scholarly journals Analgesic activity of Terminalia bellerica fruit pulp aqueous extract by using acetic acid induced writhing test in Swiss albino mice by peripheral mechanism

2018 ◽  
Vol 5 (2) ◽  
pp. 60-61
Keyword(s):  
Acetic Acid ◽  
Aqueous Extract ◽  
Analgesic Activity ◽  
Fruit Pulp ◽  
Writhing Test ◽  
Swiss Albino Mice ◽  
Terminalia Bellerica ◽  
Peripheral Mechanism ◽  
Albino Mice

scholarly journals Attenuation of anxiety on acute administration of aqueous extract of Terminalia belerica fruit pulp in Swiss albino mice

2017 ◽  
Vol 6 (2) ◽  
pp. 303
Author(s):  
Chandrashekar R. ◽  
Manohar V. R. ◽  
Poovizhi Bharathi R. ◽  
Mohandas Rai
Keyword(s):  
Aqueous Extract ◽  
Elevated Plus Maze ◽  
Acute Administration ◽  
Fruit Pulp ◽  
Swiss Albino Mice ◽  
Elevated Plus Maze Test ◽  
Maze Test ◽  
Plus Maze ◽  
Terminalia Belerica ◽  
Albino Mice

Background: The objective of this study was to evaluate the attenuation of anxiety on acute administration of aqueous extract of Terminalia belerica fruit pulp (AETBFP) by using elevated plus maze test and dark and light arena models.Methods: Thirty Swiss albino mice were divided into five groups, Group I received vehicle (1% Gum acacia suspension, 3ml/kg, orally), Group II received standard drug Diazepam (1mg/kg, orally) and Group III, IV and V received AETBFP 9, 18 and 36 mg/kg, orally respectively. In elevated plus maze test, the mouse was placed on the central platform facing towards open arm. The percentage of time spent and frequency of entries and number of rears in open arm was counted for a period of 5 min. In dark and light arena, the time spent, number of entries and number of rears in light arena was counted for a period of 5 min. The mean±SEM values were calculated for each group. The data was analyzed using one-way ANOVA followed by Dunnet’s multiple comparison tests; p< 0.05 was considered as statistically significant.Results: Significant (p<0.05) reduction in anxiety was noted in experimental animals when given at a dose of AETBFP (36mg/kg), where number of entries and duration of stay in open arm and light arena increased in elevated plus maze and light and dark arena respectively when compared with control animals.Conclusions: Our study reveals that AETBFP at a dose of 36mg/kg has significant attenuation of anxiety in Swiss albino mice.

scholarly journals Screening of analgesic activity of Phoenix sylvestris leaves in rodents

2018 ◽  
Vol 4 (1) ◽  
pp. 22-24
Author(s):  
Pankaj Jain ◽  
◽  
Sonika Jain ◽  
Surendra Kumar Swarnkar ◽  
Swapnil Sharma ◽  
...  
Keyword(s):  
Body Weight ◽  
Acetic Acid ◽  
Analgesic Activity ◽  
Leaf Extract ◽  
Methanolic Extract ◽  
Standard Drug ◽  
Swiss Albino Mice ◽  
Tail Immersion ◽  
Albino Mice ◽  
Withdrawal Reflexes

Aim: The present study evaluated the central and peripheral analgesic activity of methanolic leaf extract of Phoenix sylvestris (PSLME) in swiss albino mice. Method: Peripheral and central analgesic activity was evaluated by tail immersion and acetic acid writhing in swiss albino mice. Dextropropoxyphene was used as a standard drug in the dose of 65mg/kg body weight in both models. PSLME was tested at 100 and 500mg/kg dose level. Results: The result revealed that methanolic extract exhibit 48% and 40.5% writhing inhibition at 500 and 100 mg/kg doses whereas ~30% tail withdrawal reflexes inhibition at 500mg/kg which was analogous to the standard drug dextropropoxyphene. Conclusion: Methanolic extract of leaves of P. sylvestris possesses both peripheral and central analgesic activity in experimental animal.

