scholarly journals The role of platelet rich plasma injection in the management of early osteoarthritis of the knee

2017 ◽  
Vol 4 (1) ◽  
pp. 128
Author(s):  
Yeshwanth Subash ◽  
Kamalakumar K. ◽  
Lydia M.
Keyword(s):  
Quality Of Life ◽  
Functional Outcome ◽  
Platelet Rich Plasma ◽  
Cost Effective ◽  
Functional Results ◽  
Womac Score ◽  
Osteoarthritis Of The Knee ◽  
Early Osteoarthritis

<p class="abstract"><strong>Background:</strong> <span lang="EN-IN">Osteoarthritis of the knee is a degenerative disorder associated with significant morbidity in the form of pain, knee stiffness and decrease in the functional capacity of the affected limb leading to a decrease in the quality of life for the patient. Various modalities of treatment are available for the management of this condition. The aim of this study was to evaluate the role of platelet rich plasma (PRP) injection in the management of early osteoarthritis of the knee and to compare the functional outcome with the studies of various authors as available in literature.</span></p><p class="abstract"><strong>Methods:</strong> <span lang="EN-IN">60 patients with Kellgrenn and Lawrence grade 1 and 2 osteoarthritis of the knee were studied from January 2014 to January 2015 and were followed up for a period of 1 year</span>.<strong></strong></p><p class="abstract"><strong>Results:</strong> <span lang="EN-IN">There were 39 males and 21 female patients in our study with the right side being more commonly affected. There was a significant decrease in the VAS score and the WOMAC score at 1, 3, 6 and 12 months follow up as compared to the pre-injection baseline scores. All patients were satisfied with the procedure in terms of functional outcome. </span></p><p class="abstract"><strong>Conclusions:</strong> <span lang="EN-IN">PRP injection is a cost effective, safe and efficient procedure with easily reproducible results and gives good functional results in terms of pain relief, improvement of range of movements and mobility, and improves the quality of life in patients with early osteoarthritis of the knee.</span></p>

scholarly journals Hope, Hype, Hurdles & Future Perspective for PRP, PRP versus Hyaluronic Acid Injection in Osteoarthritis of Knee: A Review Article.

2020 ◽  
Vol 2 (1) ◽  
pp. e1-e12
Author(s):  
Ashok Kumar ◽  
Anikait Ghosh Kadamb ◽  
Krish Ghosh Kadamb
Keyword(s):  
Hyaluronic Acid ◽  
Knee Joint ◽  
Platelet Rich Plasma ◽  
Future Perspective ◽  
Osteoarthritis Of The Knee ◽  
Stiff Knee ◽  
Injection Interval ◽  
One Year

BackgroundComparative studies of platelet-rich plasma (PRP) and hyaluronic acid show variable results. PurposeA review was conducted to understand the current role of PRP and its efficacy versus hyaluronic acid in osteoarthritis (OA) of the knee joint. MethodsOut of 170 identified studies, 14 studies involving 1575 patients with 637 males and 938 females were selected based on PRISMA flow chart guidelines and were analyzed for the study. ResultsA standard PRP regimen consisting of 2–3 intra-articular injections (IA) of 4–6 mL of leucocyte poor PRP at 1–2 weekly intervals provides a better result than HA during the first 3–6 months, and which may continue up to one year. PRP and HA may have synergistic effect; pain and swelling are the two most com-mon complications with PRP, the incidence is more with leucocyte rich PRP (LP-PRP) and intra-osseous PRP treatment.ConclusionPRP provides hope and is more effective than hyaluronic acid in pain relief and improving the quality of life in mild to moderate osteoarthritis of the knee joint. However, hype, that is effective in all, irrespective of grades of OA, mal-aligned or stiff knee, ligamentous laxity, and can avoid joint replacement is a big hindrance in establishing it as a preferred treatment in OA knee. The author follows the above-mentioned PRP regimen; and recommends to combine leucocyte poor PRP with HA for IA injections & with LP-PRP injections along with the two most common painful points (medial collateral ligament, pesanisernius) in a highly painful OA knee. PRP may not address extra-articular causes of knee pain (mal-alignment, muscle wasting, tendinosis), should be corrected for optimum outcome. Contact sports, running, exercises putting pressure on knee and NSAID should be avoided during PRP treatment. Also, more randomized controlled trials are required to further standardize the PRP preparation, administration, injection interval & proper documentation of efficacy and complications in the regenerative registry.

