Serum vitamin D in Indian children with vernal keratoconjunctivitis

2021 ◽  
Vol 2 (2) ◽  
pp. 63-68
Author(s):  
Priyanka Singh ◽  
◽  
Anuj Mehta ◽  
L. Sarkar ◽  
◽  
...  
Keyword(s):  
Vitamin D ◽  
Serum Vitamin ◽  
Vernal Keratoconjunctivitis ◽  
Control Group ◽  
Healthy Children ◽  
Indian Children ◽  
Serum Vitamin D ◽  
Severe Deficiency ◽  
Vitamin D Levels ◽  
Ocular Surface Health

AIM: To determine the vitamin D levels in vernal keratoconjunctivitis (VKC) patients in Indian population. METHODS: A total of 30 non-atopic healthy children and 30 children having VKC were included in the study. The serum vitamin D levels and the time spent outside was compared between the two groups (P<0.05). RESULTS: The mean serum vitamin D level in the VKC group was significantly lower (mean 19.17±10.76 ng/mL) compared to the control group (mean 31.19±9.09 ng/mL) (P=0.0003). The vitamin D levels were found to be deficient (10-20 ng/mL) in 43.33%, whereas severe deficiency (<10 ng/mL) was found in 20% of the VKC patients. The deficiency of vitamin D correlated with the level of severity of VKC (P<0.02). The time spent outside in the VKC group was 1.07±0.76h, whereas in the healthy subjects it was 2.08±0.72h (P<0.0001), and it showed a significant correlation with the serum 25 (OH) D3 levels (r=0.478, P<0.001). CONCLUSION: The study shows that children with VKC had a significantly lower serum vitamin D levels as compared to the healthy children which correlated with time spent outside. The severity of VKC also correlated with the severity of vitamin D deficiency which suggests that vitamin D plays an important role in maintaining ocular surface health.

scholarly journals Correlation of serum vitamin D levels and anemia in childhood pneumonia: a case control study from rural area

2017 ◽  
Vol 4 (3) ◽  
pp. 756
Author(s):  
Suhas P. Kulkarni ◽  
Ashok A. Chougule
Keyword(s):  
Vitamin D ◽  
Case Control Study ◽  
Serum Vitamin ◽  
Case Control ◽  
Control Group ◽  
Immunomodulatory Activity ◽  
Healthy Children ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Control Study

Background: Pneumonia remains number one cause for morbidity and mortality in children. Vitamin D has been shown to have immunomodulatory activity. Hence to find correlation between vitamin D and pneumonia cases the study was carried out.Methods: A case control study was conducted at a rural hospital in Vadgaon. From September 2015 onwards all children under 5 years of age hospitalized with pneumonia were invited to participate in our study. Patients who consented for study underwent serum vitamin 25 (OH) D3 estimation along with other routine investigations as indicated. During the same study period, parents of otherwise healthy children fewer than 5 years age who came to our immunization clinic were invited to participate in the study as a control group.Results: Vitamin 25(OH) D3 levels in pneumonia cases study group (N=40) 12.048±6.015 ng/ml (Mean±SD) and in control (N=35) 22.65±11.77 ng/ml (mean±SD) that is statistically significant (P<0.0001) and hemoglobin (Hb) in Cases (N=40) with 8.55±1.27 gm/dl (mean±SD); control group (N=19) with 10.31±0.9 gm/dl (mean±SD)levels was found to be statistically significant (p < 0.0001).All patients with severe pneumonia needing ICU management were found to be deficient in vitamin D levels. Children with pneumonia had higher level of anemia. All children admitted to ICU had Moderate to severe anemia.Conclusions: There is a correlation between Vitamin D deficiency and severity of pneumonia and there is also correlation between level of anemia and severity of pneumonia.

scholarly journals Correlation of psoriasis and serum vitamin D

2021 ◽  
Vol 7 (4) ◽  
pp. 320-323
Author(s):  
Ritika Gujrati ◽  
Krishnendra Varma ◽  
Ujjwal Kumar
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Psoriasis Vulgaris ◽  
Systemic Disease ◽  
Serum Vitamin ◽  
Psoriatic Skin ◽  
Control Group ◽  
P Value ◽  
Serum Vitamin D ◽  
Vitamin D Levels