scholarly journals Evaluation of the analgesic activity of ethanolic extract of Populus deltoides leaves in mice

2020 ◽  
Vol 11 (4) ◽  
pp. 5942-5947
Author(s):  
Vijay Bahadur Maurya ◽  
Vishnu Prasad Yadav ◽  
Vinay Kumar
Keyword(s):  
Acetic Acid ◽  
Analgesic Activity ◽  
Populus Deltoides ◽  
Chemical Constituents ◽  
Ethanolic Extract ◽  
Scientific Basis ◽  
Traditional Use ◽  
Writhing Test ◽  
Peripheral Mechanism ◽  
Analgesic Activities

The ethanolic leaves extract of Populus deltoides was tested for the presence of various phytoconstituents and designed to evaluate the analgesic activity in mice. The peripheral analgesic activity of ethanolic leaves extract of P.deltoides (250 and 500 mg/kg) was studied by using acetic acid stimulated writhing test and central analgesic activity of P.deltoides was studied by using hotplate process. The ethanolic leaves extract of P.deltoides  professed the existence of a variety of chemical constituents like alkaloids, saponins, flavonoids, terpenes and steroids. Leaves extract of P.deltoides appreciably decreased the writhing actions in acetic acid-induced writhing test in mice and amplified the respond time in hotplate test. These results suggest that the extract may have NSAIDs like activity through the peripheral mechanism and central analgesic activities via opioid receptors. From our study, we endowed that leaves extract of P.deltoides has feasible to analgesic activity. This study reveals that it can be used in the management of pain and provide a scientific basis for its traditional use. 

scholarly journals Analgesic Activity of Methanolic Extract of Tubers of Arisaema tortuosum (Wall.) Schott. in Swiss Albino Mice

2018 ◽  
Vol 17 (1) ◽  
pp. 37-41
Author(s):  
Priyanka Chakraborty ◽  
Nripendra Nath Bala ◽  
Sudipta Das
Keyword(s):  
Acetic Acid ◽  
Analgesic Activity ◽  
Methanolic Extract ◽  
Dependent Manner ◽  
Hot Plate ◽  
Plate Method ◽  
Swiss Albino Mice ◽  
Chemically Induced ◽  
Pain Reaction ◽  
Albino Mice

The aim of the the present study was to investigate the analgesic activity of methanolic extract of Arisaema tortuosum (MEAT) using acetic acid-induced writhing and hot plate methods. The hot plate method is useful in elucidating centrally mediated antinociceptive responses, while acetic acid-induced writhing is the chemically induced pain of peripheral origin. The MEAT was used at doses of 50, 100, 200 and 400 mg/kg body weight on swiss albino mice. The percentage inhibition of the abdominal constriction reflex increased dose dependently in case of acetic acid-induced pain and in the hot plate method model the extract at the dose of 400 mg/kg significantly increased the pain reaction time (PRT). These studies conclude that A. tortuosum (Wall.) Schott. tuber possesses analgesic activity in a dose dependent manner. In case of acetic acid-induced pain, the extract at the dose of 400 mg/kg body wt. showed 41.19% inhibition of writhing reflex. In case of hot plate method, after 60 minutes the PRT increased to 7.47 ± 0.05 seconds for the extract at the dose of 400 mg/kg body wt.Dhaka Univ. J. Pharm. Sci. 17(1): 37-41, 2018 (June)

scholarly journals COMPARATIVE STUDY OF THE ANTINOCICEPTIVE ACTION OF AMITRIPTYLINE WITH FLUOXETINE AND EVALUATION OF THEIR PROBABLE MECHANISM OF THIS ACTION IN ALBINO MICE

