scholarly journals Effect of COVID-19 on congenital heart disease children: a literature review

2021 ◽  
Vol 8 (2) ◽  
pp. 900
Author(s):  
Mahmoud Ibrahim Ali ◽  
Hisham Fayiz Alkhuzaie ◽  
Saleh Abbas Alhashim ◽  
Hadeel Abdulhameed Hassan ◽  
Amal Hassan Tawhari ◽  
...  
Keyword(s):  
Congenital Heart ◽  
Heart Diseases ◽  
Extensive Literature ◽  
Medical Subject Headings ◽  
Case Volume ◽  
Comprehensive Overview ◽  
Genetic Syndrome ◽  
Management Plans ◽  
Extensive Literature Search ◽  
The Impact

Congenital heart diseases are the most common birth defects and have variable levels of severity. Some studies showed that CHD increases the odds of COVID-19 realted complications; however, others suggested that there is no such a correlation. Due to the aforementioned lack of evidence, we aim in this review to provide a comprehensive overview of the impact of COVID-19 infection on CHD patients. For that, an extensive literature search of Medline, Cochrane, and EMBASE databases was performed using the medical subject headings or a combination of all possible related terms. Patients diagnosed with both CHD and COVID-19 infection has reported that CHD patients, especially those with a genetic syndrome, are at high risk to develop moderate to severe symptoms. Moreover, CHD surgeries were postponed or even canceled, with a decline in overall admission days, due to hospital protocol or pateints’ decisions. Also, the findings suggested that congenital heart surgeries can be safely done during the pandemic when there is case volume limitation, with the safety precautions are followed by both surgical staff and patients. In conclusion, the scarce evidence along with the variety in CHD types and their different clinical presentations; makes it hard to predict the outcomes and to manage CHD-COVID-19 co-morbid children. More studies are needed to guide management plans in this particular context.

Impact of dental implant diameter on the efficiency of fatigue - a systematic review analysis

2021 ◽  
pp. 1-12
Author(s):  
Mohamed Tharwat Hamed ◽  
Hisham Abdullah Mously ◽  
Moayyad Motaz Ghulman ◽  
Ghada Hussein Naguib
Keyword(s):  
Systematic Review ◽  
Dental Implant ◽  
Extensive Literature ◽  
Wide Diameter ◽  
Review Analysis ◽  
Body Fracture ◽  
Extensive Literature Search ◽  
Technical Complication ◽  
Performance Results ◽  
The Impact

Abstract Objective: The present study explains the success and failure of dental implant diameter on the efficiency of fatigue by conducting a systematic review analysis. Methods: An extensive literature search was conducted to carry out systematic review using different scholarly platforms and libraries. A total of 12 studies published within the past 20-year time (1999-2019) were included following the inclusion and exclusion criteria based on the PRISMA guidelines. Additionally, the study outcomes were evaluated to determine their perceptions regarding the role of dental implant diameter in influencing the implant’s fatigue performance. Results: The implant diameter can be categorized into wide diameter (5-6 mm), regular diameter (3.75-4 mm), and small/narrow diameter (3-3.4 mm). The narrow diameter implants are indicated through thin alveolar ridges and mesiodistal spaces (less than 7 mm). The implants with narrow diameter would offer greater risk of fatigue failure for clinical situations with significant functional loading. No significant differences were found either in success or failure of dental implant diameter on fatigue efficiency after 1-year and 3-year follow-up. Conclusion: The technical complication of dental implant include abutment screw loosening or fracture, abutment and superstructure fracture, and implant body fracture. The study has study has mainly focused on the impact of dental implant diameter on the efficiency of fatigue and reviewed a significant impact of dental implant diameter on the fatigue efficiency. Keywords: Dental Implants, Efficiency, Perception. Continuous...

Monogenic Syndromes with Congenital Heart Diseases in Newborns (Diagnostic Clues for Neonatologists): A Critical Analysis with Systematic Literature Review

2021 ◽  
Author(s):  
Raffaele Falsaperla ◽  
Valentina Giacchi ◽  
Maria Giovanna Aguglia ◽  
Janette Mailo ◽  
Maria Grazia Longo ◽  
...  
Keyword(s):  
Systematic Review ◽  
Congenital Heart ◽  
Heart Diseases ◽  
Cost Effective ◽  
Monogenic Disease ◽  
Chromosomal Anomalies ◽  
Genetic Syndrome ◽  
Wide Range ◽  
Major Congenital Anomaly ◽  
Genomic Disorders

