scholarly journals Study the role of c-reactive protein and thrombocytopenia in diagnosing early neonatal sepsis

2021 ◽  
Vol 8 (8) ◽  
pp. 1424
Author(s):  
N. Aravind Babu
Keyword(s):  
Platelet Count ◽  
Neonatal Sepsis ◽  
C Reactive Protein ◽  
Sepsis Diagnosis ◽  
Reactive Protein ◽  
Bacterial Cultures ◽  
Negative Stain ◽  
Low Sensitivity ◽  
Culture Positive

Background: In clinical practice, early detection of neonatal sepsis remains difficult. Neonatal sepsis diagnosis is a challenge because of its non-specific presentation and the low sensitivity of the time-consuming bacterial cultures. So, many sepsis markers, like C-reactive protein (CRP) and platelet count, are emerging to improve its diagnosis. The aim of the study was to evaluate the role of CRP and platelet count in early neonatal sepsisMethods: This study was conducted in the department of SNCU in Virudhunagar Government Headquarters hospital, 50 neonates with culture-confirmed sepsis were included. Before antibiotic treatment, neonates CRP and platelet count, and other inflammatory markers were assessed.Results: In 50 newborns, culture was positive in 22 cases, CRP was positive in 24 cases, and thrombocytopenia in 18 cases. In 22 culture-positive cases, 19 cases are CRP positive, and 17 cases had thrombocytopenia. In 17 culture-positive thrombocytopenia cases, 16 cases are Gram-negative stain, 1 case is Gram-positive stain.Conclusions: CRP and Platelet can be helpful in the future diagnosis of neonatal sepsis, despite being promising and convenient markers for neonatal sepsis.

scholarly journals Haematological Parameters in Neonatal Sepsis in a Tertiary Care Centre Study

2021 ◽  
Vol 8 (13) ◽  
pp. 751-754
Author(s):  
Pruthvi D ◽  
Pavan Ramarao Kulkarni ◽  
Uma Raghavendra Jamkhandi ◽  
Shivakumar Sanganagouda Inamdar
Keyword(s):  
Blood Culture ◽  
Absolute Neutrophil Count ◽  
Neutrophil Count ◽  
Neonatal Sepsis ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Neonatal Septicaemia ◽  
Sepsis Screen ◽  
Sensitivity Specificity ◽  
Culture Positive

BACKGROUND Neonatal septicaemia is a bacterial infection with positive blood culture in first four weeks of life. The early sepsis screen is vital as it detects earlier and benefits the clinician to treat the infection reducing neonatal mortality and morbidity. We wanted to evaluate various haematological screening parameters and C-reactive protein (CRP) in blood culture positive neonates in sepsis. METHODS This prospective study was conducted for a period of one year. Blood samples from hundred clinically suspected neonatal septicaemia cases were subjected to aerobic culture and sepsis screen tests like C-reactive protein, erythrocyte sedimentation ratio (ESR), total WBC count, absolute neutrophil count, immature / total neutrophil count (I / T) ratio and platelet count. The culture results were correlated with the sepsis screen tests. RESULTS Of the hundred cases studied, 18 % were blood culture positive and 66 % were males. Early onset septicaemia was more common, seen in 64 % of cases than late onset septicaemia (26 %) cases. Staphylococcus aureus was the commonest organism isolated in 38.46 % of cases followed by Klebsiella pneumoniae & E. Coli. Among the haematological parameters, the positivity was best with Creactive protein (94.44 %) followed by immature & mature neutrophil ratio (I / M) (94.44 %), I / T ratio (88.88 %) and the least with absolute neutrophil count (66.0 %). Any two or more parameters were positive in 94.44 % of the subjects. CONCLUSIONS Sepsis screen has good sensitivity, specificity and is a valuable aid for early diagnosis of neonatal septicaemia. Sepsis screen is simple, cost effective, less time consuming and easy to perform. As an individual test C-reactive protein has shown highest sensitivity, specificity and is a sensitive and responsive indicator of neonatal sepsis. KEYWORDS Blood Culture, Neonatal Septicaemia, Sepsis Screen

scholarly journals Role of Manual Immature to Total Neutrophil (I/T) Ratio and Automated Immature Granulocyte Count (IGC) and Percentage (IG%) in the Early Diagnosis of Neonatal Sepsis

