The factors associated with co-trimoxazole hypersensitivity in people living with HIV/AIDS: a retrospective study

Background: Antibiotic adverse drug reactions (ADRs) can occurred during any treatment of infection, especially opportunistic infections in people living with HIV/AIDS (PLWHA). Co-trimoxazole is a sulfonamide fixed dose combination antibiotic, consisted of sulfamethoxazole and trimethoprim which is effective in treatment of several infections and for prophylaxis of pneumocystis jiroveci pneumonia. The universal use of co-trimoxazole for prophylaxis has been shown to decrease hospitalizations, morbidity and mortality among PLWHA, but potentially associated with ADRs include drug hypersensitivity reaction. The objective was to identify factors associated with co-trimoxazole hypersensitivity in PLWHA.Methods: A retrospective study were enrolled 404 participants PLWHA who were received co-trimoxazole due to co-trimoxazole prophylaxis therapy (CPT), between January 2015–December 2018. The independence variables such as age, sex, history of allergy, hypersensitivity reactions, duration of therapy (days), CD4 (cells/µl) and opportunistic infection to co-trimoxazole hypersensitivity reaction were analyzed using spearman test.Results: Mostly of the participants was male: 253 (62.60%). Eighteen (4.50%) with history of allergy, 64 (15.90%) were known co-trimoxazole hypersensitivity reaction. The most frequent clinical manifestation was maculopapular rash: 27 (42.3%), followed by urticaria alone: 17 (26.3%), fixed drug eruption: 12 (19.6%), and angioedema with or without urticaria: 8 (11.8%). The history of allergy, opportunistic infection and duration of treatment were associated factors to co-trimoxazole hypersensitivity reaction.Conclusions: This study was identified, that history of allergy, duration of treatment and opportunistic infection were factors associated with co-trimoxazole hypersensitivity in PLWHA.

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Prevalence of Depression in People Living with HIV/AIDS Undergoing ART and Factors Associated with it

JOURNAL FOR CLINICAL AND DIAGNOSTIC RESEARCH ◽

10.7860/jcdr/2014/7725.4927 ◽

2014 ◽

Cited By ~ 8

Author(s):

M.S. Bhatia

Keyword(s):

People Living With Hiv ◽

Factors Associated ◽

Prevalence Of Depression ◽

Living With Hiv ◽

Hiv Aids

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Spectrum of opportunistic infections and associated factors among people living with HIV/AIDS in the era of highly active anti-retroviral treatment in Dawro Zone hospital: a retrospective study

BMC Research Notes ◽

10.1186/s13104-018-3707-9 ◽

2018 ◽

Vol 11 (1) ◽

Cited By ~ 2

Author(s):

Fithamlak Bistegen Solomon ◽

Banchalem Nega Angore ◽

Hailu Chare Koyra ◽

Efrata Girma Tufa ◽

Tezera Moshago Berheto ◽

...

Keyword(s):

Retrospective Study ◽

Associated Factors ◽

Opportunistic Infections ◽

People Living With Hiv ◽

Highly Active ◽

Living With Hiv ◽

Hiv Aids

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Risk factors associated with Tuberculosis (TB) among people living with HIV/AIDS: A pair-matched case-control study in Guangxi, China

PLoS ONE ◽

10.1371/journal.pone.0173976 ◽

2017 ◽

Vol 12 (3) ◽

pp. e0173976 ◽

Cited By ~ 6

Author(s):

Zhezhe Cui ◽

Mei Lin ◽

Shaofa Nie ◽

Rushu Lan

Keyword(s):

Risk Factors ◽

Case Control Study ◽

Case Control ◽

People Living With Hiv ◽

Factors Associated ◽

Matched Case ◽

Living With Hiv ◽

Matched Case Control Study ◽

Control Study ◽

Hiv Aids

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STUDI RETROSPEKTIF KETAHANAN HIDUP ORANG DENGAN INFEKSI HIV/AIDS (ODHA) DI RSUD DR. ACHMAD MOCHTAR BUKITTINGGI

Human Care Journal ◽

10.32883/hcj.v3i3.89 ◽

2019 ◽

Vol 3 (3) ◽

pp. 175

Author(s):

Sukarsi Rusti

Keyword(s):