AbstractCongenital heart disease (CHD), the most common major congenital anomaly, is associated with a genetic syndrome (chromosomal anomalies, genomic disorders, or monogenic disease) in 30% of patients. The aim of this systematic review is to evaluate if, in the neonatal setting, clinical clues that orient the diagnostic path can be identified. For this purpose, we revised the most frequent dysmorphic features described in newborns with CHD, comparing those associated with monogenic syndromes (MSG) with the ones reported in newborns with genomic disorders. For this systematic review according to PRISMA statement, we used PubMed, Medline, Google Scholar, Scopus database, and search terms related to CHD and syndrome. We found a wide range of dysmorphisms (ocular region, ears, mouth, and/or palate and phalangeal anomalies) detected in more than half of MSGs were found to be associated with CHDs, but those anomalies are also described in genomic rearrangements syndromes with equal prevalence. These findings confirm that etiological diagnosis in newborns is challenging, and only the prompt and expert recognition of features suggestive of genetic conditions can improve the selection of appropriate, cost-effective diagnostic tests. However, in general practice, it is crucial to recognize clues that can suggest the presence of a genetic syndrome, and neonatologists often have the unique opportunity to be the first to identify abnormalities in the neonate.

scholarly journals Impact of Coronavirus Disease 2019 (COVID‐19) on Patients With Congenital Heart Disease Across the Lifespan: The Experience of an Academic Congenital Heart Disease Center in New York City

2020 ◽  
Vol 9 (23) ◽  
Author(s):  
Matthew J. Lewis ◽  
Brett R. Anderson ◽  
Michael Fremed ◽  
Melissa Argenio ◽  
Usha Krishnan ◽  
...  
Keyword(s):  
New York ◽  
Congenital Heart Disease ◽  
New York City ◽  
Heart Disease ◽  
York City ◽  
Congenital Heart ◽  
Severe Infection ◽  
Genetic Syndrome ◽  
Physiological Stage ◽  
The Impact

Background We sought to assess the impact and predictors of coronavirus disease 2019 (COVID‐19) infection and severity in a cohort of patients with congenital heart disease (CHD) at a large CHD center in New York City. Methods and Results We performed a retrospective review of all individuals with CHD followed at Columbia University Irving Medical Center who were diagnosed with COVID‐19 between March 1, 2020 and July 1, 2020. The primary end point was moderate/severe response to COVID‐19 infection defined as (1) death during COVID‐19 infection; or (2) need for hospitalization and/or respiratory support secondary to COVID‐19 infection. Among 53 COVID‐19‐positive patients with CHD, 10 (19%) were <18 years of age (median age 34 years of age). Thirty‐one (58%) had complex congenital anatomy including 10 (19%) with a Fontan repair. Eight (15%) had a genetic syndrome, 6 (11%) had pulmonary hypertension, and 9 (17%) were obese. Among adults, 18 (41%) were physiologic class C or D. For the entire cohort, 9 (17%) had a moderate/severe infection, including 3 deaths (6%). After correcting for multiple comparisons, the presence of a genetic syndrome (odds ratio [OR], 35.82; P =0.0002), and in adults, physiological Stage C or D (OR, 19.38; P =0.002) were significantly associated with moderate/severe infection. Conclusions At our CHD center, the number of symptomatic patients with COVID‐19 was relatively low. Patients with CHD with a genetic syndrome and adults at advanced physiological stage were at highest risk for moderate/severe infection.

scholarly journals Contribution of Dentist Anesthesiologists to Dental Anesthesiology Research

2011 ◽  
Vol 58 (1) ◽  
pp. 14-21
Author(s):  
Steven Ganzberg ◽  
Robert G Rashid ◽  
Edward Davidian
Keyword(s):  
Literature Search ◽  
Large Percentage ◽  
Academic Departments ◽  
Extensive Literature ◽  
Anesthesia Research ◽  
American Dental Association ◽  
New Knowledge ◽  
Extensive Literature Search ◽  
Dental Schools ◽  
The Impact

In order to determine if dentist anesthesiologists (DAs) actively contribute to research in the field of anesthesiology, and thus contribute new knowledge to the field, an extensive literature search was accomplished. DAs make up only 1.5% of dentists who actively contribute to anesthesia research but account for 10% of publications. To determine if the impact of DA research was similar to the American Dental Association (ADA) recognized specialties, h-indices of noted researchers in other specialties were compared to the h-indices of noted DA researchers. The results show that the impact of top DA researchers in dental anesthesiology is similar to the impact of top dental specialty researchers, despite lack of academic departments in dental schools where a large percentage of dental research is completed. Dentist anesthesiologists actively contribute to the research in anesthesiology for dentistry and thus, actively contribute to new knowledge in the field.

