scholarly journals Comparing Sexual Function between Opioid Dependents Consuming Methadone or Opium Tincture

2021 ◽  
Author(s):  
Sedigheh Sadat Moeeni ◽  
Reza Rastgoo Sisakht ◽  
Nasim Vousooghi ◽  
Koorosh Kamali ◽  
Firoozeh Raisi ◽  
...  
Keyword(s):  
Sexual Function ◽  
Premature Ejaculation ◽  
Methadone Maintenance ◽  
Complex Interaction ◽  
Sex Hormone Binding Globulin ◽  
Total Testosterone ◽  
Related Factors ◽  
Blood Tests ◽  
Anxiety Levels ◽  
The Difference

Objective: Sexual dysfunction is a side effect of methadone maintenance therapy (MMT). Opium Tincture (OT) has been used as a maintenance treatment. This study aimed to determine and compare the trend of sexual function and its related factors during treatment with both drugs. Method: An observational study was designed to measure the blood tests including free and total testosterone, prolactin, and sex hormone-binding globulin and a battery of questionnaires, including demographics and drug use history, in 42 and 53 patients entering MMT and OT treatment before and 1 and 3 months after the treatment. Results: Significant changes in testosterone levels were observed in the MMT but not the OT group. The difference between the two groups was not significant. Neither between nor within changes in the sexual function and premature ejaculation scores were significant (P =0.370& 0.698). Anxiety levels were significantly different (P= 0.001) within and between groups. There was a considerable difference in the trend of depression changes in the OT group, but not different in MMT group and between the two groups. Conclusion: No difference was found between MMT and OT effects on sexual function variables. The decrease in Testosterone during the three months of MMT, was not associated with diminished sexual function. In the MMT group, anxiety levels diminished during treatment. It seems that decreased testosterone in the MMT group was compensated by improved anxiety. Gonadotropin levels may not be the sole determinant in sexual activity, and complex interaction of mood and anxiety, agonist levels, and gonadotropins are involved.

A naturalistic, 9-month follow-up, comparing olanzapine and conventional antipsychotics on sexual function and hormonal profile for males with schizophrenia

2007 ◽  
Vol 21 (2) ◽  
pp. 165-170 ◽  
Author(s):  
Anna Maria Nicolai Costa ◽  
Mauricio Silva de Lima ◽  
Marité Faria ◽  
Salomão Rodrigues Filho ◽  
Irismar Reis De Oliveira ◽  
...  
Keyword(s):  
Sexual Function ◽  
Sexual Functioning ◽  
Free Testosterone ◽  
Sex Hormone Binding Globulin ◽  
Serum Prolactin ◽  
Total Testosterone ◽  
Antipsychotic Treatment ◽  
Hormonal Profile ◽  
Conventional Antipsychotics ◽  
Schizophrenic Patients

Second generation antipsychotics have less influence on prolactin levels than conventional antipsychotics (CA), which are commonly associated with sexual dysfunction and hyperprolactinaemia. However, only a few studies have been conducted assessing these newer antipsychotics and sexual function/dysfunction. The aim of this study is to evaluate the sexual function and hormonal profile of male schizophrenic patients taking olanzapine or CA. Sixty-three inpatients with acute episodes of schizophrenia were randomly assigned to take either olanzapine, or go on conventional antipsychotic treatment. The Dickson-Glazer sexual functioning questionnaire was used to assess sexual functioning where serum prolactin, luteinizing hormone, follicle-stimulating hormone, total testosterone, free testosterone, and sex hormone-binding globulin concentrations were measured. All measurements were taken on discharge from the inpatient unit (baseline), and again at 3 and 9 months after discharge. Prolactin levels in the olanzapine group decreased more rapidly and were significantly lower than in the CA group after 3 months (12.1±6.3µg/l, p=0.01; 18.1±11.2µg/l, p=0.564, respectively). After nine months, there was a tendency toward normal levels in both groups, and the frequency of sexual complaints did not differ between the groups. This study showed no difference between olanzapine and conventional antipsychotics regarding sexual complaints in the treatment of schizophrenia, but did show a difference in the hormone level normalization rate.

scholarly journals The decline of serum testosterone levels in community-dwelling men over 70 years of age: descriptive data and predictors of longitudinal changes

