scholarly journals Evaluation of adapalene alone versus combination therapy of adapalene with benzoyl peroxide and adapalene with clindamycin in treatment of acne vulgaris: a prospective, observational study

2019 ◽  
Vol 5 (4) ◽  
pp. 831
Author(s):  
Nehal R. Parikh ◽  
Shikha V. Sood ◽  
Devang Rana ◽  
Raju Chaudhary ◽  
Supriya D. Malhotra
Keyword(s):  
Combination Therapy ◽  
Observational Study ◽  
Benzoyl Peroxide ◽  
Prospective Observational Study ◽  
Age Of Onset ◽  
Negative Impact ◽  
Acne Vulgaris ◽  
Positive Influence ◽  
Female Ratio ◽  
Health Related Qol

<p class="abstract"><strong>Background:</strong> Acne vulgaris is majorly affecting adolescent population with profound negative impact on the quality of life (QOL). The objectives of the present study was to evaluate adapalene 0.1% alone vs combination therapy of adapalene 0.1% with benzoyl peroxide (BPO) 2.5% and adapalene 0.1% with clindamycin 1% in the treatment of acne vulgaris and to analyse health related QOL using the cardiff acne disability index (CADI).</p><p class="abstract"><strong>Methods:</strong> This prospective, observational study of 12 months duration involved patients who were being treated with adapalene alone and adapalene combined with either clindamycin or benzoyl peroxide in the normal course of treatment. Efficacy of treatment and QOL was assessed by the comprehensive acne severity system (CASS) and CADI respectively.<strong></strong></p><p class="abstract"><strong>Results:</strong> A total of 180 patients were enrolled (n=60 in each group). Male: female ratio was 1: 2.52. 76.7% patients were of adolescent age with the Mean age of 21.17±3.28 years. Average age of onset was 18.03±2.80 years. Most patients had moderate grade of acne (51%) followed by mild grade (46%) and almost clear (3%). Face was the common site, followed by back and chest. There was a statistically significant improvement in both number of lesions and also QOL in all the three treatment groups (p&lt;0.0001).</p><p class="abstract"><strong>Conclusions:</strong> Topical adapalene 0.1% is efficacious in the treatment of acne vulgaris both alone as well as in combination with topical benzoyl peroxide 2.5% and topical clindamycin 1%. Adapalene also has positive influence on the QOL alone as well as in combination but no superiority of one group over the other was observed with regard to efficacy as well as QOL.</p><p> </p>

scholarly journals Anaesthesia and Perioperative Care in Remote Health Camps- Patients’ Concerns

2010 ◽  
Vol 49 (179) ◽  
Author(s):  
Balkrishna Bhattarai ◽  
A Ghimire ◽  
BK Baral ◽  
A Shrestha ◽  
Y Dhungana
Keyword(s):  
Observational Study ◽  
Perioperative Care ◽  
Local Anaesthesia ◽  
Prospective Observational Study ◽  
Main Concern ◽  
Surgical Experience ◽  
Female Ratio ◽  
Male Female Ratio ◽  
The Mean ◽  
Remote Health

INTRODUCTION:Identifying patients' concerns and expectations regarding anaesthesia and perioperative care in mobile surgical camps is relevant for the camp workers. This prospective observational study was conducted to assess knowledge, concerns, and expectations about anaesthesia and perioperative care in patients undergoing surgery in mobile surgical camps in remote mountainous districts of Eastern Nepal.METHODS:A questionnaire with seven items related to anaesthesia and perioperative care was used for interviewing 80 individuals of age > or = 12 years, 20 from each camp at Solukhumbu, Sankhuwasabha, Khotang and Bhojpur districts.RESULTS:Data of two patients were lost leaving only 78 individuals for analysis. The mean age of the subjects was 30.5 (+/- 14.6) years with the male: female ratio of 43: 35. Fifty-eight (74.4%) patients had some gross idea about the modality of administration of anaesthetics. Twenty-six (33.3%) individuals preferred GA over local anaesthesia, whereas 22 (28.2%) were happy either way if there was no pain. Pain was the main concern for 73.1% of the patients. Of the 25 patients expressing fear of GA, death or not being able to wake up anymore was the main concern for 60.0%. Increasing age was associated with lower fear of GA (p < 0.05). Surgical experience was distressing for 17 (21.8%) patients. The overall experience of the anaesthesia and surgery was worse than expected for 25.6% of the patients.CONCLUSIONS:Patients presenting to these health camps have limited knowledge regarding anaesthesia and perioperative care but have valid concerns and expectations in respect of their safety, comfort and outcome.

scholarly journals Oral Azithromycin Pulse Therapy and Daily Topical Benzoyl Peroxide in the Treatment of Acne Vulgaris: An Open Clinical Trial Study

2018 ◽  
Vol 36 (1) ◽  
pp. 11-15
Author(s):  
Bilqis Akter
Keyword(s):  
Clinical Trial ◽  
Combination Therapy ◽  
Benzoyl Peroxide ◽  
Acne Vulgaris ◽  
Pulse Therapy ◽  
Controlled Clinical Trial ◽  
Combination Regimen ◽  
Lesion Count ◽  
Oral Azithromycin ◽  
Count Change

