Rationale, study design and methodology of the hypertension registry:  a Pan-India, prospective, longitudinal study to assess management and real-world outcomes of high-risk essential hypertension

Background: India contributes significantly towards a large part of the worldwide epidemic of hypertension (HTN) and its associated complications. As, there are limited longitudinal studies available in India to understand its occurrence over time, this Pan-India longitudinal study will aid to assess the real world outcomes of HTN across the country.Methods: This was a prospective, multi-centered, longitudinal, observational study investigating a large COHORT of people with HTN across India over a period of one year. The primary objective of this study was to evaluate blood pressure (BP) control and clinical outcomes in high-risk hypertensive patients distributed over 5 visits (including baseline visit). The secondary objective is to assess the co-morbidities/risk factors in different clinical settings across India. Participants (4,000) with HTN will be included from 200 centres across India and data will be recorded for the use of anti-hypertensives, demographics, socio-economic status, anthropometric measurements, family history, personal history, risk factors, co-morbid conditions and physician treatment preferences. Overall, clinical practice patterns were assessed for their relationship with clinical outcomes.Conclusions: This study is expected to reveal the trends in complications associated with HTN, treatment strategies used by physicians, and correlation among treatment, control and complications of HTN within the Indian context. The outcome of this study will help to identify the burden of HTN, along with pin-pointing the emergence of early-onset complications and dose titration patterns. This will eventually help to develop person-centred care and facilitate public health agencies to invest appropriate resources in the management of high-risk HTN across India.Trial registration: Since this is a real world evidence study no trial registration was needed as per Indian regulations.

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High resting heart rate protects against childhood risk factors in predicting adult psychopathy

Journal of Criminal Psychology ◽

10.1108/jcp-01-2021-0003 ◽

2021 ◽

Vol ahead-of-print (ahead-of-print) ◽

Author(s):

David P. Farrington ◽

Henriette Bergstrøm

Keyword(s):

Risk Factors ◽

Heart Rate ◽

Longitudinal Study ◽

Protective Factor ◽

Psychosocial Risk Factors ◽

Psychosocial Risk ◽

Resting Heart Rate ◽

Prospective Longitudinal Study ◽

Content Type ◽

Prospective Longitudinal

Purpose Previous research has indicated that low resting heart rate (RHR), measured at age 18, predicts later psychopathy, and that high RHR acts as a protective factor in nullifying the influence of several psychosocial risk factors in predicting later antisocial and criminal outcomes. This paper aims to investigate high RHR as a protective factor against age 8–10 psychosocial risk factors in predicting psychopathy factors at age 48 (measured by the PCL:SV). Design/methodology/approach Data collected in the Cambridge Study in Delinquent Development are analyzed. This is a prospective longitudinal study of 411 London males from age 8 to age 61. Findings This paper first reports the age 8–10 psychosocial risk factors that predict the interpersonal/affective Factor 1 and the lifestyle/antisocial Factor 2. Then interaction effects with high RHR are studied. The results indicate that high RHR acts as a protective factor against a convicted father and a depressed mother in predicting both psychopathy factors. It also protected against harsh discipline, large family size, low verbal IQ, high hyperactivity, poor parental supervision and a high delinquency-rate school in predicting one of these psychopathy factors, and against a convicted mother in a sensitivity analysis. Originality/value This is the first ever longitudinal study showing that high RHR acts as a protective factor in the prediction of psychopathy. The replicated results with different antisocial outcomes show that more research is warranted on the protective effects of high RHR.

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A Multi centre prospective longitudinal study evaluating the integration of Patient Reported Outcomes (PROMS) with key clinical outcomes after immediate Latissimus dorsi (LD) breast reconstruction and adjuvant treatment

European Journal of Surgical Oncology ◽

10.1016/j.ejso.2012.02.029 ◽

2012 ◽

Vol 38 (5) ◽

pp. 465

Author(s):

Zoe Winters ◽

Judith Mills ◽

Joanne Haviland ◽

Alex Reece-Smith ◽

Michelle Greenslade ◽

...

