scholarly journals A comparative study of topical retinoids tretinoin-0.04% and adapalene - 0.1% in acne grade 1 and grade 2

2021 ◽  
Vol 7 (3) ◽  
pp. 217-221
Author(s):  
Selva Sudha ◽  
Vella Pandi
Keyword(s):  
Clinical Trial ◽  
Side Effects ◽  
Comparative Study ◽  
Sample Size ◽  
Inflammatory Disease ◽  
Acne Vulgaris ◽  
Pilosebaceous Unit ◽  
Topical Tretinoin ◽  
Topical Retinoids ◽  
Grade Ii

Acne is a chronic, self-limiting inflammatory disease of pilosebaceous unit. It is multifactorial, of which Propioniobacterium acne and Sebum play an important role in etiopathogenesis.The aim of the study is to compare efficacy of Tretinoin and Adapalene in Acne Vulgaris and to compare the side effects of topical tretinoin and adapalene.Randomized prospective comparative clinical trial with sample size of 50 patients who are recruited from department of dermatology of MMCH&RI.Adapalene 0. 1% produced numerically greater lesion reduction than tretinoin 0. 04% for all lesion types. Thus, Adapalene was found superior to Tretinoin in reducing average number of lesions. Highest reduction in number of lesions with both topical retinoids was for comedones (p< 0. 001) followed by papules (p<0. 00) and pustule (p= 0.001).In Patients who applied adapalene, most of them were reduced to grade 0 and grade I and only few were in grade II. Whereas in patients who applied tretinoin only few were reduced to grade 0 and many were in grade I and grade II. Side effects were more commonly seen in patient treated with topical Tretinoin than with topical Adapalene. Adapalene was better tolerated than tretinoin. Hence adapalene is a safe and effective in treatment of acne.

scholarly journals A COMPARATIVE STUDY OF THE EFFICACY AND SAFETY OF 12 % GLYCOLIC ACID CREAM AND 10% AZELAIC ACID CREAM IN THE TREATMENT OF POST ACNE HYPERPIGMENTATION.

2021 ◽  
pp. 34-35
Author(s):  
Archana Rede ◽  
Sanjay N. Agrawal ◽  
Yoganand Kulkarni
Keyword(s):  
Comparative Study ◽  
Azelaic Acid ◽  
Glycolic Acid ◽  
Acne Vulgaris ◽  
Inflammatory Disorder ◽  
Efficacy And Safety ◽  
Common Complication ◽  
Pilosebaceous Unit ◽  
Inflammatory Lesions ◽  
Chronic Inflammatory Disorder

Acne vulgaris is a chronic inflammatory disorder of the pilosebaceous unit that is associated with significant psychosocial repercussions. Post inflammatory hyperpigmentation is a most common complication seen after post acne. Therapeutic goal of treatment include promoting degradation of melanosomes and inhibiting their formation. Patient treated with Azelaic acid / Glycolic acid experienced of significant greater reduction in number of inflammatory lesions. This study focuses on the comparison of efficacy of 12% Glycolic acid and 10% Azelaic acid in treating post acne hyperpigmentation.

scholarly journals Virulent Acne Biofilms Offer Insight into Novel Therapeutic Options

2018 ◽  
Vol 12 (1) ◽  
pp. 80-85
Author(s):  
Asha Gowda ◽  
Craig G. Burkhart
Keyword(s):  
Side Effects ◽  
Virulence Factors ◽  
Acne Vulgaris ◽  
Skin Lesions ◽  
Therapeutic Options ◽  
Pilosebaceous Unit ◽  
Adhesive Properties ◽  
Biological Glue ◽  
Insight Into ◽  
Novel Therapeutic

Acne vulgaris is a disease of the pilosebaceous unit that may manifest as either noninflammatory or inflammatory skin lesions. The microcomedone theory suggests that the first step in the pathogenesis of acne vulgaris is the noninflammatory comedone. The comedone is a collection of keratin and sebum that is trapped within the pilosebaceous unit due to hyperproliferation of keratinocytes in the follicular lining. The biofilm produced by P. acnes bacteria promotes the formation of a comedone by acting as a biological glue that prevents expulsion of the hyperkeratotic plug. In addition to its adhesive properties, the biofilm has virulence factors contributing to the pathogenicity of P. acnes in acne vulgaris. With further investigation and a better understanding of the P. acnes biofilm, new therapeutic options for acne vulgaris can be made available. By targeting the P. acnes biofilm, treatment can be made more effective and precise, without the concern of side effects seen in currently available acne medications.

