scholarly journals Reference Values for Serum Total Cholesterol Concentrations Using Percentile Regression Model: A Population Study in Mashhad

2019 ◽  
Author(s):  
Habibollah Esmaeily ◽  
Elham Dolat ◽  
Hamid Heidarian Miri ◽  
Ala Taji-Herav ◽  
Omid Kiani
Keyword(s):  
Regression Model ◽  
Total Cholesterol ◽  
Reference Values ◽  
Population Sample ◽  
Serum Total Cholesterol ◽  
High Tc ◽  
Men And Women ◽  
Cut Points ◽  
Age Related ◽  
Increased Risk

Background and Purpose: Serum total cholesterol (TC) concentrations are affected by several factors including ethnicity, diet, geographic, and environmental determinants, and are related to another disease, including hypothyroidism, and renal and liver disease. It is associated with an increased risk of cardiovascular disease, particularly if associated with high levels of serum low-density lipoprotein (LDL). The distribution of TC levels within populations may be useful, and the current study aimed to determine the reference values and specific cut points in a population sample from Mashhad, Iran.Methods: A cross-sectional study was conducted, and data was collected from 6518 individuals (2483 men and 4035 women) aged 25–64 year-old living in Mashhad city using a stratified cluster random sampling design.Reference values for borderline and high TC levels in three age groups were obtained using a percentile regression model. Data were analyzed using Quantreg Software Package and R Ver. 3.1.2 Software.Results: Within the population sample, 38% of the subjects were male and 62% of them were female. The mean and standard deviation for age were found to be 47.07±9 years and 45.28±9 years for men and women, respectively. Percentile regression showed that borderline TC levels for men and women aged 25-64 years were 198-216 mg/dl and 176-243mg/dl, respectively. The values for defining high TC levels were also 226-239 mg/dl in men and 202 - 271 mg/dl in women.Conclusion: Our study estimated reference values and cut points for borderline and high TC separately in both men and women, and age-related sub-groups for a population derived from Mashhad. These findings could be used in local policy plans to allocate health resources. 

Association of low serum total cholesterol with major depression and suicide

1999 ◽  
Vol 175 (3) ◽  
pp. 259-262 ◽  
Author(s):  
T. Partonen ◽  
J. Haukka ◽  
J. Virtamo ◽  
P. R. Taylor ◽  
J. Lönnqvist
Keyword(s):  
Total Cholesterol ◽  
Depressive Disorders ◽  
Density Lipoprotein ◽  
Serum Total Cholesterol ◽  
Hospital Treatment ◽  
Low Mood ◽  
National Hospital Discharge Register ◽  
Increased Risk ◽  
Recorded Data ◽  
Low Serum

BackgroundIt has been suggested that low serum total cholesterol is associated with an increased risk of suicide.AimsTo study the association between serum total cholesterol, depression and suicide using versatile, prospective data.MethodA total of 29 133 men aged 50–69 years were followed up for 5–8 years. Baseline blood samples were analysed for serum total and high-density lipoprotein cholesterol concentrations. Self-reported depression was recorded, data on hospital treatments due to depressive disorders were derived from the National Hospital Discharge Register and deaths from suicide were identified from death certificates.ResultsLow serum total cholesterol was associated with low mood and subsequently a heightened risk of hospital treatment due to major depressive disorder and of death from suicide.ConclusionsOur results suggest that low serum total cholesterol appears to be associated with low mood and thus to predict its serious consequences.

Dietary associates of serum total cholesterol in young men and women

2001 ◽  
Vol 2 (2) ◽  
pp. 111-112
Author(s):  
V. Rosanov ◽  
E. Shugaeva ◽  
A. Alexandrov ◽  
Ch. Pugoeva ◽  
A. Olferjev
Keyword(s):  
Total Cholesterol ◽  
Young Men ◽  
Serum Total Cholesterol ◽  
Men And Women

scholarly journals Peak oxygen uptake reference values for cycle ergometry for the healthy Dutch population: data from the LowLands Fitness Registry

