scholarly journals Effectiveness of tramadol compared to pentazocine in pain management during labour

2021 ◽  
Vol 8 (9) ◽  
pp. 4216
Author(s):  
Bushra Bano ◽  
Kalavanti Bai ◽  
Shaista Jumani ◽  
Noreen Bashir ◽  
Humaira Mohsin ◽  
...  
Keyword(s):  
Pain Relief ◽  
Rating Scale ◽  
Medical Center ◽  
Controlled Trial ◽  
Labour Pain ◽  
Labor Pain ◽  
Tramadol Hydrochloride ◽  
Visual Rating ◽  
Background Pain ◽  
Trial Drug

Background: Pain and agony during childbirth is quite often unbearable and at times beyond description. Pain relief can help in removing curb due to pain. To determine the efficacy of intramuscular tramadol hydrochloride as an analgesic during labor compared to those of pentazocine.Methods: This randomized controlled trial conducted at Jinnah post graduate medical center, ward 8 (Gynaecology and obstetrics) between 2nd December 2013 to 1st June 2014 after approval from the ethical committee of the hospital. Pregnant women aged 15 to 45 years, parity ≥1 with Gestational age between 37 to 42 weeks with a single fetus were included in this study. The subjects fulfilling inclusion criteria were enrolled after informed consent. Women were allocated randomly to pentazocine or tramadol. Labour pain was assessed immediately by 4-point visual rating scale before, at 30, and 60 minutes after injection of the trial drug and mean score was calculated. The data was analysed using SPSS version 20.Results: A total of 128 patients were randomized to ether tramadol or pentazocine. The mean age of enrolled participants is 30±7.01 years and 53.1% participants were below 30 years of age. Of 64 patients who received tramadol, 53 (82.8%) had pain relief compared to 39 (60.9%) in patient who received pentazocine (p=0.005).Conclusions: It is concluded from this study that tramadol is more effective in reducing labor pain

scholarly journals Paracetamol versus meperidine for relief of labour pain in primiparous women: a randomized controlled trial

2019 ◽  
Vol 8 (8) ◽  
pp. 3085
Author(s):  
Sherif M. Habib ◽  
Mohamed H. Mostafa ◽  
Mohamed H. Salama ◽  
Hend G. Swilam
Keyword(s):  
Pain Relief ◽  
Pain Perception ◽  
Controlled Trial ◽  
Mode Of Delivery ◽  
Neonatal Resuscitation ◽  
Active Phase ◽  
Labour Pain ◽  
Labor Pain ◽  
Intravenous Paracetamol ◽  
The Cost

Background: Most parturient women request analgesia, of which, there are two types; opioids and non-opioids. Opioids include morphine and meperidine, while non-opioids, which are milder forms of painkillers, include acetaminophen (paracetamol) and non-steroid anti-inflammatory drugs. The major concerns associated with opioids are the risk of neonatal respiratory depression, the cost and availability.Methods: The aim of this study was to compare the efficacy and safety of paracetamol versus meperidine for intra-partum pain relief. A total of 92 primiparous singleton term pregnant women were randomly allocated to receive intravenous paracetamol (1000 mg), or intramuscular meperidine (50 mg), at the beginning of the active phase of labor. The primary outcome was the labor pain perception, assessed using the visual analogue scale (VAS), at baseline, 15, 30, 60 and 120 minutes after administration of the drug.Results: Women of both groups showed significant reduction of the VAS after administration of the medication. There were no differences between both groups regarding the mode of delivery and the durations of the first or second stages of labor. However, meperidine was associated with higher rates of dizziness and nausea/vomiting. The 1-min Apgar scores were significantly lower in meperidine group. However, there were no differences in the 5-min Apgar score, need for neonatal resuscitation or neonatal respiratory distress.Conclusions: intravenous paracetamol as analgesia during labor is effective with no fetal or maternal adverse effects. Its use should have more chance for intrapartum pain relief. Additionally, it can be used as adjuvant with other types of analgesics.

scholarly journals Entonox® versus Pethidine in Labor Pain Relief: A Randomized Controlled Trial

