scholarly journals Derived neutrophil by lymphocytes ratio is a misnomer, implication of derived leucocytes ratio in diagnosing gastric cancers

2018 ◽  
Vol 6 (1) ◽  
pp. 82
Author(s):  
Naveen P. G. ◽  
K. Veena L. Karanth
Keyword(s):  
Gastric Cancer ◽  
Complete Blood Count ◽  
Malignant Neoplasms ◽  
Surgical Removal ◽  
Mortality And Morbidity ◽  
Gastric Cancers ◽  
Upper Gi Endoscopy ◽  
Gastric Cancer Patients ◽  
Gastric Malignancy ◽  
Significant Mortality

Background: Gastric malignant neoplasms are well-known common malignant disease seen in routine clinical practice. In India incidence are comparatively low but accounts for significant mortality and morbidity. Gastric malignancy incidence adds significant numbers every year to cancer related deaths worldwide. And prognosis is not satisfactory in spite of medical innovations and technological advancements. Early diagnosis helps for successful surgical removal of gastric cancer and to achieve a curative resections. Present study objectives are to solve the paradox of misnomer derived neutrophil by lymphocyte ratio and to evaluate statistical differences of blood leucocyte parameters in patients with gastric malignancies as compared to control cases and its application as screening markers in diagnosing gastric cancers.Methods: Hundred cases of gastric malignancy and hundred controls-age, gender matched to cases without malignancy or infection were included. Both groups evaluated with routine complete blood count and upper GI endoscopy reports, Data regarding WBC counts, neutrophil counts, lymphocyte counts, monocytes, eosinophils and basophils were noted and Derived Leucocytes Ratio (DLR) were calculated and compared to look for statistical differences.Results: Hematological leucocyte parameters revealed statistical differences in gastric cancer patients in comparison to controls. Neutrophils were increased and lymphocytes decreased with elevated DLR levels.Conclusions: Leucocyte parameters like neutrophils and lymphocytes shows varying trends in gastric cancer and elevated derived leucocytes ratio can be utilized as a screening marker in Gastric cancers.

scholarly journals 964 Stage Migration in Newly Diagnosed Oesophago-Gastric Cancer During the First Wave Of COVID-19 Pandemic

2021 ◽  
Vol 108 (Supplement_6) ◽  
Author(s):  
K Khan ◽  
R Chuntamongkol ◽  
C McCollum ◽  
L Gall ◽  
M Forshaw
Keyword(s):  
Gastric Cancer ◽  
Emergency Admission ◽  
Stage Migration ◽  
Newly Diagnosed ◽  
Gastric Cancers ◽  
Negative Effect ◽  
Gastric Cancer Patients ◽  
The Uk ◽  
Treatment Intent ◽  
The Impact

Abstract Aim Covid-19 has significantly disrupted elective and emergency health care provision including cancer care within the UK. The aim of the study was to investigate the impact of the pandemic on the staging of oesophago-gastric cancers at presentation, determine the time delay in performing gastroscopy and the multidisciplinary team (MDT) treatment outcomes. Method A retrospective cohort study of all newly diagnosed oesophago-gastric cancers (adenocarcinoma and squamous cell carcinoma) in a single regional MDT was performed between 1st October 2019 and 30th September 2020. Electronic records were interrogated and patients dichotomised into two groups with those presenting before the introduction of the UK national lockdown of 23rd March 2020 compared to those presenting post-lockdown. Results 349 new oesophago-gastric cancer patients were discussed in the MDT (192 pre-lockdown versus 157 post-lockdown). Demographics were evenly matched between the two groups. More patients presented as an emergency admission post-lockdown (28.0% vs 12.5%, p < 0.001). Median waiting time for gastroscopy was longer post-lockdown (23 vs 14 days, p = 0.035). Metastatic disease at presentation was more frequent post-lockdown (47.8% vs 33.3%, p = 0.008). Overall, more patients had a palliative rather than curative treatment intent post-lockdown (71.3% vs 57.8%, p = 0.005). Conclusions The Covid-19 pandemic has had a significant negative effect on the stage of oesophago-gastric cancers at presentation. This has translated into more patients receiving palliative treatment and ultimately having a poorer prognosis. This study highlights the importance of maintaining cancer services during Covid-19 pandemic.

scholarly journals Prognostic Autophagy-Related Genes of Gastric Cancer Patients on Chemotherapy

2020 ◽  
Author(s):  
xiaolong Liu ◽  
Zhen Ma ◽  
Lei Zhang ◽  
Yang Yu ◽  
Maswikiti Ewetse Paul ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Chemotherapy Resistance ◽  
Risk Groups ◽  
Treatment Regimens ◽  
Chemotherapy Administration ◽  
Product Limit ◽  
The Subject ◽  
Gastric Cancer Patients ◽  
Gastric Malignancy ◽  
Proper Analysis

