scholarly journals Acute schizophrenia-like psychotic disorder associated with immunosuppressive agent use three years after renal transplantation: a case report

2018 ◽  
Vol 4 (7) ◽  
pp. 192 ◽  
Author(s):  
Okwudili N. K. Obayi
Keyword(s):  
Case Report ◽  
Renal Transplantation ◽  
Side Effects ◽  
Early Identification ◽  
Immunosuppressive Agent ◽  
Graft Versus Host ◽  
Post Transplant ◽  
Transplant Patients ◽  
Increasing Demand ◽  
Psychiatric Manifestations

<p class="abstract">Tacrolimus is a potent immunosuppressive agent used to prevent graft-versus-host disease after organ transplantation. Though a beneficial drug that contributes in the post-transplant life of patients, it comes with various side effects including, though rarely, psychiatric manifestations such as psychosis.<strong> </strong>Reported here is the case of a 21 year old lady with no prior psychiatry history with apparent tacrolimus-induced schizophrenia-like psychosis. Withdrawal of the immunosuppressant led her to full recovery from the mental problem. To the best of my knowledge, there are only few reports that describe psychosis induced by tacrolimus but none of such reports is from Nigeria, a country with increasing demand for kidney transplant. Clinicians are reminded to regularly watch out for mental status changes in post-transplant patients as early identification of any aberration with immediate reduction of the dosage or substitution of the drug would save both the patient and the already emotionally and financially-stressed family from further distress.</p>

scholarly journals Diagnosis of a plasmoblastic lymphoma of the mandible after renal transplantation: a case report

2021 ◽  
Vol 27 (4) ◽  
pp. 46
Author(s):  
Inès Legeard ◽  
Marc-Antoine Chevrollier ◽  
Gérard Bader
Keyword(s):  
Risk Factors ◽  
Case Report ◽  
Renal Transplantation ◽  
Epstein Barr Virus ◽  
Solid Organ ◽  
Post Transplant ◽  
Barr Virus ◽  
Non Hodgkin Lymphoma ◽  
Epstein Barr

Introduction: Post-transplant lymphoproliferations (PTL) are a severe complication of solid organ transplants. Their locations can be extra-nodal. Observation: The diagnosis and management of a non-Hodgkin's plasmablastic lymphoma of mandibular localization affecting a 66-year-old kidney transplanted patient are reported here. Comment: The main risk factors for non-Hodgkin lymphoma are immunosuppression and infection with Epstein-Barr virus. Clinical and radiographic examinations, which are not specific, must be supplemented by a histological examination. Treatment which is not consensual will most often consist of a reduction in immunosuppression coupled with chemotherapy. Conclusion: Despite a constant evolution in the incidence and clinical picture of post-transplant lymphomas, the role of the dentist remains essential in the early detection of lesions.

P1769POST TRANSPLANT MALIGNANCY - OUR EXPERIENCE

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
George Kurian ◽  
Gauri Shankar Jagadesh ◽  
Sandeep Sreedharan ◽  
Zachariah Paul ◽  
Anil Mathew ◽  
...  
Keyword(s):  
Renal Transplantation ◽  
Solid Organ ◽  
Oncogenic Viruses ◽  
Factors Affecting ◽  
Post Transplant ◽  
Transplant Patients ◽  
Cell Immunity ◽  
Number Of Patients ◽  
Increased Risk ◽  
Histological Variant

Abstract Background and Aims Cancer is now increasingly recognized as a major cause of death among patients especially after kidney transplantation. Malignancy represent a major burden in transplantation medicine. The Incidence is about 12 fold higher for PTLD and 3.5 fold higher for non-cutaneous malignancy compare to age-matched population. The increased risk is multifactorial and attributed to oncogenic viruses, immunosuppression and altered T cell immunity. In the era of longer graft survival and with the introduction of more potent immunosuppressive medication, malignancy represents a major burden. The incidence of malignancy after renal transplantation is 3 to 5 times higher. Incidence is higher in transplant patients even when compared to patients on hemodialysis. Aim: We attempted to assess the incidence of post-transplant malignancies in patients who underwent renal transplantation at our centre, along with studying the presentation, type and other factors affecting their development. Method We analysed data retrospectively from 626patients who underwent renal transplantation atour centre from January 2003 to September 2018.Pre transplant history, post transplant course including duration on hemodialysis, immunosuppression details and duration till diagnosis of malignancies were collected. Details regarding type of malignancy, histopathology, staging and treatment given and outcome were collected. Results Number of transplant recipient-626. The total number of patients with malignancy is 12. Incidence of malignancy posttransplant is 1.9%.Male-7 and female-6.One patient was detected with 2 malignanciesduring her post transplant period. The types of malignancies encountered were Conclusion The incidence of malignancy – 1.9%.Probable reason for decreased incidence of malignancy is the decreased immunosuppression needed by South Asian people. The most common malignancy was solid organ tumour; tongue being the most common organ. Most common histological variant is squamous cell carcinoma.Non-Hodgkin is more common than Hodgkin. Incidence of malignancy is low. Decision regarding cancer screening should be made on individual basis.

