Frequency and trend of dengue fever in a tertiary care hospital in Kancheepuram, Tamilnadu: three-year retrospective study

Background: Dengue is a mosquito borne viral disease which is endemic in the tropical and subtropical regions. In the recent years it has become a significant public health problem and its incidence is increasing in India. In 2016 1.1 lakh new dengue cases were reported in India. The objectives of the study was to describe the frequency and distribution of dengue infection and to determine the association between dengue infection and selected variables.Methods: The study is a hospital based retrospective study conducted in a tertiary care hospital in a rural area of Kancheepuram district. Three-year data (January 2015 to December 2017) was collected from the medical records department of the hospital. Dengue cases were diagnosed by ELISA test.Results: Among 340 dengue patients admitted in the hospital 240 (74.5%) were male and 100 (25.5%) were female. In this study, 306 (90%) patients were of the classical dengue type and 34 (10%) patients belong to dengue haemorrhagic fever type. There is a spike in the case load after the monsoons. There was a positive statistical significant association (p<0.0001) between dengue infection and male sex, low socioeconomic status and platelet count at the time of admission.Conclusions: Results of the study indicate that there should be proper education of the public through various available Medias and awareness campaigns. All dengue patients must be appropriately treated in order to prevent complications. The national vector borne disease control program must extend its coverage to combat dengue infection.

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Drug utilization study in dengue infection in a tertiary care hospital

International Journal of Basic & Clinical Pharmacology ◽

10.18203/2319-2003.ijbcp20190667 ◽

2019 ◽

Vol 8 (3) ◽

pp. 569

Author(s):

Smita Bhandare ◽

Santoshkumar R. Jeevangi

Keyword(s):

Drug Utilization ◽

Leaf Extract ◽

Tertiary Care Hospital ◽

Dengue Infection ◽

Tertiary Care ◽

Specific Treatment ◽

Public Health Problem ◽

Rational Approach ◽

Care Hospital ◽

Utilization Pattern

Background: Dengue fever (DF) is a serious public health problem, gaining global attention because of its morbidity and mortality. Less studies on Drug utilization pattern of DF in India. The present study was undertaken to analyze Drug utilization pattern of dengue infection in a tertiary care hospital.Methods: A prospective cross-sectional study was conducted for a period of 2 months in a tertiary care hospital and the data was analyzed by using various drug use indicators.Results: A total of 52 prescriptions were analyzed. Male and female were (46.16%, 53.84%), A total of 330 drugs were prescribed. 86 (26.06%) antibiotics, 70 (21.21%) antipyretics, 51 (15.46%) antacids, 19 (5.76%) multivitamins, 52 (15.76%) anti-emetics and 52 (15.76%) papaya leaf extract was prescribed. 84 (25.46%) oral and 246 (74.54%) injectable drugs. IV-fluids given to all patients. 10 (19.24%) were given blood transfusion. 6.17 drugs per prescription. 96% drugs were prescribed by brand names. High DDD for drugs like diclofenac (184), doxycycline (115), metronidazole (2.5), pantoprazole (161.5), rabeprazole (34.6), ondansetron (200) was observed.Conclusions: Most commonly used drugs are antipyretics, antibiotics, antacids, antiemetic, papaya leaf extract. As the incidence of DF is increasing with epidemics, demand for specific treatment guidelines is in great need. Early recognition of the disease, with a rational approach in case management leads good clinical outcome.

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Clinical profile of dengue fever with severe thrombocytopenia and its complications: a retrospective study at a tertiary care hospital in South India

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20171543 ◽

2017 ◽

Vol 5 (5) ◽

pp. 1751 ◽

Cited By ~ 1

Author(s):

Ch. Manoj Kumar ◽

K. S. Keerthi Vyas ◽

Y. Sai Krishna

Keyword(s):

Retrospective Study ◽

Dengue Fever ◽

South India ◽

Tertiary Care Hospital ◽

Dengue Infection ◽

Tertiary Care ◽

Clinical Profile ◽

Severe Thrombocytopenia ◽

Care Hospital ◽

Haemorrhagic Fever

Background: Dengue haemorrhagic fever is a potentially lethal illness that is universally prevalent in the tropics and has become a major health concern globally in recent decades. The clinical manifestation of dengue infection varies from asymptomatic to severe life threatening illness in the form of DHF/DSS. Dengue haemorrhagic fever or DSS may be fatal in 40% to 50% of untreated patients. A hallmark of dengue infection is severe thrombocytopenia which causes concern for the patients and treating doctors. The objective of this study was to correlate clinical profile during the evolution of dengue fever with severe thrombocytopenia (platelets <10,000/mm3), and comparing frequencies between the different clinical forms in order to predict the severity of the disease. The present study includes 40 individuals who were found to be seropositive with the detection of NS1Ag, IgM and IgG antibodies for dengue infection with severe thrombocytopenia. Early diagnosis and monitoring is largely dependent on haematological parameters. As no specific antiviral therapy is available, supportive therapy is of utmost importance.Methods: This is an observational, descriptive and retrospective study of 40 patients with clinical and serological diagnosis of dengue fever with severe thrombocytopenia (platelets<10,000/mm3), in the period from August 2015 to September 2016, who were admitted in a tertiary care hospital in South India. ELISA was performed for the detection of dengue NS1, Ig M and Ig G, haematological parameters by automated analyzer and peripheral smear, coagulation profile analysis were done.Results: Out of 40 cases with severe thrombocytopenia, 50% of the patients had classical dengue fever, 30% cases had DHF with bleeding manifests and 20% cases with DHF plasma leakage signs and 5% lead to DSS. There was lack of association studied between severe thrombocytopenia and bleeding manifestations as p value<0.065 was insignificant. However, the risk of complications increased with decreasing platelet counts in the present study.Conclusions: Thrombocytopenia was most predominant haematological discrepancy. There was no predilection for any age group or gender for thrombocytopenia or bleeding among the dengue patients. The results were relevant in assessing the severity of infection and can help by enabling the adaptation of the therapeutic conduct to the needs of individual patients.