Keyword(s):

Longitudinal Study ◽

Breast Reconstruction ◽

Clinical Outcomes ◽

Adjuvant Treatment ◽

Latissimus Dorsi ◽

Patient Reported Outcomes ◽

Prospective Longitudinal Study ◽

Patient Reported ◽

Prospective Longitudinal

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Household transmission of SARS-CoV-2 in Norway; a prospective, longitudinal study showing increased transmissibility of the Alpha variant (B.1.1.7) compared with other variants

10.1101/2021.08.15.21261478 ◽

2021 ◽

Author(s):

Cathinka Halle Julin ◽

Anna Hayman Robertson ◽

Olav Hungnes ◽

Gro Tunheim ◽

Terese Bekkevold ◽

...

Keyword(s):

Risk Factors ◽

Longitudinal Study ◽

Close Contact ◽

Questionnaire Data ◽

Primary Case ◽

Prospective Longitudinal Study ◽

Household Contacts ◽

Household Transmission ◽

Alpha Variant ◽

Prospective Longitudinal

ABSTRACT Background We studied the secondary attack rate (SAR), risk factors, and precautionary practices of household transmission in a prospective longitudinal study. Moreover, we compared household transmission between the Alpha (B.1.1.7) variant and non-variants of concern (non-VOCs). Methods We recruited households of confirmed COVID-19 cases from May 2020 to May 2021. Households received 8 home visits over 6 weeks. Biological samples and questionnaire data were collected. Results We recruited 70 confirmed COVID-19 cases and 146 household contacts. Transmission occurred in 60% of the households; the overall SAR for household contacts was 49.6%. The SAR was significantly higher for the Alpha variant (77.8%) compared with non-VOC variants (42.5%) and was associated with a higher viral load. SAR was higher in household contacts aged ≥40 years (64%) than in younger contacts (40-47%), and for contacts of cases with loss of taste/smell. Close contact prior to confirmation of infection tended to give a higher SAR. A significantly lower SAR was found for sleeping separately from the primary case after confirmation of infection. Conclusion We found substantial household transmission, particularly for the Alpha variant. Precautionary practices seem to reduce SAR; however, prevention of transmission within households may become difficult with more transmissible variants.

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Training Load, Immune Status, and Clinical Outcomes in Young Athletes: A Controlled, Prospective, Longitudinal Study

Frontiers in Physiology ◽

10.3389/fphys.2018.00120 ◽

2018 ◽

Vol 9 ◽

Cited By ~ 5

Author(s):

Katharina Blume ◽

Nina Körber ◽

Dieter Hoffmann ◽

Bernd Wolfarth

Keyword(s):

Longitudinal Study ◽

Clinical Outcomes ◽

Immune Status ◽

Training Load ◽

Young Athletes ◽

Prospective Longitudinal Study ◽

Prospective Longitudinal

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Incidence of crown fracture and risk factors in the primary dentition: a prospective longitudinal study

Dental Traumatology ◽

10.1111/edt.12288 ◽

2016 ◽

Vol 32 (6) ◽

pp. 450-456 ◽

Cited By ~ 4

Author(s):

Patrícia Corrêa-Faria ◽

Saul Martins Paiva ◽

Maria Letícia Ramos-Jorge ◽

Isabela Almeida Pordeus

Keyword(s):

Risk Factors ◽

Longitudinal Study ◽

Primary Dentition ◽

Prospective Longitudinal Study ◽

Prospective Longitudinal

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A prospective, longitudinal study of risk factors for early onset of delinquency among maltreated youth

Children and Youth Services Review ◽

10.1016/j.childyouth.2019.05.023 ◽

2019 ◽

Vol 102 ◽

pp. 222-230 ◽

Cited By ~ 8

Author(s):

Minhae Cho ◽

Wendy Haight ◽

Won Seok Choi ◽

Saahoon Hong ◽

Kristine Piescher

Keyword(s):

Risk Factors ◽

Longitudinal Study ◽

Early Onset ◽

Prospective Longitudinal Study ◽

Prospective Longitudinal

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Risk factors for stress and urge urinary incontinence during pregnancy and the first year postpartum: a prospective longitudinal study

International Urogynecology Journal ◽

10.1007/s00192-021-04788-w ◽

2021 ◽

Author(s):

Shiow-Ru Chang ◽

Wei-An Lin ◽

Ting-Chen Chang ◽

Ho-Hsiung Lin ◽

Chien-Nan Lee ◽

...

