Comparative study of efficacy of platelet rich plasma injection versus corticosteroid injection in conservative management of periarthritis shoulder

Analysis of eighty patients with periarthritis shoulder was done. Patients were thoroughly evaluated and were divided into two groups in a randomized trial. Forty patients were in group-A who received 3doses of injection of PRP (4ml) 2 weeks apart within a duration of 6weeks. Equal number of patients were in group-B. They received 2ml of Injection corticosteroid 2weeks apart within a duration of 6 weeks. All participants were advised to perform a home-based hot fomentation and 15min exercise therapy. One participant from group A and 2 from group B were lost to follow up. There were 35 male and 42 female who completed the study. Analysis of 77 subjects who completed the study was done. Participant were evaluated for range of motion of shoulder as main outcome measure. Visual Analogue Scale (VAS) and (Quick DASH) was used to measure pain and functions of the shoulder. The evaluation of Participants was done at 0,3,6 and 12 weeks. ANOVA test and Chi-square test, was repeatedly used to measure the differences.Participants who were given PRP injections showed significant improvements in active and passive range of shoulder motion as measured by VAS and Quick DASH over corticosteroid injection. This was also reflected statistically. No major adverse reactions were observed during 12 weeks of intervention.In our study, the injection of PRP showed marked improvement in the range of motion of shoulder over corticosteroid injection but it needs other study to be treatment of choice. It emerged as an option for treatment in diabetes patient and condition where steroid is contraindicated.

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Stem Cell Surgery and Growth Factors in Retinitis Pigmentosa Patients: Pilot Study after Literature Review

Biomedicines ◽

10.3390/biomedicines7040094 ◽

2019 ◽

Vol 7 (4) ◽

pp. 94 ◽

Cited By ~ 1

Author(s):

Paolo Giuseppe Limoli ◽

Enzo Maria Vingolo ◽

Celeste Limoli ◽

Marcella Nebbioso

Keyword(s):

Retinitis Pigmentosa ◽

Platelet Rich Plasma ◽

Functional Results ◽

Point Of View ◽

Foveal Thickness ◽

Restoration Technique ◽

Number Of Patients ◽

Group A ◽

Cell Surgery ◽

Group B

To evaluate whether grafting of autologous mesenchymal cells, adipose-derived stem cells, and platelet-rich plasma into the supracoroideal space by surgical treatment with the Limoli retinal restoration technique (LRRT) can exert a beneficial effect in retinitis pigmentosa (RP) patients. Twenty-one eyes underwent surgery and were divided based on retinal foveal thickness (FT) ≤ 190 or > 190 µm into group A-FT and group B-FT, respectively. The specific LRRT triad was grafted in a deep scleral pocket above the choroid of each eye. At 6-month follow-up, group B showed a non-significant improvement in residual close-up visus and sensitivity at microperimetry compared to group A. After an in-depth review of molecular biology studies concerning degenerative phenomena underlying the etiopathogenesis of retinitis pigmentosa (RP), it was concluded that further research is needed on tapeto-retinal degenerations, both from a clinical and molecular point of view, to obtain better functional results. In particular, it is necessary to increase the number of patients, extend observation timeframes, and treat subjects in the presence of still trophic retinal tissue to allow adequate biochemical and functional catering.

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A comparative study of effectiveness of local injection of autologous platelet rich plasma and injection corticosteroid solution in treatment of plantar fasciitis

International Journal of Research in Orthopaedics ◽

10.18203/issn.2455-4510.intjresorthop20190801 ◽

2019 ◽

Vol 5 (2) ◽

pp. 335

Author(s):

Vithal Prakash Puri ◽

Anil Kumar Gaur

Keyword(s):

