scholarly journals An observational study on anaemia in children admitted to a tertiary teaching hospital with first episode of febrile seizures

2019 ◽  
Vol 6 (4) ◽  
pp. 1668
Author(s):  
Ashish Pradhan ◽  
Prerna Choudhury
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anaemia ◽  
Complete Blood Count ◽  
Febrile Seizures ◽  
First Episode ◽  
P Value ◽  
Deficiency Anaemia ◽  
Number Of Children ◽  
Tertiary Teaching ◽  
Significant Difference

Background: The association between anaemia and iron deficiency anaemia with febrile seizures is still not very well understood. The purpose of this study was to describe the occurrence of anaemia in children admitted with first episode of febrile seizures.Methods: This was a hospital based prospective study conducted at Central Referral Hospital, Gangtok, Sikkim, India from December 2012 to May 2014 on 50 children in the age group of 6 to 60 months admitted with first episode of febrile seizures. Detailed history and physical examination were performed and findings recorded and complete blood count, serum electrolytes and random blood sugar were done in all children. Mentzer Index was calculated from the haematological data.Results: The mean age in this study was 24.88±13.22 months. 74% of the cases were males. Twenty-eight children (56%) had anaemia out of which twenty-seven had Iron deficiency anaemia. The statistical analysis of qualitative data using Chi-square test with Yate’s correction revealed no statistically significant difference between number of children with anaemia and no anaemia (p value=0.1493) and also between number of children with Iron deficiency anaemia and children with no Iron deficiency anaemia (p value=0.4478).Conclusions: This study did not reveal a higher occurrence of anaemia as well as iron deficiency anaemia in children admitted with first episode of febrile seizures.

scholarly journals Iron Deficiency Anemia as a Risk Factor for First Febrile Seizures a Case Control Study

2020 ◽  
Vol 8 (4) ◽  
pp. 24-29
Author(s):  
V. Ramgopal Rao ◽  
P. Anil Kumar
Keyword(s):  
Risk Factor ◽  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Iron Deficiency Anaemia ◽  
Febrile Illness ◽  
Febrile Seizures ◽  
Trigger Factor ◽  
Deficiency Anemia ◽  
First Episode ◽  
Deficiency Anaemia

Background: Febrile seizures in children are a common problem. Iron deficiency anaemia is known, among other contributing factors, to be an aggravating factor in febrile seizures. Iron deficiency anaemia is a condition that can be avoided and managed. The study goal was to identify iron deficiency anaemia as a trigger factor for febrile seizures (FS). To determine the association between Iron Deficiency Anemia (IDA) and the first episode of febrile seizures (FFS). Subjects and Methods: Investigation like hemoglobin, blood indices (MCV, MCH), and serum iron and serum ferritin are done for detection of iron deficiency anaemia and their relationship with the first episode of febrile seizure was observed. Results: In our study comprising 50 cases and 50 controls, 58% (29) of cases were diagnosed as IDA with FS, 18% (9) of controls were diagnosed as IDA with Febrile Illness (FI). This suggests IDA as a risk factor for febrile seizures with a significant P value of <0.001. Among 50 cases 42% (21) cases have FS without IDA and among 50 controls 82% (41) controls have FI without IDA were present in the current study. Conclusion: IDA was more common in children with FS than in those with febrile illness (FI) disease alone. The result suggests that the IDA can be a contributing factor to the FFS. Screening of IDA of children with FFS should be regarded. Fever can worsen the negative effects of anaemia or iron deficiency on the brain, which can lead to seizures.

scholarly journals Study on association of iron status in children with simple febrile seizure and without seizures

2018 ◽  
Vol 5 (4) ◽  
pp. 1300 ◽  
Author(s):  
Anantha Narayana Gowda B. L. ◽  
Praveen C. Samuel
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anaemia ◽  
Complete Blood Count ◽  
Iron Status ◽  
Demographic Data ◽  
Venous Blood ◽  
Febrile Seizures ◽  
Laboratory Assessment ◽  
Cross Sectional ◽  
Deficiency Anaemia

