scholarly journals Protective Effect of Ocimum sanctum in Broilers Treated with High Doses of Gentamicin

2020 ◽  
Vol 9 (11) ◽  
pp. 2327-2332
Author(s):  
Arivu chelvan ◽  
S. Murugesan
Keyword(s):  
Protective Effect ◽  
Ocimum Sanctum ◽  
High Doses

scholarly journals Morphological changes in parenchymal organs of laboratory animals in acute effect of carbon tetrachloride

2020 ◽  
Vol 99 (9) ◽  
pp. 1001-1006
Author(s):  
Elvira F. Repina ◽  
Denis O. Karimov ◽  
Samat S. Baygildin ◽  
Gulnara V. Timasheva ◽  
Nadezhda Yu. Khusnutdinova ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Carbon Tetrachloride ◽  
Protective Effect ◽  
Morphological Changes ◽  
Acute Exposure ◽  
Laboratory Animals ◽  
Antihypoxic Activity ◽  
Prophylactic Administration ◽  
Morphological Studies ◽  
High Doses

Introduction. Among noninfectious diseases, one of the leading places belongs to pathologies caused by the action of industrial toxicants. In this regard, the search for drugs for the prevention and treatment of various intoxications is one of the priority tasks of public health. Treatment of intoxication with drugs with antioxidant and antihypoxic activity is more effective. The aim of this study was to investigate morphological changes in parenchymal organs (liver, kidneys, and pancreas) under acute exposure to high doses of carbon tetrachloride and to evaluate the effectiveness of their correction with a new composition of oxymethyluracil with ascorbic acid. Material and methods. The composition of 5-hydroxy-6-methyluracil with ascorbic acid was first synthesized at the Ufa Institute of Chemistry, Ufa Federal Research Center, RAS. The preventive effect of the new drug was studied in comparison with “Heptor” on the carbon tetrachloride-induced liver injury model. Morphological studies of the liver, pancreas, and kidneys of laboratory animals were carried out. Results. Studies have shown the prophylactic administration of new composition of 5-hydroxy-6-methyluracil with ascorbic acid to have a protective effect on the structure of parenchymal organs in acute carbon tetrachloride intoxication, comparable to the drug “Heptor” (possibly superior). However, reparative properties were observed only in the drug “Heptor”. Conclusion. Comparative estimation of morphological changes in parenchymal organs under acute exposure to high doses of carbon tetrachloride indicates the protective effect of prophylactic administration of the composition of 5-hydroxy-6-methyluracil with ascorbic acid, comparable to the drug “Heptor” (possibly superior).

Evaluation of the Protective Effect of Ademetionine, Cytoflavin, and Dihydroquercetetine on Blood Enzymes Activity in Rats Treated with High Doses of Sodium Valproate

2020 ◽  
Vol 170 (2) ◽  
pp. 211-214
Author(s):  
L. V. Okhremchuk ◽  
I. Zh. Seminskii ◽  
M. A. Darenskaya ◽  
L. A. Grebenkina ◽  
L. I. Kolesnikova ◽  
...  
Keyword(s):  
Protective Effect ◽  
Sodium Valproate ◽  
Enzymes Activity ◽  
High Doses

scholarly journals Phytosphingosine-1-Phosphate Is a Signaling Molecule Involved in Miconazole Resistance in Sessile Candida albicans Cells

2012 ◽  
Vol 56 (5) ◽  
pp. 2290-2294 ◽  
Author(s):  
Davy Vandenbosch ◽  
Anna Bink ◽  
Gilmer Govaert ◽  
Bruno P. A. Cammue ◽  
Hans J. Nelis ◽  
...  
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Candida Albicans ◽  
Protective Effect ◽  
Cytoplasmic Membrane ◽  
Efflux Pumps ◽  
Signaling Molecule ◽  
Content Type ◽  
Gene Coding ◽  
High Doses ◽  
Sessile Cells