Plantar Fasciitis ◽

Platelet Rich Plasma ◽

Corticosteroid Injection ◽

Care Center ◽

Tertiary Care ◽

Vas Score ◽

Visual Analog Scales ◽

Group A ◽

Group B

Background: The heel pain is the most common problem worldwide and it was associated with plantar fasciitis (PF). The condition of treatment is very complex. Platelet-rich plasma (PRP) and injection of corticosteroids is the treatment of PF. This study was designed to access the effect of local PRP and local corticosteroid injection in PF patients.Methods: Sixty patients (between 29 to 60 years of age) with chronic PF were randomized prospectively in single tertiary care center in India. The study conducted from December 2013 to December 2015. All the patients were enrolled according to inclusion criteria and divided into two groups randomized. In group A (n=30) received PRP and group B (n=30) received corticosteroids injections. Visual analog scales (VAS) were filled by all the included patients. The follow-up scheduled at one and six months after complete enrolment of patients.Results: Between both the groups the significantly different observed at one and six months follow-up from the baseline. At one month follow-up significantly improvement in mean VAS score were observed in group B (p<0.001). At six months follow-up significantly improvement in mean VAS score were observed in group A (p<0.001).Conclusions: The present study concluded from the significance difference between both the groups proved promising form of treatment in chronic PF patients. Both the treatment was safe and effective in relieving pain improving function at different time period.

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Epicondylitis Band or Corticosteroid Injection for Lateral Epicondylitis Treatment?

Orthopaedic Journal of Sports Medicine ◽

10.1177/2325967114s00163 ◽

2014 ◽

Vol 2 (11_suppl3) ◽

pp. 2325967114S0016

Author(s):

Ertuğrul Allahverdi ◽

Tülay Diken Allahverdi ◽

Uğur Türktaş

Keyword(s):

Local Anesthetic ◽

Corticosteroid Injection ◽

Combined Treatment ◽

Lateral Epicondylitis ◽

Group A ◽

Patient Groups ◽

Inflammatory Drugs ◽

Anti Inflammatory ◽

Group B ◽

Quick Dash

Objectives: Comparison of the short and medium-term results of the epicondylitis brace with corticosteroid and local anesthetic injections for lateral epicondylitis. Methods: This was a retrospective and comparative study for the treatment of acute lateral epicondylitis. The patient groups A and B received two different treatments. There were 151 patients in Group A and 205 patients in Group B. Group A received the epicondylitis brace and Group B corticosteroid and local anesthetic injections. Both groups were also given stretch exercises and nonsteroidal anti-inflammatory drugs. Patients were assessed at weeks 1, 4, 12, and 24 and the Quick DASH scoring was performed on weeks 12 and 24. Results: At the 3rd month of treatment, Group A showed recovery rates of moderate, good and full in 18.5%, 32.5% and 30.5% respectively while these rates were 33.2%, 13.7% and 25.4% in Group B. The same rates at the end of months 6 were 17.2%, 41.1% and 17.2% in Group A and 28.3%, 1% and 17.2% in Group B. Conclusion: Combined treatment (physical therapy, nonsteroidal anti-inflammatory drugs) with an epicondylitis brace was more effective than combined treatment with steroid and local anesthetic injections in acute lateral epicondylitis.

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Treatment of infantile spasms in resource limited settings: Arandomized controlled trial

Journal of the International Child Neurology Association ◽

10.17724/jicna.2019.163 ◽

2020 ◽

Author(s):

Huda Sardar ◽

Ashfa Ameer Khan ◽

Tipu Sultan

Keyword(s):

Controlled Trial ◽

Oral Prednisolone ◽

Cost Effective ◽

Infantile Spasms ◽

Chi Square ◽

Key Words Epilepsy ◽

First Line Therapy ◽

Number Of Patients ◽

Group A ◽

Group B

Objective: To compare the outcome of ACTH with oral prednisolone for treatment of infantile spasms. Methodology: This is a randomized controlled trial conducted at department of paediatric neurology, The Children Hospital, Lahore, Pakistan after ethical approval from January 1st 2014 to December 31st 2017. (Four years). Seventy patients with infantile spasms were randomized in two equal groups of 35 patients in each group. Patients in group A received prednisolone and in group B received ACTH. The two groups were compared for the spasms free period. Statistical significant determined by chi-square test (p< 0.05 was taken as significant). Non-probability purposive sampling was used and an inclusion criterion was children up to age of one year with infantile spasms. Exclusion criteria include children who had been previously treated with steroids or ACTH. Seventy patients fulfilling inclusion criteria were enrolled through neurology department of Children Hospital, Lahore. History, informed consent was taken by parents and was divided in two groups by lottery method. All the information was collected on a specially designed proforma. Results: In group A, 29 (83%) patients were spasms free, while in group B, 31 (88%) patients were spasms free. Conclusion: Significant number of patients with IS were spasms free with prednisolone which is very cost effective drug as compared to ACTH. Developing counties should considered this treatment option as a first line therapy. Key words: Epilepsy, ACTH, Prednisolone, Infantile spasms, Hypsarthymia.

