scholarly journals A Qualitative Study About Multidrug-Resistant Acinetobacter baumannii (MDRAB) in Healthcare-Associated Infection (HCAI) and Its Resistance Towards Carbapenem in Indonesia

2019 ◽  
Vol 4 (12) ◽  
pp. 255
Author(s):  
W Primaningtyas ◽  
A Putri ◽  
L Saptawati ◽  
J Sudarsono ◽  
C Cheng ◽  
...  
Keyword(s):  
Qualitative Study ◽  
Acinetobacter Baumannii ◽  
Multidrug Resistant ◽  
Healthcare Associated Infection ◽  
Healthcare Associated

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Mortality Rates Associated With Multidrug-Resistant Acinetobacter baumannii Infection in Surgical Intensive Care Units

2008 ◽  
Vol 29 (11) ◽  
pp. 1080-1083 ◽  
Author(s):  
Titus L. Daniels ◽  
Stephen Deppen ◽  
Patrick G. Arbogast ◽  
Marie R. Griffin ◽  
William Schaffner ◽  
...  
Keyword(s):  
Mortality Rate ◽  
Acinetobacter Baumannii ◽  
Length Of Hospital Stay ◽  
Mortality Rates ◽  
Multidrug Resistant ◽  
Matched Cohort ◽  
Healthcare Associated Infection ◽  
Median Length ◽  
Surgical Intensive Care ◽  
Healthcare Associated

A retrospective, propensity-matched cohort study was conducted to determine the mortality rate in patients with healthcare-associated infection (HAI) due to multidrug-resistant (MDR) Acinetobacter baumannii. The 28-day mortality rate for patients with MDR A. baumannii HAI was not significantly different than that for patients with non-MDR A. baumannii HAI. The median length of hospital stay before diagnosis of HAI was 4.5 days longer for patients with MDR A. baumannii infection than for patients with non-MDR A. baumannii infection (P <.001).

Healthcare associated pneumonia: An old concept at a hospital with high prevalence of antimicrobial resistance

MedPharmRes ◽  
2021 ◽  
Vol 5 (2) ◽  
pp. 17-21
Author(s):  
Lam Nguyen-Ho ◽  
Duong Hoang-Thai ◽  
Vu Le-Thuong ◽  
Ngoc Tran-Van
Keyword(s):  
Risk Factor ◽  
Antimicrobial Resistance ◽  
Multidrug Resistant ◽  
Community Acquired Pneumonia ◽  
Resistant Organism ◽  
Healthcare Associated Infection ◽  
Female Ratio ◽  
High Prevalence ◽  
Need To Evaluate ◽  
Healthcare Associated

Background: One of several reasons that the concept of healthcare-associated pneumonia (HCAP) was dismissed was the same presence of multidrug resistant organism (MDRO) between community-acquired pneumonia and HCAP at countries with the low prevalence of antimicrobial resistance (AMR). However, this finding could be unsuitable for countries with the high rates of AMR. Methods: A prospective observational study was conducted at the respiratory department of Cho Ray hospital from September 2015 to April 2016. All adult patients suitable for community acquired pneumonia (CAP) with risk factor for healthcare-associated infection were included. Results: We found out 130 subjects. The median age was 71 years (interquartile range 57-81). The male/female ratio was 1.55:1. Prior hospitalization was the most common risk factor for healthcare-associated infection. There were 35 cases (26.9%) with culture-positive (sputum and/or bronchial lavage). Isolated bacteria included Pseudomonas aeruginosa (9 cases), Klebsiella pneumoniae (9 cases), Escherichia coli (4 cases), Acinetobacter baumannii (6 cases), and Staphylococcus aureus (7 cases) with the characteristic of AMR similar to the bacterial spectrum associated with hospital-acquired pneumonia. Conclusion: MDROs were detected frequently in CAP patients with risk factor for healthcare-associated infection at the hospital with the high prevalence of AMR. This requires the urgent need to evaluate risk factors for MDRO infection in community-onset pneumonia when the concept of HCAP is no longer used.