2018 ◽  
Vol 10 (11) ◽  
pp. 35
Author(s):  
Phulen Sarma ◽  
Daisy Phukan
Keyword(s):  
Acetic Acid ◽  
Reaction Time ◽  
Probable Mechanism ◽  
Hot Plate ◽  
Writhing Test ◽  
Group I ◽  
Peripheral Mechanism ◽  
Albino Mice ◽  
Noradrenergic Pathway ◽  
Group B

Objective: The aim of our study was to compare the anti-nociceptive action of amitriptyline with fluoxetine and evaluation of their probable mechanism of anti-nociceptive action by observing their individual interactions with morphine, naloxone, yohimbine, and ondansetron.Methods: Albino mice weighing 25-35 grams were taken and divided into 12 groups. Group A-Control(distilled water), Group B-amitriptyline 20 mg/kg, Group C-fluoxetine 20 mg/kg, Group D-morphine 5 mg/kg, Group E-amitriptyline 20 mg/kg+ morphine 5 mg/kg, Group F-amitriptyline 20 mg/kg+ naloxone 3 mg/kg, Group G-amitriptyline 20 mg/kg+ yohimbine 2 mg/kg, Group H-amitriptyline 20 mg/kg+ ondansetron 0.1 mg/kg, Group I-fluoxetine 20 mg/kg+morphine 5 mg/kg, Group J-fluoxetine 20 mg/kg+ naloxone 3 mg/kg, Group K-fluoxetine 20 mg/kg+ yohimbine 2 mg/kg and Group L-fluoxetine 20 mg/kg+ ondansetron 0.1 mg/kg. Hot plate method and acetic acid writhing test were used to assess central and peripheral analgesic activity respectively.Results: Both the amitriptyline and fluoxetine-treated animals showed significantly increased reaction time in a hot plate (p<0.05) and a significant decrease in the number of wriths in acetic acid writhing test (p<0.05), when compared with control. Animals in amitriptyline group showed significantly higher reaction time and less number of wriths when compared to fluoxetine group. Morphine increased, while naloxone, yohimbine and ondansetron decreased the reaction time in a hot plate. In the acetic acid writhing test, a number of wriths significantly decreased when co-treated with morphine and increased when co-treated with naloxone, yohimbine and ondansetron.Conclusion: It is concluded that amitriptyline is a better antinociceptive agent than fluoxetine. Their central and peripheral mechanism of antinociception both involve opioidergic, serotonergic and noradrenergic pathway.

scholarly journals Analgesic activity of aqueous extract of Amorphophallus paeoniifolius in Swiss albino mice

2019 ◽  
Vol 8 (6) ◽  
pp. 1327
Author(s):  
Hemalatha A. ◽  
Sathiya Vinotha A. T.
Keyword(s):  
Aqueous Extract ◽  
Analgesic Activity ◽  
Group Iv ◽  
Alcoholic Extract ◽  
Swiss Albino Mice ◽  
Group I ◽  
Cox Inhibitor ◽  
Albino Mice ◽  
Group Ii ◽  
Animal House

Background: Pain is defined as an unpleasant feeling caused by intense or damaging stimuli. Amorphophallus paeoniifolius known as “Elephant foot yam” is a highly potential tropical tuber crop of Araceae family. The tubers are used as antihaemorrhoidal, haemostatic, expectorant, appetizer, anthelmintic, aphrodisiac and rejuvenating agent. Diclofenac, a COX inhibitor is used as analgesic widely. Analgesic activity of alcoholic extract of Amorphophallus paeoniifolius has been proved in previous animal studies.Methods: Swiss Albino mice of either sex (20-30g) were procured from the central animal house of KFMS&R, Coimbatore. Animals were maintained under controlled temperature and light conditions with food and water ad libitum. Mice were kept in the department to get acclimatized. 24 mice were divided into 4 groups (n=6). Drugs were given orally after 12 hours of fasting. Group I was the control received normal saline, Group II received standard-diclofenac (25mg/kg). Group III and Group IV received aqueous extract of Amorphophallus paeoniifolius 200mg/kg and 400mg/kg respectively.Results: The latency period of Group IV (aqueous extract of Amorphophallus paeoniifolius 400mg/kg) was significant (p<0.01) compared to Group I (controls) and Group II (standard) was significant (p<0.001) when compared to Group IV (aqueous extract of Amorphophallus paeoniifolius 400mg/kg) by hot plate method. In acetic acid induced writhing when compared to control, the percentage inhibition of aqueous extract of Amorphophallus paeoniifolius was 43.65% at 200mg/kg, 46.09% at 400mg/kg and that of the standard was 54.39%.Conclusions: It was concluded that aqueous extract of Amorphophallus paeoniifolius has analgesic activity due to peripheral and central inhibition of prostaglandins synthesis. The extract may have phytoconstituents which inhibit COX enzyme peripherally or act on central opioid receptors(µreceptors) for producing analgesia. It can be used as an add-on drug there by reducing side effects by conventional analgesics.

