scholarly journals Premature Ejaculation – From Physiology to Treatment

2019 ◽  
Author(s):  
Mário Pereira-Lourenço ◽  
Duarte Vieira e Brito ◽  
Bruno Jorge Pereira
Keyword(s):  
Sexual Dysfunction ◽  
Sexual Satisfaction ◽  
Literature Search ◽  
Diagnostic Method ◽  
Premature Ejaculation ◽  
Clinical History ◽  
Latency Time ◽  
Ejaculatory Latency

Objective: To review in literature about the concept of premature ejaculation from physiology to treatment. Materials and methods: A literature search conducted with Pubmed and Cochrane. Results: An accurate clinical history is the best diagnostic method, and in the majority of the cases it is enough to differentiate between primary and acquired premature ejaculation. Nowadays the treatment is not curative but is effective in increasing the Intravaginal Ejaculatory Latency Time, improving the couple’s sexual satisfaction. Conclusion: Although PE is the most frequent sexual dysfunction, it is still sub-diagnosed. Combining behavioural techniques with pharmacotherapy is the best way of treatment.

scholarly journals Observational study on the effects of a topical formulation in patients with premature ejaculation

2020 ◽  
Vol 92 (4) ◽  
Author(s):  
Giuseppe Quarto ◽  
Luigi Castaldo ◽  
Giovanni Grimaldi ◽  
Alessandro Izzo ◽  
Raffaele Muscariello ◽  
...  
Keyword(s):  
Sexual Dysfunction ◽  
Observational Study ◽  
Sexual Satisfaction ◽  
Premature Ejaculation ◽  
Clinical History ◽  
Diagnostic Approach ◽  
Latency Time ◽  
Topical Formulation ◽  
Ejaculatory Latency

Premature ejaculation (PE) has been defined as the inability to control or delay ejaculation, resulting in dissatisfaction or distress of the patient. Although PE is the most frequent sexual dysfunction, it is still underdiagnosed. An accurate clinical history is the best diagnostic approach that, in the majority of cases, is enough to differentiate between primary and acquired PE. Nowadays, treatment is not curative but is effective in increasing the intravaginal ejaculatory latency time (IELT), improving the sexual satisfaction of the couple [...].

scholarly journals The Influence of Tramadol on Intravaginal Ejaculatory Latency Time and Sexual Satisfaction Score in Treating Patients With Premature Ejaculation: A Network Meta-Analysis

2021 ◽  
Vol 15 (6) ◽  
pp. 155798832110577
Author(s):  
Youyi Lu ◽  
Zhongbao Zhou ◽  
Xiaoyi Zhang ◽  
Yuanshan Cui ◽  
Yong Zhang ◽  
...  
Keyword(s):  
Placebo Group ◽  
Adverse Events ◽  
Sexual Satisfaction ◽  
Premature Ejaculation ◽  
Meta Analysis ◽  
Satisfaction Score ◽  
Cochrane Library ◽  
Latency Time ◽  
Ejaculatory Latency ◽  
Safety Assessments

This network meta-analysis aimed at assessing the influence of tramadol on the intravaginal ejaculatory latency time (IELT) and sexual satisfaction score (SSS) in treating patients with premature ejaculation (PE). The PubMed, Embase, Cochrane Library databases (until July 2021), and original references of the included articles was systematically retrieved. The PRISMA checklist was followed. Finally, 14 articles including 1971 patients were included in this analysis. The results indicated that patients who were treated with tramadol (50 mg, 62 mg, 89 mg, and 100 mg) were superior to those treated with placebo in terms of IELT ( p = .003, p < .00001, p < .00001, and p < .00001, respectively), but 25 mg tramadol did not show a significant advantage ( p = .06). Patients who were treated with tramadol (50 mg and 100 mg) had a better efficacy than who were treated with 25 mg tramadol in the IELT ( p < .00001 and p < .00001), but the effect of 50 mg tramadol and 100 mg tramadol were not significantly different ( p = .17). The tramadol group had the better effect than the placebo group in the SSS ( p < .0001). And 50 mg tramadol showed a significant improvement compared with 20 mg paroxetine, as assessed by the IELT ( p = .03) and SSS ( p = .03). Safety assessments including adverse events suggested that tramadol was well tolerated. Tramadol showed a better improvement of IELT and SSS than placebo or paroxetine, and 50 mg tramadol may be a more reasonable therapeutic dose for patients with PE.