2008 ◽  
Vol 159 (4) ◽  
pp. 459-468 ◽  
Author(s):  
B Lapauw ◽  
S Goemaere ◽  
H Zmierczak ◽  
I Van Pottelbergh ◽  
A Mahmoud ◽  
...  
Keyword(s):  
Serum Testosterone ◽  
Community Dwelling ◽  
Sex Hormone Binding Globulin ◽  
Total Testosterone ◽  
Elderly Men ◽  
Related Factors ◽  
Longitudinal Changes ◽  
Testosterone Levels ◽  
Testosterone Production ◽  
Healthy Elderly

ObjectiveThis study was designed to assess longitudinal changes in serum testosterone levels, explore relationships with aging, genetic-, health-, and lifestyle-related factors, and investigate predictors of changes in healthy elderly men.DesignPopulation-based, longitudinal, 4-year observational study in 221 community-dwelling men aged 71–86 years at baseline.MethodsHormone levels assessed by immunoassay, anthropometry, questionnaires on general health, and genetic polymorphisms. Predictors of changes in testosterone levels explored using linear mixed-effects modeling for longitudinal analyses.ResultsTotal testosterone (TT), free testosterone, and bioavailable testosterone (BioT) levels decreased with aging, decreases in BioT being most marked. No changes in sex hormone-binding globulin (SHBG) or estradiol (E2), while LH and FSH levels increased during follow-up. Subjects who gained weight displayed a greater decline in TT levels, mainly due to decreasing SHBG levels. However, baseline body composition was not predictive of subsequent changes in testosterone levels. Baseline E2 (P=0.023 to 0.004), LH (P=0.046 to 0.005), and FSH (P<0.002) levels were independently positively associated with a faster decline in testosterone fractions, although only FSH remained significant when adjusting for baseline testosterone (P=0.041–0.035). Carriers of a ‘TA’ haplotype of the estrogen receptor α gene (ERα) PvuII and XbaI polymorphisms displayed a slower decline of TT and BioT (P=0.041–0.007).ConclusionsIn elderly men with already low serum testosterone levels, a further decline was observed, independent of baseline age. The identification of FSH levels as a predictor of this decline appears to reflect the testicular mechanisms of aging-related changes in testosterone production, whereas associations with E2 and ERα polymorphisms are suggestive of estrogen-related processes, possibly related to changes in the neuroendocrine regulation of testosterone production.

Testosterone Levels and Quality of Life in Diverse Male Patients With Cancers Unrelated to Androgens

2010 ◽  
Vol 28 (34) ◽  
pp. 5054-5060 ◽  
Author(s):  
Stewart B. Fleishman ◽  
Hina Khan ◽  
Peter Homel ◽  
Mohammad F. Suhail ◽  
Rotraud Strebel-Amrhein ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Sexual Function ◽  
Sex Hormone Binding Globulin ◽  
Total Testosterone ◽  
Hormonal Changes ◽  
Cross Sectional ◽  
Patients With Cancer ◽  
Male Patients ◽  
The Mean

Purpose Symptoms secondary to hormonal changes significantly impact quality of life (QoL) in patients with cancer. This cross-sectional study examines prevalence of hypogonadism and its correlation with QoL and sexual dysfunction. Patients and Methods We collected blood and medical histories from 428 male patients with non–testosterone-related cancer at three cancer centers. Serum was analyzed for total testosterone (TT), free testosterone (FT), bioavailable testosterone (BAT), and sex hormone binding globulin (SHBG). The Functional Assessment of Cancer Therapy-Prostate (FACT-P) QoL questionnaire measured physical, social, emotional, and functional domains as well as sexual function. Exclusion criteria were prostate, testicular, or male breast cancer; known hypogonadism; and HIV. Results Mean and median TTs were 337.46 and 310 ng/dL, respectively. The mean age of patients was 62.05 years. The crude prevalence of hypogonadism (ie, TT < 300 ng/dL) was 48%, and mean TT in hypogonadal patients was 176 ng/dL. The prevalences that were based on FT (ie, hypogonadal < 52 pg/dL) and BAT (ie, hypogonadal < 95 ng/dL) were 78% and 66%, respectively. The mean FT and BAT values in hypogonadal patients were 25 pg/dL and 45 ng/dL, respectively. Hypogonadal patients had decreased total QoL scores on FACT-P (P = .01) and decreased three-item sexual function subset (P = .003). Conclusion The prevalence of hypogonadism was unexpectedly high. Measurement of FT or BAT detected a higher prevalence than TT alone, which confirmed previous studies. Correlation of T with FACT-P showed significant reduction of both overall QoL and sexual function for hypogonadal men. BAT and FT levels showed a stronger correlation than TT with overall FACT-P and subscales. The prevalence of symptomatic hypogonadism in male patients with cancer exceeds that found in comparable studies in noncancer populations.