Background: Considering the age prevalence of iron deficiency anaemia and febrile convulsion which are the same, the role of iron in the metabolism of neurotransmitters (such as GABA and serotonin) and some enzymes (such as monoaminoxidase and aldehideoxidase), the function of hemoglobin in conveying oxygen to the brain and since fever can exacerbate symptoms that result from anaemia, a relationship between iron deficiency anaemia and febrile convulsions is probable. Thus, the present study was conducted to determine the iron profile in children with simple febrile seizures and febrile children without seizures and also to find out the association between iron levels and simple febrile seizures.Methods: A cross sectional comparative study was conducted among the infants and children aged between 6 months to 6 years with complaints of fever with/ without seizures attending Pediatrics OPD, Sri Siddartha Medical College, Tumkur during the period between 2016 to 2018. Purposive sampling of equal number of children in two study groups were made. Demographic data, seizure details, nature of febrile illness, family history of epilepsy /febrile seizures, temperature at admission and nutritional status were recorded. For laboratory assessment, 2 ml venous blood was drawn and sent for estimation of complete blood count with peripheral smear. Statistical analysis was done using SPSS version 16.Results: Among 112 study participants, 60.7% were anaemic. The indicators of iron deficiency anaemia like Hb%, MCH, TIBC and S. ferritin were associated with febrile seizures and were statistically significant.Conclusions: Anaemia prevalence in infants and young children is high and was significantly associated with febrile seizures.

scholarly journals Study of outcome of the treatment with intravenous iron sucrose in moderately anaemic pregnant women

2019 ◽  
Vol 8 (9) ◽  
pp. 3480
Author(s):  
Kohila Kalimuthu ◽  
Vanusha Avudaithangam
Keyword(s):  
Standard Deviation ◽  
Iron Deficiency ◽  
Pregnant Women ◽  
Iron Deficiency Anaemia ◽  
Intravenous Iron ◽  
Iron Sucrose ◽  
P Value ◽  
Deficiency Anaemia ◽  
The Mean ◽  
The Difference

Background: Moderate anaemia seen in about 15-20% of pregnant women. Iron sucrose complex which is used intravenously for the correction of Iron deficiency anaemia. The drug has been able to raise the haemoglobin to satisfactory level when used in moderately anaemic iron deficient pregnant women. The objective of this study was to study the improvement of Hb% after treatment with intravenous Iron sucrose complex in moderately anaemic pregnant women belonging to 24-32 weeks of gestational age.Methods: 50 antenatal patients between gestational age 24-32 weeks with hemoglobin between 8-9.5g/dl were selected and included in this study. They were subjected to blood hemoglobin estimation, hematocrit and peripheral smear study. In each infusion, the maximum total dose administered was 200 mg iron sucrose in 100 ml of normal saline, slow IV infused over 30 minutes. Monitoring was done throughout the infusion to observe for any side effects.Results: Mean hemoglobin among the 50 patients before starting the therapy was 8.172g/dl and the mean hemoglobin at the end of one month of completing the therapy was 11.066g/dl. The rise in mean hemoglobin i.e. the difference in the mean hemoglobin before and after treatment was 2.894g/dl. The p value is 0.0001 which is statistically significant. The mean hematocrit of the 50 patients studied before starting the treatment was 26.772% with a standard deviation of 1.914. The mean hematocrit after completing the therapy was 33.872% with a standard deviation of 1.321. The difference in the mean hematocrit was 7.100% with a p value of 0.0001 which is statistically significant.Conclusions: Intravenous iron sucrose complex is well tolerated and highly efficacious in improving hemoglobin, hematocrit in the treatment of iron deficiency anaemia in antenatal women.

scholarly journals Intravenous versus oral iron therapy in treatment of postpartum anaemia

