scholarly journals The clinical and laboratory profile of dengue fever in a tertiary care hospital

2019 ◽  
Vol 6 (5) ◽  
pp. 1447
Author(s):  
Katari Sujitha ◽  
M. Dorasanamm ◽  
M. V. Nagabhushana
Keyword(s):  
Dengue Fever ◽  
Tertiary Care ◽  
Control Measures ◽  
Care Hospital ◽  
Monsoon Period ◽  
Laboratory Findings ◽  
Ns1 Antigen ◽  
Medical Wards ◽  
Considerable Morbidity ◽  
Atypical Presentations

Background: Dengue fever is one of the most common acute viral illness associated with considerable morbidity and mortality. Recently, there is an alarming rise of dengue in India. This study was undertaken to know the clinical profile and laboratory findings during the evolution of dengue fever.Methods: A total of 120 patients of dengue fever who were NS1 antigen or IgM dengue positive, admitted to medical wards of Narayana Medical College, Nellore included in the study. Thorough clinical examination and relevant laboratory investigations performed in all patientsResults: Males were commonly affected (72.4%). Fever was the most common presentation (100%), followed by headache (96%) myalgia (94%), abdominal pain (24.46%), and retro-orbital pain (12.45%). Malena was the most common hemorrhagic manifestation. Laboratory findings include varying degree of thrombocytopenia in all patients, leukocytopenia (30.52%), increased hematocrit (>45%) (67.59%) and deranged liver function test (58.33%)Conclusions: Early diagnosis, monitoring, and prompt supportive management can reduce mortality in dengue. Atypical presentations of dengue should be kept in mind, which may cause a delay in the diagnosis. Increased community awareness and vector control measures need to be strengthened during the peri-monsoon period to reduce the burden of dengue cases.

scholarly journals Clinico- Serological Profile and Geographical Distribution of Dengue Fever from a Tertiary Care Hospital, South India

2021 ◽  
Author(s):  
Morubagal Raghavendra Rao ◽  
Rashmi Padmanabha Mahale ◽  
Sowmya Shivappa ◽  
Vidyavathi B. Chitharagi ◽  
Ranjitha S. Gowda ◽  
...  
Keyword(s):  
Dengue Fever ◽  
Geographical Distribution ◽  
Urban Areas ◽  
Tertiary Care ◽  
Control Measures ◽  
Care Hospital ◽  
Ns1 Antigen ◽  
Different Seasons ◽  
The Common ◽  
Geographical Maps

Dengue fever is one of the common viral illnesses linked with significant morbidity and mortality. Of late, there is rapid increase in dengue cases in India. The present study aimed to known dengue seropositivity in different seasons of a year, other laboratory parameters and its geographical distribution. During the study period of 15 months 4172 patients hospitalized with probable dengue fever were included. Dengue serology was done for all cases by ELISA(J. Mitra & Co). Demographic details were taken to create geographical maps of the disease. Of the 4172 suspected dengue cases, 817 had confirmed dengue illness. Of these 817 cases, 584 showed Ns1 antigen (71.4%), 150 IgM antibody (18.3%), and 38 had both Ns1 and Ig M (4.6%). Platelet count less than 1,00,000 were seen in 566 (69.27%) patients. Dengue was noticeably more during monsoon time (June to September) of a year. Through geographical maps major clusters were noticed urban areas of Mysuru and Krishnaraja Nagara , while few clusters were also observed in Periyapatna and T Narsipura taluks of Mysuru district. To minimize the load of dengue cases and its death rate better community awareness and vector control measures need to be strengthened during monsoon especially in areas where burden of the disease is more. This study helps in early preparedness of the authorities concerned in controlling possible epidemics in future.

scholarly journals Clinicohaematological profile of dengue in children: a hospital based study

2017 ◽  
Vol 4 (4) ◽  
pp. 1340 ◽  
Author(s):  
Irshad Abdul Majeed ◽  
K. Shreedhara Avabratha ◽  
Lokesha R. Gowda ◽  
Sadia Syeda
Keyword(s):  
Dengue Fever ◽  
Early Recognition ◽  
Tertiary Care ◽  
Clinical Manifestations ◽  
Haematological Parameters ◽  
Severe Dengue ◽  
Clinical Feature ◽  
Igm Elisa ◽  
Ns1 Antigen ◽  
Atypical Presentations