Nanocarriers as Prospective Approach in Effective Management of Acne Vulgaris

2020 ◽  
Vol 12 ◽  
Author(s):  
Tanya Lugani ◽  
Manju Nagpal ◽  
Deepinder Singh Malik ◽  
Ameya Sharma ◽  
Vivek Puri ◽  
...  
Keyword(s):  
Side Effects ◽  
Acne Vulgaris ◽  
Treatment Strategies ◽  
Secondary Effects ◽  
Pilosebaceous Unit ◽  
Developmental Factors ◽  
Novel Approach ◽  
Patent Literature ◽  
History Of ◽  
Stability Issues

Acne is a chronic disease associated with pilosebaceous unit and is affected by Propionibacterium acnes bacteria. Approximately 95% of people worldwide suffer from acne in their life span with a higher prevalence among teenagers (esp. boys). Conventional strategies incorporating antibiotics, steroid, hormones, etc. is recommended orally, systemically or topically, employed for the treatment of acne which shows various side effects (itching, scaling, redness, etc.) and is no more commercially accepted. The literature has been collected using various search engines google scholar, pubmed, science direct etc. The review highlights history of acne, its pathophysiology, developmental factors, various treatment evolutions strategies ranging from conventional to novel approach eradicating the secondary effects with enhanced efficacy and safety profile. We concluded various nanotechnological carriers (liposomes, niosomes, solid lipid nanoparticles, nanostructured lipid carriers, microsponges and other nanoscale formulations) which are formulated in last decade for effective treatment of acne. Patent literature and marketed formulations are included in last sections. Encapsulation efficiency of anti-acne drugs in different nanocarriers improves the efficacy as well as minimizes the side effects of drug. These carriers showed better bioavailability as well as better penetration effects even to pilosebaceous unit of the skin. Tolerance can be improved by increasing the concentration of anti-acne drug in the nano-carrier formulation. Conventional treatment strategies for acne had some limitations like scaling, itching, inflammation which can be overcome by nano-formulations which exhibits better efficacy. In present, various nano-technological carriers are working potentially for the treatment of the acne. These nano-formulations are also associated with some limitations like drug entrapment, stability issues but these will be overcome in the upcoming years as long as research is being continued in this area.

scholarly journals Rhodomyrtone as a New Natural Antibiotic Isolated from Rhodomyrtus tomentosa Leaf Extract: A Clinical Application in the Management of Acne Vulgaris

Antibiotics ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 108
Author(s):  
Suttiwan Wunnoo ◽  
Siwaporn Bilhman ◽  
Thanaporn Amnuaikit ◽  
Julalak C. Ontong ◽  
Sudarshan Singh ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Side Effects ◽  
Clinical Assessment ◽  
Leaf Extract ◽  
Acne Vulgaris ◽  
Treated Group ◽  
Controlled Clinical Trial ◽  
Double Blind ◽  
Treatment Groups ◽  
Rhodomyrtus Tomentosa

Rhodomyrtone, a plant-derived principal compound isolated from Rhodomyrtus tomentosa (Myrtaceae) leaf extract, was assessed as a potential natural alternative for the treatment of acne vulgaris. The clinical efficacy of a 1% liposomal encapsulated rhodomyrtone serum was compared with a marketed 1% clindamycin gel. In a randomized and double-blind controlled clinical trial, 60 volunteers with mild to moderate acne severity were assigned to two groups: rhodomyrtone serum and clindamycin gel. The volunteers were instructed to apply the samples to acne lesions on their faces twice daily. A significant reduction in the total numbers of acne lesions was demonstrated in both treatment groups between week 2 and 8 (p < 0.05). Significant differences in acne numbers compared with the baseline were evidenced at week 2 onwards (p < 0.05). At the end of the clinical trial, the total inflamed acne counts in the 1% rhodomyrtone serum group were significantly reduced by 36.36%, comparable to 34.70% in the clindamycin-treated group (p < 0.05). Furthermore, a commercial prototype was developed, and a clinical assessment of 45 volunteers was performed. After application of the commercial prototype for 1 week, 68.89% and 28.89% of volunteers demonstrated complete and improved inflammatory acne, respectively. All of the subjects presented no signs of irritation or side effects during the treatment. Most of the volunteers (71.11%) indicated that they were very satisfied. Rhodomyrtone serum was demonstrated to be effective and safe for the treatment of inflammatory acne lesions.