2017 ◽  
Vol 6 (8) ◽  
pp. 3454
Author(s):  
Neelima Agarwal ◽  
Preeti Sharma
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anaemia ◽  
Ferrous Sulphate ◽  
Intravenous Iron ◽  
Hemoglobin Level ◽  
Oral Iron ◽  
Chi Square ◽  
Deficiency Anaemia ◽  
Significant Difference ◽  
Red Cell Indices

Background: Postpartum iron deficiency anaemia (IDA) is common in women. Most women are treated with either oral iron supplementation or blood transfusion. Hence, the aim of our study was to compare the effect of treatment with either oral ferrous sulphate or intravenous ferrous sucrose on postpartum IDA.Methods: 100 postpartum women with proven iron deficiency anaemia with hemoglobin <9gm/dl and serum ferritin <15 µgm/l were included in the study. They were randomized to receive either oral ferrous sulphate 200 mg twice daily for 6 weeks (group 1) or intravenous ferrous sucrose 200 mg, two to three doses given on alternate days (group 2). Total iron deficit was calculated using a standard formula. Target hemoglobin was 11 gm/dl. Results were analysed by the students t-test and chi-square test. Hemoglobin, hematocrit, red cell indices and ferritin were measured on day 2-3, 1-2 weeks and 6 weeks postpartumResults: By 1-2 weeks, hemoglobin level in women treated with intravenous iron had risen from 7.81±0.849 to 9.88±0.760 gm/dl which was more than those treated with oral iron (p<0.01); although by 6 weeks, there was no significant difference between the two groups. Ferritin levels rose rapidly in those treated with intravenous iron and remained significantly higher than in those treated with oral iron (p<0.01).Conclusions: Intravenous iron sucrose increases the hemoglobin level more rapidly than oral ferrous sulphate in women with postpartum IDA. It also replenishes iron stores more rapidly. 

scholarly journals CASE-CONTROL STUDY OF IRON DEFICIENCY ANAEMIA IN FEBRILE SEIZURES

2017 ◽  
Vol 6 (65) ◽  
pp. 4717-4719
Author(s):  
Shailaja Potdar ◽  
Sunil Junagade ◽  
Jayesh Panot ◽  
Vandana Kumavat ◽  
Mohit Rojekar V ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anaemia ◽  
Case Control Study ◽  
Febrile Seizures ◽  
Case Control ◽  
Deficiency Anaemia ◽  
Control Study

A comparative study between the dispersible Ferric pyrophosphate particles and Ferrous sulfate in treatment of pediatric patients with iron deficiency anemia

2021 ◽  
Author(s):  
Fady M. El-Gendy ◽  
Ayat A El- Gendy ◽  
Mahmoud A. El-Hawy
Keyword(s):  
Side Effects ◽  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Ferrous Sulfate ◽  
Complete Blood Count ◽  
Deficiency Anemia ◽  
P Value ◽  
Liquid Form ◽  
Ferric Pyrophosphate ◽  
Significant Difference

Background: Iron deficiency anemia (IDA) is the most common type of anemia related to malnutrition worldwide. It represents a major problem in developing countries, especially in Egypt. Ferric pyrophosphate (FPP) is a water-insoluble iron compound often used to fortify infant cereals and chocolate drink powders. It causes no adverse color and flavor changes to food vehicles. This study was done to compare the efficacy of FPP (micro dispersed iron) and ferrous sulfate (FS) in treating childhood IDA. Materials and Methods: This prospective cohort study was conducted on 58 anemic children visiting the outpatient clinic, pediatric department of Menoufia University hospitals from March 2017 to June 2019. The inclusion criteria of the involved children were age 2 - 12 years and the diagnosis of IDA. Patients with other types of anemia were excluded from the study. Verbal permission was obtained from the parents of the children according to the ethical committee of Menoufia University. Patients were randomly divided into 2 groups. Group1 included 29 children who were treated with FPP and group2 included 29 children who were treated with oral traditional iron in the form of FS. Complete blood count and iron profile were recorded before and after 8 weeks of treatment. Results: The results showed no statistically significant difference between the FPP group and the FS group regarding clinical examinations (P-value > 0.05). There was no significant difference regarding hemoglobin, serum iron, and serum ferritin between the FPP and the FS groups after treatment (P-value> 0.05). However, side effects were significantly higher in the FS group (P-value > 0.001). Conclusion: Micro dispersed iron could be used as an alternative therapy for children with IDA who refuse oral iron therapy in a liquid form with more tolerability and fewer side effects.