Software-as-a-Medical Device: demystifying Connected Health regulations

2016 ◽  
Vol 18 (2) ◽  
pp. 186-215 ◽  
Author(s):  
Noel Carroll ◽  
Ita Richardson
Keyword(s):  
Medical Device ◽  
Medical Devices ◽  
Healthcare Service ◽  
Healthcare Sector ◽  
Future Research ◽  
Extensive Literature ◽  
Comprehensive Overview ◽  
Content Type ◽  
Connected Health ◽  
The Impact

Purpose Connected Health is an emerging and rapidly developing field never before witnessed across the healthcare sector. It has the potential to transform healthcare service systems by increasing its safety, quality and overall efficiency. However, as healthcare technologies or medical devices continuously rely more on software development, one of the core challenges is examining how Connected Health is regulated – often impacting Connected Health innovation. The purpose of this paper is to present an understanding of how Connected Health is regulated. Many of these regulatory developments fall under “medical devices”, giving rise to Software-as-a-Medical Device (SaaMD). Design/methodology/approach Through an extensive literature review, this paper demystifies Connected Health regulation. It presents the outcome of expert discussions which explore the key regulatory developments in the context of Connected Health to provide a practical guide to understanding how regulation can potentially shape healthcare innovation. Findings Several key issues are identified, and the authors present a comprehensive overview of regulatory developments relating to Connected Health with a view to support the continued growth of IT-enabled healthcare service models. The authors also identify the key challenges in Connected Health and identify areas for future research. Originality/value A key outcome of this research is a clearer understanding of the opportunities and challenges that regulation and standards present to Connected Health. Furthermore, this research is of critical importance in a first attempt towards recognising the impact of regulation and standards compliance in Connected Health.

scholarly journals Parental coping mechanisms in children with congenital heart disease at tertiary cardiac centre

2016 ◽  
Vol 7 (4) ◽  
pp. 75-79 ◽  
Author(s):  
Subina Bajracharya ◽  
Ajit Shrestha
Keyword(s):  
Congenital Heart ◽  
Heart Diseases ◽  
Sampling Technique ◽  
Chronic Illnesses ◽  
Coping Mechanism ◽  
Parental Coping ◽  
Medical Sciences ◽  
The Family ◽  
Cardiac Centre ◽  
The Impact

Background: Congenital Heart Diseases (CHD) are among the most pervasive and serious chronic illnesses. Parents of children with a chronic condition must cope with greater demands and adopt different behaviors in order to lessen the impact on the family structure.Aims and Objectives: This study aims to explore the coping mechanism used by parents of children with CHD.Materials and Methods: This descriptive study included 100 parents of children with CHD selected through non-probability purposive sampling technique. Data were collected by interview and analyzed using descriptive statistics.Result: This study revealed that parents of preschool children used more coping mechanism (mean score 30.53 out of total score 57), followed by parents of adolescence (mean score 30). Parents of first-born children with CHD used less coping mechanism (mean score 28.08). Parents of female children used more coping mechanism (mean score 29.52), fathers of children with CHD used more coping mechanism (mean score 29.78), and parents of operated children used more coping mechanism (mean score 29.11).Conclusion: Parental coping mechanism was found to be affected by age, sex, operative status and birth order of children and also by the sex of parent. These findings strongly indicate the need for proper counseling service to parents so that healthy coping is reinforced.Asian Journal of Medical Sciences Vol.7(4) 2016 75-79

scholarly journals Minute ventilation/carbon dioxide production in congenital heart disease

2021 ◽  
Vol 30 (161) ◽  
pp. 200178
Author(s):  
Alfred Hager
Keyword(s):  
Carbon Dioxide ◽  
Congenital Heart Disease ◽  
Heart Disease ◽  
Congenital Heart ◽  
Heart Diseases ◽  
Minute Ventilation ◽  
Pulmonary Stenosis ◽  
Cardiopulmonary Exercise Testing ◽  
Carbon Dioxide Production ◽  
The Impact

This review summarises various applications of how ventilatory equivalent (ventilatory efficiency or better still ventilatory inefficiency) and the minute ventilation (VʹE)/carbon dioxide production (VʹCO2) slope obtained from cardiopulmonary exercise testing (CPET) can be used in the diagnostic or prognostic workup of patients with congenital heart disease.The field of congenital heart disease comprises not only a very heterogeneous patient group with various heart diseases, but also various conditions in different stages of repair, as well as the different residuals seen in long-term follow-up. As such, various physiologic disarrangements must be considered in the analysis of increased VʹE/VʹCO2 slope from CPET in patients with congenital heart disease. In addition to congestive heart failure (CHF), cyanosis, unilateral pulmonary stenosis and pulmonary hypertension (PH) provide the background for this finding. The predictive value of increased VʹE/VʹCO2 slope on prognosis seems to be more important in conditions where circulatory failure is associated with failure of the systemic ventricle. In cyanotic patients, those with Fontan circulation, or those with substantial mortality from arrhythmia, the impact of VʹE/VʹCO2 on prognosis is not that important.

