scholarly journals Assessment of urinary interleukin-18 in the early post-burn period to predict acute kidney injury of various degrees of burn patients

2022 ◽  
Author(s):  
Sharif Qamar Uddin ◽  
M. Nazrul Islam ◽  
M. Nizamuddin Chowdhury ◽  
Nizam Uddin Ahmed Chowdhury ◽  
Mohammad Zahir Uddin ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Predictive Value ◽  
Kidney Injury ◽  
Study Data ◽  
Burn Patients ◽  
Interleukin 18 ◽  
College Hospital ◽  
Female Ratio ◽  
Medical College ◽  
Sensitivity Specificity

Background: Early detection of acute kidney injury (AKI) in burn-injured patients can help modify the treatment to prevent progression of acute renal failure and reduce the need for renal replacement therapy. The aim of the study was to evaluate urinary interleukin-18 in the early post-burn period to predict the AKI for the various degrees of burn patients.Methods: This prospective observational study was conducted in the department of nephrology, Dhaka medical college in collaboration with burn and plastic surgery unit of the same medical college hospital, from July 2017 to June 2018 for a period of one year. The 48 burn patients (Age>18 years) who attended in the burn unit of Dhaka medical college, Dhaka of both sexes were enrolled in this study. Data were analyzed by using SPSS 22.0. A value of p<0.05 was considered statistically significant for all tests.Results: In this study, mean age of the burn patients was 32.41±10.59 years. Male female ratio was 3.36:1. Urinary IL-18 in diagnosis of AKI showed accuracy, sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) were 93.8%, 91.7%, 94.4%, 84.6% and 97.1% respectively. AUC for urinary IL-18 at admission was 0.968 (CI, 0.921-1.000) and AUC for serum creatinine at admission was 0.937 (CI, 0.871-1.000). Conclusions: According to Kappa value, AUC and sensitivity and specificity urinary IL-18 is a good biomarker in predicting of early AKI in burn patients.

scholarly journals Acute Kidney Injury in Patients of Intensive Care Unit

2017 ◽  
Vol 8 (1) ◽  
pp. 38-44
Author(s):  
Nazneen Mahmood ◽  
Md Fazlur Rahman ◽  
Md Mostafizur Rahman ◽  
SM Hossain Shahid ◽  
Md Mahmudur Ahman Siddiqui
Keyword(s):  
Intensive Care Unit ◽  
Acute Kidney Injury ◽  
Intensive Care ◽  
Kidney Injury ◽  
Type I ◽  
College Hospital ◽  
Cross Sectional ◽  
Female Ratio ◽  
Failure Group ◽  
Medical College

Background: Acute Kidney Injury (AKI) is a common complication in patients admitted to the intensive care unit (ICU) and numerous causes are responsible for its development. The aim of the present study is to assess the incidence, risk factors, and outcome of patients who develop AKI in our ICU.Methodology: This study was conducted by the Department of Nephrology, Anwer Khan Modern Medical College Hospital (AKMMCH), a tertiary level center of Dhaka, during the period of January 2015 to December 2015. This is a Cross Sectional Descriptive type of Observational study on patients of Acute Kidney Injury (AKI) admitted to Intensive Care Unit (ICU) of AKMMCH.Result: A total number of 271 patients were admitted. Out of 271 patients, 59 (21.77%) patients with AKI who met our study requirements were included in the study and were evaluated. Among 59 patients 32 (54.23%) were males and 27 (45.77%) were females, with a male to female ratio of 1.19:1. The cause of admission were Diabetes mellitus with complication 11 (18.64%), Hepato-renal syndrome 10 (16.94%), Malignancy 7 (11.86%), Septicaemia 6 (10.18% ), Pneumonia 6 (10.18%), Intra-uterine death (IUD) 5 (8.48%) and others (Acute Myocardial Infarction, Non ST segment Elevated MI, Cerebro Vascular Disease, Gullain Burre Syndrome, Laparatomy, Type I and Type II Respiratory failure) 14 (23.72%). According to RIFLE's criteria most of the patients were from Injury group 32 (54.23%). Next to this, was Risk group 17 (28.83%) and in Failure, Loss and ESRD group were 7 (11.86%), 1(1.69%) and 2 (3.39%) accordingly. Regarding biochemical abnormality, mean Serum creatinine was 3.68 ± 2.15 and that of Urine output, HbA1C and HCO3 level ( in ABG ) were 4.57 ± 8.89, 6.91±1.4 and 17.14 ± 3.8 respectively. Out of 59 patients 10 (16.95%) needed Haemodialysis. According to RIFLE's criteria 7 (70%) were from Failure group, 1 patient from Loss group and 2 from ESRD group who received haemodialysis. 72.88% (43) patients improved, out of which 57.62% (34) got discharged from ICU after full recovery. 6.48% (4) patients expired and 3.38% (2) turned into ESRD and advised for regular haemodialysis.Conclusion: The incidence of AKI is high in patients admitted to ICU, and the development of AKI is associated with poor outcome and reduced survival. AKI significantly increases the duration of ICU stay, and this is likely to add to the healthcare burden. Age, gender or the presence of comorbidities do not appear to influence the incidence of AKI in our ICU patients.Anwer Khan Modern Medical College Journal Vol. 8, No. 1: Jan 2017, P 38-44

