scholarly journals A Single-Blinded, Randomized Controlled Study - Role of Probiotics on Glucose and Lipid Metabolism in Patients with Type - 2 Diabetes Mellitus in a Tertiary Care Hospital, Odisha

2021 ◽  
Vol 8 (22) ◽  
pp. 1797-1802
Author(s):  
Santosh Kumar Swain ◽  
Aswini Kumar Rout ◽  
Sriprasad Mohanty ◽  
Prabhat Kumar Padhi ◽  
Roma Rattan ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Lipid Metabolism ◽  
Intestinal Permeability ◽  
Density Lipoprotein ◽  
Controlled Study ◽  
Randomized Controlled ◽  
Glucose And Lipid Metabolism ◽  
Type 2 Dm

BACKGROUND Diabetes mellitus (DM) is a metabolic disorder, characterized by hyperglycaemia, insulin deficiency and insulin resistance. Along with diet, exercise, and oral antidiabetic drugs (OADs), probiotic intervention in novel food formulations enriched with specific bacterial strains could also be effective. In patients with type 2 DM and obesity, there is alteration in composition of the gut microbiota resulting in moderation of intestinal permeability and increasing endotoxin secretion. The utility of probiotic therapy in the management of type 2 DM has not been fully explored. Probiotics also regulate gut microflora and plasma lipids. The study was designed with a purpose of assessing the role of probiotics in glucose and lipid metabolism and its effectiveness in controlling blood sugar and lipid profile in type 2 DM. METHODS The single-blind randomized controlled study was conducted from February 2019 to January 2020 in the Department of Medicine, SCB Medical College and Hospital, Cuttack, in patients of type 2 DM. A total of 80 patients were included in the study with 40 as cases and another 40 as controls. Statistical analysis was performed using SPSS version 20. The mean ± standard deviation, median and ranges were calculated using chi square test and independent t-test. The level of significance was considered as P < 0.05. RESULTS The FBS and HbA1C levels were decreased by 16 mg / dl and 0.5 % respectively after consuming probiotics (P < 0.001). The total cholesterol, triglyceride, low density lipoprotein was decreased and high density lipoprotein level was increased after taking probiotics which was significant (P < 0.001). Probiotics help in cholesterol reduction through different mechanisms. CONCLUSIONS Probiotics have a definite role in improving glycaemic status and lipid levels in type 2 DM. KEYWORDS Glycosylated Haemoglobin, Type 2 DM, Probiotics, Intestinal Permeability

SEX DIFFERENCES OF CARBOHYDRATE AND LIPID METABOLISM IMPAIRMENT IN RATS WITH TYPE 2 DIABETES MELLITUS

2018 ◽  
Vol 64 (2) ◽  
pp. 39-45 ◽  
Author(s):  
Nataliia Gorbenko ◽  
Oleksii Borikov ◽  
Olha Ivanova ◽  
K. V. Taran ◽  
T. S. Litvinova ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Body Weight ◽  
Lipid Metabolism ◽  
Female Rats ◽  
Glucose And Lipid Metabolism ◽  
Carbohydrate And Lipid Metabolism ◽  
Lipid Metabolism Disorders

A sex difference of carbohydrate and lipid metabolism disorders in rats with type 2 diabetes has been studied. It was established that type 2 diabetes leads to a more pronounced deterioration in carbohydrate toleranceand insulin sensitivity in males compared to female rats, but the sex doesn’t affect basal glycemia and fructosamine levels. It was found that the increase of body weight and visceral fat in rats with type 2 diabetes is moremanifested in females than in males. It has been determined that hypertriglyceridemia is higher in diabeticmales compared to diabetic females, and the level of common lipids in the liver, both intact females and femaleswith type 2 diabetes, is lower than that of the males. The obtained results indicate a more expressive impairment of glucose and lipid metabolism in males compared to females with type 2 diabetes

scholarly journals Effects of Probiotic Supplementation on Dyslipidemia in Type 2 Diabetes Mellitus: A Meta-Analysis of Randomized Controlled Trials

Foods ◽  
2020 ◽  
Vol 9 (11) ◽  
pp. 1540
Author(s):  
Chen Wang ◽  
Chengcheng Zhang ◽  
Sijia Li ◽  
Leilei Yu ◽  
Fengwei Tian ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Randomized Controlled Trials ◽  
Meta Analysis ◽  
Density Lipoprotein ◽  
Controlled Trials ◽  
Probiotic Supplementation ◽  
Randomized Controlled

The effectiveness of probiotic consumption in controlling dyslipidemia in type 2 diabetes mellitus (T2DM) has been unclear. We reviewed relevant randomized controlled trials (RCTs) to clarify the effect of probiotic intake on dyslipidemia in T2DM patients. The Web of Science, Scopus, PubMed and Cochrane Library databases were used for searching relevant RCTs published up to October 2020. The total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) concentrations were selected as the primary indicators for dyslipidemia. The results of 13 eligible RCTs showed that probiotic intake could significantly reduce TC (SMD: −0.23, 95% CI: (−0.37, −0.10)) and TG (SMD: −0.27, 95% CI: (−0.44, −0.11)) levels, but did not regulate LDL-C or HDL-C concentrations. Subgroup analysis showed that multispecies probiotics (≥two species), but not single-species probiotics, significantly decreased TC and TG concentrations. Furthermore, powder, but not liquid, probiotics could reduce TC and TG concentrations. This meta-analysis demonstrated that probiotic supplementation is helpful in reducing TC and TG concentrations in T2DM patients. However, more well-controlled trials are needed to clarify the benefits of probiotics on dyslipidemia in T2DM patients.

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