2021 ◽  
Author(s):  
Nalika Jayasekara ◽  
Chandima Kulathilake ◽  
Saraji Wijesekara ◽  
Indira Wijesiriwardena
Keyword(s):  
Neonatal Sepsis ◽  
Cross Sectional Study ◽  
Reference Intervals ◽  
Full Blood Count ◽  
Cross Sectional ◽  
Granulocyte Count ◽  
Reactive Protein ◽  
Immature Granulocyte ◽  
Low Sensitivity

Abstract Background: The diagnosis of neonatal sepsis is challenging due to non-specific and subtle clinical features, low sensitivity and delay in routine laboratory tests. Current study was conducted to evaluate the role of manual immature/total (I/T) neutrophil ratio and automated immature granulocyte count (IGC) and immature granulocyte percentage (IG%) in the diagnosis of neonatal sepsis. Materials and Methods: An analytical cross-sectional study was done during a period of 6 months with a sample of 55 neonates admitted to Colombo South Teaching Hospital, Sri Lanka. A combination of clinical and laboratory parameters including full blood count, C-reactive protein and blood culture were used to identify the neonates with probable sepsis. The population was subcategorized into five (5) groups and manual immature/total neutrophil (I/T) ratio, immature granulocyte count (IGC) and immature granulocyte%(IG%) were done in each neonate. Results: The sensitivity of manual I/T ratio was 93.75% and negative predictive value (NPV) was 95.24%. The sensitivity for lower cut off values, IGC of 0.03x103/µL and IG% of 0.5% was 80% and 73.33% respectively. The NPV for above cut-off values were 25% and 0.5% respectively. The NPV was improved with higher cut-off values with 70.90% for IGC 0.3 and 70.59% for IG 3%, but sensitivity remained low with 40% and 33.33% respectively.Conclusion: Manual I/T ratio remains as a useful diagnostic tool in diagnosing and excluding neonatal sepsis with a very good sensitivity and NPV. However, further studies and well defined reference intervals are required in automated IGC and IG%.

Role of C-Reactive Protein for Late-Onset Neonatal Sepsis

2021 ◽  
Vol 175 (1) ◽  
pp. 101
Author(s):  
Brett Burstein ◽  
Marc Beltempo ◽  
Patricia S. Fontela
Keyword(s):  
Neonatal Sepsis ◽  
Late Onset ◽  
C Reactive Protein ◽  
Reactive Protein

scholarly journals Role of presepsin compared to C-reactive protein in sepsis diagnosis and prognostication

2017 ◽  
Vol 5 (1) ◽  
pp. 1-12 ◽  
Author(s):  
Mohamed El-Saied El-Shafie ◽  
Khaled M. Taema ◽  
Moataz M. El-Hallag ◽  
Abdallah Mohamed Abdallah Kandeel
Keyword(s):  
C Reactive Protein ◽  
Sepsis Diagnosis ◽  
Reactive Protein

scholarly journals Morphofunctional properties of platelets in patients with rheumatoid arthritis

2021 ◽  
pp. 55-61
Author(s):  
Z. V. Zubkova ◽  
I. A. Novikova
Keyword(s):  
Rheumatoid Arthritis ◽  
Platelet Count ◽  
Disease Activity ◽  
Peripheral Blood ◽  
Maximum Degree ◽  
Inflammatory Process ◽  
C Reactive Protein ◽  
Platelet Activity ◽  
Reactive Protein

Objective: to assess the morphofunctional properties of platelets in patients with rheumatoid arthritis (RA) in combination with other clinical and laboratory characteristics of the disease.Materials and methods. The parameters of platelet hemostasis were studied in 51 RA patients with varying degrees of disease activity according to the DAS28 index.Results. It has been found that the count of platelets in the peripheral blood and their aggregation properties depend on the indicators of the activity of the inflammatory process (degree of activity, ESR, level of C-reactive protein). Platelet indices (MPV, P-LCR, PDW) are interrelated with the relative counts of lymphocytes and segmented neutrophils in the peripheral blood. In RA patients who are seropositive for rheumatoid factor, its titer is associated with the morphofunctional properties of platelets (platelet count, MPV, maximum degree of aggregation in the ADP test).Conclusion. The role of platelets in the RA pathogenesis is not limited exclusively to the hemostatic function. The associations we identified between the platelet activity and the clinical and laboratory characteristics of the disease are indicative of their active participation in immunological processes.

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