scholarly journals Vitamin D Food Fortification is an Effective Approach for Improving Vitamin D Status; A Systematic Review

2019 ◽  
Author(s):  
Roya Sakhaei ◽  
Nasir Talenezhad ◽  
Mohammad Mohammadi ◽  
Nahid Ramezani-Jolfaie
Keyword(s):  
Systematic Review ◽  
Vitamin D ◽  
Serum Levels ◽  
Food Sources ◽  
Food Fortification ◽  
The People ◽  
25 Hydroxy Vitamin D ◽  
Limited Food ◽  
Effect Of Food ◽  
The Impact

Background: Low vitamin D (vit D) serum levels have been linked to various diseases such as multiple sclerosis, cardiovascular diseases, and diabetes. Maintenance of optimal vit D level should be supported by foods and supplements. Limited food sources of vit D made researchers focus on food fortification in recent years. Methods: A systematic review of randomized controlled trials reporting the impact of vit D food fortification on 25-hydroxy vitamin D [25(OH)D] level was conducted on PubMed, Scopus, ISI Web of Science and Google Scholar from inception up to August 2017. Results: Sixteen studies met the inclusion criteria and most of them (n =14) have represented the significant effect of food fortification on the improvement of vit D status of the participants. However, two studies failed to find any reasonable associations. Furthermore, it was observed that vit D food fortification has a greater impact on the people with lower 25(OH)D serum levels. Conclusions: Fortification of foods with vit D has a significant impact on serum 25(OH)D concentrations. Therefore, food enrichment is an economical and effective approach for different populations to prevent vit D deficiency.

scholarly journals The impact of vitamin D food fortification and health outcomes in children: a systematic review and meta-regression

2020 ◽  
Vol 9 (1) ◽  
Author(s):  
Reem Al Khalifah ◽  
Rawan Alsheikh ◽  
Yossef Alnasser ◽  
Rana Alsheikh ◽  
Nora Alhelali ◽  
...  
Keyword(s):  
Systematic Review ◽  
Vitamin D ◽  
Health Outcomes ◽  
Food Fortification ◽  
Meta Regression ◽  
The Impact

scholarly journals Potential of Vitamin D Food Fortification in Prevention of Cancer Deaths—A Modeling Study

Nutrients ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 3986
Author(s):  
Tobias Niedermaier ◽  
Thomas Gredner ◽  
Sabine Kuznia ◽  
Ben Schöttker ◽  
Ute Mons ◽  
...  
Keyword(s):  
Vitamin D ◽  
Cancer Mortality ◽  
Vitamin D Supplementation ◽  
Food Fortification ◽  
Vitamin D Levels ◽  
Total Cancer ◽  
25 Hydroxy Vitamin D ◽  
Prevention Of Cancer ◽  
Meta Analyses ◽  
The Impact

Meta-analyses of randomized controlled trials (RCTs) have estimated a 13% reduction of cancer mortality by vitamin D supplementation among older adults. We evaluated if and to what extent similar effects might be expected from vitamin D fortification of foods. We reviewed the literature on RCTs assessing the impact of vitamin D supplementation on cancer mortality, on increases of vitamin D levels by either supplementation or food fortification, and on costs of supplementation or fortification. Then, we derived expected effects on total cancer mortality and related costs and savings from potential implementation of vitamin D food fortification in Germany and compared the results to those for supplementation. In RCTs with vitamin D supplementation in average doses of 820–2000 IU per day, serum concentrations of 25-hydroxy-vitamin D increased by 15–30 nmol/L, respectively. Studies on food fortification found increases by 10–42 nmol/L, thus largely in the range of increases previously demonstrated by supplementation. Fortification is estimated to be considerably less expensive than supplementation. It might be similarly effective as supplementation in reducing cancer mortality and might even achieve such reduction at substantially larger net savings. Although vitamin D overdoses are unlikely in food fortification programs, implementation should be accompanied by a study monitoring the frequency of potentially occurring adverse effects by overdoses, such as hypercalcemia. Future studies on effectiveness of vitamin D supplementation and fortification are warranted.

