scholarly journals Post-operative hypocalcemia in patients undergoing thyroid surgeries in tertiary care hospital: an observational study

2021 ◽  
Vol 7 (8) ◽  
pp. 1293
Author(s):  
Tabish Maqbool ◽  
Showkat Ahmad Showkat ◽  
Kulvinder Singh Mehta
Keyword(s):  
Thyroid Surgery ◽  
Tertiary Care Hospital ◽  
Statistical Significance ◽  
Tertiary Care ◽  
Perioperative Period ◽  
Female Gender ◽  
Care Hospital ◽  
Thyroid Resection ◽  
Strong Risk Factor ◽  
Permanent Hypocalcemia

<p><strong>Background: </strong>Post-operative hypocalcaemia is one of the most common complications of thyroid and parathyroid surgery. Temporary hypocalcaemia has been reported to occur in 1.6-50% of the patients undergoing bilateral thyroid resection. Permanent hypoparathyroidism results in 0-13% of patients after bilateral thyroid surgery.</p><p><strong>Method: </strong>We have analyzed the data of 34 patients undergoing total thyroid surgery (with or without neck dissection) and completion thyroidectomy at the department of ENT and HNS, SMHS hospital over a period of 1.5 years between May 2019 to November 2020.</p><p><strong>Results:</strong> Hypocalcemia was found in a total of 15 patients out of 34 patients in the post-op period. Among the total patients who developed hypocalcemia 5 (14.7%) were males and 10 (29.4%) were females. Among the patients who developed post-op hypocalcemia 14 patients developed transient hypocalcemia (p&gt;0.01) which is not statistically significant and 1 patient developed permanent hypocalcemia (p&gt;0.01) which also has no statistical significance.</p><p><strong>Conclusions: </strong>The study suggests that female gender is a strong risk factor for developing post-operative hypocalcemia, other factors that play a role include difference in serum calcium levels in the perioperative period and type of surgery.</p>

scholarly journals Frequency Of Post-operative Hypocalcaemia Following Thyroid Surgery At A Tertiary Care Hospital Of Sindh

2017 ◽  
Vol 08 (01) ◽  
pp. 07-10
Author(s):  
Summaya Qazi ◽  
Khalil ahmed Almani ◽  
Rizwanullah Junaid Bhanbhro ◽  
Diya Ram Khatri
Keyword(s):  
Serum Calcium ◽  
Thyroid Surgery ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
University Hospital ◽  
P Value ◽  
Care Hospital ◽  
Long Duration ◽  
Symptomatic Hypocalcemia ◽  
Laboratory Investigations

Objective: The present study was conducted to determine the frequency of post-operative hypocalcaemia following thyroid surgery at a tertiary care hospital of Sindh Study design: Observational study Place and Duration: Department of surgery, Isra University Hospital from December 2014 to July 2017. Materials and Methods: 100 cases of thyroid swellings were selected according to inclusion and exclusion criteria. Pre- operative patient history, physical examination, thyroid gland examination and laboratory investigations were performed. A serum calcium levels <8 mg/dl was taken as hypocalcemia. Data was analyzed on SPSS 21 version and P value (P< 0.05) was considered significant. Results: Of 100 patients, 67% were female and 33% were male (P=0.0001). Female dominancy was noted with female to male ratio of 2.03:1. Age (mean± SD) was noted as 37.5 ± 9.5 years (19 – 48 years). Frequency of symptomatic hypocalcaemia was noted in 23% subjects post operatively. Mean± SD serum calcium and phosphate in post operative hypocalcemia subjects was noted as 7.31 ± 0.38 mg/dl and 2.95 ± 0.63 mg/dl respectively. Majority of symptomatic hypocalcemia were noted within 72 hours post operatively. Conclusion: The present study reports 23% frequency of post thyroidectomy hypocalcemia noted within 72 hours post operatively. Goiters of long duration, recurrent goiters, hyperthyroidism and goiters with retro sternal extensions were found risk factors for the post thyroidectomy hypocalcemia.