Central and Peripheral Antinociceptive Activity of Terminalia Belerica Fruit Pulp Aqueous Extract in Swiss Albino Mice

2016 ◽  
Vol 3 (1) ◽  
pp. 13
Author(s):  
V.R. Manohar ◽  
Mohandas Rai ◽  
R. Chandrashekar ◽  
Smitha Sivan ◽  
D Bharath Kumar ◽  
...  
Keyword(s):  
Aqueous Extract ◽  
Antinociceptive Activity ◽  
Fruit Pulp ◽  
Swiss Albino Mice ◽  
Terminalia Belerica ◽  
Albino Mice

scholarly journals Methanol, ethyl acetate and n-hexane extracts of Tragia involucrata L. leaves exhibit anxiolytic, sedative and analgesic activity in Swiss albino mice

Heliyon ◽  
2021 ◽  
Vol 7 (1) ◽  
pp. e05814
Author(s):  
Md. Shofiqul Islam ◽  
Samiron Sana ◽  
Md. Ehsanul Haque ◽  
S.M. Mushiur Rahman ◽  
Abdus Samad ◽  
...  
Keyword(s):  
Ethyl Acetate ◽  
Analgesic Activity ◽  
Swiss Albino Mice ◽  
Hexane Extracts ◽  
Albino Mice

scholarly journals Immunomodulatory activity of an aqueous extract of Polygonum minus Huds on Swiss albino mice using carbon clearance assay

2014 ◽  
Vol 4 (5) ◽  
pp. 398-400 ◽  
Author(s):  
Annie George ◽  
Sasikala Chinnappan ◽  
Yogendra Choudhary ◽  
Praveen Bommu ◽  
Murthy Sridhar
Keyword(s):  
Aqueous Extract ◽  
Immunomodulatory Activity ◽  
Swiss Albino Mice ◽  
Carbon Clearance ◽  
Polygonum Minus ◽  
Albino Mice

scholarly journals Analgesic effect of the aqueous extract of Artimisia herba alba Arial part

2010 ◽  
Vol 9 (3) ◽  
pp. 28
Author(s):  
Sh. M. Al-khazrji , and I. K. Khalil
Keyword(s):  
Acetic Acid ◽  
Aqueous Extract ◽  
Cold Water ◽  
Hot Plate ◽  
Hot Plate Test ◽  
Writhing Test ◽  
Plate Test ◽  
Analgesic Effects ◽  
Rats And Mice ◽  
Dose Dependent

The present study was aimed to investigate the analgesic effects of the aqueous extract of Artemisia herba alba Arial part in rats and mice ( AEAHA ). The AEAHA (400- 700 mg/kg; p.o.) was evaluated for its analgesic activity by employing acetic acid-induced writhing test, hot plate test and tail immersion tests i.e. in hot and cold water. AEAHA (400- 700 mg/kg; p.o.) showed significant (P<0.01) reduction in the number of writhing induced by acetic acid,increased reaction time in hot plate test and elevated pain threshold in hot and cold water tests. AEAHA exhibited the dose-dependent analgesic effects

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