Background: Dengue fever is one of the most common arbo virus mediated outbreaks, being reported from different parts of the world. Now as the outbreaks are hitting different geographic locations, different clinical manifestations are being reported recently. The aim of this study is to document varied clinical manifestations and haematological parameters of dengue patients in a tertiary care centre.Methods: A total 130 cases of any of NS1 antigen, IgM card test positive or IgM ELISA positive dengue patients were included in this observational study. Clinical and haematological parameters were noted and analysed statistically.Results: Most common clinical feature was fever (100%) followed by headache (51.5%). Atypical features like seizures due to encephalitis was seen in a child with dengue. Seizure were present in 1.5% of cases, two children died due to severe dengue with shock and multi organ failure. In our study 26.92% of patients had thrombocytopenia. The mean Hb was 12.86 g/dl and platelet count was 104202/mm3.Conclusions: Fever and headache are the main features of dengue. However, one should be aware of different atypical presentations of dengue fever to diagnose and intervene timely. Early recognition of complication and timely intervention are required in the management of dengue cases. 

scholarly journals CLINICAL AND HEMATOLOGICAL PROFILE OF PATIENTS WITH DENGUE FEVER AT A TERTIARY CARE HOSPITAL – AN OBSERVATIONAL STUDY

2018 ◽  
Vol 10 (1) ◽  
pp. e2018021 ◽  
Author(s):  
Vishal Vishnu Tewari ◽  
Kunal Tewari ◽  
Ritu Mehta
Keyword(s):  
Dengue Fever ◽  
Tertiary Care ◽  
Dengue Shock Syndrome ◽  
Hemorrhagic Fever ◽  
Annual Data ◽  
Care Hospital ◽  
Igg Antibody ◽  
Hematological Profile ◽  
Ns1 Antigen ◽  
Duration Of Hospitalization

AbstractBackground: Dengue is a major health issue with seasonal rise in dengue fever cases imposing an additional burden on hospitals, necessitating bolstering of services in the emergency department, laboratory with creation of additional dengue fever wards.Objectives: To study the clinical and hematological profile of dengue fever cases presenting to a hospital.Methods: Patients with fever and other signs of dengue with either positive NS1 antigen test or IgM or IgG antibody were included. Age, gender, clinical presentation, platelet count and hematocrit were noted and patients classified as dengue fever (DF), dengue hemorrhagic fever (DHF) or dengue shock syndrome (DSS). Duration of hospitalization, bleeding manifestations, requirement for platelet component support and mortality were recorded.Results: There were 443 adults and 57 children between 6 months to 77 year age. NS1 was positive in 115 patients (23%). Fever (99.8%) and severe bodyache (97.4%) were the commonest presentation. DF was seen in 484 (96.8 %), DHF in 10 (2%) and DSS in 6 cases (1.2%). OPD treatment was needed in 412 (82%) and hospitalization in 88 (18%). Intravenous fluid resuscitation was needed in 16 (3.2%) patients. Thrombocytopenia was seen in 335 (67%) patients at presentation. Platelet transfusion was needed in 46 (9.2%). PRC transfusion was given in 3 patients with DF and 10 of DHF. Death occurred in 03 DSS and 2 DHF patients. Conclusions: Majority of DF cases can be managed on OPD basis. DHF and DSS carry high mortality. Hospitals can analyze annual data for resource allocation for capacity expansion.

scholarly journals Clinico-epidemiological study of dengue cases in a tertiary care hospital, Guwahati, Assam, India

2017 ◽  
Vol 4 (6) ◽  
pp. 1605
Author(s):  
Lalit Mohan Bhardwaj ◽  
Swapnav Borthakur ◽  
Prabhas Chandra Bhattacharyya
Keyword(s):  
Dengue Fever ◽  
Large Scale ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Epidemiological Data ◽  
Care Hospital ◽  
Monsoon Period ◽  
Town Hospital ◽  
Male Preponderance ◽  
Government Level