scholarly journals Serum levels of 25-hydroxy vitamin D in psoriatic patients

2015 ◽  
Vol 90 (3) ◽  
pp. 430-432 ◽  
Author(s):  
Manuela Ferrasso Zuchi ◽  
Paula de Oliveira Azevedo ◽  
Anber Ancel Tanaka ◽  
Juliano Vilaverde Schmitt ◽  
Luis Eduardo Agner Machado Martins
Keyword(s):  
Vitamin D ◽  
Serum Levels ◽  
25 Hydroxy Vitamin D

scholarly journals Serum levels of 25‐hydroxy‐vitamin D in patients with oral squamous cell carcinoma: Making a case for chemoprevention

2020 ◽  
Vol 6 (4) ◽  
pp. 428-432
Author(s):  
Samuel E. Udeabor ◽  
Abdullah M. Albejadi ◽  
Waleed A. K. Al‐Shehri ◽  
Chidozie I. Onwuka ◽  
Saeed Y. Al‐Fathani ◽  
...  
Keyword(s):  
Vitamin D ◽  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Serum Levels ◽  
25 Hydroxy Vitamin D

scholarly journals Vitamin D Serum Levels in the UK Population, including a Mathematical Approach to Evaluate the Impact of Vitamin D Fortified Ready-to-Eat Breakfast Cereals: Application of the NDNS Database

Nutrients ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1868
Author(s):  
Wim Calame ◽  
Laura Street ◽  
Toine Hulshof
Keyword(s):  
Vitamin D ◽  
Daily Intake ◽  
Serum Levels ◽  
Vitamin D Status ◽  
Nutrition Survey ◽  
Breakfast Cereals ◽  
Vitamin D Intake ◽  
The Uk ◽  
The Impact ◽  
The Relationship

Vitamin D status is relatively poor in the general population, potentially leading to various conditions. The present study evaluates the relationship between vitamin D status and intake in the UK population and the impact of vitamin D fortified ready-to-eat cereals (RTEC) on this status via data from the National Diet and Nutrition Survey (NDNS: 2008–2012). Four cohorts were addressed: ages 4–10 (n = 803), ages 11–18 (n = 884), ages 19–64 (n = 1655) and ages 65 and higher (n = 428). The impact of fortification by 4.2 μg vitamin D per 100 g of RTEC on vitamin D intake and status was mathematically modelled. Average vitamin D daily intake was age-dependent, ranging from ~2.6 (age range 4–18 years) to ~5.0 μg (older than 64 years). Average 25(OH)D concentration ranged from 43 to 51 nmol/L, the highest in children. The relationship between vitamin D intake and status followed an asymptotic curve with a predicted plateau concentration ranging from 52 in children to 83 nmol/L in elderly. The fortification model showed that serum concentrations increased with ~1.0 in children to ~6.5 nmol/L in the elderly. This study revealed that vitamin D intake in the UK population is low with 25(OH)D concentrations being suboptimal for general health. Fortification of breakfast cereals can contribute to improve overall vitamin D status.

scholarly journals Periodontitis Impact in Interleukin-6 Serum Levels in Solid Organ Transplanted Patients: A Systematic Review and Meta-Analysis

Diagnostics ◽  
2020 ◽  
Vol 10 (4) ◽  
pp. 184 ◽  
Author(s):  
Vanessa Machado ◽  
João Botelho ◽  
Joana Lopes ◽  
Mariana Patrão ◽  
Ricardo Alves ◽  
...  
Keyword(s):  
Systematic Review ◽  
Serum Levels ◽  
Case Control ◽  
Risk Of Bias ◽  
Solid Organ ◽  
Systemic Complications ◽  
Moderate Quality ◽  
Meta Analyses ◽  
The Impact ◽  
Quality Evidence