2019 ◽  
Vol 5 (2) ◽  
pp. 00056-2018 ◽  
Author(s):  
Caspar Frederik Mylius ◽  
Wilhelmus Petrus Krijnen ◽  
Cornelis Peter van der Schans ◽  
Tim Takken
Keyword(s):  
Oxygen Uptake ◽  
Regression Model ◽  
Reference Values ◽  
Cross Validation ◽  
Peak Oxygen Uptake ◽  
Cycle Ergometry ◽  
Additive Models ◽  
Dutch Population ◽  
Age Related ◽  
Best Fitting

Peak oxygen uptake (V′O2peak) is recognised as the best expression of aerobic fitness. Therefore, it is essential that V′O2peak reference values are accurate for interpreting a cardiopulmonary exercise test (CPET). These values are country specific and influenced by underlying biological ageing processes. They are normally stratified per paediatric and adult population, resulting in a discontinuity at the transition point between prediction equations. There are currently no age-related reference values available for the lifespan of individuals in the Dutch population. The aim of this study is to determine the best-fitting regression model for V′O2peak in the healthy Dutch paediatric and adult populations in relation to age.In this retrospective study, CPET cycle ergometry results of 4477 subjects without reported somatic diseases were included (907 females, age 7.9–65.0 years). Generalised additive models were employed to determine the best-fitting regression model. Cross-validation was performed against an independent dataset consisting of 3518 subjects (170 females, age 6.8–59.0 years).An additive model was the best fitting with the largest predictive accuracy in both the primary (adjusted R2=0.57, standard error of the estimate (see)=556.50 mL·min−1) and cross-validation (adjusted R2=0.57, see=473.15 mL·min−1) dataset.This study provides a robust additive regression model for V′O2peak in the Dutch population.

scholarly journals Investigating Causal Relations Between Circulating Metabolites and Alzheimer’s Diseases: A Mendelian Randomization Study

2021 ◽  
Author(s):  
Shu-Yi Huang ◽  
Yu-Xiang Yang ◽  
Ya-Ru Zhang ◽  
Kevin Kuo ◽  
Hong-Qi Li ◽  
...  
Keyword(s):  
Total Cholesterol ◽  
Ldl Cholesterol ◽  
Mendelian Randomization ◽  
Density Lipoprotein ◽  
Serum Total Cholesterol ◽  
Causal Effects ◽  
Sensitivity Analyses ◽  
Primary Analysis ◽  
Standard Deviation Increase ◽  
Increased Risk

Abstract BackgroundMetabolomics is a promising approach that can be used to understand pathophysiological pathways of Alzheimer disease (AD). However, the relationships between metabolism and AD are poorly understood. The aim of this study is to investigate the causal association between circulating metabolites and risk of AD by combining metabolomics with genomics through two-sample Mendelian randomization (MR) approach.MethodsGenetic associations with 123 circulating metabolic traits were utilized as exposures. A large summary statistics data from International Genomics of Alzheimer’s Project was used in primary analysis, including 21,982 AD cases and 41,944 controls. Validation was further performed using family history of AD data from UK Biobank (27,696 cases of maternal AD, 14,338 cases of paternal AD and 272,244 controls). We utilized the inverse-variance weighted method as primary analysis and four additional MR methods (MR-Egger, weighted median, weighted mode, and MR pleiotropy residual sum and outlier) for sensitivity analyses.ResultsWe found one-fold increased risk of developing AD per standard deviation increase in the levels of circulating ApoB (odd ratio (OR)=3.18; 95% confidence interval (CI): 1.52–6.66, P=0.0022) and glycoprotein acetyls (OR=1.21; 95% CI: 1.05–1.39, P=0.0093), serum total cholesterol (OR=2.73; 95% CI: 1.41-5.30, P=0.0030), and low-density lipoprotein (LDL) cholesterol (OR=2.34; 95% CI: 1.53-3.57, P=0.0001). Whereas glutamine (OR=0.81; 95% CI: 0.71-0.92, P=0.0011) were significantly associated with lower risk of AD. We also detected causal effects of several different composition of LDL fractions on increased AD risk, which has been verified in validation. However, we found no association between circulating high-density lipoprotein cholesterol and AD.ConclusionsOur findings provided robust evidence supporting causal effects of circulating glycoprotein acetyls, ApoB, LDL cholesterol, and serum total cholesterol on higher risk of AD, whereas glutamine showed the protective effect. Further research is required to decipher the biological pathways underpinning associations.

