scholarly journals ASSESSMENT OF PROTECTIVE EFFECT ADEMETIONINE, CYTOFLAVIN AND Dihydroquercetin on activity RAT BLOOD ENZYMES AT ADMINISTRATION HIGH DOSES OF SODIUM VALPROATE

2020 ◽  
Author(s):  
◽  
L.V. Ohremchuk ◽  
I.ZH. Seminskij ◽  
M.A. Darenskaya ◽  
L.A. Grebenkina ◽  
...  
Keyword(s):  
Protective Effect ◽  
Sodium Valproate ◽  
Rat Blood ◽  
High Doses

Evaluation of the Protective Effect of Ademetionine, Cytoflavin, and Dihydroquercetetine on Blood Enzymes Activity in Rats Treated with High Doses of Sodium Valproate

2020 ◽  
Vol 170 (2) ◽  
pp. 211-214
Author(s):  
L. V. Okhremchuk ◽  
I. Zh. Seminskii ◽  
M. A. Darenskaya ◽  
L. A. Grebenkina ◽  
L. I. Kolesnikova ◽  
...  
Keyword(s):  
Protective Effect ◽  
Sodium Valproate ◽  
Enzymes Activity ◽  
High Doses

scholarly journals Morphological changes in parenchymal organs of laboratory animals in acute effect of carbon tetrachloride

2020 ◽  
Vol 99 (9) ◽  
pp. 1001-1006
Author(s):  
Elvira F. Repina ◽  
Denis O. Karimov ◽  
Samat S. Baygildin ◽  
Gulnara V. Timasheva ◽  
Nadezhda Yu. Khusnutdinova ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Carbon Tetrachloride ◽  
Protective Effect ◽  
Morphological Changes ◽  
Acute Exposure ◽  
Laboratory Animals ◽  
Antihypoxic Activity ◽  
Prophylactic Administration ◽  
Morphological Studies ◽  
High Doses

Introduction. Among noninfectious diseases, one of the leading places belongs to pathologies caused by the action of industrial toxicants. In this regard, the search for drugs for the prevention and treatment of various intoxications is one of the priority tasks of public health. Treatment of intoxication with drugs with antioxidant and antihypoxic activity is more effective. The aim of this study was to investigate morphological changes in parenchymal organs (liver, kidneys, and pancreas) under acute exposure to high doses of carbon tetrachloride and to evaluate the effectiveness of their correction with a new composition of oxymethyluracil with ascorbic acid. Material and methods. The composition of 5-hydroxy-6-methyluracil with ascorbic acid was first synthesized at the Ufa Institute of Chemistry, Ufa Federal Research Center, RAS. The preventive effect of the new drug was studied in comparison with “Heptor” on the carbon tetrachloride-induced liver injury model. Morphological studies of the liver, pancreas, and kidneys of laboratory animals were carried out. Results. Studies have shown the prophylactic administration of new composition of 5-hydroxy-6-methyluracil with ascorbic acid to have a protective effect on the structure of parenchymal organs in acute carbon tetrachloride intoxication, comparable to the drug “Heptor” (possibly superior). However, reparative properties were observed only in the drug “Heptor”. Conclusion. Comparative estimation of morphological changes in parenchymal organs under acute exposure to high doses of carbon tetrachloride indicates the protective effect of prophylactic administration of the composition of 5-hydroxy-6-methyluracil with ascorbic acid, comparable to the drug “Heptor” (possibly superior).

INFANTILE SPASMS TREATED WITH HIGH DOSES OF SODIUM VALPROATE: INITIAL RESPONSE AND FOLLOW-UP

2008 ◽  
Vol 33 (7) ◽  
pp. 617-625 ◽  
Author(s):  
J. M. Prats ◽  
C. Garaizar ◽  
M. J. Rua ◽  
M. L. Garcia-Nieto ◽  
P. Madoz
Keyword(s):  
Sodium Valproate ◽  
Initial Response ◽  
Infantile Spasms ◽  
High Doses

scholarly journals Phytosphingosine-1-Phosphate Is a Signaling Molecule Involved in Miconazole Resistance in Sessile Candida albicans Cells

2012 ◽  
Vol 56 (5) ◽  
pp. 2290-2294 ◽  
Author(s):  
Davy Vandenbosch ◽  
Anna Bink ◽  
Gilmer Govaert ◽  
Bruno P. A. Cammue ◽  
Hans J. Nelis ◽  
...  
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Candida Albicans ◽  
Protective Effect ◽  
Cytoplasmic Membrane ◽  
Efflux Pumps ◽  
Signaling Molecule ◽  
Content Type ◽  
Gene Coding ◽  
High Doses ◽  
Sessile Cells

ABSTRACTPrevious research has shown that 1% to 10% of sessileCandida albicanscells survive treatment with high doses of miconazole (a fungicidal imidazole). In the present study, we investigated the involvement of sphingolipid biosynthetic intermediates in this survival. We observed that theLCB4gene, coding for the enzyme that catalyzes the phosphorylation of dihydrosphingosine and phytosphingosine, is important in governing the miconazole resistance of sessileSaccharomyces cerevisiaeandC. albicanscells. The addition of 10 nM phytosphingosine-1-phosphate (PHS-1-P) drastically reduced the intracellular miconazole concentration and significantly increased the miconazole resistance of a hypersusceptibleC. albicansheterozygousLCB4/lcb4mutant, indicating a protective effect of PHS-1-P against miconazole-induced cell death in sessile cells. At this concentration of PHS-1-P, we did not observe any effect on the fluidity of the cytoplasmic membrane. The protective effect of PHS-1-P was not observed when the efflux pumps were inhibited or when tested in a mutant without functional efflux systems. Also, the addition of PHS-1-P during miconazole treatment increased the expression levels of genes coding for efflux pumps, leading to the hypothesis that PHS-1-P acts as a signaling molecule and enhances the efflux of miconazole in sessileC. albicanscells.

scholarly journals The effect of toluene on oxidative processes in rat blood

2009 ◽  
Vol 74 (1) ◽  
pp. 15-25 ◽  
Author(s):  
Silvana Stajkovic ◽  
Suncica Borozan ◽  
Gordana Gadjanski-Omerovic
Keyword(s):  
Body Weight ◽  
Plasma Proteins ◽  
Structural Changes ◽  
Oxidative Modification ◽  
Control Group ◽  
Rat Blood ◽  
Female Wistar Rats ◽  
Oxidative Processes ◽  
High Doses ◽  
Radical Processes

This study was designed to investigate the effects of toluene treatment on oxidative stress in rat blood. Since toluene metabolism produces reactive oxygen and nitrogen species, it was hypothesized that the toluene treatment would: 1) provoke changes in the activities of antioxidant enzymes, 2) impair the integrity of the cell membrane and 3) induce structural changes in the plasma proteins. Female Wistar rats were treated with toluene intraperitonally, at a daily dose of 0.38 mmol/kg body weight for 12 days, and 5 mmol/kg body weight for 6 days, respectively, with propylene glycol as the carrier. Toluene significantly increased superoxide dismutase activity at low doses, catalase activity at high doses and the level of erythrocytes malondialdehyde in both treated groups when compared to the control group. The nitrite ( ? 2 NO ) level in both treated groups was not different from that in the control animals. Toluene caused oxidative modification of plasma proteins and, consequently, changes in the concentration of glycoproteins and lipoproteins when compared to the control group. The observed alterations indicate that toluene treatment might be involved in free radical processes.

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