scholarly journals Elegant Security: Concept, Evidence and Implications

2020 ◽  
Author(s):  
Graham Farrell ◽  
Nick Tilley
Keyword(s):  
Quality Of Life ◽  
Case Studies ◽  
Crime Prevention ◽  
Civil Liberties ◽  
Cost Effective ◽  
Continual Improvement ◽  
Security Technologies ◽  
Life Issue

Some security devices can be ugly, inconvenient or an infringement on civil liberties. This means that security is a quality of life issue as well as one of crime prevention. Here we propose that, in addition to preventing crime and being cost effective, security should preferably be ethical and unobtrusive, aesthetically neutral or pleasing, and the easy-to-use or default option. We describe security with such characteristics as ‘elegant’. We use two case studies to explore how, as many types of crime have declined in recent decades, there was an increase in elegant and a decrease in inelegant security. We suggest that the lifecycle of some security technologies sees them evolve from inelegant to elegant, that continual improvement is required to keep ahead of offender adaptations, and that inelegant security can fall into disuse even if it prevents crime. It is hoped that this conceptual contribution might inform discussions about the appropriate form and role of security.

scholarly journals Unicompartmental Knee Arthroplasty: Short-Term Results

2021 ◽  
Vol 27 (1) ◽  
pp. 153-165
Author(s):  
V. Yu. Murylev ◽  
N. E. Erokhin ◽  
P. M. Elizarov ◽  
G. A. Kukovenko ◽  
A. V. Muzychenkov ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Functional Outcome ◽  
Postoperative Period ◽  
Functional Results ◽  
Early Postoperative Period ◽  
X Rays ◽  
Operating Technique ◽  
Sf 36 ◽  
The Face

Background. Among the methods of surgical treatment of early stages medial knee osteoarthritis in the partial knee replacement (PKR) becomes more and more relevant. The relevance and increasing number of PKR are confirmed by data from various national registers.The aim of the study was to research the early functional results of PKR and to analyze the complications at various stages of the postoperative period.Material and Methods. Study design: a single-center prospective study. The results of 90 operations of PKR in the period from March 2018 to April 2020 are presented. Assessment of knee function and quality of life of patients was performed according to three scalesquestionnaires: KOOS, WOMAC, SF-36, which were filled in preoperatively and then at 3, 6, 9, 12, 18 months. after surgery. Patients within the reporting period provided X-rays and filled in the scales at the face-to-face examination and at remote contact.Results. The most significant improvement of quality of life and median values of the functional results observed after 3 months, and after 18 months. After replacement the best median functional outcome scales KOOS, WOMAC, SF-36 — 79,4 (73,6–84,3); 27,1 (24,8–30,6); 89,1 (85,3–92,6) compared with the functional results obtained before surgery 32,3 (22,8–38,4); 73,6 (63,6–78,8); 35,2 (31,3–42,1); p = 0,027; p = 0.023; p = 0,028, respectively. A negative correlation was obtained between BMI and functional outcome (p = 0.027, R = -0.7).Conclusion. PKR allowed us to achieve an improvement in the quality of life and functional results already in the early postoperative period (from 3 to 18 months after the operation). The improvement of the operating technique, the analysis of errors and the regularity of the performed PKR will improve the results of PKR and minimize the number of complications.

Functional outcome and quality of life in patients undergoing salvage radical prostatectomy (SRPE).

2018 ◽  
Vol 36 (6_suppl) ◽  
pp. 212-212 ◽  
Author(s):  
David Pfister ◽  
Jasmin Pullankavumkal ◽  
Friederike Haidl ◽  
Vahudin Zugor ◽  
Tobias Kohl ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Radical Prostatectomy ◽  
Functional Outcome ◽  
Functional Results ◽  
High Rate ◽  
Surgical Interventions ◽  
Eortc Qlq ◽  
Salvage Radical Prostatectomy

212 Background: Salvage radical prostatectomy is one option for patients with locally recurrent disease with proven long term oncologic control. There are concerns about worse functional results due to fibrotic tissue after radiotherapy and patients are treated with palliative systemic androgendreptivation. We retrospectively analyzed continence and quality of life in patients undergoing SRPE. Methods: After biopsy proven local recurrent prostate cancer 138 patients were offered SRPE and extended lymphadenectomy. Continence and quality of life had been collected before 6 and 12 months after surgery. Validated questionaires with ICIQ and EORTC qlq 30 had been used. Results: Präoperatively at 6 monts and 12 months the feed back was available in 93, 84 and 82 patients respectively. Präoperatively there was no or mild incontinence in 38(40.8%), moderate in 33 (35.5%) and strong incontinence in 22 (23.7%) of the patients. There is a significant decrease in the rate of continence after 6 and 12 months to no or mild in 19 (23.1%), moderate in 19 (23.2%) and strong incontinence in 44 (53.7%) of the patients. In 5 patients an artifitial sphinkter was implanted. Quality of life did not change significantly before and 12 months after surgery. Median value of Question 30 was 6 and five respectively. Conclusions: Patients need to be informed about a worse functional outcome and the potential need for further surgical interventions as artificial sphinkter implantion compared to primary radical prostatectomy. Quality of life seems to be affected only moderatly. Nevertheless there is already a rather high rate of any incontinence before surgery that needs to be taken into account.