Background: Dengue fever (DF) is a common mosquito borne disease caused by dengue virus and is transmitted by Aedes mosquito. It is one of the major public health problems in India. A large-scale outbreak of dengue fever occurred in 2016 involving several districts of Assam. Here we report our experience with Dengue cases. The present study was aimed to assess clinical and epidemiological aspects of dengue cases presenting in down town hospital, Guwahati, Assam.Methods: A record based retrospective study conducted in our centre. Total 880 fever cases, fulfilling WHO criteria for dengue suspicion were included in our study. Required data from the entire laboratory confirmed cases from 1st January to 31st December 2016 were collected from MRD (medical record department) and analysed. Epidemiological data were compared with previous year’s available data from 1st January to 31st December 2015.Results: The number of dengue cases in 2016 clearly outnumbered the dengue cases in past years. Most of the cases were in the age group 20-50 years with a male preponderance. The outbreak occurred during the months of August-November indicating increased vector transmission in the monsoon and post monsoon periods. Average days of hospital stay were 6 days.Conclusions: Measures can be taken both at personal and government level to reduce morbidity and mortality from dengue particularly during the monsoon period.  

scholarly journals Serological co-infection of dengue and COVID-19: case series in Bangladesh

2021 ◽  
Author(s):  
Tahmina Zahan ◽  
Morshed Nasir ◽  
Afzal Akhtar ◽  
A. F. M. Mohibur Rahman ◽  
Tanha E. Nahin
Keyword(s):  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Case Series ◽  
Health Concern ◽  
Care Hospital ◽  
Laboratory Findings ◽  
Ns1 Antigen ◽  
Serological Data ◽  
Antibody Tests ◽  
Positive Results

Parallel symptoms and laboratory findings between dengue and coronavirus disease 2019 (COVID-19) pretense a diagnostic contest in some dengue-endemic countries in Asia. In this study, we described ten cases of suspected COVID-19-dengue co-infection in a tertiary care hospital in Bangladesh. Serological data showed that patients with positive results for dengue virus (DENV) NS1 antigen and anti-dengue IgG and IgM were also reactive to COVID-19 rapid antibody tests, suggesting dengue with COVID-19 coinfection. The present study indicated a public health concern regarding COVID-19 and dengue detection in Bangladesh as well as in other dengue-endemic countries and it was important for these nations to manage both pathogens concurrently.

scholarly journals THE STUDY OF DETECTION OF DENGUE CASES BY NS1 ANTIGEN AND IGM ANTIBODY IN RIMS, ADILABAD, INDIA.

2019 ◽  
Vol 3 (11) ◽  
Author(s):  
Dr. Tanajee Zade ◽  
Dr. K. Srinivas ◽  
Dr. Akshay Berad
Keyword(s):  
Early Diagnosis ◽  
Dengue Fever ◽  
Dengue Infection ◽  
Tertiary Care ◽  
High Morbidity ◽  
Care Hospital ◽  
Serum Samples ◽  
Igg Antibody ◽  
Igm Antibody ◽  
Ns1 Antigen

Dengue fever is an acute febrile arboviral disease affecting tropical & subtropical regions of the world. Dengue infection produces a spectrum of clinical illness, ranging from an asymptomatic to its most severe form like dengue haemorrhagic fever and dengue shock syndrome. In view of high morbidity and mortality, it is imperative to have a rapid and sensitive laboratory assay for early detection of the dengue infection. The newer parameter NS1 antigen has gained a lot of interest for early diagnosis of the disease. Detection of non-structural antigen (NS1 Ag), IgM and IgG antibody may help in the early diagnosis. The present study was conducted in a RIMS Adilabad, tertiary care hospital & medical college in the Department of  General Medicine. A total of 100 serum samples were processed from suspected cases of dengue fever by using dengue test for detection of NS1 antigen and IgG antibodies. Platelet counts of all these cases were noted. . Of these 100 subjects 85 were serologically proved to have dengue illness, 57 patients were NS1 antigen positive, 28 patients were IgM antibody positive patients. As the NS1 antigen is detectable in blood from day one after onset of fever, its assay is an effective tool for early diagnosis of dengue infection so as to avoid complications. Key words:  Dengue, NS1 Antigen, IgM antibody, Platelet

scholarly journals Clinical and laboratory profile of dengue fever in hospitalized children among South Indian population