"A clinical study to assess efficacy of rasapachaka kashaya in rasapradoshaja vyadhi - panduroga (iron deficiency anaemia) in females in reproductive age."

2020 ◽  
Vol 8 (02) ◽  
Author(s):  
Sonal Lohiya
Keyword(s):  
Clinical Study ◽  
Iron Deficiency ◽  
Iron Deficiency Anaemia ◽  
Modern Science ◽  
Reproductive Age ◽  
Muscle Cramp ◽  
Deficiency Anaemia ◽  
Blood Indices ◽  
Significant Difference ◽  
Loss Of Appetite

Background: Pandu is a Rasa Pradoshaja Vyadhi described by Acharya Charaka. Pandu causes extreme debility as it is dominated by the symptoms like Palpitation, Fatigue, Dyspnoea on exertion etc, due to the vitiation of Rasa and Rakta Dhatu, which are the essential factors for nourishment of body. There is a correlation of Pandu with Anaemia of Modern science. Females in reproductive age are more susceptible for Iron Deficiency Anaemia due to regular menstrual flow and dietary inadequacies and ultimately suffer complications in pregnancy as well in delivery. The present clinical study was conducted to assess efficacy of Rasapachaka Kashaya in Rasapradoshaja Vyadhi - Panduroga (Iron Deficiency Anaemia) in females in reproductive age. Methods: Total 30 female patients of Panduroga in the age group 18-45 years were selected randomly. The study subjects were given Rasapachaka Kashaya in the dose of 1 gm twice a day after meals. Total study duration was of 90 days and assessment was done before initiation of study and at the end of every month. Results: The relief in symptom scores such as Panduta (Pallor), Hrutspandan (Palpitation), Shunakshikut (Periorbital oedema), Daurbalya (Weakness), Hatanal (Loss of Appetite), Arohanayas (Exhaustion during climbing), Pindikodveshta (Calf muscle cramp), Aruchi (Anorexia), Shrama (fatigue), Bhrama (giddiness) and Nidralu (Sleepiness) symptom was statistically significant (p < 0.01). Statistically significant difference was observed in objective parameters such as Haemoglobin level and RBC count (p < 0.05 and < 0.001 respectively) also in PCV and MCMC after 3 months of treatment. No significant improvement was noticed in blood indices such as MCV and MCH. WBC count found to be improved to significant level whereas ESR showed decline to statistically significant level. No significant change in Platelet count was seen over a period of three months, i. e. completion of treatment. Conclusion: The Rasapachaka Kashaya is found to be effective in the management of Rasapradoshaja Vyadhi– Panduroga in females in reproductive age.

Comparison between Iberet Folic® and Zincofer® in treatment of iron deficiency anaemia in pregnancy

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Muhammad Azrai Abu ◽  
Azniza Suriati Borhan ◽  
Abdul Kadir Abdul Karim ◽  
Mohd Faizal Ahmad ◽  
Zaleha Abdullah Mahdy
Keyword(s):  
Adverse Effect ◽  
Iron Deficiency ◽  
Serum Ferritin ◽  
Iron Deficiency Anaemia ◽  
Serum Ferritin Level ◽  
Controlled Trial ◽  
Ferritin Level ◽  
P Value ◽  
Deficiency Anaemia ◽  
Randomised Controlled