scholarly journals Significance of Immunohistochemical Biomarker in Breast Carcinoma from a Single Tertiary Care Hospital of Southern Assam

2021 ◽  
Author(s):  
Naiding Momota ◽  
Choudhury Biswadeep ◽  
Bezbaruah Babul ◽  
Nivedita Dasgupta ◽  
Deuri Biman ◽  
...  
Keyword(s):  
Lymph Node ◽  
Breast Carcinoma ◽  
Tumor Size ◽  
Tertiary Care Hospital ◽  
Histological Grade ◽  
Statistical Significance ◽  
Tertiary Care ◽  
Tumor Grade ◽  
Lymph Node Status ◽  
Care Hospital

Abstract Background: Breast carcinoma is the most common malignancy in female worldwide, leading cause of death in women.immunohistochemistry plays a very important role in the prognostication and treatment determination of breast carcinoma patients. Objective: To analyze the immunohistochemical markers in invasive carcinoma of breast and to correlate the expression of hormonal receptors with age of the patient, tumor size, histological grade and lymph node metastasis.Materials and method: The study was conducted on 88 infiltrating ductal breast carcinoma sample in a tertiary care hospital of Southern Assam for a period of two year (January2018- December 2019). Data including age, tumor size, and histologic grade and lymph node status retrieved from pathology department. Chi- square was used to determine the statistical significance between ER/PR status HER2/neu status along with their correlation with various clinicopathological parametres with respect to infiltrating ductal breast carcinoma.Result: The mean age of the patients was 56.6 years. We observed correlation between ER and PR expression with age, tumor size, tumor grade. There was correlation between HER2/neu expression and age only. None of the markers showed correlation with lymph node involvement (P>0.05).Conclusion: Our findings showed the importance of biomarkers (ER, PR, HER2/neu) expression as prognostic factors for therapeutic decision.

scholarly journals Interactive effects of asparagine and aspartate homeostasis with sex and age for the risk of type 2 diabetes risk

2020 ◽  
Author(s):  
Hui-Huan Luo ◽  
Xiao-Fei Feng ◽  
Xi-Lin Yang ◽  
Rui-Qin Hou ◽  
zhongze fang
Keyword(s):  
Type 2 Diabetes ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Female Gender ◽  
Elevated Risk ◽  
Interactive Effects ◽  
Care Hospital ◽  
Secondary Interaction ◽  
Increased Risk

Abstract Background Asparagine and aspartate homeostasis link with type 2 diabetes (T2D). This study aimed to explore whether asparagine and aspartate metabolism interacted with sex and age to increase the risk of T2D.Methods From 27 May 2015 to 3 August 2016, we consecutively retrieved 1032 T2D patients and 1522 subjects without T2D from a tertiary care hospital in Liaoning, China. Restricted cubic spline nested in the logistic regression was used to draw odds ratio curves of plasma asparagine to aspartate ratio for T2D by sex and age. Cutoff point was select where curves went apart, indicating possible interaction. Addictive interactions of asparagine to aspartate ratio with sex or age and secondary interaction with copresence of unfavorable sex and age were further estimated using relative excess risk due to interaction (RERI), attributable proportion due to interaction (AP), and synergy index (S). Results Ratio of asparagine to aspartate >1.5 was associated with elevated risk of T2D (OR: 7.99, 95%CI: 5.50 to 11.6), which was enhanced by female gender to 13.6, (95%CI: 8.10-22.9) and by >50 years of age to 28.7 (14.6-56.3), with significant additive interactions. There was a significant secondary-interaction of copresence of female sex and > 50 years of age with high asparagine to aspartate ratio for increased T2D risk with the OR being further increased to 34.4 (20.5 - 57.5). Conclusions High asparagine to aspartate ratio was associated with markedly increased risk of T2D, which was further amplified by either female gender or >50 years of age, and especially both.

scholarly journals Interactive effects of asparagine and aspartate homeostasis with sex and age for the risk of type 2 diabetes risk