scholarly journals Low Fertility in Men with Epilepsy: Unhappy, Uninterested, Unable

2009 ◽  
Vol 9 (3) ◽  
pp. 69-70 ◽  
Author(s):  
Warren T. Blume
Keyword(s):  
Sexual Function ◽  
Sexual Desire ◽  
Erectile Function ◽  
Depression Scale ◽  
Sexual Response ◽  
Low Fertility ◽  
Sex Hormone Binding Globulin ◽  
Anxiety And Depression ◽  
Total Testosterone ◽  
Spearman Rank

Sexual Function in Men with Epilepsy: How Important Is Testosterone? Talbot JA, Sheldrick R, Caswell H, Duncan S. Neurology 2008;70(16):1346–1352. OBJECTIVE: To ascertain the effects on sexual function of men with epilepsy (MWE) of testosterone levels and indices of anxiety and depression. METHODS: Sixty MWE taking one antiepileptic drug only (AED), with no comedication, were compared with 60 control men. Total testosterone (TT), free testosterone (FT), bioactive testosterone (BAT), dehydroepiandrosterone sulfate (DHEAS), androstenedione, and sex hormone–binding globulin (SHBG) were measured. Each man also completed validated questionnaires exploring sexual desire (Sexual Desire Inventory [SDI]), sexual response (Sexual Response Inventory [SRI]), erectile function (Sexual Self-Efficacy Scale [SSES]), and anxiety and depression (Hospital Anxiety and Depression Scale). RESULTS: MWE reported lower levels of sexual desire and lower erectile function compared with controls. They had significantly higher levels of anxiety, depression, and psychological distress. MWE had significantly higher SHBG levels and significantly lower DHEAS. There were no significant differences between the groups’ TT, FT, or BAT levels. BAT levels were significantly lower in men taking enzyme-inducing AEDs than in those taking non–enzyme-inducing AEDs. Visual inspection of TT and BAT levels showed that the majority of MWE and controls had TT and BAT levels above the “androgen threshold” levels of 12 nmol/L TT or 3.8 nmol/L BAT considered necessary for normal sexual function. There was a significant correlation (Spearman rank and simple linear regression) between sexual function and indices of anxiety and depression. There was no significant relationship between SDI and SSES and TT, FT, or BAT (Spearman rank correlation). CONCLUSIONS: Concentrating on hormone levels alone as an explanation of sexual dysfunction in epilepsy represents an overly simplistic approach to the problem. Future studies should include measures of quality of life, anxiety, and depression.

scholarly journals Sexual Dysfunction and Metabolic/Hormonal Changes in Women Using Long-Term Hormonal and Non-Hormonal Contraceptives

2020 ◽  
Author(s):  
Igor Fernando de aquino Moreira ◽  
Maria Passos Bianchini ◽  
Gabrielle Rodrigues Campos Moreira ◽  
Alessandra Maciel Almeida ◽  
Bruno Almeida Rezende
Keyword(s):  
Sexual Dysfunction ◽  
Sexual Function ◽  
Ovarian Function ◽  
Emotional Health ◽  
Statistical Significance ◽  
Intrauterine Device ◽  
Sex Hormone Binding Globulin ◽  
Hormonal Contraceptives ◽  
Total Testosterone ◽  
Hormonal Changes