Outbreak of Healthcare-Associated Infection and Colonization With Multidrug-ResistantSalmonella entericaSerovar Senftenberg in Florida

2007 ◽  
Vol 28 (7) ◽  
pp. 805-811 ◽  
Author(s):  
Robyn S. Kay ◽  
Alexander G. Vandevelde ◽  
Paul D. Fiorella ◽  
Rebecca Crouse ◽  
Carina Blackmore ◽  
...  
Keyword(s):  
Infection Control ◽  
Chronically Ill ◽  
Multidrug Resistant ◽  
Control Measures ◽  
Healthcare Associated Infection ◽  
Healthcare Facilities ◽  
Infection Control Measures ◽  
Healthcare Associated ◽  
Chronically Ill Patients

Background.In July 1999, a rare strain of multidrug-resistantSalmonella entericaserovar Senftenberg was isolated from the sputum of a trauma patient. Over a 6-year period (1999-2005) in northeast Florida, thisSalmonellaserovar spread to 66 other patients in 16 different healthcare facilities as a result of frequent transfers of patients among institutions. To our knowledge, this is the first outbreak of healthcare-associated infection and colonization with a fluoroquinolone-resistant strain of S. Senftenberg in the United States.Objectives.To investigate an outbreak of infection and colonization with an unusual strain of S. Senftenberg and assist with infection control measures.Design.A case series, outbreak investigation, and microbiological study of all samples positive forS.Senftenberg on culture.Setting.Cases ofS.Senftenberg infection and colonization occurred in hospitals and long-term care facilities in 2 counties in northeast Florida.Results.The affected patients were mostly elderly persons with multiple medical conditions. They were frequently transferred between healthcare facilities. ThisSalmonellaserovar was capable of long-term colonization of chronically ill patients. AllS.Senftenberg isolates tested shared a similar pulsed-field gel electrophoresis (PFGE) pattern.Conclusion.A prolonged outbreak of infection and colonization with multidrug-resistantS.Senftenberg was identified in several healthcare facilities throughout the Jacksonville, Florida, area and became established when infection control measures failed. The bacterial agent was capable of long-term colonization in chronically ill patients. Because the dispersal pattern of this strain suggested a breakdown of infection control practices, a multipronged intervention approach was undertaken that included intense education of personnel in the different institutions, interinstitutional cooperation, and transfer paperwork notification.

Relationships Among Cleaning, Environmental DNA, and Healthcare-Associated Infections in a New Evidence-Based Design Hospital

2015 ◽  
Vol 36 (10) ◽  
pp. 1130-1138 ◽  
Author(s):  
Emil Lesho ◽  
Philip Carling ◽  
Eve Hosford ◽  
Ana Ong ◽  
Erik Snesrud ◽  
...  
Keyword(s):  
Genetic Relatedness ◽  
Environmental Dna ◽  
Multidrug Resistant ◽  
Healthcare Associated Infection ◽  
Bacterial Dna ◽  
E Coli ◽  
Hospital Environments ◽  
Before And After ◽  
Evidenced Based ◽  
Healthcare Associated

OBJECTIVEHospital environments influence healthcare-associated infection (HAI) patterns, but the role of evidenced-based design (EBD) and residual bacterial DNA (previously thought to be clinically inert) remain incompletely understood.METHODSIn a newly built EBD hospital, we used culture-based and culture-free (molecular) assays, pulsed-field gel electrophoresis (PFGE), and whole-genome sequencing (WGS) to determine: (1) patterns of environmental contamination with target organisms (TOs) and multidrug-resistant (MDR) target organisms (MDR-TOs); (2) genetic relatedness between environmentally isolated MDR-TO and those from HAIs; and (3) correlation between surface contamination and HAIs.RESULTSA total of 1,273 high-touch surfaces were swabbed before and after terminal cleaning during 77 room visits. Of the 2,546 paired swabs, 47% had cultivable biomaterial and 42% had PCR-amplifiable DNA. The ratios of TOs detected to surfaces assayed were 85 per 1,273 for the culture-based method and 106 per 1,273 for the PCR-based method. Sinks, toilet rails, and bedside tables most frequently harbored biomaterial. Although cleaned surfaces were less likely to have cultivable TOs than precleaned surfaces, they were not less likely to harbor bacterial DNA. The rate of MDR-TOs to surfaces swabbed was 0.1% (3/2546). Although environmental MDR-TOs and MDR-TOs from HAIs were genetically related by PFGE, WGS revealed that they were unrelated. Environmental levels of cultivable Enterococcus spp. and E. coli DNA were positively correlated with infection incidences (P<.04 and P<.005, respectively).CONCLUSIONMDR-TOs were rarely detected during surveillance and were not implicated in HAIs. The roles of environmental DNA and EBD, particularly with respect to water-associated fixtures or the potential suppression of cultivable environmental MDR-TOs, warrant multicenter investigations.Infect Control Hosp Epidemiol 2015;36(10):1130–1138

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