scholarly journals A prospective clinico-etiological study of 100 cases of pancytopenia in a tertiary care hospital in Eastern India

2021 ◽  
Vol 11 (2) ◽  
pp. 236-240
Author(s):  
Palai Sabita ◽  
Swain Santosh Kumar ◽  
Nayak Rajeeb Kumar ◽  
Majhi Majha ◽  
Padhi Prabhat Kumar ◽  
...  
Keyword(s):  
Aplastic Anemia ◽  
Megaloblastic Anemia ◽  
Correct Diagnosis ◽  
Tertiary Care ◽  
Macrocytic Anemia ◽  
General Medicine ◽  
Good Prognosis ◽  
Total Leucocyte Count ◽  
Care Hospital ◽  
Hematological And Biochemical Parameters

Pancytopenia is a hematological entity which is relatively common. Its evaluation is important for arriving at an early and correct diagnosis, to aid in appropriate management.It was an observational study conducted in the Department of General Medicine and Clinical Hematology of our institute from June 2019 to May 2020. Clinical, hematological and biochemical parameters of 100 pancytopenic patients were evaluated and descriptive statistics was used. The age ranged from 18-75 years. The commonest presentation was easy fatigability and fever. Besides pallor, splenomegaly and hepatomegaly were the presenting signs. Megaloblastic anaemia was detected in 64% followed by aplastic anaemia in 12% and acute leukemia in 6% patients. Among infective etiologies, two cases of malaria (P. falciparum). And each case of HIV, tuberculosis and dengue were seen. Lowest Hb% of 1.8 gm/dl, lowest total leucocyte count (TLC) of 500cells/cmm and lowest total platelet count (TPC) of 4000 cells/cmm was noted in a case of aplastic anemia. Macrocytic anemia was predominant blood picture. Hypercellular marrow was noted in 70(70%) cases and common cause was megaloblastic anemia, followed by leukaemia. Hypocellular marrow was noted in 12(12%) patients with aplastic anemia being commonest cause. In our study diagnosis of pancytopenia and its causes were ascertained by hematological investigations. An early and prompt treatment was given according to the cause and severity. Most of the cases had good prognosis due to a treatable cause.

scholarly journals Vitamin Cobalamin deficiency in macrocytic anemia reporting at a Tertiary Care Hospital.

2021 ◽  
Vol 28 (04) ◽  
pp. 527-532
Author(s):  
Kashif Rasheed Shaikh ◽  
Shumaila Shaikh ◽  
Sadia Tabassum ◽  
Shagufta Memon ◽  
Umair Ali Soomro ◽  
...  
Keyword(s):  
Tertiary Care Hospital ◽  
Megaloblastic Anemia ◽  
Tertiary Care ◽  
Macrocytic Anemia ◽  
Cobalamin Deficiency ◽  
Categorical Variables ◽  
Care Hospital ◽  
Female Ratio ◽  
Male And Female ◽  
Significant Difference

Objective: Determine the frequency of vitamin cobalamin deficiency in macrocytic anemia cases reporting at tertiary care hospital. Study Design: Cross Sectional study. Setting: Faculty of Medicine and Allied Medical Sciences, Isra University, Hyderabad, Sindh Pakistan. Period: January 2017 to October 2018. Material & Methods: 450 cases of both genders, diagnosed as macrocytic- megaloblastic anemia were studied for the vitamin Cobalamin levels. Cases were collected through non- probability convenient sampling by inclusion and exclusion criteria. Consenting volunteers were asked for blood sampling. 5 mL blood was taken from ante – cubital fossa. Samples were centrifuged and sera were collected for the estimation of vitamin cobalamin by ELISA – assay kit. Continuous and categorical variables were entered in SPSS (version 21.0) and analyzed by Student t-test and Chi-square test respectively at 95% CI (P ≤ 0.05). Results: Male and female comprised 225 (43.3%) and 294 (56.6%) of 519 subjects. Male to female ratio was noted 1.30:1. MCV, MCH and MCHC show statistically significant difference between male and female (P<0.05). MCV in male was 96.8±9.92 fl vs. 105.5±12.04 fl in female (P=0.0001). Normal cobalamin was noted in 15.2% (n= 79) and any type of cobalamin deficiency was noted in 84.7% (n= 440) (P=0.0001). Conclusion: The present study reports frequency of 84.7% Cobalamin deficiency in macrocytic anemia reporting at Indus Medical College Hospital. Further studies are recommended by the treating physicians.