Abstract Background Female sexual dysfunction is a common condition that negatively impacts the emotional health and quality of life of the affected individuals. Long-acting reversible contraceptives (LARCs) are becoming increasingly popular due to their effectiveness and convenience. LARCs can be hormonal (etonogestrel releasing implant—ENG and Levonorgestrel intrauterine system—LNG) or non-hormonal (copper intrauterine device—CuIUD and copper-silver intrauterine device—SIUD). There are very few studies that assess the influence on LARCS on sexual function are lacking.This study aimed to assess changes in sexual function as well as metabolic and hormonal parameters in women after implantation with LARCs. Methods In this prospective cohort study, we assessed 80 women who visited the Military Police Hospital in Brazil for LARCs placement. The study participants were divided into 4 groups according to the type of LARC received: ENG n = 17; LNG n = 21, CuIUD n = 18 and SIUD n = 23. The four groups were evaluated twice (prior to LARC placement and approximately 3 months later) for sexual function, using the Female Sexual Function Index (FSFI) and Female Sexual Quotient (QS-F) questionnaires. Metabolic and hormonal parameters were also assessed using blood tests. p < 0.05 was considered to indicate statistical significance. Results We observed an improvement in sexual function with CuIUD placement according to QS-F (p < 0.017) and SIUD (FSFI: p = 0.06 and QS-F: p < 0.001). However, ENG worsened sexual function according to FSFI and QS-F (p < 0.001 and p = 0.003), across all domains. A decrease in sex hormone-binding globulin (SHBG) was observed for all groups (LNG: p = 0.019; ENG: p = 0.024; CuIUD: p = 0.010; SIUD: p = 0.022) and an increase in total testosterone levels (p = 0.007 and p = 0.003) and prolactin (p = 0.049 and p = 0.001) with CuIUD and SIUD placement. Hemoglobin levels increased with LIS (p < 0.001) and ENG (p = 0.025) and decreased with CuIUD placement (p < 0.001). Conclusion The use of non-hormonal LARCS improved sexual function, especially in the desire domain. Etonogestrel implants, had a negative influence on sexual function, probably by blocking ovarian function, and thus reducing the production of androgens and estrogens. SIUD placement was superior as it improved sexual function, interfered less with hormonal levels, and did not decrease hemoglobin levels.

scholarly journals Sexual Function in Chinese Women with Polycystic Ovary Syndrome and Correlation with Clinical and Biochemical Characteristics

2021 ◽  
Author(s):  
Xuanxuan Tian ◽  
Xiangyan Ruan ◽  
Juan Du ◽  
Juan Wang ◽  
Dongmei Yin ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Sexual Function ◽  
Chinese Women ◽  
Polycystic Ovary ◽  
Clinical Signs ◽  
Sex Hormone Binding Globulin ◽  
Sexual Life ◽  
Total Testosterone ◽  
Ovary Syndrome ◽  
Biochemical Characteristics

AbstractTo investigate sexual function in Chinese women with polycystic ovary syndrome (PCOS) and to explore the correlation with clinical and biochemical characteristics. A cross-sectional study was designed in 1000 PCOS women, aged 18–45 years, via the Chinese version of Female Sexual Function Index (FSFI) evaluating sexual function, with additional questions possibly related to sexual life. Clinical and biochemical characteristics likely to affect sexual function were determined, including anthropometric indicators, serum levels of hormones, luteinizing hormone to follicle-stimulating hormone ratio (LH/FSH ratio), prolactin (PRL), total testosterone (TT), free androgen index (FAI), sex-hormone-binding globulin (SHBG), glucose, and lipid metabolism indicators. Nine hundred ten PCOS women participated in the study, 685 patients were included after screening, and 211 were suitable to detect correlations of clinical and biochemical characteristics with sex function parameters. The mean total FSFI score was 24.19 ± 2.8; 79.56% of the women were at risk of female sexual dysfunction (FSD). Women doing regular aerobic exercise and use of contraception had higher FSFI scores, while those with a desire to conceive and clinical signs of hyperandrogenism had lower FSFI scores. There were negative associations of FSFI scores with age and body fat distribution. No significant associations between FSFI scores and hormonal factors (surprisingly including SHBG) were found, except for total testosterone and satisfaction (OR = 0.976, p = 0.002). HOMA-IR was significantly related to reduced desire score (OR = 0.914, p = 0.004) and lubrication score (OR = 0.964, p = 0.044). PCOS was associated with a high risk of FSD (defined according to FSFI) in about 80% of the women in our study, and clinical characteristics play a more important role.

Is Sexual Function in Female Partners of Men With Premature Ejaculation Compromised?