2018 ◽  
Vol 5 (6) ◽  
pp. 2258
Author(s):  
Raghava Badabagni ◽  
Rajesh Kumar Sethi
Keyword(s):  
Pleural Effusion ◽  
Dengue Fever ◽  
Tertiary Care ◽  
Common Symptom ◽  
South Indian Population ◽  
Care Hospital ◽  
Male Predominance ◽  
South Indian ◽  
Ns1 Antigen ◽  
Laboratory Profile

Background: Dengue fever is currently regarded globally as one of the most important mosquito-borne viral diseases. Children suffering from dengue fever shows a large variation in clinical features and laboratory parameters.   This study was focused to evaluate the clinical presentation, associated laboratory and radiological profiles that may be useful to diagnose dengue fever.Methods: Prospective observational study including 500 children with serological positive dengue fever admitted in a tertiary care hospital in South India.Results: In this study mean age of presentation of children with dengue fever was 8.4±1.2 years with male predominance. The incidence of children presenting with DF, DHF and DSS was 61%, 23% and 16% respectively. The most common symptom was fever in 100% patients followed by vomiting in 69%, abdominal pain in 64.2%, bleeding manifestations in 43% and periorbital pain in 28.8% of patients. The NS1 was positive in 39.2% cases, dengue IgM in 29% of cases and IgG positive in 30.4% cases. By ultrasonography it was observed that 34% of patients had ascites, 28% with pericholecystic edema, 12% with bilateral pleural effusion, 10% with right sided Pleural effusion and hepatomegaly and 5% with splenomegaly. The most common cause of death was cardiorespiratory arrest secondary to DIC.Conclusions: Detection of Ns1 antigen to diagnose dengue is proposed to be superior when compared to antibodies detection. It is also concluded that diagnosis of dengue should be made comprehensively by clinical examination with supporting laboratory and radiological investigations.

scholarly journals Clinical profile and outcomes of dengue fever during monsoon season at a tertiary care hospital in South India

2021 ◽  
Author(s):  
Santosh R. Goudar ◽  
Heshweaanth R. D. ◽  
Jobin Mathew ◽  
Vipul Agarwal ◽  
Rohith George
Keyword(s):  
Dengue Fever ◽  
Monsoon Season ◽  
Public Awareness ◽  
Bladder Wall ◽  
Tertiary Care ◽  
Warning Signs ◽  
Control Measures ◽  
Care Hospital ◽  
Age Group ◽  
Female Ratio

Background: Dengue is a mosquito-borne infectious disease of the tropical and subtropical countries which is rapidly becoming a global burden. It is caused by any of the four serotypes of dengue virus. Dengue disease presentation varies from mild fever with myalgia and fatigability to severe conditions of dengue haemorrhagic fever and shock syndrome. This study describes the clinical features, laboratory parameters and outcomes of the dengue fever patients during the monsoon season in a tertiary care hospital.Methods: This is retrospective, single centre study carried out at Yenepoya medical college and hospital (YMCH), Mangalore a coastal town in southern India. All patients who were adults (aged>16 years), positive for rapid (NS1 antigen) test or dengue IgM Elisa and admitted from 1-5-2019 to 31-9-2019 (monsoon season) were included in this study. Data was collected from the medical records of YMCH.Results: The male to female ratio of patients in this study was about 4:1. About 70.1% belonged to the age group between 16-35 years. The predominant symptoms on admission were fever, headache, myalgia, nausea and vomiting, abdominal pain, loose stools, bleeding manifestations and skin rashes. Average days of hospitalization are 5.88 days (SD 2.94). Thrombocytopenia leukopenia raised hematocrit and transaminases are the commonly observed laboratory findings. Ascites, pleural effusion, gall bladder wall edema, sepsis, bradycardia, hypotension, ARDS, and acute kidney injury are the complications observed during the illness. Mortality rate in this study is 1.9%.Conclusions: As seen in this study dengue fever is predominantly affecting the younger age group. The early confirmation of diagnosis, identifying the warning signs and prompt supportive management will help in preventing the further complications and in reducing the mortality. Increased public awareness and vector control measures are important factors to be taken into consideration in the prevention of dengue.