Abstract Background Chemotherapy resistance based on fluorouracil and cisplatin is one of the most encountered postoperative clinical problems in patients diagnosed with gastric cancer (GC), resulting in poor prognosis. Methods This study aimed to combine autophagy-related genes (ATGs) to investigate the susceptibility of victims with gastric malignancy to postoperative chemotherapy. Based on the TCGA database, gene expression data for GC patients undergoing and during chemotherapy were integrated and analyzed. Prognostic genes were screened based on univariate and various analysis regression models. Subjects were divided into high-risk and low-risk groups and analyzed by the median risk score approach. The product limit estimator method was used to evaluate the OS and DFS. The accuracy of the prediction was resolved by the subject curve analysis. In addition, proper analysis carrying out was done in our work for some detailed assessments. The differential expression of ATGs is mainly related to chemotherapy resistance. Results A total of 9 ATGs of chemotherapy administration outcomes in these suffers were screened. Based on GEO and TCGA databases, the model accurately predicted DFS and OS after chemotherapy administration. Conclusions This study established prognostic markers based on 9 genes, predicting that ATGs are related to chemotherapy susceptibility of GC patients, which can provide better individualized treatment regimens for clinical practice.

scholarly journals Profiling the Prognosis of Gastric Cancer Patients: Is It Worth Correlating the Survival with the Clinical/Pathological and Molecular Features of Gastric Cancers?

2013 ◽  
Vol 2013 ◽  
pp. 1-9
Author(s):  
Laura Lorenzon ◽  
Paolo Mercantini ◽  
Mario Ferri ◽  
Marco La Torre ◽  
Alessandra Sparagna ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Patients ◽  
Roc Curves ◽  
Statistical Correlation ◽  
Her2 Overexpression ◽  
Consecutive Series ◽  
Gastric Cancers ◽  
T Stage ◽  
Molecular Features ◽  
Gastric Cancer Patients

Background. The prognosis of gastric cancer patients still remains poor. The aim of this study was investigating the prognostic value of several clinical/pathological/molecular features in a consecutive series of gastric cancers.Methods. 150 R0 gastrectomies plus 77 gastric cancer patients evaluated for the HER2 overexpression were selected. Survival was calculated and patients stratified according to the stage, the T-stage, the LNRs, the LNH, and the HER2 scoring system. ROC curves were calculated in order to compare the performance of the LRN and LNH systems.Results. Prognosis correlated with the stage and with the T-stage. We documented a statistical correlation between the LNRs and the survival. Conversely, a LNH > 15 did not correlate with the outcomes. The ROC curves documented a significant performance of the LRN system, whereas a statistical correlation was documented for the LNH exclusively with the endpoint of disease-free survival. We documented a trend of worse prognosis for patients with an HER2 overexpression, even though it was not of statistical value.Conclusion. The LNR and the evaluation of the HER2 overexpression might be useful since they correlate with survival, might identify patients with a higher risk of recurrence, and might select patients for a tailored medical treatment.

scholarly journals Blood count and C-reactive protein evolution in gastric cancer patients with total gastrectomy surgery

2014 ◽  
Vol 27 (4) ◽  
pp. 234-236
Author(s):  
Attila CSENDES J. ◽  
Andrea MUÑOZ Ch. ◽  
Ana María BURGOS L.
Keyword(s):  
Gastric Cancer ◽  
Cancer Patients ◽  
Total Gastrectomy ◽  
Blood Count ◽  
Normal Values ◽  
Complete Blood Count ◽  
Maximum Level ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Gastric Cancer Patients

BACKGROUND: The complete blood count (CBC) and C-reactive protein (CRP) are useful inflammatory parameters for ruling out acute postoperative inflammatory complications. AIM: To determine their changes in gastric cancer patients submitted to total gastrectomy. METHODS: This is a prospective study, with 36 patients with gastric cancer who were submitted to elective total gastrectomy. On the first, third and fifth postoperative day (POD), blood count and CRP changes were assessed. Patients with postoperative complications were excluded. RESULTS: Twenty-one (58%) were men and 15 (42%) women. The mean age was 65 years. The leukocytes peaked on the 1st POD with a mean of 13,826 u/mm³, and decreased to 8,266 u/mm³ by the 5th POD. The bacilliforms peaked on the 1st POD with a maximum value of 1.48%. CRP reached its maximum level on the 3rd POD with a mean of 144.64 mg/l±44.84. Preoperative hematocrit (HCT) was 35% and 33.67% by the 5th POD. Hemoglobin, showed similar values. CONCLUSIONS: Leukocytes increased during the 1st POD but reached normal values by the 5th POD. CRP peaked on the 3rd POD but did not reach normal values by the 5th POD.

scholarly journals The differences of c-Met expression between AFP-producing gastric cancer and common gastric cancer

2017 ◽  
Author(s):  
Fen Luo ◽  
Zhongwen Zhou ◽  
Xiang Mao ◽  
Jun Wang ◽  
Zhiming Wang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Liver Metastasis ◽  
Cancer Patients ◽  
Immunohistochemical Analysis ◽  
Distinct Type ◽  
Gastric Cancers ◽  
High Incidence ◽  
Positive Rate ◽  
Gastric Cancer Patients ◽  
Afp Production