scholarly journals VALGANCICLOVIR INDUCED THROMBOCYTOPENIA: A CASE REPORT

2017 ◽  
Vol 10 (7) ◽  
pp. 3 ◽  
Author(s):  
Amita D ◽  
Balaji O ◽  
Navin Patil
Keyword(s):  
Case Report ◽  
Renal Transplantation ◽  
Renal Transplant ◽  
Adverse Effects ◽  
Transplant Patient ◽  
Hematological Toxicity ◽  
Severe Immunosuppression ◽  
Platelet Counts ◽  
Transplant Patients ◽  
Renal Transplant Patients

Triple immunosuppression is very pivotal in maintaining the graft in case of renal transplantation. But because of severe immunosuppression, always there is chance of severe adverse effects. Hematological toxicity is usually very common but dreaded in case of renal transplant patients. Here, we report a case of valganciclovir-induced drop in platelet counts in a postrenal transplant patient.

scholarly journals A Case Report on Post-Transplant Erythrocytosis

2019 ◽  
Vol 9 (2) ◽  
pp. 170-173
Author(s):  
Mohammad Mehfuz E Khoda ◽  
Ishrat Jahan Shimu ◽  
Md Golzar Hossain ◽  
Mirza Shariful Haque ◽  
Moontasim Akhter Moon ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Case Report ◽  
Renal Transplantation ◽  
Transplant Recipient ◽  
Haemoglobin Level ◽  
Kidney Transplant Recipient ◽  
Post Transplant ◽  
History Of ◽  
High Haematocrit ◽  
Uncommon Complication

Post-transplant erythrocytosis is defined as persistently elevated haemoglobin and haematocrit levels that occur following renal transplantation and persist for more than six months in the absence of thrombocytosis, leukocytosis or other potential causes of erythrocytosis. Here, we report the case history of a 35-year-old male, who underwent live related kidney transplantation ten months ago, presented with high haemoglobin level and high haematocrit. It is an uncommon complication of kidney transplant recipient,whichprompted us to report the case Birdem Med J 2019; 9(2): 170-173

scholarly journals Clotrimazole troches can alter everolimus pharmacokinetics in post‐transplant patients: A case report

2019 ◽  
Vol 85 (9) ◽  
pp. 2176-2178 ◽  
Author(s):  
Takaya Uno ◽  
Kyoichi Wada ◽  
Sachi Matsuda ◽  
Megumi Ikura ◽  
Hiromi Takenaka ◽  
...  
Keyword(s):  
Case Report ◽  
Post Transplant ◽  
Transplant Patients

Post-transplant lymphoproliferative disorder presenting as epistaxis

2004 ◽  
Vol 118 (11) ◽  
pp. 906-908 ◽  
Author(s):  
Jonathan D. Clarke ◽  
David Stock ◽  
Vijay Singh
Keyword(s):  
Computed Tomography ◽  
Renal Transplantation ◽  
B Cell ◽  
Nasal Cavity ◽  
Lymphoproliferative Disorder ◽  
Unusual Case ◽  
Polypoid Lesion ◽  
Post Transplant ◽  
Transplant Patients ◽  
Tonsil Tissue

An unusual case of epistaxis resulting from post-transplant lymphoproliferative disorder is described.A 30-year-old woman who had undergone renal transplantation 12 years previously presented with profuse, posterior, unilateral epistaxis. The initial findings, workup and treatment are presented. A post-nasal space (PNS) mass was detected and biopsy showed this to be an Epstein-Barrvirus-positive polymorphous B-cell post-transplant lymphoproliferative disorder. Computed tomography findings showed a polypoid lesion protruding from the sphenoethmoidal recess and filling the left PNS.Post-transplant lymphoproliferative disorder is well known to involve tonsil tissue. Commonly, this is the first presentation of the disease in children. However, until now post-transplant lymphoproliferative disorder has not been described in the PNS or nasal cavity presenting as epistaxis. We conclude that all transplant patients presenting with epistaxis should be followed up for an accurate examination of the PNS and nasal cavity after the acute episode.