scholarly journals XKR6 rs7014968 SNP Increases Serum Total Cholesterol Levels and the Risk of Coronary Heart Disease and Ischemic Stroke

2020 ◽  
Vol 26 ◽  
pp. 107602962090284
Author(s):  
Kai-Guang Li ◽  
Rui-Xing Yin ◽  
Feng Huang ◽  
Wu-Xian Chen ◽  
Jin-Zhen Wu ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Ischemic Stroke ◽  
Total Cholesterol ◽  
Serum Lipid ◽  
Serum Total Cholesterol ◽  
Control Group ◽  
Nucleotide Polymorphisms ◽  
Related Family ◽  
Increased Risk

The X Kell blood group complex subunit-related family member 6 ( XKR6) gene single-nucleotide polymorphisms (SNPs) have been associated with serum lipid profiles and the risk of coronary heart disease (CHD) and ischemic stroke (IS) in several previous studies, but the association between the XKR6 rs7014968 SNP and serum lipid levels and the risk of CHD and IS has not been detected previously. This study aims to explore the association between the XKR6 rs7014968 SNP and serum lipid traits and the susceptibility to CHD and IS in the Guangxi Han Chinese population. Snapshot technology was used to determine the genotypes of the XKR6 rs7014968 SNP in 624 controls, 588 patients with CHD, and 544 patients with IS. The XKR6 rs7014968C allele carriers in the control group had higher serum total cholesterol (TC) levels than the C allele noncarriers ( P = .025). The XKR6 rs7014968C allele carriers also had an increased risk of CHD and IS ( P < .05-.01). Stratified analysis showed that the patients with the rs7014968C allele in the female, age >60 years, body mass index (BMI) >24 kg/m2, and hypertension subgroups had a higher risk of CHD than those in the subgroup counterparts. The patients with the rs7014968C allele in the male, BMI > 24 kg/m2, smoker, and hypertension subgroups also had a higher risk of IS than those in the subgroup counterparts. These results suggest that the XKR6 rs7014968 SNP is likely to increase the risk of CHD and IS by increasing serum TC levels in our study populations.

Changes in Serum Total Cholesterol Levels over 18 Years in a Cohort of Men and Women: The Nijmegen Cohort Study

2000 ◽  
Vol 30 (2) ◽  
pp. 138-145 ◽  
Author(s):  
J.C Bakx ◽  
H.J.M van den Hoogen ◽  
P Deurenberg ◽  
J van Doremalen ◽  
W.J.H.M van den Bosch
Keyword(s):  
Cohort Study ◽  
Total Cholesterol ◽  
Serum Total Cholesterol ◽  
Men And Women ◽  
Cholesterol Levels

scholarly journals Clinical Correlates of Early-Onset Hypertension

2021 ◽  
Author(s):  
Karri Suvila ◽  
Joao A C Lima ◽  
Susan Cheng ◽  
Teemu J Niiranen
Keyword(s):  
Logistic Regression ◽  
Regression Model ◽  
Total Cholesterol ◽  
Early Onset ◽  
Logistic Regression Model ◽  
Multinomial Logistic Regression ◽  
Hdl Cholesterol ◽  
Multinomial Logistic Regression Model ◽  
Clinical Correlates ◽  
Increased Risk