Psoriasis is an immuno-mediated chronic systemic disease involving cytokines of helper Th1 pathway. Vitamin D has an effect on keratinocyte proliferation, differentiation and immune modulation of immune system especially Th1 pathway, which is altered in psoriatic skin suggesting that Vitamin D may have a role in pathogenesis of psoriasis. To study correlation between psoriasis vulgaris and serum vitamin D. To evaluate serum vitamin D level in psoriasis cases and in control group and correlating vitamin D level with severity and duration of the psoriasis. 57 cases (&#62;15years of age) with psoriasis and 57 healthy subjects were recruited. Psoriasis was clinically diagnosed and severity evaluated by PASI scale. Vitamin D was analysed by enhanced chemilumine scence on vitrus Eci autoanalyzer of Orth clinical diagnostic. Vitamin D deficiency defined as &#60;20ng/ml, insufficiency 20-30ng/ml and sufficient 30-100ng/ml. Vitamin D deficiency in the study was 22.8% in patients and 14% in control group. Vitamin D insufficiency was found in 42.1% of cases and 19.3% of control. According to chi-square the p-value is 0.003 showing significant association. There was a tendency towards decrease in vitamin D level with increase in disease duration. There was negative correlation between vitamin D and PASI score. The study found a significant relationship between vitamin D and psoriasis. Further metanalysis involving larger study population will be required to establish whether vitamin D levels benefits patient with psoriasis vulgaris.

scholarly journals Association of serum vitamin D levels and transient tachypnea of newborn: a case control study

2017 ◽  
Vol 4 (3) ◽  
pp. 827 ◽  
Author(s):  
Gurmeet Singh ◽  
Reena Sood ◽  
Gursharan Singh Narang ◽  
Harnoorjit Kaur Brar ◽  
Amanjeet Kaur Bagga
Keyword(s):  
Vitamin D ◽  
Serum Vitamin ◽  
Transient Condition ◽  
Control Group ◽  
Term Neonates ◽  
Serum Vitamin D ◽  
Increased Risk ◽  
Vitamin D Levels ◽  
Control Study ◽  
Structured Questionnaire

Background: Transient tachypnea of newborn (TTN) is a common cause of respiratory distress in newborns with estimated incidence of 1-2% of all newborns. Although a self-limiting transient condition but it may cause severe morbidities. This study was conducted to find association of serum vitamin D levels in neonates who develop TTN as compared to normal healthy neonates.Methods: With thorough history with structured questionnaire and lab tests, serum vitamin D levels of 45 neonates who develop TTN were compared with 56 healthy neonates in control group.Results: Out of 45 neonates who develop TTN 39(86.7%) were deficient in vitamin D as compared to control group where 33(58.9%) out of 56 healthy neonates were deficient in vitamin D.Conclusions: Lower vitamin D levels at birth in term neonates is associated with increased risk of developing TTN and vitamin D may have a role in its pathogenesis. 

scholarly journals Vitamin D levels in children with COVID-19: a report from Turkey

2021 ◽  
Vol 149 ◽  
Author(s):  
Aysegul Alpcan ◽  
Serkan Tursun ◽  
Yaşar Kandur
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Statistical Significance ◽  
Serum Vitamin ◽  
University Hospital ◽  
Control Group ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Normal Vitamin ◽  
The Mean

Abstract Several studies have demonstrated that higher levels of vitamin D are associated with better prognosis and outcomes in infectious diseases. We aimed to compare the vitamin D levels of paediatric patients with mild/moderate coronavirus disease 2019 (COVID-19) disease and a healthy control group. We retrospectively reviewed the medical records of patients who were hospitalised at our university hospital with the diagnosis of COVID-19 during the period between 25 May 2020 and 24 December 2020. The mean age of the COVID-19 patients was 10.7 ± 5.5 years (range 1–18 years); 43 (57.3%) COVID-19 patients were male. The mean serum vitamin D level was significantly lower in the COVID-19 group than the control group (21.5 ± 10.0 vs. 28.0 ± 11.0 IU, P < 0.001). The proportion of patients with vitamin D deficiency was significantly higher in the COVID-19 group than the control group (44% vs. 17.5%, P < 0.001). Patients with low vitamin D levels were older than the patients with normal vitamin D levels (11.6 ± 4.9 vs. 6.2 ± 1.8 years, P = 0.016). There was a significant male preponderance in the normal vitamin D group compared with the low vitamin D group (91.7% vs. 50.8%, P = 0.03). C-reactive protein level was higher in the low vitamin D group, although the difference did not reach statistical significance (9.6 ± 2.2 vs. 4.5 ± 1.6 mg/l, P = 0.074). Our study provides an insight into the relationship between vitamin D deficiency and COVID-19 for future studies. Empiric intervention with vitamin D can be justified by low serum vitamin D levels.