scholarly journals Evaluation of bone marrow in cases of pancytopenia in a tertiary care hospital

2015 ◽  
Vol 5 (9) ◽  
pp. 691-695
Author(s):  
S Vaidya
Keyword(s):  
Bone Marrow ◽  
Aplastic Anemia ◽  
Tertiary Care Hospital ◽  
Megaloblastic Anemia ◽  
Tertiary Care ◽  
Bone Marrow Aspiration ◽  
Bone Marrow Examination ◽  
Care Hospital ◽  
Diagnostic Modality ◽  
Number Of Patients

Background: A spectrum of primary and secondary disorders that affect the bone marrow may manifestwith pancytopenia. This study was carried out to identify the various causes of pancytopenia in patients attending a tertiary care hospital in Lalitpur, Nepal.Materials and Methods: A descriptive study of 83 cases of pancytopenia was carried out in the Department of Pathology, Patan Academy of Health Sciences, Lalitpur, Nepal over a two year period from August 2010 to July 2012.Results: Eighty three patients underwent bone marrow examination. Mean age of the patients was 34 years (range: 4 to 75 years). Maximum number of patients (31.33%) was seen in the age group of 16 - 30 years. The commonest cause of pancytopenia was megaloblastic anemia which was seen in 34.94% (29/83) cases followed by aplastic anemia and hematological malignancies in 31.32% (26/83) and 14.46% (12/83) cases, respectively.Conclusion: This study concluded that megaloblastic anemia and aplastic anemia were the two most common causes of pancytopenia. Bone marrow aspiration is an established diagnostic modality in the evaluation of pancytopenia.Journal of Pathology of Nepal (2015) Vol. 5, 691 - 695

HEMATOLOGICAL STUDY OF MACROCYTIC ANEMIA: STUDY AT A TERTIARY CARE HOSPITAL

2021 ◽  
pp. 69-71
Author(s):  
Sonali Smita Xess ◽  
Vaishali Anand
Keyword(s):  
Megaloblastic Anemia ◽  
Tertiary Care ◽  
Macrocytic Anemia ◽  
Care Hospital ◽  
Biochemical Tests ◽  
Common Causes ◽  
History Of ◽  
Study Population ◽  
Medical Materials ◽  
Set Up

Introduction: Anemia is one of the most commonly diagnosed conditions in a health care set up. Iron deciency anemia is the predominant cause of anemia across countries and in both sexes (1,2) . Although, in approximately 2 to 4 % of patients, laboratory evidence of macrocytosis is found (3) .The cause of macrocytic anemia is classied into megaloblastic or non-megaloblastic (4). Common causes of macrocytosis are different by region and setting. The present study aims at studying patients admitted in Civil Hospital Ahmedabad during the study period with MCV value more than 100 fL and utilizing the clinical prole and other biochemical parameters to further classify anemia into Megaloblastic and NonMegaloblastic type. The study period is January 1, 2018 to July 31, 2019. Relevant medical Materials and Methods: history of the patients participating in the study was considered. MCV value was determined from complete hemogram which was performed using Automatic Hematological Analyser. Peripheral smear examination was done with slides stained in Giemsa stain. Biochemical tests were performed using Automated Biochemistry Analysers. The data obtained from the above was then utilized in establishing the incidence of various causes of macrocytic anemia in our study population. Result: Out of the total 325 patients 160 (49%) were found to have megaloblastic anemia and 128 patients (40%) were found to have non-megaloblastic anemia. In the remaining 37 (11%) patients, no cause of macrocytosis was identied. The etiologies of macrocytic anemia identied in the present study were Vitamin B12 deciency, hepatic dysfunction, hypothyroidism, renal dysfunction and accelerated erythropoiesis (due to hemolysis or blood loss). Conclusion: The most common cause of macrocytic anemia in our study population was found to be Megaloblastic anemia.

scholarly journals Etiology of Pancytopenia: An Observation from a Referral Medical Institution of Eastern Region of India

2015 ◽  
Vol 7 (02) ◽  
pp. 090-095 ◽  
Author(s):  
Senjuti Dasgupta ◽  
Prakas K Mandal ◽  
Sudipta Chakrabarti
Keyword(s):  
Aplastic Anemia ◽  
West Bengal ◽  
Complete Blood Count ◽  
Tertiary Care Hospital ◽  
Megaloblastic Anemia ◽  
Tertiary Care ◽  
Eastern Region ◽  
Care Hospital ◽  
Common Cause ◽  
Etiological Factors