This systematic review aimed to investigate the influence of periodontitis on post-transplant IL-6 serum levels of solid organ transplanted patients as compared to healthy subjects. Four databases (PubMed, Scholar, EMBASE, and CENTRAL) were searched up to February 2020 (PROSPERO CRD42018107817). Case-control and cohort studies on the association of IL-6 serum levels with a periodontal status of patients after solid organ transplantation were included. The risk of bias of observational studies was assessed through the Newcastle-Ottawa Scale (NOS). Random effects meta-analyses were thoroughly conducted. GRADE assessment provided quality evidence. Four case-control studies fulfilled the inclusion criteria (274 transplant recipients and 146 healthy controls), all of low risk of bias. Meta-analyses revealed significantly higher IL-6 levels in transplanted patients than healthy individuals with low-quality evidence (Mean Difference (MD): 2.55 (95% confidence interval (CI): 2.07, 3.03)). Transplanted patients with periodontitis have higher serum IL-6 levels than transplanted patients without periodontitis with moderate quality evidence (MD: 2.20 (95% CI: 1.00, 3.39)). We found low-quality evidence of higher IL-6 levels than healthy patients in patients with heart and kidney transplant. In these transplanted patients, there was moderate quality evidence that periodontitis is associated with higher IL-6 serum levels. Future research should consider the impact of such a difference in organ failure and systemic complications.

Efficacy of vitamin D food fortification and biofortification in children and adults: a systematic review protocol

2020 ◽  
Vol 18 (12) ◽  
pp. 2694-2703
Author(s):  
Eleanor Dunlop ◽  
Mairead Kiely ◽  
Anthony P. James ◽  
Tanya Singh ◽  
Lucinda J. Black
Keyword(s):  
Systematic Review ◽  
Vitamin D ◽  
Food Fortification ◽  
Systematic Review Protocol ◽  
Review Protocol

scholarly journals Assessing the impact of a mushroom-derived food ingredient on vitamin D levels in healthy volunteers

2020 ◽  
Vol 17 (1) ◽  
Author(s):  
Jorge Marques Pinto ◽  
Viviane Merzbach ◽  
Ashley G. B. Willmott ◽  
Jose Antonio ◽  
Justin Roberts
Keyword(s):  
Vitamin D ◽  
Healthy Volunteers ◽  
Venous Blood ◽  
Vitamin D Insufficiency ◽  
Food Sources ◽  
Natural Food ◽  
Vitamin D Status ◽  
Food Ingredient ◽  
Vitamin D Levels ◽  
The Impact

Abstract Background Prevalence of vitamin D insufficiency/deficiency has been noted in athletic populations, although less is known about recreationally active individuals. Biofortification of natural food sources (e.g. UV radiated mushrooms) may support vitamin D status and is therefore of current scientific and commercial interest. The aim of this study was to assess the impact of a mushroom-derived food ingredient on vitamin D status in recreationally active, healthy volunteers. Methods Twenty-eight participants were randomly assigned to either: 25 μg (1000 IU) encapsulated natural mushroom-derived vitamin D2; matched-dose encapsulated vitamin D3 or placebo (PL) for 12 weeks. Venous blood samples were collected at baseline, week 6 and 12 for analysis of serum 25(OH)D2 and 25(OH)D3 using liquid chromatography mass spectrometry. Habitual dietary intake and activity were monitored across the intervention. Results Vitamin D status (25(OH)DTOTAL) was significantly increased with vitamin D3 supplementation from 46.1 ± 5.3 nmol·L− 1 to 88.0 ± 8.6 nmol·L− 1 (p < 0.0001) across the intervention, coupled with an expected rise in 25(OH)D3 concentrations from 38.8 ± 5.2 nmol·L− 1 to 82.0 ± 7.9 nmol·L− 1 (p < 0.0001). In contrast, D2 supplementation increased 25(OH)D2 by + 347% (7.0 ± 1.1 nmol·L− 1 to 31.4 ± 2.1 nmol·L− 1, p < 0.0001), but resulted in a − 42% reduction in 25(OH)D3 by week 6 (p = 0.001). A net + 14% increase in 25(OH)DTOTAL was established with D2 supplementation by week 12 (p > 0.05), which was not statistically different to D3. Vitamin D status was maintained with PL, following an initial − 15% reduction by week 6 (p ≤ 0.046 compared to both supplement groups). Conclusions The use of a UV radiated mushroom food ingredient was effective in maintaining 25(OH)DTOTAL in healthy, recreationally active volunteers. This may offer an adjunct strategy in supporting vitamin D intake. However, consistent with the literature, the use of vitamin D3 supplementation likely offers benefits when acute elevation in vitamin D status is warranted.

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