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Comparison of Plantar Fasciitis Injected With Platelet-Rich Plasma vs Corticosteroids

Foot & Ankle International ◽

10.1177/1071100718762406 ◽

2018 ◽

Vol 39 (7) ◽

pp. 780-786 ◽

Cited By ~ 19

Author(s):

Sumit Kumar Jain ◽

Kumar Suprashant ◽

Sanjeev Kumar ◽

Arun Yadav ◽

Stephen R. Kearns

Keyword(s):

Plantar Fasciitis ◽

Platelet Rich Plasma ◽

Corticosteroid Injection ◽

Plantar Fascia ◽

Subjective Rating ◽

Level Of Evidence ◽

Outcome Instrument ◽

Significant Difference ◽

Group A ◽

Group B

Background: Plantar fasciitis is one of the most common causes of heel pain. This prospective study compared the efficacy of local injection of corticosteroids vs platelet-rich plasma (PRP) in the treatment of plantar fasciitis. Methods: Patients were randomly allocated into 2 groups of 40 each (group A and group B). Patients were treated with local corticosteroid injection in group A and autologous PRP injection in group B. Clinical assessment was done prior to the injection and at 1 month, 3 months, and 6 months following the injection, which included visual analog pain scale, subjective rating using the modified Roles and Maudsley score, functional outcome score by the Foot and Ankle Outcome Instrument (FAI) core scale, and the American Orthopaedic Foot & Ankle Society (AOFAS) ankle-hindfoot scale. Radiological assessment was done by measuring the thickness of the plantar fascia using ultrasonography. The mean age, sex, and body mass index of both groups were comparable. Results: Postinjection, there was significant improvement of visual analog score, modified Roles and Maudsley score, FAI core scale, AOFAS ankle-hindfoot score, and plantar fascia thickness in both the groups. However, with the numbers available, no significant difference in improvement could be detected between the above-mentioned variables in the 2 groups. Conclusion: We found that the treatment of plantar fasciitis with steroid or PRP injection was equally effective. Level of Evidence: Level II, prospective randomized comparative series.

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COMPARATIVE STUDY OF PLATELET-RICH PLASMA AND CORTICOSTEROID INJECTION IN THE TREATMENT OF PLANTAR FASCIITIS

International Journal of Medical and Biomedical Studies ◽

10.32553/ijmbs.v3i11.750 ◽

2019 ◽

Vol 3 (11) ◽

Author(s):

Dr. S. A. Mustafa Johar ◽

Dr. Rajeev Parmar ◽

Dr. Tushaar Ghodawat

Keyword(s):

Clinical Evaluation ◽

Plantar Fasciitis ◽

Platelet Rich Plasma ◽

Corticosteroid Injection ◽

Functional Results ◽

Blood Component ◽

Maximum Point ◽

Group A ◽

Autologous Platelet Rich Plasma ◽

Group B

Background: Plantar fasciitis is defined as localized inflammation due to chronic repeated microinjury to the substance of plantar aponeuroses and the patients present to the clinic for pain in heel. In this study, autologous platelet-rich plasma (PRP), a concentrated bioactive blood component rich in growth factors, was compared to traditional steroid injection usually methylprednisolone in the treatment of plantar fasciitis resistant to traditional nonoperative management. Methods: Eighty patients with plantar fasciitis were included in the study and randomly categorised into group A (steroid inj) and Group B (prp inj). 3 cc PRP or 40 mg DepoMedrol injected into plantar aponeurosis at maximum point of tenderness, in both groups separately. Results of both groups comparedand Score of both the groups tellied by using vas score. Study Design and Time: Prospective cohort study of 6 months duration. Inclusion criteria: All cases of plantar fasciitis except cases of metabolic disorder Exclusion criteria: other plantar pathologies and deformities. calcaneum fractures Old treated with injections. Results: The instillation of PRP found to be more effective than Steroids injection in terms of pain and functional results in the treatment of plantar fasciitis. Clinical evaluation was performed before treatment and at the 6th week, 12th week and 24th weeks from instillation of PRP/steroid in follow up visits. Visual analog scale were used in the clinical evaluation. Keywords: Platelet-Rich, Plasma, Corticosteroid, Plantar & Fasciitis.