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Hui-Huan Luo ◽  
Xiao-Fei Feng ◽  
Xi-Lin Yang ◽  
Rui-Qin Hou ◽  
Zhong-Ze Fang
Keyword(s):  
Type 2 Diabetes ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Female Gender ◽  
Elevated Risk ◽  
Interactive Effects ◽  
Care Hospital ◽  
Secondary Interaction ◽  
Increased Risk

Abstract Background Asparagine and aspartate homeostasis are linked with type 2 diabetes (T2D). This study aimed to explore whether asparagine and aspartate metabolism interacted with sex and age to increase the risk of T2D. Methods From 27 May 2015 to 3 August 2016, we consecutively retrieved 1032 T2D patients and 1522 subjects without T2D from a tertiary care hospital in Liaoning, China. Restricted cubic spline nested in the logistic regression was used to draw odds ratio curves of plasma asparagine to aspartate ratio for T2D by sex and age. Cut-off point was selected where curves went apart, indicating possible interaction. Addictive interactions of asparagine to aspartate ratio with sex or age and secondary interaction with copresence of unfavorable sex and age were further estimated using relative excess risk due to interaction (RERI), attributable proportion due to interaction (AP), and synergy index (S). Results Ratio of asparagine to aspartate > 1.5 was associated with elevated risk of T2D (OR 7.99, 95%CI 5.50 to 11.6), which was enhanced by female gender to 13.6, (95%CI 8.10–22.9) and by > 50 years of age to 28.7 (14.6–56.3), with significant additive interactions. There was a significant secondary-interaction of copresence of female sex and > 50 years of age with high asparagine to aspartate ratio for increased T2D risk with the OR being further increased to 34.4 (20.5–57.5). Conclusions High asparagine to aspartate ratio was associated with markedly increased risk of T2D, which was further amplified by either female gender or > 50 years of age, and especially both.

scholarly journals Clinicodemographic Profile of Children with Seizures in a Tertiary Care Hospital: A Cross-Sectional Observational Study

2017 ◽  
Vol 2017 ◽  
pp. 1-6 ◽  
Author(s):  
Nagendra Chaudhary ◽  
Murli Manohar Gupta ◽  
Sandeep Shrestha ◽  
Santosh Pathak ◽  
Om Prakash Kurmi ◽  
...  
Keyword(s):  
Hospital Admissions ◽  
Tertiary Care Hospital ◽  
Statistical Significance ◽  
Tertiary Care ◽  
Age Groups ◽  
Idiopathic Epilepsy ◽  
Care Hospital ◽  
Partial Seizures ◽  
Cross Sectional ◽  
Mortality And Morbidity

Seizures are one of the common causes for hospital admissions in children with significant mortality and morbidity. This study was conducted to study the prevalence and clinicodemographic profile of children with seizures in a tertiary care hospital of western Nepal. This prospective cross-sectional study conducted over a period of 2 years included all admitted children (2 months–16 years) with seizures. Among 4962 admitted children, seizures were present in 3.4% (n=168) of children, with male preponderance. 138 (82.1%) children had generalized tonic-clonic seizures (GTCS) and 30 (17.9%) children had partial seizures. GTCS were more common than partial seizures in both sexes (male = 82.7%; female = 81.2%) and age groups. There was no statistical significance in the distribution of seizures (GTCS and partial seizures) with sexes (P=0.813) and age groups (P=0.955). Mean ages of children having GTCS and partial seizures were 8.2±4.6 years and 8.2±4.2 years, respectively. Loss of consciousness (55.4%), fever (39.9%), vomiting (35.1%), and headache (16.1%) were common complaints in seizure patients. Significant number of GTCS cases had fever (P=0.041) and neurocysticercosis (n=72; 43%) was the most common etiology in seizure patients. Idiopathic epilepsy (38 (22.6%)), meningoencephalitis (26 (15.5%)), and febrile convulsions (14 (8.33%)) were other leading disorders in children with seizures.