2021 ◽  
Vol 18 (23) ◽  
pp. 12571
Author(s):  
Rasrawee Chantrasiri ◽  
Chanane Wanapirak ◽  
Theera Tongsong
Keyword(s):  
Side Effects ◽  
Pain Relief ◽  
Rating Scale ◽  
Controlled Trial ◽  
Satisfaction Score ◽  
Labor Pain ◽  
P Value ◽  
Group 4 ◽  
Pain Scores ◽  
Secondary Outcomes

Background: Pain relief during labor is a part of standard care in modern obstetrics. Several modalities used for pain relief have their own disadvantages and benefits in terms of side effects, effectiveness, availability, and satisfaction. The objectives of this study are primarily to compare the effectiveness and patients’ satisfaction for pain relief during labor between pethidine and inhaled 50% nitrous oxide (Entonox®). Methods: Laboring women at 37–41 + 6 weeks of gestation were randomly allocated to receive pethidine (50 mg intravenously) or Entonox® for reducing labor pain. Pain scores were evaluated at 0, (baseline), 30, 60, 90, and 120 min after initiation, using the visual analog scale (VAS) and also satisfaction score after delivery using the verbal rating scale (VRS). The secondary outcomes were also assessed, including APGAR scores, labor course, side effects, and cesarean section rate. Results: A total of 136 laboring women underwent randomization into two groups, but only 58 and 65 in the pethidine group and the Entonox® group were available for analysis. The median pain scores at baseline, 30, 60, and 90 min were comparable between both groups (p-value > 0.05); however, pain score at 120 min in the pethidine group was significantly higher (p-value: 0.038). The median of satisfaction score was significantly higher in the Entonox® group (4 vs. 3; p-value 0.043). All of the secondary outcomes were comparable between the two groups. Conclusions: Both have comparable effectiveness, but Entonox® has a higher satisfaction score. Entonox® could be an alternative to pethidine for reducing labor pain, because of its efficacy, ease for self-adjustment for satisfaction, and no serious effects on the labor course and newborns.

scholarly journals Postendodontic Pain after Pulpotomy or Root Canal Treatment in Mature Teeth with Carious Pulp Exposure: A Multicenter Randomized Controlled Trial

2020 ◽  
Vol 2020 ◽  
pp. 1-14
Author(s):  
Mohammad Jafar Eghbal ◽  
Ali Haeri ◽  
Arash Shahravan ◽  
Ali Kazemi ◽  
Fariborz Moazami ◽  
...  
Keyword(s):  
Postoperative Pain ◽  
Pain Relief ◽  
Root Canal ◽  
Rating Scale ◽  
Numerical Rating Scale ◽  
Controlled Trial ◽  
Mineral Trioxide Aggregate ◽  
Preoperative Pain ◽  
Multicenter Randomized Controlled Trial ◽  
The Mean

This equivalence, randomized, clinical trial aimed to compare the postoperative pain of root canal therapy (RCT) with pulpotomy with mineral trioxide aggregate (PMTA) or calcium-enriched mixture (PCEM) in permanent mature teeth. In seven academic centers, 550 cariously exposed pulps were included and randomly allocated into PMTA (n = 188), PCEM (n = 194), or RCT (n = 168) arms. Preoperative “Pain Intensity” (PI) on Numerical Rating Scale and postoperative PIs until day 7 were recorded. Patients’ demographic and pre-/intra-/postoperative factors/conditions were recorded/analysed. The arms were homogeneous in terms of demographics. The mean preoperative PIs were similar (P=0.998), the mean sum PIs recorded during 10 postoperative intervals were comparable (P=0.939), and the trend/changes in pain relief were parallel (P=0.821) in all study arms. The incidences of preoperative moderate-severe pain in RCT, PMTA, and PCEM arms were 56.5%, 55.7%, and 56.7%, which after 24 hours considerably decreased to 13.1%, 10.6%, and 12.9%, respectively (P=0.578). The time span of endodontic procedures was statistically different; RCT = 69.73, PMTA = 35.37, and PCEM = 33.62 minutes (P<0.001). Patients with greater preoperative pain, symptomatic apical periodontitis, or presence of PDL widening suffered more pain (P=0.002, 0.035, and 0.023, resp.); however, other pre-/intra-/postoperative factors/conditions were comparable. Pulpotomy with MTA/CEM and RCT demonstrate comparable and effective postoperative pain relief.

scholarly journals The Effect of Epidural-Spinal Anesthesia on Labor Outcome and Satisfaction in Parturient Mothers: A Randomized Controlled Trial

