scholarly journals A comparison of arrived dose to the heart in the treatment of breast cancer in different modes of proton radiation by proton therapy using Monte Carlo simulation

Author(s):  
Hassan Javidi ◽  
Zahra Ahmadi Ganjeh

Introdution: Today, the Advantages of radiation therapy by charged particles is indicated for the treatment of cancerous. During the passing of proton beam in the body tissues, secondary particles produce, which penetrate to the body healthy tissues and cause damage. The aim of this research was calculating the Spread out Bragg Peak for covering the breast cancer and investigating arrived dose to the different parts of the heart during the treatment process. Methods: In this simulation study, a spherical tumor with a diameter of 1 cm considered in right breast tissue in MIRD phantom and then irradiated by proton of right and front sides of the body. Simulations are performed using the MCNPX code. Results: The Spread out Brag Peak calculated to cover the breast cancer in two cases of radiation. In the radiation of front and right, the deposited Dose due to The Proton Particle in tumor are 4.25 nGy and 4.12 nGy, respectively. The dose due to the protons and secondary particles in different parts of the heart calculated and compared for two modes of radiation. Energy Ranges of neutrons was about 55 MeV and for electrons and photons was less than 20 MeV. Although, the dose due to the secondary particles was very low in comparison of protons dose. Conclusion: In proton therapy, a large portion of the dose is evacuated in the tumor. Proton radiation of the front in comparison of the right leads to the more dose deposit in the tumor and heart.

1970 ◽  
Vol 9 (4) ◽  
pp. 395-400
Author(s):  
Prof. Samir Kumar Bandyopadhyay

Cancer can be brain cancer, breast cancer, cervical cancer, etc. depending on theoccurrence on the different parts of the body. to name a few. Cancer detected in laterstage and it results into high mortality within few months. Early detection is the onlyhope for better prognosis and treatment. This paper proposed methods that digitalmammogram image pair is initially pre-processed, the right oriented mammogram isflipped and any unwanted artifacts are removed from the image. Next noise removalis made using the Gaussian kernel.Key words: Digital mammography–Computer Aided Diagnosis–Breast Region–Seed


Medicina ◽  
2020 ◽  
Vol 56 (10) ◽  
pp. 505
Author(s):  
Iwona Głowacka-Mrotek ◽  
Magdalena Tarkowska ◽  
Tomasz Nowikiewicz ◽  
Magdalena Hagner-Derengowska ◽  
Aleksander Goch

Background and objectives: Surgery is the primary and most effective treatment of breast cancer. Unilateral mastectomy disrupts the distribution of muscle tension between the right and the left sides of the body. The aim of the study was to evaluate postural balance in patients treated for breast cancer by mastectomy. Materials and methods: A controlled clinical study was conducted on 90 patients who have undergone surgical treatment for breast cancer (mastectomy) 5–6 years prior (Breast Group—BG). The control group (CG) consisted of 74 healthy female volunteers. Analysis of balance was performed using the Alfa stabilography platform. A static test (Romberg’s test) with open and closed eyes was used to assess balance. The following balance parameters were analyzed: path length, statokinesigram area, parameters of deflection and velocity of the foot pressure center. Results: The study demonstrated that patients from BG (5–6 years after surgery) obtained worse results in both tests with open (maximum back deviation, maximum forward deviation, average Y deviation, average Y velocity, path length and path surface area) (p < 0.05) as well as with closed eyes (maximum backward deviation, maximum forward deviation, mean Y deviation and path length) (p < 0.05). Conclusions: Our study demonstrated that women 5–6 years after surgery for breast cancer have impaired balance compared to healthy women, despite physiotherapy.


1940 ◽  
Vol 31 (1) ◽  
pp. 45-56
Author(s):  
G. H. L. Dicker ◽  
S. C. Pearce

At least 30 specimens of each form of Macrosiphum rubiellum, Theobald, and Aphis idaei, van der Goot, were collected, mounted and their principal organs measured.Correlations were calculated between different parts on the right side and the conclusion reached that the ratios of lengths of organs were unstable characteristics of the species examined. High correlations were obtained between the same part on different sides of the body.The mean values and standard errors are tabulated and a method given for assigning limits of variation within a species. The standard errors obtained were of the order of 7 per cent. of the mean.The asymmetry, kurtosis and skewness of the distributions were calculated to test the effect of possible non-normality on the foregoing work.