ABSTRACTPrevious research has shown that 1% to 10% of sessileCandida albicanscells survive treatment with high doses of miconazole (a fungicidal imidazole). In the present study, we investigated the involvement of sphingolipid biosynthetic intermediates in this survival. We observed that theLCB4gene, coding for the enzyme that catalyzes the phosphorylation of dihydrosphingosine and phytosphingosine, is important in governing the miconazole resistance of sessileSaccharomyces cerevisiaeandC. albicanscells. The addition of 10 nM phytosphingosine-1-phosphate (PHS-1-P) drastically reduced the intracellular miconazole concentration and significantly increased the miconazole resistance of a hypersusceptibleC. albicansheterozygousLCB4/lcb4mutant, indicating a protective effect of PHS-1-P against miconazole-induced cell death in sessile cells. At this concentration of PHS-1-P, we did not observe any effect on the fluidity of the cytoplasmic membrane. The protective effect of PHS-1-P was not observed when the efflux pumps were inhibited or when tested in a mutant without functional efflux systems. Also, the addition of PHS-1-P during miconazole treatment increased the expression levels of genes coding for efflux pumps, leading to the hypothesis that PHS-1-P acts as a signaling molecule and enhances the efflux of miconazole in sessileC. albicanscells.

scholarly journals Protective Effect ofBaccharis trimeraExtract on Acute Hepatic Injury in a Model of Inflammation Induced by Acetaminophen

2014 ◽  
Vol 2014 ◽  
pp. 1-14 ◽  
Author(s):  
Bruno da Cruz Pádua ◽  
Joamyr Victor Rossoni Júnior ◽  
Cíntia Lopes de Brito Magalhães ◽  
Míriam Martins Chaves ◽  
Marcelo Eustáquio Silva ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Protective Effect ◽  
Clinical Problem ◽  
Hepatic Damage ◽  
Histopathological Analysis ◽  
Potential Candidate ◽  
Apap Overdose ◽  
Candidate Drug ◽  
Antioxidant Parameters ◽  
High Doses

Background. Acetaminophen (APAP) is a commonly used analgesic and antipyretic. When administered in high doses, APAP is a clinical problem in the US and Europe, often resulting in severe liver injury and potentially acute liver failure. Studies have demonstrated that antioxidants and anti-inflammatory agents effectively protect against the acute hepatotoxicity induced by APAP overdose.Methods. The present study attempted to investigate the protective effect ofB. trimeraagainst APAP-induced hepatic damage in rats. The liver-function markers ALT and AST, biomarkers of oxidative stress, antioxidant parameters, and histopathological changes were examined.Results. The pretreatment withB. trimeraattenuated serum activities of ALT and AST that were enhanced by administration of APAP. Furthermore, pretreatment with the extract decreases the activity of the enzyme SOD and increases the activity of catalase and the concentration of total glutathione. Histopathological analysis confirmed the alleviation of liver damage and reduced lesions caused by APAP.Conclusions. The hepatoprotective action ofB. trimeraextract may rely on its effect on reducing the oxidative stress caused by APAP-induced hepatic damage in a rat model.General Significance. These results make the extract ofB. trimeraa potential candidate drug capable of protecting the liver against damage caused by APAP overdose.

Nicotine might have a protective effect in the etiology of multiple sclerosis

2013 ◽  
Vol 19 (8) ◽  
pp. 1009-1013 ◽  
Author(s):  
AK Hedström ◽  
J Hillert ◽  
T Olsson ◽  
L Alfredsson
Keyword(s):  
Multiple Sclerosis ◽  
Immune Responses ◽  
Protective Effect ◽  
Lower Risk ◽  
Population Based ◽  
Case Control ◽  
Case Control Studies ◽  
Swedish Population ◽  
Moist Snuff ◽  
High Doses