scholarly journals A study of trend of incidence of dengue cases attending a tertiary care hospital in urban Maharashtra

2020 ◽  
Vol 7 (8) ◽  
pp. 3218
Author(s):  
Prerna Shankar ◽  
Anand Nair
Keyword(s):  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Control Measures ◽  
Care Hospital ◽  
Monsoon Period ◽  
Factors Associated ◽  
Retrospective Data Analysis ◽  
Average Rainfall ◽  
Average Monthly Rainfall ◽  
Public Health Challenge

Background: Presently, dengue is one of the most important mosquito-borne viral diseases in the world. The burden of the disease has drastically risen over the years with over 70% contributed by the Asia region. India is endemic to the disease and all four serotypes of the virus have been isolated from the country. This study aimed to describe the trends of incidence of dengue cases at a tertiary care hospital in urban Maharashtra.Methods: Retrospective data analysis with respect to admitted dengue cases in the preceding five years was carried out from the records available at the hospital. Year-wise trend as well as correlation with average monthly rainfall were also analysed.Results: The number of admitted cases of dengue showed a rising trend which was statistically significant. The study brought forth a change in the seasonality of occurrence of cases. The number of cases also showed a positive and statistically significant correlation with the monthly average rainfall in the Madhya Maharashtra region.Conclusions: There is evidence for an increase in the burden of dengue. With the overall number, there is also change in seasonality of the disease, indicating a requirement of control measures to be instituted earlier than the usual pre-monsoon period. The rising burden will pose a public health challenge and requires tailormade remedial activities taking into consideration various factors associated.

scholarly journals Study of clinical and laboratory profile of dengue fever in a tertiary care hospital

2020 ◽  
Vol 7 (2) ◽  
pp. 222
Author(s):  
Sangram S. Mangudkar ◽  
Sachin K. Shivnitwar ◽  
Atiullah I. Malik
Keyword(s):  
Dengue Fever ◽  
Biochemical Parameters ◽  
Tertiary Care Hospital ◽  
Dengue Infection ◽  
Tertiary Care ◽  
Care Hospital ◽  
Conjunctival Injection ◽  
Structural Protein ◽  
Considerable Morbidity ◽  
Morbilliform Rash

Background: Dengue fever is one of the most common arboviral mediated outbreaks reported with increased prevalence over the last few years with considerable morbidity and mortality. This study was designed to study the clinical and biochemical parameters in dengue fever patients.Methods: Prospective observational study was undertaken among adult patients in a tertiary care hospital. fifty patients were studied and analysed. All patients who were NS1 (Non-Structural Protein 1) antigen or IgM dengue positive were included in the study. Clinical features, haematological and biochemical parameters were noted.Results: Of the 50 patients studied, majority were males (68%). Fever was the major symptom (100%) followed by Body ache (84%), Headache (64%), Retro-orbital pain (52%), Myalgia (48%), conjunctival injection (40%), Itching (40%), abdominal pain (36%), Bradycardia (34%), Rash (30%), pleural effusion and ascites both seen in (28%). Significant derangements in platelet (76%), leucocyte counts (84%) and serum transaminases (58%) were noted.Conclusions: Fever associated with headache, retroorbital pain, erythematous morbilliform rash, conjunctival injection and itching over palms and soles along with thrombocytopenia, leukopenia, elevated liver transaminases should prompt a clinician on the possibility of dengue infection. Platelet transfusions have little role in management of dengue patients unless patients having active bleeding secondary to thrombocytopenia due to dengue fever.

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