scholarly journals Working to establish ‘normality’ post-transplant: A qualitative study of kidney transplant patients

2013 ◽  
Vol 10 (4) ◽  
pp. 247-258 ◽  
Author(s):  
Annette Boaz ◽  
Myfanwy Morgan
Keyword(s):  
Side Effects ◽  
Kidney Transplant ◽  
Personal Construct ◽  
Post Transplant ◽  
Transplant Patients ◽  
Wide Range ◽  
Transplant Failure ◽  
Kidney Transplant Patients ◽  
One Year

Objectives To explore patients’ perceptions and experiences of ‘normality’ and the influences on this at three time points post-transplant. Methods In-depth interviews with 25 patients at three months, one year and more than three years following kidney transplant. Patients’ accounts were compared with Sanderson et al.’s typology of types of normality. Findings Post-transplant, patients worked hard to re-establish normality, albeit in a ‘reset’ form. This normality was a very personal construct, shaped by a wide range of factors including age, gender and personal circumstances. Some patients encountered significant challenges in regaining normality, both at three months for those experiencing acute and distressing side effects, and later relating to the long-term side effects of transplant medication and co-morbidities. However, the most dramatic threat to normality (disrupted normality) came from episodes of rejection and transplant failure. Conclusions The main types of normality achieved vary for different conditions. Moreover, despite improvements in health post-transplant and opportunities to build a new, reset normality, the participants recognised the need to pay careful attention to the spectre of future ill health and transplant failure. Transplant failure was therefore a source of disruption that was central to their illness narratives and perceived as an ever present risk.

scholarly journals Early Post-transplant Renal Functions Predict Incidence of Acute Rejection in Kidney Transplantation

2020 ◽  
pp. 45-56
Author(s):  
Khulud Alhelal ◽  
Wejdan Almutairi ◽  
Yousef Al-Rajhi ◽  
Rakan Khalid Alfouzan ◽  
Senthilvel Vasudevan ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Renal Transplantation ◽  
Renal Transplant ◽  
Acute Rejection ◽  
Serum Creatinine ◽  
Normal Level ◽  
Potassium Level ◽  
Post Transplant ◽  
Transplant Patients

Objectives: After renal transplantation, a remarkable improvement of impaired patient’s kidney function is often observed. Preserving improved kidney function ensures long-term renal allograft survival. However, there are different risk factors; the acute rejection is the major risk factor. Therefore, the aim of the present study was to examine renal function within the first six months as independent variables in predicting long-term survival and incidence of acute rejection. Methods: Fifty-three patients who underwent kidney transplantation in 2016 and 2017 in King Abdulaziz Medical City- National Guard were evaluated consecutively1 and 2-month pre-transplant up to six months’ post-transplant. Time course of changes in kidney functions; measurements of serum creatinine (Scr), blood urea nitrogen(BUN), albumin, calcium, sodium and potassium were recorded. Estimated glomerular filtration rate (eGFR) and anion gap (AGAP) were also reported. In addition, age, anthropometric factors and causes of ESRD were analyzed. Results: Lower level of calcium was observed in 40% of patient’s two-month pre-transplantation and 69% of patients one month before. Normalization of calcium was achieved in all patients starting from second month post-transplantation. All patients presented elevated serum potassium level in pre-transplant months, however, renal transplant normalize potassium level starting from first month. A remarkable higher level of serum BUN was observed in all pre-transplant patients followed by dramatically decreased after renal transplant for first four months and remain in normal level starting from month 5. Likewise, serum creatinine was highly elevated in all pre-transplant patients. A profound reduction in serum creatinine started from month 1 post-transplant and normalizes at month 4. Moreover, both eGFR and AGAP were kept in normal level immediately after renal transplantation. All patients with early acute rejection during mean follow-up period have a remarkable elevated level of serum creatinine and profound decrease in eGFR starting from first month. While a significant higher level of serum BUN observed in fifth month only and serum albumin in third month. Conclusion: Significant elevation of serum creatinine and reduction in eGFR starting from first month were associated with post-transplanted patients with early acute rejection. The clinical use of eGFR and serum creatinine may aid in predicting incidence of early acute rejection.

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