Introduction: Combination therapy is an effective approach to simultaneously target multiple pathogenic factor of acne. A unique combination of oral azithromycin pulse therapy and daily topical benzoyl peroxide has been developed for treatment of acne.Material & Methods: It was an open, controlled, clinical trial, conducted on 37 out patients with acne vulgaris. Patients were clinically assessed at baseline &at week 0,4, 8 and 12. Evaluation included success rate (subjects clear or excellent improvement, good response), lesion count & percentage change in lesion count from baseline, cutaneous tolerability & adverse events.Results: The combination of oral azithromycin pulse therapy & daily topical benzoyl peroxide was very safe & effective with significant differences in percentage of lesion count change observed as early as 1-4 weeks .Adverse events were more frequent with the combination therapy that occurred early in the study &were transient.Conclusion: This study revealed that combination regimen of azithromycin &benzoyl peroxide (4%) is indeed very much efficacious & safe in the management of acne vulgaris.J Bangladesh Coll Phys Surg 2018; 36(1): 11-15

scholarly journals Prevalence and pattern of PCOS in women presenting with acne, a hospital based prospective observational study

2018 ◽  
Vol 6 (3) ◽  
pp. 899
Author(s):  
Raja Shareef A. ◽  
P. V. S. Prasad ◽  
P. K. Kaviarasan
Keyword(s):  
Observational Study ◽  
Prospective Observational Study ◽  
Polycystic Ovarian Syndrome ◽  
Acne Vulgaris ◽  
Strong Association ◽  
Tertiary Care ◽  
Final Analysis ◽  
Endocrine Disorders ◽  
Medical College ◽  
Ovarian Syndrome

Background: Acne is one of the most common dermatological conditions encountered in day to day practice. Many recent studies have reported a strong association between acne and underlying systemic endocrine disorders, more particularly Poly cystic ovarian syndrome. But there is scarcity of literature on the subjects in Indian population. Hence the present study was conducted with an objective of studying the association between acne and polycystic ovarian syndrome, in women presenting with adult onset acne to a tertiary care teaching hospital.Methods: A prospective observational study was carried out in department of dermatology, Dhananalakshmi Srinivasan medical college and hospital, Permabalur from January 2016 to August 2017. The study population included women above 18 years of age clinically diagnosed with acne vulgaris. The presence of polycystic ovarian syndrome was assessed using Rotterdam criteria.Results: The final analysis had included 100 women with acne. The most common type of lesion observed was comedone in 91% of women. The other most common lesions were papule seen in 73%, pustule in 35% of women. The proportion with grade I, Grade II and grade III acne was 58%, 29% and 13% respectively. The prevalence of PCOS was 30% (95% CI 21.89% to 39.58%). PCOS had shown no statistically significant association with age, marital status and regularity of menstrual cycle. The factors which have shown statistically significant association were higher BMI, presence of Hirsutism and higher waist circumference.Conclusions: PCOS is highly prevalent among women with acne. Presence of hirsutism, obesity are strong risk factors for PCOS.

scholarly journals Negative Impact of Postoperative Early Surgical Incision Dressing: A Prospective Observational Study

2019 ◽  
Vol 20 (4) ◽  
pp. 322-324
Author(s):  
Alpaslan Kaban ◽  
Olcay Seval ◽  
Karolin Ohanoğlu ◽  
Işık Kaban ◽  
Fatma Ferda Verit
Keyword(s):  
Observational Study ◽  
Prospective Observational Study ◽  
Negative Impact ◽  
Surgical Incision

scholarly journals Incidence and management of intestinal perforation in typhoid: a prospective, observational study

2020 ◽  
Vol 7 (5) ◽  
pp. 1570
Author(s):  
Bhanwar L. Yadav ◽  
Somendra Bansal ◽  
Shalu Gupta ◽  
Pradeep K. Verma
Keyword(s):  
Observational Study ◽  
Intestinal Perforation ◽  
Prospective Observational Study ◽  
Primary Repair ◽  
Bowel Perforation ◽  
Loop Ileostomy ◽  
Mortality Data ◽  
Time Interval ◽  
Female Ratio ◽  
Enteric Perforation