Opportunistic Infection ◽

Opportunistic Infections ◽

Analysis Data ◽

P Value ◽

People Living With Hiv ◽

Chi Square ◽

The People ◽

Living With Hiv ◽

Hiv Aids

HIV/AIDS disease is a health problem in indonesia. The problem cause of the number of morbility and mortality that still hight. It is cause of long term infection, adherance consuming the drungs and opportunistic that can deastroy the imun system of People Living With HIV/AIDS (PLHIV). The purpose of this research is to identify the factors related to the people living with PLHIV in Achmad Muchtar Hospital Bukittinggi2016.This research was conducted by a retrospective cohort design approach, doing research of the death of people who living with HIV by observing the patient’s medical record from 2014-2015. The research of study were 215 patient’s who is criteria inclusion. Analysis data using test chi-square. who became the independent variable is long infection, adherance comsuming the Anti Retroviral (ARV) , and opportunistic infection and dependent variable that survive the HIV people life.The research showed that among 215 patients with the number of deaths 39 people ( 18,% ), stages 3 and 4 (>5 th) is 89 people ( 41.4% ), not adherence is 77 people ( 35.8% ), and who suffered an opportunistic infection were 61 people (28.4% ). The statistical test relationships survival of people living with HIV with long-term infection obtained p value = 0,000 and RR = 0,019 ( confidence interfal 95 % with alpha = 0.05 ), adherance comsuming the ARV obtained p value = 0,000 and RR = 0,494 ( confidence interfal 95 % with alpha = 0.05 ), infection opportunistic obtained p value = 0,000 and RR = 0,361 ( confidence interfal 95 % with αlpha = 0.05 ).From these findings, it can be concluded that the long-term infection, adherence ARV and opportunistic infections associated with survival of people living with HIV. Of the three variables obtained interrelated and value the highest association is long-term infection.

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Factors Associated with Religious Congregation Members’ Support to People Living with HIV/AIDS in Kumasi, Ghana

AIDS and Behavior ◽

10.1007/s10461-006-9191-6 ◽

2007 ◽

Vol 11 (6) ◽

pp. 936-945 ◽

Cited By ~ 16

Author(s):

Eva S. Bazant ◽

Marc Boulay

Keyword(s):

People Living With Hiv ◽

Religious Congregation ◽

Factors Associated ◽

Congregation Members ◽

Living With Hiv ◽

Hiv Aids

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Undernutrition and associated factors among HIV-Infected adults receiving ART at Health centers, Lega Tafo and Surrounding, Ethiopia, 2021

10.21203/rs.3.rs-850430/v1 ◽

2021 ◽

Author(s):

Lelisa Worku Belcha

Keyword(s):

Opportunistic Infection ◽

Associated Factors ◽

Dietary Diversity ◽

Simple Random Sampling ◽

Household Food Security ◽

People Living With Hiv ◽

Cross Sectional ◽

Household Food ◽

Living With Hiv ◽

Hiv Aids

Abstract Background: Globally 38 million people were living with HIV in 2019. In Africa, 25 million people are living with HIV/AIDS undernutrition and food insecurity is endemic. Hence the study aimed to assess the magnitude of undernutrition and associated factors among HIV-infected adults receiving ART. Methods: Institutional based cross-sectional study was conducted among HIV/AIDS patients who following the ART service was selected by a simple random sampling method. The data were collected by direct interview, using a structured questionnaire. Descriptive statistics and a Logistic regression model were employed. Result: The study revealed that the magnitude of under-nutrition was 18.8%. The history of opportunistic infection (AOR=4.518:95% CI: 2.304-8.857), Patients taking ART for less than one year (AOR=3.675:95% CI: 1.831-7.377) household food insecure (AOR= 3.113:95% CI: 1.628-5.950) and dietary diversity score (AOR=2.340:95% CI: 1.221-4.485) were found to have a statistically significant association with undernutrition. Conclusion: The magnitude of undernutrition among people living with HIV/AIDS was found to be high. Having an opportunistic infection, duration of taking ART treatment, household food security status, and dietary diversity status were found to statistically significant association with undernutrition.

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Prevalence and socioeconomic factors associated with smoking in people living with HIV by sex, in Recife, Brazil

Revista Brasileira de Epidemiologia ◽

10.1590/s1415-790x2013000200018 ◽

2013 ◽

Vol 16 (2) ◽

pp. 432-443 ◽

Cited By ~ 11

Author(s):

Joanna d’Arc Lyra Batista ◽

Maria de Fátima Pessoa Militão de Albuquerque ◽

Ricardo Arraes de Alencar Ximenes ◽

Demócrito de Barros Miranda-Filho ◽

Heloisa Ramos Lacerda de Melo ◽

...

Keyword(s):

Smoking Cessation ◽

Socioeconomic Factors ◽

Low Income ◽

People Living With Hiv ◽

Cross Sectional ◽

Heavy Alcohol ◽

Factors Associated ◽

Risk Of Death ◽

Living With Hiv ◽

Hiv Aids

Introduction: Smoking is the leading cause of preventable death in the world. The prevalence of smoking is higher in people infected with HIV than in the general population. Although it is biologically plausible that smoking increases the morbidity and mortality of people living with HIV/AIDS, few studies in developing countries have analyzed the determinants and consequences of smoking in HIV infected people. Objective: To estimate the prevalence of smoking and identify the socioeconomic factors associated with smoking and smoking cessation in patients with HIV by sex. Methods: A cross-sectional study was conducted with baseline data, obtained from an ongoing prospective cohort study of patients with HIV attending two referral centers in Recife, Northeast Region of Brazil, between July 2007 and October 2009. Results: The prevalence of current smoking was 28.9%. For both sexes, smoking was independently associated with heavy alcohol drinking and marijuana use. Among women, smoking was associated with living alone, not being married and illiteracy; and among men, being 40 years or older, low income and using crack. Compared with ex-smokers, current smokers were younger and more likely to be unmarried, heavy drinkers and marijuana users. Conclusions: It is important to incorporate smoking cessation interventions for the treatment of heavy alcohol drinkers and marijuana users with HIV/AIDS, which may increase life expectancy and quality of life, as smoking is related to risk of death, relapse of tuberculosis, and non communicable diseases.

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