scholarly journals A study on the prevalence of chronic obstructive pulmonary disease among adults in Madurai, Tamil Nadu

2017 ◽  
Vol 4 (11) ◽  
pp. 4113
Author(s):  
Mohamed Saleem ◽  
Sivasubramanian Priya ◽  
Manimaran Pradeep ◽  
Kalifulla Sabeetha
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Tamil Nadu ◽  
Population Sample ◽  
Public Health Problem ◽  
Chronic Obstructive ◽  
Cluster Sampling ◽  
Major Public Health Problem ◽  
Obstructive Pulmonary Disease ◽  
Study Population

Background: Chronic obstructive pulmonary disease (COPD) is a major public health problem with increasing prevalence especially in developing countries. Burden of disease estimation is important for decision making, planning, prioritising and allocating funds. It has been found that the recent data on prevalence of COPD is less in south India, especially Tamil Nadu. Hence this study was undertaken in order to estimate the prevalence of COPD in Madurai among adults and its association with socio demographic variables. Methods: This is a community based cross-sectional study done in Kallendiri block of Madurai district with adults aged >30 years of both the sexes as study population. Sample size was 480. Using cluster sampling method, study participants were interviewed with semi-structured questionnaire and peak expiratory flow rate was measured using peak flow meter. Results: Prevalence of COPD was 22.1% among the study population. Males (39.2%) had higher prevalence than females (12.2%). COPD prevalence was significantly higher among increasing age, male sex, illiteracy, low BMI, smokers, inadequate ventilation and those using biomass fuels for cooking. Conclusions: This study has established the fact that COPD is highly prevalent among adults in rural area. For practitioners, the results call for a high index of suspicion of COPD among >30 years with substantial exposure to risk factors. For health policy makers, the results of the current study urge for the development of COPD prevention programs failing which the burden of COPD might result in increased mortality, morbidity and economic burden. 

scholarly journals Development and first validation of a patient-reported experience measure in chronic obstructive pulmonary disease (PREM-C9)

Thorax ◽  
2019 ◽  
Vol 74 (6) ◽  
pp. 600-603 ◽  
Author(s):  
Matthew Hodson ◽  
C Michael Roberts ◽  
Sharon Andrew ◽  
Laura Graham ◽  
Paul W Jones ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Severe Disease ◽  
Depression Scale ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Patient Reported ◽  
Item List ◽  
Study Population ◽  
Experience Measure

We developed a chronic obstructive pulmonary disease (COPD) patient-reported experience measure (PREM-C9). 174 patients with COPD (86 [49%] with a confirmed diagnosis and 88 [51%] with a self-reported diagnosis of COPD) completed a 38-item list, COPD Assessment Test (CAT) and Hospital Anxiety and Depression Scale (HADS). Hierarchical and Rasch analysis produced a 9-item list (PREM-C9). It demonstrated fit to the Rasch model (χ² p=0.33) and correlated moderately with CAT (r=0.42), HAD-anxiety (r=0.30) and HAD-depression (r=0.41) (p<0.05). A substudy confirmed its ability to detect change prepulmonary and postpulmonary rehabilitation. The PREM-C9 is a simple, valid measure of experience of patients living with COPD, validated in this study population with mild to very severe disease; it may be a useful measure in research and clinical audits.

Comparison of DECAF (dyspnea, eosinopenia, consolidation, acidaemia, and atrial fibrillation) and APACHE II (acute physiology and chronic health evaluation ii) scoring system to predict mortality among patients with acute exacerbation of chronic obstructive pulmonary disease

2021 ◽  
pp. 1-14
Author(s):  
Wiky Raja ◽  
Naseem Ahmed ◽  
Nadeem Ahmed Rizvi ◽  
Anita Vallacha ◽  
Dinesh Kumar
Keyword(s):  
Atrial Fibrillation ◽  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Acute Exacerbation ◽  
Chronic Health Evaluation ◽  
Chronic Obstructive ◽  
Health Evaluation ◽  
Obstructive Pulmonary Disease ◽  
Chronic Health ◽  
Study Population