Objective: The use of moist snuff is common in Sweden and leads to exposure to high doses of nicotine. Recent studies indicate that exposure to nicotine could modulate immune responses. The aim of this study was to investigate the influence of snuff use on the risk of developing multiple sclerosis (MS), taking smoking habits into consideration. Methods: In two Swedish population-based, case-control studies (7883 cases, 9437 controls), subjects with different snuff use habits were compared regarding MS risk, by calculating odds ratios (ORs) with 95% confidence intervals (CIs). Results: Snuff-takers have a decreased risk of developing MS compared with those who have never used moist snuff (OR 0.83, 95% CI 0.75–0.92), and we found clear evidence of an inverse dose-response correlation between cumulative dose of snuff use and the risk of developing the disease. We further observed that subjects who combined smoking and snuff use had a significantly lower risk for MS than smokers who had never used moist snuff, also after adjustment for amount of smoking. Conclusions: Our results add evidence to the hypothesis that nicotine exerts anti-inflammatory and immune-modulating effects in a way that might decrease the risk of developing MS.

scholarly journals Wpływ humianu sodowego z węgla brunatnego na rozwój roślin [Effect of sodium humate from lignite on plants grown under various culture conditions]

2015 ◽  
Vol 24 (2) ◽  
pp. 143-170
Author(s):  
Z. Gumińska ◽  
M. Gracz-Nalepa ◽  
B. Łukasiewicz ◽  
M. Koniarek ◽  
M. Osmelak ◽  
...  
Keyword(s):  
Protective Effect ◽  
Harmful Effect ◽  
Culture Conditions ◽  
Optimum Conditions ◽  
Concentrated Solutions ◽  
Yield Increase ◽  
Sodium Humate ◽  
Natural Medium ◽  
High Doses ◽  
Fe Ions

The effect of humate on the uptake of Fe-ions has already been proved. In the present paper other advantages of humate are indicated. If plants are grown in optimum conditions humate has no effect. In more concentrated solutions humate acts as a preventive factor and provides for more economical use of the solution (yield increase 40%). When high doses of P and Cu are used, humate weakens their harmful effect on plants; with pH too low or too high, it acts protectively. Humate was tested also in the transplantation of vegetatively propagated young orchid plants from sterile conditions into a natural medium; in that case it also showed a protective effect.

scholarly journals Investigation of the possible protective effect of Smilax fluminensis steud. leaf in mice subjected to oxidative stress by paracetamol

2021 ◽  
Vol 37 ◽  
pp. e37070
Author(s):  
Ana Paula Simões da Cunha ◽  
Larissa Scremin Ferreira ◽  
Ana Júlia Pasuch Gluzezak ◽  
Edith Eunice Arthur Petrica ◽  
Adilson Paulo Sinhorin ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Protective Effect ◽  
Thiobarbituric Acid ◽  
High Dose ◽  
Glutathione S Transferase ◽  
Leaf Extracts ◽  
Plasma Analysis ◽  
Tropical Regions ◽  
The Face ◽  
High Doses

Paracetamol (PCM) is a drug widely used by the population as an antipyretic and analgesic. If administered in high doses it can cause liver damage, leading to hepatoxicity. The genus Smilax, found in temperate and tropical regions, is traditionally used by the population through the extract of leaves and roots for several conditions, such as in the treatment of syphilis, diabetes, asthma and as a diuretic action. Through this, Smilax fluminensis leaf extracts were used to evaluate the protective effect against oxidative stress induced by a high dose of PCM in mice that received the drug and after receiving treatment with crude extract and fractions. Plasma analysis was performed using as partate aminotransferase (AST), alanine aminotransferase (ALT), glucose, triglycerides and cholesterol, in addition to biochemical techniques such as catalase (CAT), glutathione-S-transferase (GST), reduced glutathione (GSH), ascorbic acid (ASA), substances reactive to thiobarbituric acid (TBARS) and carbonylated proteins (CARBONYL) of liver, brain and kidneys. Fraction 1 of the extract was the most promising, decreasing the plasma levels of AST and ALT, the levels of CAT and GST of the liver, together with GSH and in the renal and brain tissue there was a decrease in carbonylated proteins (PCM + F1 versus PCM ). Besides, fraction 1 proved to be hypoglycemic and hypocholesterolemic. It is concluded that fraction 1 of Smilax fluminensis leaves has good antioxidant activity in the face of the damage caused by the high dose of paracetamol.  

Sign in / Sign up

Export Citation Format

Share Document