scholarly journals PREVALENCE OF COGNITIVE DECLINE IN PATIENTS WITH STROKE

2020 ◽  
Vol 70 (6) ◽  
pp. 1604-08
Author(s):  
Fatima Naseem Malik ◽  
Usama Bin Zubair ◽  
Wasim Alamgir ◽  
Asif Hashmat ◽  
Saeed Arif ◽  
...  
Keyword(s):  
British Columbia ◽  
Cognitive Decline ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Female Gender ◽  
Physical Impairment ◽  
Sample Population ◽  
Care Hospital ◽  
Cognitive Complaints ◽  
Cross Sectional

Objective: To determine the prevalence of cognitive decline among the patients of stroke and analyze the associated socio demographic factors. Study Design: Cross sectional study. Place and Duration of Study: Tertiary care hospital of Rawalpindi, from May 2018 to Aug 2018. Methodology: The sample population comprised of n=180 patients of hemorrhagic or ischemic stroke presenting at a tertiary care hospital in Rawalpindi, Pakistan. Cognitive decline was assessed by using the British Columbia Cognitive Complaints Inventory (BC-CCI) four weeks after the acute stroke. Relationship of age, gender, marital status, education, type of stroke, presence of physical impairment and tobacco smoking was assessed with the presence of cognitive decline among the patients of stroke. Results: Out of 180 patients of stroke screened through British Columbia Cognitive Complaints Inventory, 129 (71.7%) showed the presence of cognitive decline while 51 (28.3%) had no cognitive decline. After applying the logistic regression we found that female gender and presence of physical impairment had significant association with the presence of cognitive decline among the patients of stroke. Conclusion: This study showed a high prevalence of cognitive decline among the patients of stroke in Pakistan. Routine screening for cognitive decline should be done at the stroke follow up clinic and special attention should be paid to the female patients of stroke and those with physical impairment.

scholarly journals Hospital Based Study among Glaucoma Patients to Assess Their Knowledge Regarding Various Aspects of Glaucoma

Healthline ◽  
2020 ◽  
Vol 11 (2) ◽  
pp. 60-66
Author(s):  
Sandhya Somasundaran ◽  
Susheela Bindu ◽  
Jyothi P.T.
Keyword(s):  
Disease Duration ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Female Gender ◽  
Current Level ◽  
Prolonged Treatment ◽  
Care Hospital ◽  
Cross Sectional ◽  
Educational Levels ◽  
Level Of Knowledge

Introduction:Glaucoma is a chroniccondition and if not properly controlled will lead to blindness. So it is very important that patients on treatment for glaucoma should know about the course and outcome of the disease. Many patients stop the treatment because of treatment cost and also due to the prolonged treatment duration. Objectives: To find out the current level of knowledge of their disease among glaucoma patients attending a tertiary care hospital in south India.Methods: It was a cross sectional hospital-based study.Study participants included already diagnosed patients attending glaucoma clinic. A structured validated pretested questionnaire was given to collect data. The questionnaire was given to 320 patients attending glaucoma clinic during their routine visit. Grading was done based on the percentage of questions answered. Data were analyzed with SPSS version 18; (SPSS Inc; Chicago, IL)Results:The mean age was 59.34 ± 8. 86years.Femaleswere more aware compared to males. Only 40% (108) of patients knew that glaucoma can cause blindness. Socioeconomic factors had significant association only with awareness of the disease.Educational status had significant association with awareness about the disease as well as the treatment received. Disease duration did not have any significant association with awareness about glaucoma.Conclusion:Determinants of knowledge about glaucoma in this study were female gender, higher socioeconomic status and higher educational levels. Even glaucoma patients who are on treatment for glaucoma did not have sufficient knowledge about their disease.

scholarly journals Comparing the Outcomes of Thyroid Surgical Procedures for Benign Diseases with Expertise of the Surgeon in a Tertiary Care Hospital in Rawalpindi, Pakistan