Author(s):  
Patrycja Łobodzińska

<p>Krucyfiks z kościoła Bożego Ciała we Wrocławiu, należącego niegdyś do zakonu joannitów, znajduje się dziś w Muzeum Narodowym w Warszawie. Rzeźba jest różnie datowana przez badaczy, od drugiej do czwartej ćwierci XIV wieku. Dokładny opis formalno-stylistyczny figury z kościoła Bożego Ciała pozwala na uchwycenie właściwości wizualnych, które częściowo potwierdzają postulowaną przez badaczy łączność z czternastowiecznym nurtem c<em>rucifixi dolorosi.</em>Bliskie formalnie rozwiązania sylwetki Ukrzyżowanego pochodzą z różnych terenów europejskich, jednocześnie jednak dzieło wrocławskie jawi się jako osobne na tle przywołanej grupy rzeźb pod względem stopnia wyniszczenia ciała, silnego przechylenia korpusu w prawą stronę, mocnego podkurczenia nóg i poszczególnych detali rzeźbiarskich. Figura wrocławska nawiązuje do zgeometryzowanych form znanych z krucyfiksów bolesnych z pierwszej połowy XIV wieku i jednocześnie w  miękkości wygięcia torsu, w płynności kształtów żeber dostrzec można antycypację stylu pięknego. Zestawienie krucyfiksu z kościoła Bożego Ciała z wybranymi przykładami czternastowiecznej rzeźby śląskiej także wyklucza związki formalno-stylistyczne oraz warsztatowe. Jego wyraz ideowy, pokrewny Piecie z Lubiąża, łączy się ze specyficzną dla drugiej połowy XIII i całego XIV wieku  pobożnością, zorientowaną na rozpatrywanie Męki Pańskiej i indywidualne przeżycie religijne. Choć poszczególne detale rzeźbiarskie właściwie figurze z kościoła joannitów, można łączyć z niektórymi wrocławskimi krucyfiksami, tak ekspresyjne ujęcie ciała nie znajduje sobie równych.</p><p>SUMMARY</p><p>The crucifi x from the Corpus Christi church in Wroclaw, which (the church) used to belong to the Hospitallers of St. John of God, is now the property of the National Museum in Warsaw. According to the art theorists, the sculpture is dated from the second to the fourth quarter of the fourteenth century. The detailed, formal and stylistic description of the sculpture from the Corpus Christi church enables the rendering of visual properties which partially confi rm the suggested connection between this fi gure and the fourteenth-century trend in sculpture known as crucifi xi dolorosi. The formally related structural solutions of the silhouette of the Crucifi ed come from different parts of Europe; at the same time, however, the sculpture from Wrocław seems to stand out as compared with the sculptures in question as regards the destroyed body of Christ, the strong inclination of His torso to the right, the squatted legs and particular sculptural details. The fi gure from the church in Wrocław refers to geometrized forms known from crucifi xi dolorosi of the fi rst half of the fourteenth century; at the same time the softness of the curved torso and the smoothness of the ribs anticipate the emergence of the beau style. The comparison of the crucifi x from the Corpus-Christi church with the selected examples of fourteenth- century Silesian sculptures also excludes formal-stylistic and technical connections. Its ideological meaning is close to the Pietà of Lubiąż (Leubus) and is associated with the specifi c type of devotion – typical of the second part of the thirteenth and the whole fourteenth century – oriented towards considering the Passion of Christ, and towards individual religious experiences. Although individual sculptural details characteristic of the Hospitallers of St. John church can be linked with some other Wrocław crucifi xes, the presentation of the body in such an expressive manner is unmatchable.</p>


Author(s):  
M.J. Gibb ◽  
W.E. Ivings ◽  
J.D. Sutton

One of the major limitations in nutritional studies of lactation in dairy cows is the unknown contribution of body tissues to the energy status of the animal. Both fat and protein are thought to be mobilised in early lactation (Bauman and Elliot, 1983) when nutrient intake is insufficient to meet the demands for energy and amino acids. The present experiment investigates the effects of diet on changes in weights of chemically determined fat and crude protein (CP) in the carcass and non-carcass fractions over the first 29 weeks of lactation.Body composition was measured by serial slaughter of autumn-calving dairy cows offered grass silage (206 g CP and 18.56 MJ GE per kg DM)ad libitumand 3(L), 6(M) or 9(H) kg DM/day of concentrate (206 g CP/kg DM)(Sutton, Aston, Beever and Fisher, 1992). Cows with post-calving live weights between 500 and 700 kg and previous lactation yields between 5000 and 7000 litres were used, and were blocked for parity and expected calving date before allocation across treatments and slaughter times. Six cows were slaughtered at 2 to 4 dayspost partum(week 0), and two from each treatment (one 2nd, and one 3rd or 4th parity) at 2, 5, 8, 11,14,19, 24 or 29weeks post partum.After slaughter the right half carcass and all other non-carcass components were frozen and minced before chemical analysis for fat, CP, ash and water. All weights were adjusted by covariance for live weightpost partumand parity. Energy content was calculated assuming values of 39.19 and 23.23 MJ/kg for fat and CP respectively.


Author(s):  
Mateus Aquino Gonçalves ◽  
Bruna Pereira ◽  
Camila Tavares ◽  
Taináh Martins ◽  
Elaine Cunha ◽  
...  