scholarly journals Platelet rich plasma for the treatment of osteoarthrosis knee

2017 ◽  
Vol 3 (2) ◽  
pp. 242
Author(s):  
Prashant Maheshwari ◽  
Hemeshwar Harshwardhan
Keyword(s):  
Quality Of Life ◽  
Growth Factors ◽  
Platelet Rich Plasma ◽  
Womac Score ◽  
Knee Function ◽  
Vas Scores ◽  
The Mean ◽  
Grade 3

<p class="abstract"><strong>Background:</strong> New studies focused on modern therapeutic methods which stimulate cartilage healing and repair the damage, including the use of platelet-rich plasma (PRP) as a cocktail of growth factors. This study has the purpose to present the use of PRP in management of knee osteoarthrosis and its outcomes up to 6 month follow up.</p><p class="abstract"><strong>Methods:</strong> 58 patients with 100 knees (32 male, 26 female) with Kellgren Lawrence grade 1, 2,3 and 4, aged between 50 to 65 years between February 2015 to December 2015 treated with 4 ml of intra-articular PRP injections at 4 week interval in each affected knee and evaluated using WOMAC and VAS scores before injection and on follow up at end of the 1<sup>st</sup>, 3<sup>rd</sup>, and 6<sup>th</sup> month.<strong></strong></p><p class="abstract"><strong>Results:</strong> The mean age was 58.29 years. Improvement in WOMAC score for KL grade 1 (32.61%), grade 2 (31.12%), grade 3(26.54%) whereas only 13.68% in KL grade 4 at end of 6month follow up. Improvement in VAS score for KL grade 1 (41.30%), grade 2 (38.02%), grade 3 (47.68) whereas only 12.74% in grade 4 at the end of 6 month follow up. Results show statistically higher significant improvement seen in WOMAC and VAS for KL grade 1, 2, and 3 as compared to grade 4 at 6 months follow up.</p><p><strong>Conclusions:</strong> The results of our study illustrated that the treatment with intra articular PRP injections is safe and effective in reducing pain and stiffness as well as improve knee function and quality of life in early stages of knee osteoarthrosis. </p>

scholarly journals Does intra articular platelet rich plasma injection improve function, pain and quality of life in patients with osteoarthritis of the knee? A randomized clinical trial

2014 ◽  
Vol 6 (3) ◽  
Author(s):  
Seyed Mansoor Rayegani ◽  
Seyed Ahmad Raeissadat ◽  
Morteza Sanei Taheri ◽  
Marzieh Babaee ◽  
Mohammad Hassan Bahrami ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Platelet Rich Plasma ◽  
Short Form ◽  
Control Group ◽  
Osteoarthritis Of The Knee ◽  
Therapeutic Exercise ◽  
Platelet Concentration

We designed a randomized clinical trial with control group, to investigate the effects of platelet rich plasma (PRP) on pain, stiffness, function and quality of life in patients with knee osteoarthritis. Patients were randomly divided in two groups. For both groups of participants, therapeutic exercise was prescribed. In the PRP group, two courses of leukocyte rich PRP (5.6 fold higher platelet concentration) with a 4-week interval was injected. For each participant, Western Ontario and McMaster University’s Arthritis Index (WOMAC) and the SF-36 questionnaire (Farsi version) were filled at the baseline and 6 months after treatments. Thirty-one patients in the PRP group and 31 patients in the control group were studied. Mean changes of total WOMAC, physical component summery and mental component summery of Short Form-36 in PRP group showed better improvement than control group (P&lt;0.05). This study showed that intra articular PRP knee injection combined with therapeutic exercise can be more effective in pain reduction and improvement of stiffness and quality of life, compared with therapeutic exercise alone.

scholarly journals Effectiveness of intra-articular injection of platelet-rich plasma versus triamcinolone in osteoarthritis of knee – A hospital-based randomized clinical trial