scholarly journals Predictive value of urine interleukin-18 in the evolution and outcome of acute kidney injury in critically ill adult patients

2015 ◽  
Vol 114 (3) ◽  
pp. 460-468 ◽  
Author(s):  
S. Nisula ◽  
R. Yang ◽  
M. Poukkanen ◽  
S.T. Vaara ◽  
K.M. Kaukonen ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Critically Ill ◽  
Predictive Value ◽  
Kidney Injury ◽  
Adult Patients ◽  
Interleukin 18

scholarly journals Acute Kidney Injury due to Rhabdomyolysis

2016 ◽  
Vol 11 (1) ◽  
pp. 93-95
Author(s):  
Tania Mahbub ◽  
Ferdous Jahan ◽  
Dewan Masudul Haque ◽  
Md Nizam Uddin Chowdhury
Keyword(s):  
Acute Kidney Injury ◽  
Muscle Injury ◽  
Kidney Injury ◽  
Armed Forces ◽  
Clinical Syndrome ◽  
College Hospital ◽  
Medical College ◽  
High Rise ◽  
Dark Colour ◽  
Common Clinical Presentation

Rhabdomyolysis was first described as crush syndrome, during the London blitz of world war-ll. lt is a common clinical syndrome resulting from muscle injury there after release of toxic cellular component especially myoglobin. Muscle injury may results from a variety of causes. Most common clinical presentation of rhabdomyolysis is triad of myalgia, weakness and dark colour urine. But presentation may be varied. Very often it causes acute kidney injury and demands renal replacement therapy. Acute Renal Failure (ARF) is usually associated with very high rise of Creatinine Kinase(CK) >10,000 u/L1. In this series, there are few cases with rhabdomyolysis who were admitted and treated in Dhaka Medical College Hospital (DMCH) during July 2010 to April 2011. These cases of rhabdomyolysis normally developed acute kidney injury who were managed with dialysis support.Journal of Armed Forces Medical College Bangladesh Vol.11(1) 2015: 93-95

scholarly journals A study of incidence and outcome of acute kidney injury in common undifferentiated febrile illnesses

2020 ◽  
Vol 8 (2) ◽  
pp. 497
Author(s):  
Jacob Cherian ◽  
Divya Deodhar
Keyword(s):  
Acute Kidney Injury ◽  
Kidney Injury ◽  
Febrile Illness ◽  
Risk Category ◽  
Acute Febrile Illness ◽  
Female Ratio ◽  
Delay In Diagnosis ◽  
Medical College ◽  
Injury Category ◽  
One Year

Background: Patients presenting with acute undifferentiated febrile illness may have delay in diagnosis due to nonspecific symptoms and signs. Kidney injury in these patients can cause detrimental effect on their prognosis and hence early diagnosis is warranted.Methods: This is an observational prospective study conducted in the Department of Medicine at Christian Medical College and Hospital, Ludhiana for a period of one year from 1st November 2014 till 31st October 2015.Results: Among the 532 patients acute febrile illness included in the study, 437(82.1%) were diagnosed with dengue fever. A total of 190(35.7%) patients were diagnosed to have AKI. The incidence of AKI in specific diseases was found to be the highest in Malaria 8(61.5%) out of 13 patients). In AKI, majority of them were in the risk category with 97(51.0%). A total of 26(13.6%) patients with AKI required Hemodialysis. Among the 190 patients who had AKI 43(22.6%) died.Conclusions: Dengue was the most common acute febrile illness. Among the patients with acute kidney injury majority were in the risk category with 97(18.2%). 326(61.2%) patients were males with a male to female ratio was found to be 1.5: 1. Dengue with acute kidney injury had the most proportion of patients in the risk and injury category and malaria with acute kidney injury having the highest proportion in failure category. The highest incidence of patients with AKI requiring hemodialysis was seen in scrub typhus. Leptospirosis with AKI had the highest proportion of mortality. The failure category had the highest proportion of mortality. 