ABSTRACT Background: Pancytopenia is a relatively common hematological condition, the etiological factors of which vary widely in different geographic location. Determining the specific etiology is of immense importance for appropriate management. Aims and Objectives: The present study was undertaken to delineate etiological factors leading to pancytopenia in a Tertiary Care Hospital of West Bengal from Eastern Region of India. Aims and Objectives:The present study was undertaken to delineate etiological factors leading to pancytopenia in a Tertiary Care Hospital of West Bengal from Eastern Region of India. Materials and Methods: A prospective study was conducted for a period of 2 years in which 248 patients were included. After obtaining a relevant clinical history, physical examination was done followed by complete blood count including peripheral blood smears examination, relevant biochemical, and radiological investigations. Afterward, bone marrow aspiration and biopsy were performed and microscopically examined. Results: Among 248 patients studied, 156 (62.9%) were males and 92 (37.09%) were females. The mean age of the patients was 33 years. Aplastic anemia was the most common cause of pancytopenia that was observed in 83 cases (33.47%) followed by megaloblastic anemia in 52 cases (20.97%), leishmaniasis in 34 patients (13.71%), hypersplenism also in 34 patients (13.71%), and tuberculosis and other connective tissue disorders in 18 cases (7.26%). The occurrence of aplastic anemia was statistically significant in pediatric (≤15 years) age group. Conclusion: Aplastic anemia was found to be the most common cause of pancytopenia in this study, which is in contrast to studies conducted from other regions of India. Delineation of etiologies of pancytopenia in various regions can help in defining diagnostic and therapeutic strategies, which is expected to contribute toward the better management of such patients.

scholarly journals Incidence of Drug-Drug Interactions among Patients Admitted to the Department of General Medicine in a Tertiary Care Hospital

2018 ◽  
Vol 10 (4) ◽  
pp. 450-455 ◽  
Author(s):  
Namrata Bajracharya ◽  
Ann Mary Swaroop ◽  
Saraswathy Ganesan Rajalekshmi ◽  
Subeesh K Viswam ◽  
Maheswari Maheswari E
Keyword(s):  
Drug Interactions ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
General Medicine ◽  
Care Hospital

A comparative study of bone marrow aspirate with trephine biopsy in pancytopenia disorders

2021 ◽  
Vol 6 (3) ◽  
pp. 201-206
Author(s):  
Kavya J ◽  
Kalpana Kumari MK
Keyword(s):  
Bone Marrow ◽  
Sensitivity And Specificity ◽  
Megaloblastic Anemia ◽  
Tertiary Care ◽  
Bone Marrow Aspiration ◽  
Bone Marrow Examination ◽  
Care Hospital ◽  
Trephine Biopsy ◽  
Hematological Disorders ◽  
Hematoxylin And Eosin

Pancytopenia is commonly reported in clinical hematology practice. Due to its varied marrow pathology and underlying ailments, diagnosis is often misleading and delayed. Bone marrow examination would provide a comprehensive diagnosis of both blood and bone marrow, since aspirate investigates the cytological morphology and biopsy evaluates the cellularity, architecture, and compact marrows.To compare bone marrow aspiration and trephine biopsy results in the diagnosis of pancytopenia, and to determine the sensitivity and specificity of aspirate examination in pancytopenia diagnosis.This prospective study was conducted at a tertiary care hospital from July 2014 to June 2016. A total of 320 samples were received at the department of pathology for bone marrow examination (aspirate and biopsy). Romanowsky (Leishman) stain was used to investigate aspirate samples. All biopsy samples were processed into 3-5 μ blocks and stained using hematoxylin and eosin after decalcification with 5.5% EDTA. Data analysis was performed using SPSS19.Pancytopenia constituted 56 (18.7%) cases with the mean age of 41.79 years. Of the total pancytopenia cases, hematological disorders constituted 50 (89.3%) cases and 6 (10.7%) were non-hematological cases. Aspirate and biopsy diagnosis positively correlated in 76.79% of cases. A 100% sensitivity and specificity of aspirate diagnosis was observed in, acute myeloid leukemia, hypersplenism, myelodysplastic syndrome, megaloblastic anemia, hematological malignancy in remission and negative for lymphoma infiltrate. Aspirate had no role in diagnosis of uremic osteodystrophy and myelofibrosis, whereas leishmaniasis was diagnosed on aspirate alone.Pancytopenia includes multiple underlying ailments which requires a differential diagnosis approach. Combining both aspirate and biopsy for diagnosis would benefit the patient in prognosis as they are complementary to each other.

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