Abstract Background Early-onset hypertension has been established as a heritable trait and a risk factor for cardiovascular disease outcomes. However, the clinical correlates of early-onset hypertension remain unidentified. Methods In this study we assessed the demographic characteristics and lifestyle factors related to hypertension onset age in a sample of 3286 Coronary Artery Risk Development in Young Adults (CARDIA) study participants (mean baseline age 25±4 years, 57% women). We examined the association between the participants’ baseline characteristics and age of hypertension onset subgroups (&lt;35 years, 35‒44 years or ≥45 years) using a multinomial logistic regression model with those who did not develop hypertension as the reference group. Hypertension onset was defined as blood pressure ≥140/90 mmHg or antihypertensive medication use on two consecutively attended follow-up visits. Results In the multinomial logistic regression model, individuals who were black (OR, 5.08; 95% CI, 3.17–8.14), were more obese (OR, 1.57; 95% CI, 1.32–1.88), or had higher total cholesterol (OR, 1.34; 95% CI, 1.13–1.60 per SD) had increased odds of early-onset hypertension (onset at &lt;35 years) versus not developing hypertension. In contrast, 1-SD higher HDL-cholesterol was related to decreased odds of early-onset hypertension (OR, 0.71; 0.57–0.89). The odds for having earlier hypertension onset increased linearly across age of onset categories in black individuals and individuals with lower HDL-cholesterol (p&lt;0.05 for trend for both). Conclusions Our findings suggest that individuals who are black, obese, have higher total cholesterol, or have lower HDL-cholesterol level, are potentially at an increased risk of having early-onset hypertension.

Abstract P210: Risk Factors for Intraparenchymal Hemorrhage Subtypes: The Circulatory Risk in Communities Study (CIRCS)

Circulation ◽  
2013 ◽  
Vol 127 (suppl_12) ◽  
Author(s):  
Tetsuya Ohira ◽  
Eri Eguchi ◽  
Hironori Imano ◽  
Akihiko Kitamura ◽  
Masahiko Kiyama ◽  
...  
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Systolic Blood Pressure ◽  
Total Cholesterol ◽  
Ethanol Intake ◽  
Serum Total Cholesterol ◽  
Intraparenchymal Hemorrhage ◽  
Effective Prevention ◽  
Cholesterol Levels ◽  
Increased Risk

Background: To evaluate risk factors for intraparenchymal hemorrhage (IPH) by its subtypes may contribute to more effective prevention of IPH, but few prospective studies have characterized risk factors for specific subtypes of IPH. Hypothesis: We assessed the hypothesis that the associations between traditional risk factors such as blood pressures and risk of IPH vary by IPH subtype. Methods: A prospective study of Japanese subjects aged 40-69 years was undertaken using the data collected from 9,086 participants (3,560 men and 5,526 women) in cardiovascular risk surveys of three communities between 1985 and 1994. The incidence of IPH between 1985 and 2008 was ascertained by systematic surveillance. The location of hemorrhage was assigned based on admission CT scan or MRI by trained physicians. IPH selectively involving the thalamus, basal ganglia or brainstem was defined as deep IPH, while IPH isolated to the cortex was defined as lobar. The hazard ratios (HRs) of incidence of IPH and its subtypes (deep IPH and lobar or cerebellar IPH) and 95% confidence intervals (CI) relative to the baseline variables were calculated with adjustment for age and other potential confounding factors using the Cox proportional hazards model. Results: During an average follow up of 19.2-years, 139 incident IPHs (103 deep, 31 lobar or cerebellar, and 5 mixed or unclassified IPHs) occurred. Systolic blood pressure, major ST-T abnormality on electrocardiogram, and excess ethanol intake (≥46g/day) were associated with increased risk of deep IPH, while serum total cholesterol levels was inversely associated with incidence of lobar and cerebellar IPH, even after adjustment for potential confounding variables. Serum total cholesterol levels also tended to be inversely associated with incidence of deep IPH, although it did not reach statistically significance. The multivariate-adjusted HRs (95%CI) of deep IPH were 1.14 (1.05-1.23) for systolic blood pressure (10mmHg), 2.09 (1.19- 3.66) for major ST-T abnormality, and 1.86 (1.02- 3.38) for excess ethanol intake. The adjusted HR (95%CI) of lobar and cerebellar IPH was 0.22 (0.07- 0.76) for the participants with higher total cholesterol levels (≥220 mg/dL), compared with those with lower total cholesterol levels (<160mg/dL). There were no associations of diabetes mellitus and smoking with both deep and lobar/cerebellar IPH. Conclusions: Impact of risk factors on incidence of IPH varied according to its subtype.

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