Purpose. AFP-producing gastric cancer is a distinct type of gastric cancer and has a high incidence of liver metastasis. c-Met is considered to play an important role in liver metastasis of gastric cancer. The purpose of this study is to compare the expression of c-Met in AFP-producing gastric cancer and gastric cancers not producing AFP. Methods. 23 patients with AFP-producing gastric cancers[AFP(+)] and 18 gastric cancer patients without AFP production[AFP(-)] were evaluated for c-Met expression using immunohistochemical analysis. Results. The frequencies of c-Met expression in two groups are the same (p>0.05), but AFP(+) group has a much higher strong positive rate of c-Met expression than AFP(-) group (p<0.01). Conclusion. The higher expression of c-Met might be the reason for the high incidence of liver metastasis of AFP-producing gastric cancer.

scholarly journals O-OGC02 Stage Migration in Newly Diagnosed Oesophago-gastric Cancer during the first wave of COVID-19 Pandemic

2021 ◽  
Vol 108 (Supplement_9) ◽  
Author(s):  
Khurram Khan ◽  
Lewis Gall ◽  
Rongkagorn Chuntamongkol ◽  
Catherine McCollum ◽  
Stephan Dreyer ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Emergency Admission ◽  
Stage Migration ◽  
Newly Diagnosed ◽  
Gastric Cancers ◽  
Negative Effect ◽  
Gastric Cancer Patients ◽  
The Uk ◽  
Treatment Intent ◽  
The Impact

Abstract Background Covid-19 has significantly disrupted elective and emergency health care provision including cancer care within the UK. The aim of the study was to investigate the impact of the pandemic on the staging of oesophago-gastric cancers at presentation, determine the time delay in performing gastroscopy and the multidisciplinary team (MDT) treatment outcomes. Methods A retrospective cohort study of all newly diagnosed oesophago-gastric cancers (adenocarcinoma and squamous cell carcinoma) in a single regional MDT was performed between 1st October 2019 and 30th September 2020. Electronic records were interrogated and patients dichotomised into two groups with those presenting before the introduction of the UK national lockdown of 23rd March 2020 compared to those presenting post-lockdown. Results 349 new oesophago-gastric cancer patients were discussed in the MDT (192 pre-lockdown versus 157 post-lockdown). Demographics were evenly matched between the two groups. More patients presented as an emergency admission post-lockdown (28.0% vs 12.5%, p < 0.001). Median waiting time for gastroscopy was longer post-lockdown (23 vs 14 days, p = 0.035). Metastatic disease at presentation was more frequent post-lockdown (47.8% vs 33.3%, p = 0.008). Overall, more patients had a palliative rather than curative treatment intent post-lockdown (71.3% vs 57.8%, p = 0.005). Conclusions The Covid-19 pandemic has had a significant negative effect on the stage of oesophago-gastric cancers at presentation. This has translated into more patients receiving palliative treatment and ultimately having a poorer prognosis. This study highlights the importance of maintaining cancer services during the Covid-19 pandemic.

scholarly journals Prognostic Autophagy-Related Genes of Gastric Cancer Patients on Chemotherapy

2020 ◽  
Author(s):  
Xiaolong Liu ◽  
Zhen Ma ◽  
Yang Yu ◽  
Maswikiti Ewetse Paul ◽  
YanLin Ma ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Chemotherapy Resistance ◽  
Risk Groups ◽  
Treatment Regimens ◽  
Chemotherapy Administration ◽  
Post Operation ◽  
Product Limit ◽  
The Subject ◽  
Gastric Cancer Patients ◽  
Gastric Malignancy

Abstract Background, Chemotherapy resistance based on the use of fluorouracil and cisplatin is one of the most encountered clinical problems resulting from post operation and gives rise to poor prognosis in patients diagnosed with gastric cancer (GC). Methods , this study aims to combine autophagy-related genes (ATGs) to provide an investigation of the susceptibility of victims with gastric malignancy to postoperative chemotherapy. Based on the TCGA database, gene expression data for GC patients undergoing and are using chemotherapy were integrated and analyzed. Prognostic genes were screened based on univariate and various analysis regression models. Subjects were divided into those with high and low-risk groups. This was analyzed by the utilization of the median risk score approach. The product limit estimator method had to be used to evaluate the OS and DFS. The accuracy of the prediction was resolved by the subject curve analysis. In addition, the carrying out of proper analysis was done in our work for some detailed assessments. The differential expression of ATGs is mainly related to chemotherapy resistance. Results, a total of 9 ATGs of chemotherapy administration outcomes in these suffers were screened. Based on GEO and TCGA databases, the model accurately predicted DFS and OS after chemotherapy administration. Conclusions, this study established prognostic markers based on 9 genes, which can predict ATGs related to chemotherapy susceptibility of GC patients, and provide better individualized treatment regimens for clinical practice.

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