Abstract Scoring systems are frequently used to predict mortality and then guiding therapeutic interventions in the patients with acute exacerbation of chronic obstructive pulmonary disease. Objective: Compare the diagnostic accuracy of Dyspnea, Eosinopenia, Consolidation, acidaemia, and atrial fibrillation and acute physiology and chronic health evaluation II scoring system to predict mortality among patients with acute exacerbation of chronic obstructive pulmonary disease. Methods: A cross sectional study was conducted during November 2017 to June 2018 in the Department of Chest Medicine, Jinnah Postgraduate Medical Center, Karachi. N=210 patients with acute exacerbation of chronic obstructive pulmonary disease, were included in the study after getting written informed consent. Patients were selected using non-probability consecutive sampling technique. Mortality scores were calculated for each patient and the individual parameters used in calculating the scores were also recorded. SPSS version 21 was used for statistical analysis. Results: The study population consisted of 210 consecutive patients, of those n=147 (70%) were males and n= 63 (30%) females. A statistically significant difference was observed between survivors and those who died in hospital related to acute exacerbation of chronic obstructive disease. The mean Dyspnea, Eosinopenia, Consolidation, acidaemia, and atrial fibrillation score 2.31 + 0.93 and acute physiology and chronic health evaluation II score 15.8 + 7.2 was recorded in whole study population. A decision threshold of Dyspnea, Eosinopenia, Consolidation, acidaemia, and atrial fibrillation score >2 was found to have a sensitivity of 84.6% and specificity of 82.3% while acute physiology and chronic health evaluation II score have sensitivity Continuous...

scholarly journals Recent advances on animal models related to chronic obstructive pulmonary disease

2019 ◽  
Vol 02 (03) ◽  
pp. 93-104
Author(s):  
Shan Jiang ◽  
Nabjian Mohammadtursun ◽  
Jian Qiu ◽  
Qiuping Li ◽  
Jing Sun ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Animal Model ◽  
Animal Models ◽  
Pulmonary Disease ◽  
Economic Burden ◽  
Public Health Problem ◽  
Chronic Obstructive ◽  
Important Public Health Problem ◽  
Obstructive Pulmonary Disease ◽  
Short Period

Chronic obstructive pulmonary disease (COPD) has become an important public health problem in the world. According to reports, COPD ranks fourth in the global cause of death, causing a serious economic burden on society. The pathogenesis of COPD is complex, making it difficult to simulate the pathological changes and clinical features of COPD. Moreover, the COPD animal model has an irreplaceable role in the study of etiology, pathology and treatment. It is worth noting that the risk factors for chronic obstructive pulmonary disease persist, and the economic burden of global chronic obstructive pulmonary disease is expected to continue to increase in the coming decades. Establishing a standardized, a clinically realistic COPD animal model has always been a research direction that scholars are keen on. Therefore, it is essential to establish an economical animal model. The establishment of a suitable animal model can accurately simulate the pathological features of human chronic obstructive pulmonary disease and help to develop effective interventions and treatments in a short period of time. This review integrates the experimental animal species selected in the animal models used in COPD studies. Subsequently, different methods and mechanisms for establishing animal models were summarized according to different modeling factors. Finally, the criteria for evaluating existing animal models are discussed. It is hoped that the summary of this paper will guide the establishment of relevant animal models for future COPD research.

scholarly journals A CLINICAL STUDY ON SAFETY AND EFFICACY OF FORMOTEROL AND TIOTROPIUM COMBINATION COMPARED TO FORMOTEROL AND TIOTROPIUM WITH ROFLUMILAST COMBINATION IN TREATMENT OF MODERATE TO SEVERE CHRONIC OBSTRUCTIVE PULMONARY DISEASE PATIENTS

2018 ◽  
Vol 11 (3) ◽  
pp. 184 ◽  
Author(s):  
Kavitha Devi M ◽  
Sarumathy S ◽  
Sarath Lal Sasidharan ◽  
Sarumathy S ◽  
Mehanaz Shaik ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Chronic Obstructive ◽  
Comorbid Condition ◽  
Obstructive Pulmonary Disease ◽  
Safety And Efficacy ◽  
Copd Patients ◽  
Before And After ◽  
Study Population ◽  
Group B

 Objectives: The objective of this study is to assess the safety and efficacy of formoterol and tiotropium combination compared to formoterol and tiotropium with roflumilast combination in treatment of moderate-to-severe chronic obstructive pulmonary disease (COPD) patients on inhaled combination therapy. Methods: A comparative prospective interventional study was carried out in 61 COPD patients who were visiting the pulmonary medicine ward during 6 months (October 2016 to March 2017). The patients were randomized into two groups. Group A patients received a combination of formoterol and tiotropium, whereas Group B patients received roflumilast along with formoterol and tiotropium combination. Spirometry tests were done to both the study population. Forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC) were noted at the initial visit and after the treatment. All the statistical analyses such as mean and p values were calculated using SPSS 14.0 version software. Results: The average age group of the study population was 57.63±8.3 years. Comorbid condition such as diabetes mellitus was higher in the study groups. Comparison of spirometry reports before and after drug administration in both groups was done. FEV1 and FVC were found to be statistically significant between the study group (0.001, p<0.05).The average mean change of FEV1 before and after treatment in Group B was found to be improved as compared to Group B (0.66). Conclusion: Tiotropium and formoterol with roflumilast combination were found to be safe and effective in moderate-to-severe COPD patients.

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