abstract"><strong><span lang="EN-US">Conclusions:</span></strong><span lang="EN-US"> Avery high prevalence of thyroid dysfunction in this part of world in contrast to Europe &amp; US suggest routine screening for thyroid disorder in recently diagnosed type 2 diabetes mellitus.</span></p>

scholarly journals Study on Thyroid Dysfunction in Patients with Type-2 Diabetes

2020 ◽  
Vol 7 (52) ◽  
pp. 3142-3147
Author(s):  
Senthil Chander ◽  
Kalpana Dev Venkatesan ◽  
Christina Mary Paul
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Subclinical Hypothyroidism ◽  
Thyroid Dysfunction ◽  
General Medicine ◽  
Diabetic Patients ◽  
Endocrine Disorders ◽  
Cross Sectional ◽  
Patients With Diabetes

BACKGROUND Diabetes mellitus is one of the leading endocrine disorders worldwide. Thyroid dysfunction is a common endocrine disorder affecting the general population next to diabetes. The objective of this study was to determine the prevalence of thyroid dysfunction among patients with Type 2 diabetes. METHODS This analytical cross sectional study was conducted from June 2019 to Dec 2019. One hundred and fifty type–2 diabetes patients who attended the outpatient clinic of General Medicine Department, ACS Medical College and Hospital were included in the study. A detailed history and examination was done after getting informed consent. Blood samples were collected and sent to the laboratory for the evaluation of thyroid profile. RESULTS Thyroid dysfunction was found in 27 % of the patients with diabetes. Subclinical hypothyroidism was the most common thyroid dysfunction reported (14.7 %) followed by clinical hypothyroidism (10 %), subclinical hyperthyroidism (2 %) and clinical hyperthyroidism (0.6 %). CONCLUSIONS Thyroid dysfunction is common in patients with type-2 diabetes. A substantial proportion of the diabetic patients with thyroid dysfunction have subclinical hypothyroidism. Unidentified thyroid dysfunction could negatively impact diabetes and its complications. Therefore, early and routine screening of thyroid is recommended in all patients with diabetes to reduce the burden of the disease. KEYWORDS Type-2 Diabetes Mellitus, Thyroid Dysfunction, Hypothyroidism

scholarly journals Insulin Resistance Syndrome in Children

2004 ◽  
Vol 89 (6) ◽  
pp. 2526-2539 ◽  
Author(s):  
Svetlana Ten ◽  
Noel Maclaren
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Polycystic Ovarian Syndrome ◽  
Indian Subcontinent ◽  
Phenotypic Expression ◽  
Insulin Resistance Syndrome ◽  
Early Puberty ◽  
Major Health Problem ◽  
Ovarian Syndrome

Abstract The insulin resistance syndrome (syndrome X, metabolic syndrome) has become the major health problem of our times. Associated obesity, dyslipidemia, atherosclerosis, hypertension, and type 2 diabetes conspire to shorten life spans, while hyperandrogenism with polycystic ovarian syndrome affect the quality of life and fertility of increasing numbers of women. Whereas a growing number of single genetic diseases affecting satiety or energy metabolism have been found to produce the clinical phenotype, strong familial occurrences, especially in racially prone groups such as those from the Indian subcontinent, or individuals of African, Hispanic, and American Indian descents, together with emerging genetic findings, are revealing the polygenetic nature of the syndrome. However, the strong lifestyle factors of excessive carbohydrate and fat consumption and lack of exercise are important keys to the phenotypic expression of the syndrome. The natural history includes small for gestational age birth weight, excessive weight gains during childhood, premature pubarche, an allergic diathesis, acanthosis nigricans, striae compounded by gynecomastia, hypertriglyceridemia, hepatic steatosis, premature atherosclerosis, hypertension, polycystic ovarian syndrome, and focal glomerulonephritis appearing increasingly through adolescence into adulthood. Type 2 diabetes, which develops because of an inherent and/or an acquired failure of an insulin compensatory response, is increasingly seen from early puberty onward, as is atheromatous disease leading to coronary heart disease and stroke. A predisposition to certain cancers and Alzheimer’s disease is also now recognized. The looming tragedy from growing numbers of individuals affected by obesity/insulin resistance syndrome requires urgent public health approaches directed at their early identification and intervention during childhood. Such measures include educating the public on the topic, limiting the consumption of sucrose-containing drinks and foods with high carbohydrate and fat contents, and promoting exercise programs in our nation’s homes and schools.

scholarly journals Relationship Between Serum Ferritin Level and Hba1c in Bangladeshi Type 2 Diabetic Patients

2018 ◽  
Vol 9 (1) ◽  
pp. 29-33
Author(s):  
Farhana Khondker ◽  
Manindra Nath Roy ◽  
Purnima Rani Saha ◽  
Rubena Huq ◽  
Rumana Ahmed ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Serum Ferritin ◽  
Pearson Correlation ◽  
Control Group ◽  
Case Group ◽  
Diabetic Patients ◽  
Endocrine Disorders ◽  
Medical College

Background: Diabetes mellitus (DM) type 2 is one of the most common endocrine disorders affecting more than 135 million people in the world. The etiology of the disease is not fully understood, but recently subclinical hemochromatosis has been considered as one of the probable causes of DM. This study was carried out to examine the relationship between serum ferritin as a marker of iron overload with DM and HbA1c.Materials & Method: This study was conducted in the Biochemistry department of Sir Salimullah Medical College, Dhaka; over a period of 18 months from July 2013 to December 2014. In this case control study, 46 patients with type 2 diabetes were taken as case, who were referred to theoutpatient department of "Ibrahim General Hospital & Diabetic care & Educational Center"(DCEC). 46 normal individuals were included as the control group, who were matched with the case group regarding age, sex, BMI and Hb%. Ferritin, hemoglobin, HbA1c and fasting plasma sugar were measured in blood samples. Exclusion criteria included anaemia, or any other disease or drug that could affect ferritin levels.Result: Results were analyzed statistically by Chi-square test, Student's t-test, Pearson correlation coefficient test and Odds ratio.Mean serum ferritin was significantly higher in diabetics than in the control group (197.97±75.99 µgm/L vs. 64.24±27.83 µgm/L, p<0.001). There was significant positive correlation between serum ferritin and HbA1cin diabetic patients (p<0.001). In this study, OR of 11.64 was also found.Conclusion: Serum ferritin is positively correlated with type 2 Diabetes Mellitus. And this may be an important and independent predictor for development of diabetes mellitus.Anwer Khan Modern Medical College Journal Vol. 9, No. 1: Jan 2018, P 29-33

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