scholarly journals To Study and Compare the Effect of Pre-Operative Skin Preparation with Aqueous Povidone Iodine Only and in Combination with Alcoholic Chlorhexidine on Surgical Site Infection in Tertiary Care Hospital SVRRGGH, Tirupati

2021 ◽  
Vol 8 (35) ◽  
pp. 3252-3256
Author(s):  
Adeppa P ◽  
Gandikota Venkata Prakash ◽  
Purushotham G ◽  
Sumesh Raja Shanmugapandi
Keyword(s):  
Povidone Iodine ◽  
Bacterial Colonization ◽  
Bacterial Flora ◽  
Tertiary Care ◽  
Site Preparation ◽  
Care Hospital ◽  
Skin Preparation ◽  
Healthy Humans ◽  
Povidine Iodine ◽  
Colonization Rates

BACKGROUND Even the normal skin of healthy humans usually harbours a rich bacterial flora, which are usually non-pathogenic. But these organisms always have a potential to cause infection of the surgical site. The aim of surgical site preparation with antiseptics is to remove microorganisms harbouring the skin surface to a lower level. Povidine iodine (iodophors) and chlorhexidine are the agents most often used for pre-operative surgical site antisepsis. In this study, we wanted to determine the efficacy of pre-operative skin preparation with aqueous povidone iodine alone and when used in combination with alcoholic chlorhexidine for surgical site asepsis. METHODS This is a cross-sectional study. 200 patients (100 in each group) were considered for the study who were undergoing clean elective surgery. Pre-operative preparation of skin in the surgical area was done by the respective antiseptic which was planned accordingly, after such application, sterile saline swab culture was taken immediately from the site of incision during surgery. In the cases which showed growth of organisms, they were isolated from colonies and subjected to gram staining, coagulase test and antibiotic sensitivity test. The organisms thus isolated were identified by their morphological and cultural characteristics and difference in colonization rates were considered as a measure of antiseptic regimen efficacy. RESULTS The results showed that, usage of povidine iodine along with alcoholic chlorhexidine is more efficacious and showed significant reduction of colonization rates at the site of incision, in comparison to using povidone iodine alone. Postoperative wound infections were lower, when povidine iodine is used in combination with chlorhexidine is used for pre-operative surgical site preparation. CONCLUSIONS Pre-operative skin preparation with the chlorhexidine gluconate 2.5 % v/v in 70 % propanol followed by aqueous povidone-iodine solution is an ideal for broad spectrum asepsis and the post-operative wound infection rate is much lower as compared to povidone iodine alone. KEYWORDS Skin Disinfection; Chlorhexidine; Propanol; Povidone-iodine; Bacterial Colonization

scholarly journals Effect of Povidone Iodine Versus Chlorhexidine Mouthwash on Oral Mucositis among Cancer Patients

2021 ◽  
Author(s):  
. Jyothi ◽  
S Latha ◽  
K Pavithra ◽  
M Nalini ◽  
Sowmya J Rao ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Cancer Patients ◽  
Oral Mucositis ◽  
Povidone Iodine ◽  
Tertiary Care ◽  
World Health ◽  
Care Hospital ◽  
Group I ◽  
Grading Scale ◽  
Group Ii

Introduction: Radiation therapy and chemotherapy are the standard treatment given for cancer, which leads to the variety of adverse effects of which Oral Mucositis (OM) is one of the common side-effects. It is responsible for patient discomfort and decreases their level of functioning. Both Chlorhexidine and Povidone Iodine have got antimicrobial and antifungal activity which decreases the severity of mucositis. Aim: To compare the effectiveness of Povidone Iodine and Chlorhexidine mouthwash on OM among cancer patients undergoing radiation therapy or chemotherapy. Materials and Methods: A prospective observational study was conducted in the tertiary care hospital of Mangaluru, Karnataka, India for the duration of one year and three months from December 2015-March 2017. Fifty cancer subjects aged between 25 to 65 years and who developed OM after radiation therapy or chemotherapy were selected by purposive sampling technique. Data were collected using the demographic profile, clinical proforma and World Health Organisation (WHO) OM grading scale (2004) from 19.09.2016 to 17.12.2016. Experimental group I received 10 mL of diluted Povidone Iodine mouthwash and group II received 10 mL of diluted chlorhexidine mouthwash. Level of OM in the group I and group II were assessed on the 1st, 3rd, 5th and 7th day using WHO OM grading scale (2004). The data were analysed by descriptive and inferential statistics (Wilcoxon signed- rank test, Mann-Whitney U test, Repeated measures ANOVA) using SPSS version 16.0. Results: Among the 50 cancer subjects, majority 30 (60%) were in the age group between 55-64 years and majority 35 (70%) were receiving radiation therapy. On day seven, in the group I (Povidone Iodine) majority 14 (56%) subjects had mild level of mucositis whereas in the group II (Chlorhexidine) majority 14 (56%) subjects had moderate mucositis. Comparison of the effect of Povidone Iodine and Chlorhexidine mouthwash using Friedman’s ANOVA showed that there was a difference in the level of mucositis (p<0.05) at 5% level of significance among two groups. The study findings also revealed a difference in the level of mucositis between day 1 to day 3, 5 and 7 (Mann-Whitney U test) (p<0.05) in both the groups. Conclusion: Povidone Iodine mouth wash was more effective than Chlorhexidine mouthwashes in reducing OM, and the patients were more comfortable after the use of the mouthwash.