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Stem Cell Surgery and Growth Factors in Retinitis Pigmentosa Patients: Pilot Study After Literature Review

10.20944/preprints201907.0347.v1 ◽

2019 ◽

Author(s):

Paolo Giuseppe Limoli ◽

Enzo Maria Vingolo ◽

Marco Ulises Morales ◽

Celeste Limoli ◽

Marcella Nebbioso

Keyword(s):

Growth Factors ◽

Retinitis Pigmentosa ◽

Platelet Rich Plasma ◽

Functional Results ◽

Point Of View ◽

Foveal Thickness ◽

Restoration Technique ◽

Number Of Patients ◽

Group A ◽

Group B

To evaluate whether autologous mesenchymal cells, adipose derived stem cells and platelet-rich plasma, grafted into the supracoroideal space by surgical treatment according to Limoli retinal restoration technique (LRRT), can produce growth factors in order to exert a beneficial effect in retinitis pigmentosa (RP) patients. Twenty-one eyes underwent surgery and divided based on retinal foveal thickness ≤ 190 or >190 µm into group A and group B, respectively. The specific LRRT triad was grafted in a deep scleral pocket above the choroid of each eye. At 6-month follow-up, group B showed an improvement in residual close-up visus and sensitivity at microperimetry compared to group A. After an in-depth review of molecular biology studies concerning degenerative phenomena underlying the etiopathogenesis of RP, it can be confirmed that further research is needed on tapeto-retinal degenerations both from a clinical and molecular point of view to obtain better functional results. In particular, it is necessary to increase the number of patients, extend observation times, and treat subjects in the presence of still trophic retinal tissue to allow adequate biochemical and functional catering.

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COMPARISON OF PAIN RELIEF EFFICACY OF PLATELET-RICH PLASMA VERSUS CORTICOSTEROIDS IN KNEE OSTEOARTHRITIS

Pakistan Armed Forces Medical Journal ◽

10.51253/pafmj.v71i5.4135 ◽

2021 ◽

Vol 71 (5) ◽

pp. 1764-68

Author(s):

Amir Sohail ◽

Ameer Yasser Zaid ◽

Shizan Hamid Feroz ◽

Mohammed Saeed ◽

Syed Khurram Naseer ◽

...

Keyword(s):

Pain Relief ◽

Knee Osteoarthritis ◽

Rating Scale ◽

Platelet Rich Plasma ◽

Corticosteroid Injection ◽

Numeric Rating Scale ◽

Rating Score ◽

Numerical Rating ◽

Group A ◽

Group B

Objective: To compare the pain relief efficacy of platelet rich plasma injection with corticosteroid injection in knee osteoarthritis using numeric rating scale. Study Design: Quasi experimental study. Place and Duration of Study: Department of Anesthesia and Pain Management, Combined Military Hospital Peshawar, from Jan 2018 to Dec 2019. Methodology: Total of 310 patients who underwent knee injection for osteoarthritis were included in this study. Patients were divided into two groups; group A and group B comprising of 155 patients each. Patients in group ‘A’ received intra articular corticosteroid injection while patients in group ‘B’ received intra articular platelet rich plasma injection for knee osteoarthritis. Pain assessment via numerical rating score was done at the start of the treatment and at 6 months. Results: In group A female to male ratio was 2.69:1 while in group B the female to male ratio was 2.78:1. Mean age of ‘group A’ was 58.52 ± 11.87 years and that of ‘group B’ was 58.79 ± 11.15 years. Numerical rating score pre-treatment in ‘group A’ vs ‘group B’ was 8.35 ± 1.17 vs 8.42 ± 1.14. While numeric rating scale post treatment in ‘group A’ vs ‘group B’ was 5.74 ± 1.37 vs 4.06 ± 1.19, respectively with p-value of 0.001, which is statistically significant. Conclusion: Patients who received intra-articular platelet rich plasma had significantly more pain relief as compared to patients who received intra-articular steroid on numerical rating score.