scholarly journals Ultrasonographic Evaluation of Hepatic Metastases of Malignant Diseases with Cytopathological Correlation

2015 ◽  
Vol 23 (2) ◽  
pp. 239-244 ◽  
Author(s):  
Farhana Sultana ◽  
Salahuddin Al Azad ◽  
Asifa Sattar ◽  
Mohammed Zaid Hossain ◽  
Zereen Sultana Deepa ◽  
...  
Keyword(s):  
Hepatic Metastasis ◽  
Predictive Value ◽  
Abdominal Mass ◽  
Hepatic Metastases ◽  
Metastatic Lesion ◽  
Common Symptom ◽  
College Hospital ◽  
Female Ratio ◽  
Medical College ◽  
Imaging Department

Objective: A prospective study was carried out to evaluate the role of ultrasonography in the diagnosis of hepatic metastasis and also to preoperative determination of hepatic metastasis and its validity in diagnostic process.Methods: A total of 52 patients having hepatic metastasis were enrolled in this study taken from Department of Hepatology of two tertiary level medical institutions. After sonographic evaluation of the metastatic lesion, cytopathology was done in all these patients. With written informed consent they were taken care of from the admission up to diagnosis of the hepatic metastasis, and subsequent management in hepatology unit.Place and period of study: Department of Radiology & Imaging, Department of Pathology and Department of Hepatology of Bangabandhu Sheikh Mujib Medical University (BSMMU) Hospital and of Dhaka Medical College Hospital (DMCH), during the period between July 2006 and June 2007.Results: The mean age of the patients was 51.20±11.9 years, ranging from 21 to 69 years. The highest incidence was in 60-69 years age group. The male and female ratio was 3.7:1. The most common symptom was pain with upper abdominal mass (73.1%), and others were anorexia and nausea with weight loss (67.3%), jaundice (28.8%) and ascites (23.1%). Only the right lobe of the liver was involved in 51.9% cases, left lobe in 28.8% and in 19.2% both lobes of the liver were affected. Hepatic metastasis was found as unifocal lesion in 7.7% and multifocal lesions in 92.3% cases. The echopattern was found 57.7% hyperechoic, 28.8% hypoechoic, and rest 13.5% mixed pattern. All cases were metastasis in sonography findings whereas 90.4% cases were metastasis and 9.6% other lesions in cytopathological findings. The validity of ultrasonography were determined by calculating sensitivity, specificity, accuracy, positive predictive value and negative predictive value which were 93.6%, 80.0%, 92.3%, 97.8% and 57.1% respectively.J Dhaka Medical College, Vol. 23, No.2, October, 2014, Page 239-244

scholarly journals Sensitivity and Spesificity of Interleukin 18 as Biomarker for Acute Kidney Injury

2018 ◽  
Vol 2 (4) ◽  
pp. 20-29
Author(s):  
Febri Jaya Gunawan ◽  
F Heru Irwanto ◽  
Andi Miarta ◽  
Theodorus Theodorus
Keyword(s):  
Acute Kidney Injury ◽  
Predictive Value ◽  
Kidney Injury ◽  
Inclusion Criteria ◽  
Interleukin 18 ◽  
Urine Level ◽  
Urine Examination ◽  
Early Biomarker ◽  
Process Studies ◽  
The Subject