2021 ◽  
Vol 7 (1) ◽  
pp. 6-11
Author(s):  
S K Saidapur ◽  
Rajendra B Uppin ◽  
Nitish K ◽  
Gangadhar Bhuti ◽  
Satish Bachchu
Keyword(s):  
Quality Of Life ◽  
Platelet Rich Plasma ◽  
Osteoarthritis Of The Knee ◽  
Short Term ◽  
Relieve Pain ◽  
Randomized Control ◽  
Control Study ◽  
Better Than

Osteoarthritis of the knee is one of the most common conditions which clinicians have to deal with in their day-to-day practice. There are various pharmacologic therapies recommended for OA knee. Intra-articular Platelet Rich Plasma (PRP) and Intra-articular Triamcinolone have been shown to relieve pain and improve quality of life in patients with OA knee. This study is conducted to compare the effectiveness of PRP and Triamcinolone intra-articular injections in Grade 1 & 2 OA knee.We conducted a randomized control study including 70 patients with Grade 1 & 2 (Kellgrenn & Lawrence grading) OA knee. 35 patients each were divided into the PRP group and Triamcinolone group. Intra-articular PRP 5ml and Intra-articular Triamcinolone 80mg were injected twice 3 weeks apart. The effectiveness of the treatment was evaluated by using VAS, KOOS, and WOMAC scores at 3 weeks, 3 months, and 6 months of the follow-up period.At 3 weeks follow up both the groups showed similar results decreasing pain and improving quality of life. At 6 months follow-up, the PRP group showed better results, and the same effect was observed at 6 months of follow-up. Overall, the PRP group showed better VAS, KOOS, and WOMAC scores compared to the Triamcinolone group.In the present study both the groups showed improvement in function and reduction in pain in patients with Osteoarthritis of the knee but Triamcinolone had a short-term effect compared to PRP. The study showed the effect of intra-articular injection of platelet-rich plasma was better than triamcinolone in early osteoarthritis of the knee.

Non-pharmacological approaches to dementia: An overview of foundations & considerations

2017 ◽  
Vol 9 (4) ◽  
pp. 254
Author(s):  
Linda Carozza ◽  
Lisa-Marie Serrone ◽  
Lara Sugatan
Keyword(s):  
Quality Of Life ◽  
Cost Effective ◽  
Yield Potential ◽  
Pharmacological Treatments ◽  
Dance Movement ◽  
Medical Interventions ◽  
Progressive Degeneration ◽  
Technological Interventions

Dementia is a syndrome characterized by the progressive degeneration of one's cognitive function. The syndrome inflicts one in every nine individuals 65 and older; and 200,000 individuals under the age of 65. Currently, no cure exists; thus, finding the highest quality treatment to reduce the symptoms of the disease must become priority. Maintaining or increasing one’s quality of life is the utmost goal of any therapy for individuals with dementia. Currently, non-pharmacological approaches for suppressing concomitant symptoms of the disease have become highly debated and researched for their usefulness and for their ability to achieve this goal. Several therapeutic methods that can be considered non-pharmacological - music therapy, narrative telling , poetry, art therapy, technological interventions, and exercise and dance movement programs. A literature review was completed in order to determine the role of theseapproaches on dementia. Findings indicate that there is a small effect on cognition during these therapies presently, but there is still insufficient research in the area to conclude a sufficient difference. Non-pharmacological treatments yield potential quality of life benefits while additionally being cost-effective compared to medical interventions. Due its prevalence, further research on this topic is warranted and necessary.

scholarly journals The role of the balneo-physical-kinetic treatment on the ligamentous stability in osteoarthritis of the knee

2019 ◽  
Vol 10 (Vol.10, No.3) ◽  
pp. 272-277
Author(s):  
Marius Sorin CHIRIAC ◽  
Petru BORDEI ◽  
Sergiu CHIRILA 2, ◽  
Tony HANGAN ◽  
Mihaela ZAMFIRESCU
Keyword(s):  
Quality Of Life ◽  
Rehabilitation Program ◽  
Osteoarthritis Of The Knee ◽  
Successive Treatment ◽  
Physical Kinetic ◽  
Womac Questionnaire ◽  
Kinetic Treatment

Osteoarthritis of the knee is one of the disabling conditions with a major impact on the quality of life of the patients. Existing therapies focus on reducing pain and disability caused by the disease. The existence of scores that evaluate the different aspects of patients quality of life are often used in monitoring the treatment and its results. The study is performed on a batch of 21 patients, between June 2017 and June 2018. They performed a complex rehabilitation program being evaluated every six months by applying the WOMAC questionnaire and performing specific maneuvers. The study has shown that by performing complex rehabilitation treatments the patients ability to perform some actions as well as their quality of life is improved and the effect following repeated treatments every six months is maintained during two treatments successive treatment.

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