2017 ◽  
Vol 2 (4) ◽  
pp. 178-183
Author(s):  
Faegheh Golalizadeh Bibalan ◽  
Fatemeh Shobeiri ◽  
Akram Ranjbar ◽  
Pooran Hagian
Keyword(s):  
Randomized Controlled Trial ◽  
Pain Relief ◽  
Apgar Score ◽  
Controlled Trial ◽  
Labor Pain ◽  
Normal Vaginal Delivery ◽  
Second Stage Of Labor ◽  
Randomized Controlled ◽  
Nulliparous Women ◽  
Significant Difference

Introduction: One of the health system concerns is the use of medications for pain relief during labor and its side effects. Therefore, the aim of this study was to investigate the effect of epiduralspinal anesthesia (combined anesthesia [CA]) on labor outcome and satisfaction in pregnant women. Methods: In this randomized controlled trial study, we included 80 nulliparous women who had been admitted to Fatemieh hospital (Hamadan, Iran) during 2015-2016 due to spontaneous onset of labor. They were randomly assigned into 2 groups of 40, one group with CA versus normal vaginal delivery (NVD) group. Data were collected by using of demographic questionnaire, satisfaction questionnaire, and baby truck scales. Data were analyzed by descriptive and analytical statistics in SPSS version 16.0. Results: Average maternal age (mean ± SD) in the CA group was 26.94 ± 4.34 and in the NVD group was 25.89 ±5.18, respectively. There was a significant difference between the 2 groups in terms of length of second stage of labor (P=0.001), headache (P=0.04), and Apgar score (first minute) (P=0.001). Chi-square test showed a significant difference between the 2 groups in terms of satisfaction with childbirth (P=0.004). Conclusion: In this study, labor pain relief by using the spinal-epidural anesthesia (CA) increased the labor satisfaction. Nevertheless, this approach was associated with some maternal and neonatal complications such as: headaches, length of third stage of labor, and low Apgar score. It seems that the use of this method for painless delivery requires further studies.

scholarly journals IL-7, IL-18, MCP-1, MIP1-β, and OPG as Biomarkers for Pain Treatment Response in Patients with Cancer

2012 ◽  
Vol 6;15 (6;12) ◽  
pp. 499-510
Author(s):  
Andreas Sandner-Kiesling
Keyword(s):  
Pain Relief ◽  
Serum Level ◽  
Pain Intensity ◽  
Rating Scale ◽  
Pain Treatment ◽  
Medical Center ◽  
Primary Objective ◽  
Diagnostic Tools ◽  
Healthy Controls ◽  
Patients With Cancer

Background: Pain is one of the most common symptoms in patients suffering from advanced cancer and receiving palliative care and is often responsible for a poor quality of life. To date, there exists no published correlation between biological, measurable biomarkers and pain intensity. Objectives: The primary objective was to search and identify pain-associated cytokines (biomarkers) correlating with changes in numeric rating scale (NRS) pain scores in patients with cancer before and after pain treatment. The secondary objectives were to assess cytokine serum level differences between patients and healthy controls and to evaluate possible relationships between pain entities, pain intensity (in NRS), gender, location of primary tumor, and the patients’ cytokine baseline concentrations. Study Design: Controlled, prospective study. Setting: University medical center. Methods: Eligible patients with exacerbated cancer-related pain (NRS ≥ 5) and healthy controls with no pain were included. Serum level changes of 19 cytokines were analyzed before and during opioid treatment. Results: Of 19 analyzed biomarkers, 5 (IL-7, IL-18, MCP-1, MIP-1α, MIP-1β and OPG) turned out to correlate significantly with pain relief. In healthy controls, all analyzed cytokines showed no significant differences. In the secondary analysis, only one significant correlation was detected between OPG and pain entities. Furthermore, IL-4, IL-7, IFN-γ and OPG appeared to account for the ability to predict a patient’s gender. Limitations: Our findings should be considered as preliminary and need to be confirmed in further studies. Conclusion: Our results provide preliminary evidence of a significant correlation of pain relief in patients with cancer and at least 5 cytokines. These biomarkers may serve as the basis for development of diagnostic tools for pain assessment and could serve as potential new targets for pain control. Key words: Biomarker, cytokine, pain intensity, pain reduction, cancer-related pain, IL-7, IL-18, MCP-1, MIP-1α, MIP-1β, OPG.

scholarly journals Is metronidazole a panacea for post-hemorrhoidectomy pain?