AbstractObjectivesTo compare the effect of Iberet Folic® and Zincofer® on haemoglobin (Hb) and serum ferritin level; and its adverse effect.MethodsThis randomised controlled trial conducted from January 2018 until December 2018. Pregnant women below 34 weeks of gestation, with Hb concentration less than 11 g/dL and serum ferritin level less than 12 ug/L were randomised to receive either one tablet Zincofer® or one tablet Iberet Folate® daily for four weeks. Both groups were compared in terms of effect on Hb level, serum ferritin level, and other haematological indices adverse effect related to treatment, and treatment cost.ResultsHundred and thirty patients were recruited in this study with 68 patients in Iberet Folic group and 62 patients in Zincofer group. The change in the Hb and serum ferritin level from baseline to day 30 did not differ significantly between treatment groups. The mean (±SD) change from baseline to day 30 was 2.15 (±0.59) g/dL in the Iberet Folic group, and 1.98 (±0.49) in the Zincofer (p value = 0.08). Mean serum ferritin at day 30 was 17.2 (±3.68) ug/L and 16.7 (±4.28) ug/L with 8.44 (±3.41) and 8.55 (±3.50) difference, respectively (p = 0.86). Adverse events were comparable in between groups, with p value >0.05. GI intolerance and constipation were among the common side effects, occurred in 34.6 and 29.2% cases, respectively.ConclusionsZincofer® offers equivalent efficacy and side effect profile in comparison with Iberet Folic® for the treatment of iron deficiency anaemia (IDA) during pregnancy, but with lower cost.

Iron-deficiency anaemia, gastric hyperplasia, and elevated gastrin levels due to potassium channel dysfunction in the Jervell and Lange-Nielsen Syndrome

2012 ◽  
Vol 23 (3) ◽  
pp. 325-334 ◽  
Author(s):  
Annika Winbo ◽  
Olof Sandström ◽  
Richard Palmqvist ◽  
Annika Rydberg
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anaemia ◽  
Clinical Symptoms ◽  
Gastrointestinal Symptoms ◽  
Gastrin Level ◽  
P Value ◽  
Faecal Calprotectin ◽  
Deficiency Anaemia ◽  
History Of ◽  
Record Review

AbstractAimWe investigated extra-cardiac clinical symptoms and signs in the rare Jervell and Lange-Nielsen Syndrome, characterised by impairedKCNQ1function, a gene essential for gastric acid secretion.MethodsAll Swedish Jervell and Lange-Nielsen cases with doubleKCNQ1mutations (14 cases) were investigated by medical record review, an interview, and were offered laboratory testing for iron-deficiency anaemia and gastrointestinal markers.ResultsA history of iron-deficiency anaemia in 12 of 14 patients and subjective gastrointestinal symptoms in 13 of 14 patients was revealed. Previous endoscopy in five cases had revealed no case of coeliac or inflammatory bowel disease but three cases of mucosal hyperplasia/dysplasia. Current signs of anaemia or iron substitution were present in 9 of 12 tested cases. Elevated levels of gastrin in seven of nine cases, pepsinogen in six of seven cases, and faecal calprotectin in nine of nine cases were present. A significant correlation between elevated gastrin levels and concurrent iron-deficiency and/or anaemia was revealed (p-value 0.039).ConclusionsA high frequency of extra-cardiac clinical symptoms and previous medical investigations was found. We propose that the Jervell and Lange-Nielsen Syndrome phenotypically includes gastrointestinal symptoms/signs and secondary iron-deficiency anaemia owing to hypochlorhydria on the basis ofKCNQ1mutations. The resultant elevated gastrin level is a potential risk factor for later gastrointestinal cancer. Clinical monitoring with regard to developing anaemia and hypergastrinaemia should be considered in the Jervell and Lange-Nielsen Syndrome.

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