2021 ◽  
Vol 10 (2) ◽  
pp. 68-75
Author(s):  
Nadir Mehmood Mehmood ◽  
Liaquat Ali Bhatti ◽  
M. Idrees Anwar ◽  
M. Aslam Chaudhry ◽  
Malik Irfan Ahmed ◽  
...  
Keyword(s):  
Total Thyroidectomy ◽  
Surgical Procedures ◽  
Thyroid Surgery ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
Subtotal Thyroidectomy ◽  
Care Hospital ◽  
Benign Diseases ◽  
Cross Sectional ◽  
Permanent Hypocalcemia

Background: There is a lack of standardized guidelines regarding selection of appropriate thyroid surgery for patients with benign diseases. As a result, an inexperienced surgeon may select a more aggressive surgical option, which may increase the complication rate. The objective of this study was to compare the outcomes of thyroid surgical procedures for benign diseases with the expertise of the surgeon.Material and Methods: A retrospective cross-sectional study from 1999 to 2018. The study setting is of a public sector tertiary care teaching hospital. Patients undergoing thyroid surgery (lobectomy with isthmusectomy, subtotal thyroidectomy (STT), near total thyroidectomy (NTT), or total thyroidectomy (TT)) were included. Expertise level 1, 2 and 3 (L1, L2, L3) of the surgeon was based on years of experience or number of thyroid surgeries to their credit. Postoperative complications (hypocalcemia, recurrent laryngeal nerve (RLN) damage, airway obstruction, hemorrhage and mortality) were measured against type of thyroid surgery and expertise of the surgeon.Results: A total of 833 thyroid surgeries were performed on 695 (83.43%) females and 138 (16.57%) males. About 502 (60.26%) STT, 228 (27.37%) TT, 61 (7.32%) NTT, 42 (5.04%) lobectomies with isthmusectomies were performed, with LI, 2, and 3 surgeons performing 21.25%, 45.74% and 33% of these procedures, respectively. Surgeons with L1, 2 and 3 levels of expertise caused 49.47%, 33.45% and 17.08% of adverse events, respectively. Permanent hypocalcemia, RLN damage and mortality were significantly more common in surgeries performed by L1 compared with L2 and L3 surgeons (P<.05). Transient and permanent hypocalcemia, transient and permanent RLN damage and mortality were significantly more common for total thyroidectomy compared to subtotal thyroidectomy (P<.01).Conclusions: Minimizing the occurrence of complications like permanent hypocalcemia, RLN damage and mortality, expertise of the surgeon and anticipated difficulty of the procedure needs to be taken into account while selecting a thyroid procedure.

Identifying the etiological profile of children presented with hepatomegaly admitted to a tertiary care hospital

2020 ◽  
Author(s):  
Chau Duc Nguyen Huu
Keyword(s):  
Tertiary Care Hospital ◽  
Statistical Significance ◽  
Tertiary Care ◽  
Care Hospital ◽  
Age Group ◽  
Central Hospital ◽  
Hematological Disorders ◽  
Study Results ◽  
Common Causes ◽  
Congenital Biliary Atresia

Objectives: To identify the pattern and etiology of diseases in children presented hepatomegaly at Pediatrics Department in Hue Central Hospital, Vietnam. Material and Methods: The Present study was conducted to evaluate the possible etiology and clinical features of children presented with hepatomegaly. A total of 107 children, from one month to fifteen years of age with hepatomegaly admitted in the Pediatric Department of Hue Central Hospital, Vietnam from May 2018 to April 2019 were included in this study. Results: The most common causes of hepatomegaly were inflammation/infection of the liver (miscellaneous cause included), hematological diseases and congestion heart failure with the percentage of 50.5%; 27,1% and 12,1%; respectively. Among the hepatitis group, viral agents account for nearly 50.0%, of which the most common one was Cytomegalovirus accounting for nearly 30.0%. Distribution of causes by age group revealed most cases in 1 year-old or younger children was caused by inflammation (53.8%), and in the older than 1 year-old children were hematological disorders (47.3%) which has statistical significance (P<0.05). Conclusions: Our research observed that the most common causes of the group of ≤ 1 year old were hepatitis, followed by cardiovascular disease and biliary obstruction due to congenital biliary atresia, and in the older than 1 year group, hematological disorders was the most common.

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