Background: Intestinal perforation is a common surgical problem, which need proper attention. Typhoid is the most common cause of bowel perforation. With the concept of a correct diagnosis of perforation in reference to its etiology and further study of etiological factor (typhoid) in relation to epidemiology, surgical treatment and outcome, the present study has been undertaken.Methods: It is a prospective, observational study in which 50 cases of enteric perforation admitting in SMS Hospital at JAIPUR were observed. All patients of enteric perforation peritonitis were evaluated by detailed history, clinical examination and radiological as well as laboratory investigations. After initial resuscitation patient were treated by operative procedures. Postoperatively progress report, morbidity and mortality data were observed.Results: Mean age of patients was 26.38 years. Male to female ratio was 4:1. Enteric perforation is more common in patients with poor nutritional status and rural area. Primary repair of perforation was done in patient with small perforation with relatively healthy bowel, while ileostomy was done in patients with large perforation of longer duration, multiple perforations and edematous bowel with necrotic patches. Mortality was highest in patients who underwent primary repair and proximal loop ileostomy (33.3%) and lowest in patients in which exteriorization of the perforation as loop ileostomy was done (10.3%).Conclusions: The time interval between occurrence of perforation and starting of specific therapy is the most important factor in deciding the ultimate outcome of the typhoid perforation patient and operative procedure is another important factor in deciding the outcome.

scholarly journals Morbidity and mortality pattern of intramural and extramural neonate: a prospective observational study

2021 ◽  
Vol 8 (6) ◽  
pp. 1006
Author(s):  
Rajkumar M. Meshram ◽  
Dipty L. Jain ◽  
Mohini U. Apte ◽  
Abhishek Denge
Keyword(s):  
Observational Study ◽  
Respiratory Distress ◽  
Prospective Observational Study ◽  
Very Low Birth Weight ◽  
Morbidity And Mortality ◽  
Preterm Neonates ◽  
Mortality Pattern ◽  
Female Ratio ◽  
Common Cause ◽  
Risk Of Death

Background: Neonatal period carries higher risk of death inspite of advances in perinatal and neonatal services. The objective of the study was to assess the morbidity/mortality pattern of intramural and extramural neonates.Methods: Prospective observational study was undertaken on all intramural and extramural neonates who fulfill the inclusion criteria at a tertiary institute for one year. Morbidity and mortality patterns were analyzed.Results: A total 1770 intramural and 997 extramural neonates required admission during the study period. Mortality rate in intramural neonate was 22.26% while in extramural neonate was 28.79%. The male to female ratio was 1.27:1 in intramural while 1.3:1 in extramural neonates. Preterm neonates with extremely/very low birth weight were predominant in intramural group and term neonates in extramural group (p<0.001). Maternal illness during pregnancy were significantly more in mothers of extramural neonates compared to that of intramural neonates (p<0.001). Lethargy and hypothermia was significantly more in extramural group (p<0.001) while respiratory distress was significantly higher in intramural group (p=0.01). The leading causes of admission in intramural neonates was prematurity with respiratory distress syndrome (31.64%) while sepsis (37.01%) in extramural group of neonates. Preterm birth complication (51.52%) was the common cause of mortality in intramural neonates while sepsis (42.16%) in extramural neonates.Conclusions: Sepsis is the most common cause of morbidity/mortality in extramural neonates while prematurity and its complication in intramural neonates.

Isotretinoin-induced Spondyloarthropathy-related Symptoms: A Prospective Study

2015 ◽  
Vol 42 (11) ◽  
pp. 2106-2109 ◽  
Author(s):  
Samet Alkan ◽  
Nuriye Kayiran ◽  
Orhan Zengin ◽  
Ali Kalem ◽  
Gezmis Kimyon ◽  
...  
Keyword(s):  
Observational Study ◽  
Prospective Observational Study ◽  
Acne Vulgaris ◽  
Chronic Inflammatory Disease ◽  
Inflammatory Back Pain ◽  
Average Dose ◽  
Effective Treatment Option ◽  
Significant Difference ◽  
A Prospective Study ◽  
Age And Sex

Objective.Acne vulgaris is a chronic inflammatory disease involving the pilosebaceous unit of the skin. Isotretinoin is a systemic retinoid that is often used as an effective treatment option for severe and treatment-resistant acne. Isotretinoin may also cause rheumatologic symptoms. The aim of this prospective observational study was to present followup results regarding the rheumatologic symptoms of patients who received systemic therapy for the treatment of acne (isotretinoin and tetracycline).Methods.For inclusion in the study, all consecutive patients with acne who were aged > 18 years were evaluated by the same dermatologist. The first 42 consecutive patients were included in the isotretinoin group, and after matching for age and sex, 32 consecutive patients were included in the tetracycline group. Isotretinoin treatment was planned as an average dose of 30 mg daily and a total dose of 120–150 mg/kg for 4–6 months. The patients were administered a dose of 1 g/day of tetracycline as 2 equal doses for 3 months.Results.Forty-two patients diagnosed with acne vulgaris were treated with isotretinoin 20.6 ± 4.4 (male/female: 17/22), and 32 patients were treated with tetracycline 20.6 ± 2.7 (male/female: 8/24). There was no significant difference between the 2 groups with respect to age and sex. Unilateral Achilles enthesopathy developed in 3 patients, whereas both Achilles enthesopathy and unilateral sacroiliitis developed in 1 patient. Inflammatory back pain developed in 6 patients in the isotretinoin group.Conclusion.To our knowledge, this was the first prospective observational study that assessed the rheumatologic symptoms of isotretinoin treatment. The spondyloarthropathy findings were identified in 23.1% of the patients who used isotretinoin.

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