Relationship between bacterial colonization of external cerebrospinal fluid drains and secondary meningitis: a retrospective analysis of an 8-year period

2010 ◽  
Vol 113 (6) ◽  
pp. 1309-1313 ◽  
Author(s):  
David J. Hetem ◽  
Peter A. Woerdeman ◽  
Marc J. M. Bonten ◽  
Miquel B. Ekkelenkamp
Keyword(s):  
Clinical Symptoms ◽  
Bacterial Colonization ◽  
Tertiary Care ◽  
Laboratory Data ◽  
Significant Risk ◽  
Prophylactic Antibiotic ◽  
Positive Culture ◽  
Care Hospital ◽  
Drain Removal ◽  
Microbiological Laboratory

Object A frequent complication of CSF drains is secondary meningitis. This study was designed to assess the predictive value of a positive culture from a CSF drain tip for the development of secondary meningitis. Methods The authors conducted a retrospective study of an 8-year period in which patients were treated in a tertiary care hospital in The Netherlands. Patients with positive cultures from CSF drain tips were identified from the microbiology database. Patient charts were reviewed to retrieve demographic, clinical, and laboratory data. Statistical analysis was performed using multivariate logistic regression to determine significant risk factors for the development of secondary meningitis. Results A total of 139 patients with positive CSF-drain cultures were included; 72 patients (52%) suffered secondary meningitis at the time of CSF drain removal, or developed it consecutively. Development of secondary meningitis was associated with use of ventricular drains (OR 3.4 vs lumbar drains; 95% CI 1.7–6.8), with age less than 18 years (OR 4.7; 95% CI 1.3–17.3), and with colonization with Staphylococcus aureus (OR 3.1 vs other microorganisms; CI 1.2–8.5). Thirty-two patients (44% of total secondary meningitis) were diagnosed with secondary meningitis 24 hours or more after CSF drain removal; in 13 patients (18%) the diagnosis was made after 48 hours or more. Conclusions Positive CSF-drain cultures are strongly associated with development of secondary meningitis. A positive CSF-drain culture may precede clinical symptoms and should therefore be communicated to the treating physician by the microbiological laboratory as soon as possible, and prophylactic antibiotic therapy should be considered.

scholarly journals Prevalence of microorganisms causing catheter associated urinary tract infections (CAUTI) among catheterised patients admitted in a tertiary care hospital

2017 ◽  
Vol 5 (6) ◽  
pp. 2367 ◽  
Author(s):  
Vinoth M. ◽  
Prabagaravarthanan R. ◽  
Bhaskar M.
Keyword(s):  
Escherichia Coli ◽  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Bacterial Colonization ◽  
Tertiary Care ◽  
Age Groups ◽  
Care Hospital ◽  
Cross Sectional ◽  
Tract Infections

Background: Catheter-associated urinary tract infection (CAUTI) is an important cause of morbidity and mortality in Indian subjects, affecting all age groups. Bacteriuria orcandiduria is almost inevitable in nearly half of the patients who require an indwelling urinary catheter for more than 5 days. The objective of this study was to find the prevalence of CAUTI infection and to determine their antibiotic profileMethods: The present cross-sectional study included 50 patients admitted to medicine and surgery wards in our hospital. The urine from catheter is collected from each patient and subjected to culture and antibiotic susceptibility testing.Results: The prevalence of catheter associated urinary tract infection in our hospital is about 20% and asymptomatic bacterial colonization is 50% which is nearequal to Danchaivijitr S et al study. The common pathogens found in this study are Escherichia coli (22%), Klebsiella (18%), Enterobacter (8%), Staph. aureus (6%) which include MRSA (4%), Pseudomonas (6%), Enterococcus (4%), Candida sps. (4%) Andproteus (2%).Conclusions: CAUTI has low prevalence 20% and asymptomatic colonisation 50% in our hospital with common pathogen being Escherichia coli. It is one of the important notable pathogen causing nosocomial infection among admitted patients. The patients present mainly as asymptomatic bacterial colonisation and risk of CAUTI increases with longer duration of catheterisation. All patients those who had catheter for more than 6 days, aged 60 and above, should be checked for UTI symptoms. And their urine should be cultured regularly in order to diagnose and prevent CAUTI and its complications which are very dangerous and difficult to treat.

scholarly journals STUDY OF BACTERIAL FLORA OF HANDS OF HEALTH CARE GIVERS IN A TERTIARY CARE HOSPITAL IN EASTERN INDIA

2015 ◽  
Vol 4 (27) ◽  
pp. 4644-4648 ◽  
Author(s):  
Asim Sarfraz ◽  
Sayan Bhattacharyya ◽  
Mohammed Aftab Alam Ansari ◽  
Nitesh Kumar Jaiswal ◽  
Hema Roy ◽  
...  
Keyword(s):  
Health Care ◽  
Tertiary Care Hospital ◽  
Bacterial Flora ◽  
Tertiary Care ◽  
Care Hospital ◽  
Eastern India ◽  
Care Givers
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