scholarly journals Standard daily dosage versus pulse dosage of Isotretinoin in acne vulgaris: A hospital based comparative study

2018 ◽  
Vol 7 (2) ◽  
pp. 68-74
Author(s):  
Eliz Aryal ◽  
SB Shrestha ◽  
G Pokhrel ◽  
S Bhattarrai
Keyword(s):  
Side Effects ◽  
Comparative Study ◽  
Acne Vulgaris ◽  
College Teaching ◽  
Poor Response ◽  
Lumbosacral Spine ◽  
Daily Regimen ◽  
Severe Acne ◽  
Pulse Dose ◽  
Oral Isotretinoin

Background: Acne is a multi factorial disease ranging from a couple of comedones and pustules to severe nodulocystic fulminantacne. Isotretinoin (13-cis-retinoic-acid) drug affect all the factors involved in pathogenesis of acne and approved by Food and Drug Administration in 1982. It causes several dose-dependent mucocutaneous and systemic side effects and cost effectObjective: To assess and compare the efficacy and tolerability of two regimens (daily conventional and pulse dose) in moderate to severe acne vulgaris.Methodology: This is a prospective randomized comparative study in moderate to severe acne vulgaris in Kathmandu Medical College Teaching Hospital. The patients were randomly divided into two groups (A and B). In group A conventional dose of 20 mg of oral isotretinoin was given daily and in group B 20 mg of oral isotretinoin was given thrice (Pulse Dosage in alternate day) in a week for six months. The baseline haematological, biochemical and radiological (lumbosacral spine) was compare on first, third and six month.Results: Seventy-four patients were enrolled with mean age of 21.73 years. Patients with daily regimen show good response throughout the therapy for six months (1st, 3rd 6th months), where as those in pulse therapy show moderate to poor response during early month and gradually improve by end of sixth month. At end of sixth month, both the regimen show good response and was statistically significant.Conclusion: However, the pulse dose regimen makes the treatment more acceptable, for patients with acne than the classical standard daily regimen, in term of side effects and cost effectiveness and patient compliance. Journal of Kathmandu Medical CollegeVol. 7, No. 2, Issue 24, Apr.-Jun., 2018, Page: 68-74

Profile of side effects on a sample of outpatient treated with long-lasting injection paliperidone (LLIP)

2017 ◽  
Vol 41 (S1) ◽  
pp. S462-S462
Author(s):  
V. Martí Garnica ◽  
M.D. Ortega García ◽  
J.R. Russo de León ◽  
S. García Marín
Keyword(s):  
Side Effects ◽  
Sexual Dysfunction ◽  
Comparative Study ◽  
Sample Size ◽  
Competing Interest

AimAssess the profile of side effects on sample of outpatients treated with long-lasting injection paliperidone LLIP.MethodStudy of a population of 67 patients, 25 people are female and 42 are male. In female sample, more than 52% are diagnosed of Schizophrenia and the majority of female do not refer side effects (88%) and only a little percentage of 12 refer side effects such as amenorrhea (F20), stiffness (F20) and relapse (F25). In male sample, more than 54.7% are diagnosed of Schizophrenia and the majority of male do not refer side effects (80%) and only a little percentage of 20 refer side effects (F70) such fear of injection and sexual dysfunction (F21).Results and conclusionsIn our sample, the number of women diagnosed with schizophrenia have a greater number of side effects respects to men with the same diagnosis. However, it would be important to increase the sample size of women to conduct a comparative study men/women to assess research in this field.Disclosure of interestThe authors have not supplied their declaration of competing interest.