scholarly journals Prevalence of Extra-Cardiac Malformations with Congenital Heart Disease among Hospital Admitted Children- A Study in a Tertiary Level Hospital of Bangladesh

2015 ◽  
Vol 10 (2) ◽  
pp. 50-54
Author(s):  
Md Ferdousur Rahman Sarker ◽  
Zahir Sadique ◽  
Nurun Nahar Fatema Begum ◽  
Mushtaq Ahmad
Keyword(s):  
Hospital Admission ◽  
Congenital Heart ◽  
Genetic Basis ◽  
Heart Diseases ◽  
Significant Proportion ◽  
Admission Rate ◽  
Congenital Heart Diseases ◽  
Hospital Admission Rate ◽  
Genetic Syndrome ◽  
Cardiac Malformations

Introduction: Congenital anomalies are a major cause of stillbirths and infant mortality. In this post genomic era, congenital heart diseases (CHDs) are still the most common and lethal of all birth defects in children. Although most of the CHD occur as a sporadic event many of them have a well-defined genetic basis. This genetic basis is expressed in the form of concomitant occurrence of extra-cardiac malformations (ECM) which may occur alone or as a part of a syndrome.Objective: The present study was designed to find out the burden of CHDs in the hospital admitted children and to find out the prevalence of occurrence of clinically recognizable ECM associated with CHDs.Methods: This is a cross-sectional hospital based study. Total patients admitted during the study period were 5264. Of these 335 patients were found suffering from different types of congenital heart diseases. This gives the hospital admission rate for CHD, as 63.6 per 1000 admission (6.36%). Out of total 335 cases of CHD, 273 (81.5%) were acyanotic and 62 (18.5%) were cyanotic. Among the CHD patients 68 (20.3%) had a significant ECM. Out of the 68 patients with a significant ECM 53 (77.9%) had a clinically recognizable genetic syndrome, whereas 15 cases (22.1%) had a major ECM which was not a part of a syndrome.Conclusion: A high rate of hospital admission is found for CHDs in the pediatric setting, signifying the need for improvement of pediatric cardiology infrastructure in Bangladesh, which should help in providing better medical and surgical care for the patients with CHD. A significant proportion of patients with CHD have associated ECM, implicating a genetic background for the etiology of CHD. It also emphasizes the need for thorough evaluation of patient with CHD for ECM.Journal of Armed Forces Medical College Bangladesh Vol.10(2) 2014

Crayfish population genetic studies: assessment and trends

2016 ◽  
Vol 22 (1) ◽  
pp. 19-42
Author(s):  
Chester R. Fieiel
Keyword(s):  
Conservation Status ◽  
Geographic Location ◽  
Ecological Group ◽  
Extensive Literature ◽  
As Species ◽  
Extant Species ◽  
Management Plans ◽  
Conservation Actions ◽  
Extensive Literature Search ◽  
Crayfish Population

Abstract I surveyed the peer-reviewed literature for studies on crayfish population genetics over the last 20 years (1996 to 2015). My objectives were to determine if there is research disparities based on crayfish conservation status, ecological group, geographic location, and genetic methods used. Additionally, I wished to determine overall trends in crayfish genetics related to population variability, systematics, and technique development. An extensive literature search yielded 201 peer-reviewed articles with genetic information published on 335 of the 590 crayfish species found worldwide. The majority of peer-reviewed articles took place in Europe and Australia/Oceania despite the fact that crayfish biodiversity is greatest in North America. Crayfish within each ecological group (primary burrowers, lotic inhabitants, lentic inhabitants, and stygobitic species) are represented in these published papers. I found published articles on ~ 57% of the estimated 590 extant species. Further, of the 173 species listed as critically endangered, endangered, vulnerable, or as near threatened by the International Union for Conservation of Nature, I found published research on ~ 62% of these species in these classifications thus indicating a knowledge gap for many imperiled species. This lack of basic genetic (and ecological) information is significant as species designation is often used to determine where we should focus our conservation actions. Understanding what constitutes a single interbreeding population and identifying taxonomic designations are priorities for defining conservation management plans.

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