2014 ◽  
Vol 41 (4) ◽  
pp. 379-383 ◽  
Author(s):  
Cevdet Kaya ◽  
Mustafa Gunes ◽  
Ali Murat Gokce ◽  
Senad Kalkan
Keyword(s):  
Sexual Function ◽  
Premature Ejaculation ◽  
Female Partners

scholarly journals Heterotopic ossification in the post cruciate ligament of the knee: a case report and literature review

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Cun Li ◽  
Zonggui Huang ◽  
K. C. Anil ◽  
Chendeng Lao ◽  
Qianghua Wu ◽  
...  
Keyword(s):  
Literature Review ◽  
Heterotopic Ossification ◽  
Knee Pain ◽  
Cruciate Ligament ◽  
Complete Recovery ◽  
X Rays ◽  
Related Factors ◽  
Knee Motion ◽  
Adequate Treatment ◽  
The Difference

Abstract Background Heterotopic ossification (HO) is noted most frequently in periarticular muscles and has not yet been reported in the cruciate ligaments of the knee. We present a rare case of symptomatic ossification of the posterior cruciate ligament (PCL). Case presentation A 59-year-old woman had a 2-year history of knee pain that was getting worse during knee motion and had restricted knee motion for 1 year. X-rays could not show the lesion clearly. Multi-planar computed tomography demonstrated ossification within the PCL with mild osteoarthritic changes and excluded any other intra-articular pathology. The patient underwent arthroscopic debridement and then experienced immediate relief of pain and complete recovery of range of motion. Conclusion This is the first report of HO in the PCL as a possible cause of knee pain and restricted knee motion. On the basis of literature review, this case elaborates the difference between HO and calcification in the ligaments, the related factors inducing HO and the undefined pathogenesis, and favorable prognosis after adequate treatment.

scholarly journals Hypogonadism and liver fibrosis in HIV-infected patients

2021 ◽  
Author(s):  
E. Quiros-Roldan ◽  
T. Porcelli ◽  
L. C. Pezzaioli ◽  
M. Degli Antoni ◽  
S. Paghera ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Univariate Analysis ◽  
Free Testosterone ◽  
Sex Hormone Binding Globulin ◽  
Total Testosterone ◽  
Cross Sectional ◽  
Pituitary Dysfunction ◽  
Consequent Reduction ◽  
Secondary Hypogonadism ◽  
The Relationship

Abstract Purpose Hypogonadism is frequent in HIV-infected men and might impact on metabolic and sexual health. Low testosterone results from either primary testicular damage, secondary hypothalamic-pituitary dysfunction, or from liver-derived sex-hormone-binding-globulin (SHBG) elevation, with consequent reduction of free testosterone. The relationship between liver fibrosis and hypogonadism in HIV-infected men is unknown. Aim of our study was to determine the prevalence and type of hypogonadism in a cohort of HIV-infected men and its relationship with liver fibrosis. Methods We performed a cross-sectional retrospective study including 107 HIV-infected men (median age 54 years) with hypogonadal symptoms. Based on total testosterone (TT), calculated free testosterone, and luteinizing hormone, five categories were identified: eugonadism, primary, secondary, normogonadotropic and compensated hypogonadism. Estimates of liver fibrosis were performed by aspartate aminotransferase (AST)-to-platelet ratio index (APRI) and Fibrosis-4 (FIB-4) scores. Results Hypogonadism was found in 32/107 patients (30.8%), with normogonadotropic (10/107, 9.3%) and compensated (17/107, 15.8%) being the most frequent forms. Patients with secondary/normogonadotropic hypogonadism had higher body mass index (BMI) (p < 0001). Patients with compensated hypogonadism had longer HIV infection duration (p = 0.031), higher APRI (p = 0.035) and FIB-4 scores (p = 0.008), and higher HCV co-infection. Univariate analysis showed a direct significant correlation between APRI and TT (p = 0.006) and SHBG (p = 0.002), and between FIB-4 and SHBG (p = 0.045). Multivariate analysis showed that SHBG was independently associated with both liver fibrosis scores. Conclusion Overt and compensated hypogonadism are frequently observed among HIV-infected men. Whereas obesity is related to secondary hypogonadism, high SHBG levels, related to liver fibrosis degree and HCV co-infection, are responsible for compensated forms.

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