scholarly journals Efficacy of Oral Isotretinoin in Combination with Desloratadine in the Treatment of Common Vulgaris Acne in Vietnamese Patients

2019 ◽  
Vol 7 (2) ◽  
pp. 217-220
Author(s):  
Thuong Nguyen Van ◽  
Lan Duong Thi ◽  
Hao Nguyen Trong ◽  
Tro Chau Van ◽  
Trang Trinh Minh ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Side Effects ◽  
Treatment Time ◽  
Acne Vulgaris ◽  
Control Group ◽  
Inflammatory Lesions ◽  
Comparative Clinical Trial ◽  
Oral Isotretinoin ◽  
The Mean

AIM: To evaluate the efficacy of oral isotretinoin used alone and in combination with desloratadine in the treatment of moderate acne vulgaris. METHODS: A comparative clinical trial was undertaken to evaluate the efficacy of oral isotretinoin alone and in combination with desloratadine in the treatment of 62 moderate acne vulgaris patients. Patients were randomised into two groups with 31 patients in each group. Each studied group's patient took 20 mg isotretinoin and 5 mg desloratadine per day. In the control group, patients took only 20 mg isotretinoin per day. The treatment time was 16 weeks. The evaluation and follow-up were done at week 2, 4, 8, 12 and 16 of the treatment. RESULTS: The studied group had a better curative rate than the control group (45.2% versus 22.6%). The average number of inflammatory lesions in the studied group was significantly lower than the control group (0.19 versus 0.94). The mean GAGS score of the studied group was significantly lower than the control group (3.71 versus 6.52). Acne outbreaks rate of the studied group was lower than the control group (in week 2: 22.6% versus 45.2% and in week 4: 16.1% versus 38.7%, respectively). The rate of itchy was lower in the studied group. CONCLUSION: In the treatment of moderate acne vulgaris, oral isotretinoin in combination with desloratadine is more effective and has fewer side effects than using isotretinoin alone.

scholarly journals The Comparative Study of the Effectiveness of Cimetidine, Ranitidine, Famotidine, and Omeprazole in Treatment of Children with Dyspepsia

2011 ◽  
Vol 2011 ◽  
pp. 1-5 ◽  
Author(s):  
Seyed Mohsen Dehghani ◽  
Mohammad Hadi Imanieh ◽  
Roya Oboodi ◽  
Mahmood Haghighat
Keyword(s):  
Clinical Trial ◽  
Abdominal Pain ◽  
Side Effects ◽  
Comparative Study ◽  
Functional Dyspepsia ◽  
Medical Therapy ◽  
Visceral Hypersensitivity ◽  
Chronic Disorder ◽  
Upper Abdominal ◽  
The Comparative Study

Background. Functional dyspepsia is a common chronic disorder with non specific upper abdominal pain or discomfort. Different approaches with anti-secretory, spasmolytic, prokinetic and anti-inflammatory effects and most preferably reduction of visceral hypersensitivity seem logical. In this study, we compared the effectiveness of the four most drugs used for treatment of dyspepsia in children. Methods. 169 patients between 2 to 16 years old that 47.3% was male and 52.7% was female were enrolled in this clinical trial study by the diagnosis of functional dyspepsia. Then for each patient one of the drugs; Omeprazole, Famotidine, Ranitidine or Cimetidine was administered, for a period of 4 weeks. Patients were followed after 2 and 6 weeks from the beginning of the treatment. Results. The distribution of drugs between these patients were including; 21.9% with Cimetidine, 21.3% with Famotidine, 30.8% with Omeperazole and 26% with Ranitidine that the proportion of patients with all symptoms relief were: 21.6% for Cimetidine, 44.4% for Famotidine, 53.8% for Omeprazole and 43.2% for Cimetidine (). In followups within 2 and 6 weeks after beginning medical therapy, no side effects due to drugs were seen. Conclusion. If a cure is defined as all symptoms relief after a period of 4 weeks treatment, our findings showed that Omeperazole are superior to Ranitidine, Famotidine, and Cimetidine for management of functional dyspepsia.

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