Vitamin D levels in children with otitis media with effusion

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Ahmed Adly Mohamed ◽  
Marwa Mohamed EL-Begermy ◽  
Ahmed Abdelmoneim Teaima ◽  
Mohamed Ali Abdelghafar
Keyword(s):  
Vitamin D ◽  
Otitis Media ◽  
Otitis Media With Effusion ◽  
Serum Vitamin ◽  
Control Group ◽  
University Hospitals ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
25 Hydroxy Vitamin D ◽  
The Mean

Abstract Objective To investigate the relationship between otitis media with effusion (OME) and serum vitamin D level in children. Methods This prospective case control study was conducted at Ain Shams University Hospitals between February 2018 and May 2019. The study population included 50 children with OME confirmed by tympanometry type (B) who will undergo adenotonsillectomy and grommet tube insertion compared to 50 children without OME confirmed by tympanometry type (A) who will undergo adenotonsillectomy. Measurement of serum 25-hydroxy vitamin D using electrochemiluminescence technique from a blood sample (3cm) taken from them on the day of surgery. Results In this study, the mean age of the cases was 4.24 ± 0.80 and 5.34 ± 1.19 years for the controls besides 23 (46%) of the OME group were boys and 27 (54%) were girls, compared with 29 (58%) boys and 21 (42%) were girls in the control group. The mean levels of vitamin D in children with OME was 16.24 ± 7.14 ng/mL and in children in the control group was 15.89 ± 5.84 ng/mL (P = 0.815) and it was statistically non significant. Conclusion There was no significant relation between vitamin D serum level and the incidence of OME in children.

Serum Vitamin D Levels in Children with Vernal Keratoconjunctivitis

2016 ◽  
Vol 26 (3) ◽  
pp. 435-439 ◽  
Author(s):  
Banu Bozkurt ◽  
Hasibe Artac ◽  
Hulya Ozdemir ◽  
Ali Ünlü ◽  
Mete Kaan Bozkurt ◽  
...  
Keyword(s):  
Vitamin D ◽  
Serum Vitamin ◽  
Vernal Keratoconjunctivitis ◽  
Serum Vitamin D ◽  
Vitamin D Levels

scholarly journals Relationship between Serum 25(OH)D Levels and Blood Pressure in Children with Nephrotic Syndrome

2021 ◽  
Vol 9 (B) ◽  
pp. 260-264
Author(s):  
Rosmayanti Syafriani Siregar ◽  
Oke Rina Ramayani ◽  
Winson Chitra ◽  
Rafita Ramayati
Keyword(s):  
Blood Pressure ◽  
Vitamin D ◽  
Nephrotic Syndrome ◽  
Diastolic Blood Pressure ◽  
Negative Correlation ◽  
Serum Vitamin ◽  
Serum Vitamin D ◽  
Severe Deficiency ◽  
Vitamin D Levels ◽  
Weak Negative Correlation

BACKGROUND: Vitamin D plays an eminent role in the renin-angiotensin system that may interfere with blood pressure regulation. Children with nephrotic syndrome (NS) are often observed with low serum vitamin D levels that may lead to Vitamin D deficiency status. AIM: This study aimed to investigate the correlation between serum vitamin D [25(OH)D] levels and blood pressure in children with NS. METHODS: A cross-sectional, observational analytic study was conducted in 35 children NS with minimal change diseases from February to August 2019 in Haji Adam Malik General Hospital, Medan. Blood pressure was examined and serum Vitamin D levels along with serum creatinine, albumin, and calcium were measured. RESULTS: Of 35 children, 21 children (60%) had proteinuria. Regarding the category of Vitamin D status, there were 40% and 34.3% with deficiency and severe deficiency of Vitamin D, respectively. The median serum Vitamin D levels were not significantly different among the age group. Children with proteinuria showed lower serum Vitamin D levels (P < 0.001). There was an elevation of systolic and diastolic blood pressure in children with proteinuria (P = 0.039 and P = 0.036, respectively). Our study showed a weak negative correlation between serum Vitamin D levels and either systolic or diastolic blood pressure (r-0.114 and r-0.174, respectively). CONCLUSION: Both Vitamin D deficiency and severe deficiency are common in children with NS. In this study, serum Vitamin D levels have been shown to have a weak negative correlation with blood pressure in children with NS.

Serum vitamin D levels in patients with vernal keratoconjunctivitis and its relationship with disease severity

2020 ◽  
pp. 112067212097888
Author(s):  
Rana Sorkhabi ◽  
Mohammad Hosein Ahoor ◽  
Amir Ghorbanihaghjo ◽  
Sasan Jafari
Keyword(s):  
Vitamin D ◽  
Healthy Subjects ◽  
Serum Vitamin ◽  
Vernal Keratoconjunctivitis ◽  
Hydroxyvitamin D ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
25 Hydroxyvitamin D ◽  
The Difference ◽  
Grade 3