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Comparative Study of effectiveness of mobilization with movement (MWM) and End range mobilization (ERM) techniques in frozen shoulder

Research in Pharmacy and Health Sciences ◽

10.32463/rphs.2018.v04i04.22 ◽

2018 ◽

Vol 4 (4) ◽

pp. 519-522

Author(s):

Jeyakumar S ◽

Jagatheesan Alagesan ◽

T.S. Muthukumar

Keyword(s):

Range Of Motion ◽

Frozen Shoulder ◽

Type I ◽

Mean Values ◽

Functional Activities ◽

Group A ◽

The Mean ◽

Group B

Background: Frozen shoulder is disorder of the connective tissue that limits the normal Range of motion of the shoulder in diabetes, frozen shoulder is thought to be caused by changes to the collagen in the shoulder joint as a result of long term Hypoglycemia. Mobilization is a therapeutic movement of the joint. The goal is to restore normal joint motion and rhythm. The use of mobilization with movement for peripheral joints was developed by mulligan. This technique combines a sustained application of manual technique “gliding” force to the joint with concurrent physiologic motion of joint, either actively or passively. This study aims to find out the effects of mobilization with movement and end range mobilization in frozen shoulder in Type I diabetics. Materials and Methods: 30 subjects both male and female, suffering with shoulder pain and clinically diagnosed with frozen shoulder was recruited for the study and divided into two groups with 15 patients each based on convenient sampling method. Group A patients received mobilization with movement and Group B patients received end range mobilization for three weeks. The outcome measurements were SPADI, Functional hand to back scale, abduction range of motion using goniometer and VAS. Results: The mean values of all parameters showed significant differences in group A as compared to group B in terms of decreased pain, increased abduction range and other outcome measures. Conclusion: Based on the results it has been concluded that treating the type 1 diabetic patient with frozen shoulder, mobilization with movement exercise shows better results than end range mobilization in reducing pain and increase functional activities and mobility in frozen shoulder.

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Home physiotherapy with vs. without supervision of physiotherapist for assessing manipulation under anaesthesia after total knee arthroplasty

Arthroplasty ◽

10.1186/s42836-020-00063-3 ◽

2021 ◽

Vol 3 (1) ◽

Author(s):

Sanjay Bhalchandra Londhe ◽

Ravi Vinod Shah ◽

Amit Pankaj Doshi ◽

Shubhankar Sanjay Londhe ◽

Kavita Subhedar ◽

...

Keyword(s):

Total Knee Arthroplasty ◽

Range Of Motion ◽

Knee Arthroplasty ◽

Forgotten Joint Score ◽

Group A ◽

Manipulation Under Anaesthesia ◽

Total Knee ◽

The Mean ◽

Group B ◽

Discharge From Hospital

Abstract The aim of this retrospective cohort study was to compare home physiotherapy with or without supervision of physiotherapist for assessing manipulation under anaesthesia after total knee arthroplasty. Methods A total of 900 patients (including 810 females and 90 males) who had undergone total knee arthroplasty were divided into group A (n = 300) and group B (n = 600). Patients in group A had home physiotherapy on their own after discharge from hospital. The physiotherapist did not visit them at home. Patients in group B received home physiotherapy under supervision of physiotherapist for 6 weeks after discharge from hospital. Patients’ age, range of motion of the knee, and forgotten joint score-12 were assessed. A p < 0.05 was considered statistically significant. Results In group A, the mean age was 69.1 ± 14.3 years (range: 58 to 82 years); in group B, the mean age was 66.5 ± 15.7 years (range: 56 to 83 years) (p > 0.05). Preoperatively, the mean range of motion of the knee in group A and B was 95.8° ± 18.1° and 95.4° ± 17.8°, respectively (p > 0.05). The mean forgotten joint score-12 of group A and B were 11.90 ± 11.3 and 11.72 ± 12.1 (p > 0.05), respectively. Six weeks after total knee arthroplasty, the mean ROM of the knee in group A and B was 109.7° ± 22.3° and 121° ± 21.5°, respectively (p < 0.05). The mean postoperative forgotten joint score-12 of the group A and B was 24.5 ± 16.4 and 25.6 ± 17.4, respectively (p > 0.05). The rate of manipulation under anaesthesia was 3% in group A and 0.2% in group B (p < 0.05). Conclusion After total knee arthroplasty, frequent physiotherapist’s instruction helps the patients improve knee exercises and therefore decrease the risk of revision surgery. The home physiotherapy under supervision of physiotherapist lowers the rate of manipulation under anaesthesia. Level of evidence Therapeutic study, Level IIa.

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