Keyword(s):

Risk Factors ◽

Urinary Incontinence ◽

Longitudinal Study ◽

Urge Urinary Incontinence ◽

First Year ◽

Prospective Longitudinal Study ◽

Prospective Longitudinal

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Pre-morbid Psychopathology in Schizophrenia Spectrum

The British Journal of Psychiatry ◽

10.1192/s0007125000018109 ◽

1989 ◽

Vol 155 (05) ◽

pp. 623-627 ◽

Cited By ~ 17

Author(s):

Josef Parnas ◽

Aage Jørgensen

Keyword(s):

Longitudinal Study ◽

High Risk ◽

Prospective Longitudinal Study ◽

Schizophrenia Spectrum ◽

Prospective Longitudinal

In a prospective, longitudinal study of high-risk offspring of schizophrenic mothers, of several dimensions of pre-morbid behaviour ‘peculiarity’ predicted subsequent schizophrenia or schizotypy. Peculiarity/eccentricity may represent a subtle marker of the schizophrenic genotype. ‘Pre-schizophrenics', as compared with ‘pre-schizotypes', were characterised by affective dyscontrol, reflected in less introverted and more disturbed behaviour.

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A Prospective Longitudinal Study Evaluating The Influence of Immunosuppressives and Other Factors On COVID-19 in Autoimmune Rheumatic Diseases

10.21203/rs.3.rs-805748/v1 ◽

2021 ◽

Author(s):

Abhishek Patil ◽

Chanakya K ◽

Padmanabha Shenoy ◽

Chandrashekara S ◽

Vikram Haridas ◽

...

Keyword(s):

Risk Factors ◽

Longitudinal Study ◽

General Population ◽

Lung Disease ◽

Rheumatic Diseases ◽

Case Fatality ◽

Geographic Region ◽

Prospective Longitudinal Study ◽

Autoimmune Rheumatic Diseases ◽

Prospective Longitudinal

Abstract Background We conducted this study to identify the influence of prolonged use of hydroxychloroquine(HCQ), glucocorticoids (GC) and other immunosuppressants (IS) on occurrence and outcome of COVID-19 in patients with autoimmune rheumatic diseases (AIRDs). Methods This was a prospective, multicenter, non-interventional longitudinal study across 15 specialist rheumatology centers. Consecutive AIRD patients on treatment with immunosuppressants were recruited and followed up longitudinally to assess parameters contributing to development of COVID-19 and its outcome. Results COVID-19 occurred in 314(3.45%) of 9212 AIRD patients during a median follow up of 177 (IQR 129,219) days. Long term HCQ use had no major impact on the occurrence or the outcome of COVID-19. Glucocorticoids in moderate dose (7.5-20mg/day) conferred higher risk (RR = 1.72) of infection. Among the IS, Mycophenolate mofetil (MMF), Cyclophosphamide (CYC) and Rituximab (RTX) use was higher in patients with COVID 19. However, the conventional risk factors such as male sex (RR = 1.51), coexistent diabetes mellitus (RR = 1.64), pre-existing lung disease (RR = 2.01) and smoking (RR = 3.32) were the major contributing risk factors for COVID-19. Thirteen patients (4.14%) died, the strongest risk factor being pre-existing lung disease (RR = 6.36, p = 0.01). Incidence ((17.5 vs 5.3 per 1 lakh (Karnataka) and 25.3 vs 7.9 per 1 lakh(Kerala) ) and case fatality (4.1% vs 1.3 % (Karnataka) and 4.3% vs 0.4% (Kerala)) rate of COVID-19 was significantly higher (p < 0.001) compared to the general population of the corresponding geographic region. Conclusions Immunosuppressants have a differential impact on the risk of COVID-19 occurrence in AIRD patients. Older age, males, smokers, hypertensive, diabetic and underlying lung disease contributed to higher risk. The incidence rate and the case fatality rate in AIRD patients is much higher than that in the general population.

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