Purpose To evaluate the serum vitamin D levels of patients with vernal keratoconjunctivitis (VKC) Method A total of 39 VKC patients (21 males and 18 females) and 32 healthy individuals (19 males and 13 females) were enrolled in this study with the mean age of 18.38 ± 8.83 and 21.6 ± 9.43, respectively. The type and the grade of VKC were identified for each patient and serum 25-hydroxyvitamin D (25(OH)D) levels of all subjects were evaluated. Results The patients affected by VKC had statistically significant lower 25(OH)D levels (27.64 ± 8.50 ng/mL) than healthy subjects group (35.96 ± 11.34 ng/mL) ( p = 0.001). A reverse correlation was found between the serum vitamin D levels and the severity of the VKC but it was not statistically significant ( r = −0.159, p = 0.33). Besides, there were a few cases with severe and very severe VKC (2 in grade 3 and 4 in grade 4). Patients with the mixed type of the disease had lower serum vitamin D levels in comparison to tarsal and limbal forms but the difference was not statistically significant ( p = 0.38). Conclusion This study shows that the patients affected by VKC have lower vitamin D levels in comparison to healthy subjects and the screening of all patients with VKC for vitamin D levels seems rational.

scholarly journals SERUM VITAMIN D LEVEL IN TYPE 2 DIABETIC PATIENTS

2018 ◽  
Vol 21 (05) ◽  
pp. 992-997
Author(s):  
Imran Ali Shaikh ◽  
Naila Masood ◽  
Shazia Memon
Keyword(s):  
Vitamin D ◽  
Serum Vitamin ◽  
Control Group ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Cross Sectional ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Type 2 Diabetic

Objective: To find out serum vitamin D levels in type 2 DM patients in Hyderabad.Design: Cross sectional study. Setting: Private clinics, OPDs of government hospitals likeQasimabad, Latifabad and Pretabad. Duration: January to July 2013. Patients and Methods:Total 550 patients were selected, 450 patients (250 males and 200 females) taken from differentOPDs of Hyderabad and towns or Tehsils with diagnosis of type 2 Diabetes mellitus andanother 100 patients were taken as control (60 males and 40 females). The mean age was45.6 years. The written consent was obtained and demographic features were noted, 3cc ofblood was taken for estimation of vitamin D levels. The level of vitamin D was done on anElectrochemiluminescence Immuno Assay (ECLIA) at Diagnostic & Research laboratory LiaquatUniversity of Medical &Health sciences (LUMHS) Jamshoro, Sind. Results and Observations:Out of 550, 450 diabetic subjects tested for vitamin D, females were 44.4%and 55.5% weremales. The deficiency was seen in 33.7% patients (p <0.04) and Vitamin D insufficiency wasobserved in20% in both sex. In control group, the deficiency was observed in 23% in femalesand 20% in males while insufficiency noted in 5% in both sex. Conclusions: The study showedsignificant decreased levels of vitamin D in type 2 Diabetic subjects than normal individuals. Thevitamin D deficiency increased considerably in females with diabetes type 2.

scholarly journals VITAMIN D DEFICIENCY IN PATIENTS WITH PSORIASIS AND PSORIATIC ARTHRITIS

2020 ◽  
pp. 168-170
Author(s):  
JINAN Q MOHAMMED ◽  
ABDULSATAR J MATHKHOR ◽  
AMER S KHUDHAIRY
Keyword(s):  
Vitamin D ◽  
Psoriatic Arthritis ◽  
Vitamin D Deficiency ◽  
Disease Duration ◽  
Serum Vitamin ◽  
Control Group ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Significant Difference ◽  
Lower Vitamin

Objective: The objective of this study is to investigate the association between Vitamin D level and psoriasis, in particular in our city of the long, hot, and sunny weather, in an attempt to add a clarification to this controversial subject. Methods: A case–control study included 120 patients with psoriasis and 38 patients with psoriatic arthritis (PsA); 89 (56.3%) patients were male. Psoriasis area and severity index (PASI) was calculated for all patients with psoriasis and disease activity score using 28 joints (DAS28) and erythrocyte sedimentation rate (DAS28) was measured for all patients with PsA. The control group comprised 164 age- and sex-matched participants (91 males and 73 females). Vitamin D serum level was performed for both patients and controls. Results: Vitamin D levels in both patients and controls were 17.4±7.7 and 28.3±5.6, respectively. The level of Vitamin D was lower in a patient with disease duration equal and more than 10 years than those with a disease duration <10 years. There is no significant difference in Vitamin D levels between the two patient subgroups. Lower Vitamin D levels were associated with high PASI and high DAS28 in psoriasis and PsA, respectively. Conclusion: Patients with psoriasis and PsA associated with low levels of serum Vitamin D. Vitamin D deficiency was found to be associated with long disease duration in both psoriasis and PsA. Patients with active disease have lower Vitamin D levels.

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