2018 ◽  
Vol 5 (11) ◽  
pp. 3598 ◽  
Author(s):  
Probal Neogi ◽  
Anuvrat Sinha ◽  
Mayank Singh
Keyword(s):  
Pain Relief ◽  
Controlled Trial ◽  
Control Group ◽  
Post Operative Period ◽  
Post Operative Pain ◽  
Topical Metronidazole ◽  
Background Pain ◽  
The Difference ◽  
Clinically Significant ◽  
Grade 3

Background: Pain following Milligan Morgan hemorrhoidectomy is a significant cause of morbidity. The present study was carried out to find out if using metronidazole in the post-operative period of these patients results in less post-operative pain.Methods: This was a prospective randomized controlled trial which was conducted on 67 consecutive patients attending the Surgical OPD at SRN Hospital, Allahabad during the study period between August 2016 and July 2017 who underwent surgery for grade 2, grade 3 and grade 4 hemorrhoids. The patients were allocated to 3 groups-one group was the control group, the second group received oral metronidazole post-operatively for 7 days while the third group received only topical metronidazole for 7 days. All the three groups received 500 mg of metronidazole in 100 ml infusion pre-operatively. The post-operative analgesic usage was standardized for all the three groups. Appropriate tests of significance were applied to assess if the difference in the intensity of post-operative pain was significant in the immediate post-operative period and on days 1, 3 and 7 post-surgery.Results: Pain relief was significantly better in the groups using metronidazole at post-operative day 1, 3 and 7 and this was also borne in the lesser number of analgesics used by the patients of these groups.Conclusions: Use of oral or topical metronidazole in the post-operative period results in clinically significant pain relief. There is no additional benefit of one over the other and hence either can be used.

scholarly journals Epidural Anesthesia in Liver Surgery—A Propensity Score–Matched Analysis

Pain Medicine ◽  
2020 ◽  
Vol 21 (11) ◽  
pp. 2650-2660
Author(s):  
Cornelia Knaak ◽  
Claudia Spies ◽  
Alice Schneider ◽  
Maximilian Jara ◽  
Gerald Vorderwülbecke ◽  
...  
Keyword(s):  
Liver Resection ◽  
Postoperative Complications ◽  
Propensity Score ◽  
Epidural Anesthesia ◽  
Liver Surgery ◽  
Rating Scale ◽  
Medical Center ◽  
Controlled Trial ◽  
Academic Medical Center ◽  
One Year

Abstract Objective To assess the effects of epidural anesthesia (EA) on patients who underwent liver resection. Design Secondary analysis of a prospective randomized controlled trial. Setting This single-center study was conducted at an academic medical center. Methods A subset of 110 1:1 propensity score–matched patients who underwent liver resection with and without EA were analyzed. Outcome measures were pain intensity ≥5 on a numeric rating scale (NRS) at rest and during movement on postoperative days 1–5, analyzed with logistic mixed-effects models, and postoperative complications according to the Clavien-Dindo classification, length of hospital stay (LOS), and one-year survival. One-year survival in the matched cohorts was compared using a frailty model. Results EA patients were less likely to experience NRS ≥5 at rest (odds ratio = 0.06, 95% confidence interval [CI] = 0.01 to 0.28, P &lt; 0.001). These findings were independent of age, sex, Charlson comorbidity index, baseline NRS, and surgical approach (open vs laparoscopic). The number and severity of postoperative complications and LOS were comparable between groups (P = 0.258, P &gt; 0.999, and P = 0.467, respectively). Reduced mortality rates were seen in the EA group one year after surgery (9.1% vs 30.9%, hazard ratio = 0.32, 95% CI = 0.11 to 0.90, P = 0.031). No EA-related adverse events occurred. Earlier recovery of bowel function was seen in EA patients. Conclusions Patients with EA had better postoperative pain control and required fewer systemic opioids. Postoperative complications and LOS did not differ, although one-year survival was significantly improved in patients with EA. EA applied in liver surgery was effective and safe.

Sign in / Sign up

Export Citation Format

Share Document