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A Retrospective Study of Clinical and Laboratory Profile of Dengue Fever in Tertiary Care Hospital, Wardha, Maharashtra, India

Journal of Pure and Applied Microbiology ◽

10.22207/jpam.14.3.32 ◽

2020 ◽

Vol 14 (3) ◽

pp. 1935-1939

Author(s):

Praful S. Patil ◽

Dhruba Hari Chandi ◽

Smita Damke ◽

Shital Mahajan ◽

R. Ashok ◽

...

Keyword(s):

Retrospective Study ◽

Dengue Fever ◽

Monsoon Season ◽

Dengue Infection ◽

Tertiary Care ◽

Public Health Problem ◽

High Morbidity ◽

Care Hospital ◽

Age Group ◽

Post Monsoon

Dengue disease is caused by dengue virus which is a vector born viral infection. The prevalence of dengue has increased dramatically from past few decades. The clinical symptoms vary from asymptomatic to severe hemorrhagic fever leads to high morbidity and mortality. Method- This retrospective study was carried out during January 2019 to December 2019. The laboratory test was done by using J Mitra & Co on Day 1 of their visit to the hospital which shows NS1, IgM and IgG reactivity towards dengue fever. The clinical profile information data was collected from patient records. Out of 640 samples 62.18% (398) was positive. The percentage of positive males and females were 60.78%, 64.23% respectively. The highest prevalence of dengue infection was observed more in age group between 31-40 years (81.69%) and least prevalence in age group 71-80 years (36.36%). Most of the patients were positive for NS1Ag121 (30.4%) followed by IgM positive 87 (21.9%) & 59 (14.8%) positive for both IgM and NS1 Ag The highest number of infections was seen during October (75.8%) post monsoon season. All patients had a fever, followed by head ache (82%) and body pains (66.4%), 64.84% stayed in the hospital less than 5 days. In tropical and sub-tropical regions dengue is still a leading public health problem especially during rainy and post monsoon seasons. Both NS1 Ag and IgM detection in early acute phase has potential diagnostic value. So, to reduce mortality there need to initiate community-based cohort studies to predict the pace of dengue spread based on clinical presentation and laboratory findings during epidemics in India. Aedesaegypti is a common vector for transmission of DENV, CHIKV and ZIKV, so there is a need to screen for these infections in endemic areas.

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Unravelling the Poisoning Cases Admitted to a Tertiary Care Hospital - A Retrospective Study

Journal of Evidence Based Medicine and Healthcare ◽

10.18410/jebmh/2020/504 ◽

2020 ◽

Vol 7 (42) ◽

pp. 2435-2438

Author(s):

Chandrashekhar E ◽

Suresh C ◽

Naveen Gowda R.S.

Keyword(s):

Retrospective Study ◽

Organophosphorus Compound ◽

Tertiary Care Hospital ◽

Organophosphorus Compounds ◽

Tertiary Care ◽

Public Health Problem ◽

Acute Poisoning ◽

World Health ◽

Care Hospital ◽

Health Organization

BACKGROUND Accidental and intentional poisoning are major preventable contributors to death and illness. According to World Health Organization (WHO) estimates, 0.3 million people die every year due to various poisoning agents. Earlier the initial resuscitation, gastric decontamination, and use of specific antidotes, better the outcome. In order to improve clinical management, proper planning and prevention is. This study was conducted in a tertiary care hospital to evaluate the pattern of acute poisoning cases in that region. METHODS This is a retrospective study conducted among 57 patients with poisoning admitted over a 2-year period. Data was collected from ICU registry and Medical Records Department, ESIC MH. RESULTS Females represented 59.6 % (n = 57). Most of our patients were in the age group 18 – 28 yrs. (35.08 %). Notably majority of the cases had consumed organophosphorus compounds (25 patients, 43.85 %) and tablets (22 patients, 38.60 %). Majority (22 patients, 38.59 %) stayed at ICU for less than three days; overall mortality from all poisoning was low (2 patients, 3.50 %). CONCLUSIONS Use of organophosphorus compound and tablets for intentional poisoning continues to be pervasive in India. Education on poison, counselling and strict pesticide and drugs regulation laws will reduce the incidence of this public health problem. KEYWORDS Organophosphorus Compound, Poisoning, Mortality

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