Background : Incidence of AKI in intensive care unit patients reach 60-70%, and the mortality rate is about 60%.  IL-18 is a pro-inflammatory cytokine which increased in endogenous inflammation process. Studies in human showed that IL-18 concentration increased prior to AKI. Objective : The aims of this research is to determine the sensitivity and specificity of Interleukin-18 urine examination as an early biomarker for acute kidney injury. Methods : There’re total of 66 subjects who met the inclusion criteria. All the subject were checked for the IL-18 urine level with Cloud Clone kit and creatinine serum were also checked 48 hours after admission. Results :The results showed in the cut-off point of 411.25 Pg/mL , urine IL-18 has a sensitivity of 54.3 % and specificity 83.9%, positive predictive value 79.17%, negative predictive value 61.9% and accuracy of 68.18% Conclusions : Our result suggest that IL-18 urine holds a promise as an early biomarker of AKI and more sensitive and specific as an early biomarker for AKI compared to creatinine serum. Key words : Acute Kidney Injury, Interleukin-18, sensitivity, spesificity

scholarly journals Acute kidney injury is a common complication after acute stroke in Mymensingh Medical College Hospital

2016 ◽  
Vol 44 (2) ◽  
pp. 82-86
Author(s):  
Nitai Chandra Ray ◽  
Md Ayub Ali Chowdhury ◽  
Ashutosh Saha Roy ◽  
Md Abdul Muqueet ◽  
Binoy Paul ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Acute Stroke ◽  
Kidney Injury ◽  
Developed Countries ◽  
Common Complication ◽  
Stroke Patients ◽  
College Hospital ◽  
Cross Sectional ◽  
Medical College ◽  
Significant Burden

Stroke represents a continuously evolving medical and social problem, being the third leading cause of death after heart disease and cancer in developed countries. Acute kidney injury (AKI) may develop as a possible complication after acute stroke. Insufficient care of acute stroke patients is an important factor behind it. It may be associated with a significant burden of morbidity and mortality. This cross sectional observational study was conducted in Mymensingh Medical College & Hospital, Mymensingh from July 2012 to June 2014. A total of 240 patients with newly detected acute stroke confirmed by CT scan of brain were included in this study. According to this study, 15.42% of acute stroke patients developed AKI. Majority (54.05%) of the AKI patients were in >60 years age group. 17.93 % of male patients developed AKI and 11.58% of female patients developed AKI. So, AKI was a common complication after acute stroke. Early diagnosis and management of AKI may be an important part of management of these stroke patients.Bangladesh Med J. 2015 May; 44 (2): 82-86

scholarly journals Postpartum Acute Kidney Injury - a Study at Faridpur Medical College Hospital

2021 ◽  
Vol 15 (2) ◽  
pp. 62-64
Author(s):  
Swapan Kumar Mondal ◽  
Ananta Kumar Biswas ◽  
Swapna Biswas Joy ◽  
MM Shahin Ul Islam ◽  
Bablu Kumar Pal ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Laboratory Data ◽  
Kidney Injury ◽  
Developed Countries ◽  
Medical College Hospital ◽  
Contributing Factors ◽  
College Hospital ◽  
Timely Initiation ◽  
Mortality And Morbidity ◽  
Medical College

Postpartum Acute Kidney Injury (AKI) is one of the serious complications of pregnancy and is associated with high mortality and morbidity. Although Postpartum AKI has decreased markedly in developed countries in the last 50 years, but it is a challenging health problem in pregnant women, specially in the developing countries like Bangladesh. Aim of this study was to determine the contributing factors and outcome of postpartum AKI. This observational study was conducted in the department of nephrology, Faridpur Medical College Hospital from January 2018 to December 2019. During that study period thirty two patients with postpartum AKI were admitted in the above mentioned department. Demographic, clinical and laboratory data of those patients were recorded. Mean age of patients was 25.3 ± 4.2 years, and the 72% patients underwent cesarean section. Oliguria was the main presentation (91%). Puerperal sepsis (38%), postpartum hemorrhage (22%), and Eclampsia (16%) were the common contributing factors. Hemodialysis was required for most of the patients (75%). Therefore early diagnosis, identification and treatment of cause, timely initiation of renal replacement therapy is mandatory. Faridpur Med. Coll. J. 2020;15(2): 62-64

Predictive Value of Urine Interleukin-18 in the Evolution and Outcome of Acute Kidney Injury in Critically Ill Adult Patients

2015 ◽  
Vol 59 (6) ◽  
pp. 256-257 ◽  
Author(s):  
S. Nisula ◽  
R. Yang ◽  
M. Poukkanen ◽  
S. T. Vaara ◽  
K. M. Kakounen ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Critically Ill ◽  
Predictive Value ◽  
Kidney Injury ◽  
Adult Patients ◽  
Interleukin 18
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