scholarly journals Evolving therapeutic strategies for premature ejaculation: The search for on-demand treatment – topical versus systemic

2012 ◽  
Vol 6 (5) ◽  
Author(s):  
Alvaro Morales
Keyword(s):  
Clinical Trials ◽  
Sexual Dysfunction ◽  
Sexual Satisfaction ◽  
Selective Serotonin Reuptake Inhibitors ◽  
Premature Ejaculation ◽  
Therapeutic Strategies ◽  
Phase 3 ◽  
On Demand ◽  
Sexual Dissatisfaction ◽  
Ejaculatory Control

Premature ejaculation (PE) is a common sexual dysfunction affecting20% to 30% of men worldwide. Definitions of PE vary, but itis typically characterized by short intravaginal ejaculatory latencytime (IELT) with concomitant sexual dissatisfaction and distress.PE may be lifelong or acquired, but its etiology remains unclear.Treatment of PE typically involves pharmacotherapy, particularlywhen lifelong. Although there are numerous reports on the offlabeluse of selective serotonin reuptake inhibitors (SSRIs) andother compounds, only 2 treatments have been evaluated in randomizedcontrolled phase 3 clinical trials: PSD502 and dapoxetine(SSRI). Both significantly improved IELT and patient-reportedoutcome domains of ejaculatory control, sexual satisfaction, anddistress as measured by the index of premature ejaculation (IPE),compared with placebo. They constitute the focus of this review.Evidence demonstrated that PSD502, dapoxetine and other SSRIsall significantly improve the symptoms of PE. Systemic use of SSRIspresents risks associated with the known pharmacology of thisclass. PSD502 allows for topical on-demand treatment appliedapplied immediately before intercourse, and is not associated withsystemic adverse events.

scholarly journals The comparison of on-demand caffeine consumption with squeezing technique on treating patients with premature ejaculation; a randomized clinical trial

2021 ◽  
Vol 15 (6) ◽  
pp. 2005-2010
Author(s):  
Seyyed Hassan Saadat ◽  
Khodabakhsh Ahmadi
Keyword(s):  
Sexual Satisfaction ◽  
Premature Ejaculation ◽  
Post Treatment ◽  
Common Disease ◽  
Latency Time ◽  
Caffeine Consumption ◽  
On Demand ◽  
Ejaculation Latency ◽  
Significant Difference ◽  
Pre Treatment

Background: The present study was aimed at evaluating the effect of on-demand caffeine consumption on treating patients with premature ejaculation (PE compared to squeezing technique. Methods: In this non-blind RCT, 42 otherwise healthy individuals with PE were divided into 2 groups of caffeine and squeezing technique group. The former received 100 mg of encapsulated caffeine for 3 weeks, 2 hours prior to each intercourse. Intra-vaginal ejaculation latency time and index of sexual satisfaction were calculated before and after treatment in both groups. Results: Mean age of the participants was 39.48±7.62 years. Despite the fact that there was no significant difference between pre-treatment and post-treatment values of both IELT and ISS between our 2 groups, significant difference was seen in both groups between pre-treatment and post-treatment values. Furthermore, no strong correlation was seen in pre-treatment IELT and ISS; however, statistically significant correlation was found in post-treatment values. Conclusion: Regarding the fact that caffeine is a well-known and widely-used drug in common disease, the use of this compound is highly unlikely to bear any stigma. Our study demonstrates that 100 mg of on-demand caffeine can equally increase both IELT and ISS significantly as squeezing technique. Further investigations are needed. Keywords: caffeine, premature ejaculation, squeezing technique, intra-vaginal ejaculation latency time, index of sexual satisfaction,

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