: This review article aims to address the main features of breast cancer. Thus, the general aspects of this disease have been shown since the first evidence of breast cancer in the world until the numbers today. In this way, there are some ways to prevent breast cancer, such as the woman's lifestyle (healthy eating habits and physical activities) that helps to reduce the incidence of this anomaly. The first noticeable symptom of this anomaly is typically a lump that feels different from the rest of the breast tissue. More than 80% of breast cancer are discovered when the woman feels a lump being present and about 90% of the cases, the cancer is noticed by the woman herself. Currently, the most used method for the detection of cancer and other injuries is the Magnetic Resonance Imaging (MRI) technique. This technique has been shown to be very effective, however, for a better visualization of the images, contrast agents (CAs) are used, which are paramagnetic compounds capable of increasing the relaxation of the hydrogen atoms of the water molecules present in the body tissues. The most used CAs are Gd3+ complexes, although they are very efficient, they are toxic to the organism. Thus, new contrast agents have been studied to replace Gd3+ complexes, we can mention iron oxides as a promising substitute.


1919 ◽  
Vol 52 (2) ◽  
pp. 257-302 ◽  
Author(s):  
D. Waterston

Examination of living embryos has shown that the heart is a functionally active organ from a very early stage of its development. At all periods of life the result of the functional activity is in essentials the same, viz. the propulsion of the blood in a definite direction through the heart into the vessels arising from it; but the mechanism for effecting this propulsion undergoes profound alterations, and the heart becomes transformed from a simple continuous tube, destitute of valves, whose walls contract in a rhythmic peristaltic wave, into a complex four-chambered organ, divided into right and left portions, which are ultimately completely separated from one another, possessing valves, and contracting not in a peristaltic wave but in alternating consecutive contractions of the atria and ventricles of the right and left sides simultaneously. Coincidently with the changes in the heart itself, profound alterations occur in the vessels leading to and from the heart. In this combination of simultaneous development and functional activity the heart differs from the other organs of the body, and hence its development presents special problems involving the function as well as the structure of the different parts. Our knowledge of the development of the heart in man cannot yet be said to be complete.


2021 ◽  
Author(s):  
EZGİ YILDIZ GÜVERCİN ◽  
Sibel EYİGÖR ◽  
Göksel Tanigor ◽  
Menekse Inbat ◽  
Sedef Kabayel

Abstract ObjectiveThe aim of this study was to assess and compare the response to the BCRL treatment with CLUE scores, bioimpedence spectroscopy and the volume-assessments /measurements. A secondary aim of the study was to show whether CLUE has a place in the treatment response, and its correlation with the other measures of lymphedema.DesignThe design of our study is a retrospective study.SettingA rehabilitation center.ParticipantsA total of 40 patients were included in the study. Mean age and the body mass indices of the patients weres 57.8±12.46, and 30.99±4.69, respectively. Ninety-five percent of the patient were right handed, and the prevalence of the right arm lymphedema was 50%.InterventionsNot applicable.Main Outcome MeasuresAssessment of the upper-extremity volumes, CLUE (Breast Cancer-Related Lymphedema of the Upper Extremity) score, functional assessment of the upper extremities, bioimpedance Spectroscopy, hand-grip strength.ResultsCorrelation analyses showed that CLUE total score and BIS values were correlated with the reduction in the volumes (p=0.04 and p<0.001, respectively). Moreover, CLUE total score was also found to be positively correlated with the BIS values (p<0.001). Hand grip strength and QuickDASH scores were not found to be correlated with the changes in the volume (p=0.475 and p=0.210, respectively) and CLUE total scores (p=0.21 and p=0.57, respecively).ConclusionsIn conclusion, development of a structured clinical assessment like CLUE provides clinicians a standardized evaluation for BCRL. For the novel studies aiming to assess treatment responses to patients with BCRL, use of CLUE and BIS alongside with routinely used volumetric methods are encouraged.


2021 ◽  
Vol 23 (2) ◽  
pp. 79
Author(s):  
Milah Fadhilah Kusuma Fasihu ◽  
Andang Widi Harto ◽  
Isman Mulyadi Triatmoko ◽  
Gede Sutrisna Wijaya ◽  
Yohannes Sardjono

Radiotherapy is one of the cancer treatments conducted by giving a high dose to the tumor target and minimizing the dose exposed in the healthy organs. One of the methods is proton therapy. Proton therapy is usually used in several breast cancer cases by minimizing the damage in the surrounding tissues due to having good precision. In this study, proton therapy in breast cancer will be simulated. This study aims to identify the optimal dose in breast cancer therapy using proton therapy and to identify the dose exposed in the healthy organs surrounding cancer. This study is PHITS program simulation-based to model the geometry and the components of breast cancer and the surrounding organs. The source of radiation used is proton which is the output of proton therapy with proton/sec firing intensity. The variation in beam modelling towards the dose profile of the tumor used is uniform and pencil beam. The proton energy used is 70 MeV up to 120 MeV. The result of this study shows that the dose from using pencil beam scanning technic of proton therapy for breast cancer is 50.3997 Gy (W) with the total amount of fraction is 25 and the result of dose below the threshold dose in the healthy organs is the skin gets 4.4.0553 Gy per fraction, the left breast gets 0,0011 Gy per fraction, the right breast gets 2.6469 Gy per fractions, the right lung gets 0.0125 Gy per fraction, the left lung gets 0.029 Gy per fraction, the rib gets 0.0179 Gy per fraction, and the heart gets 0.0077 Gy per fraction.


2011 ◽  
Vol 1 (4) ◽  
pp. 97 ◽  
Author(s):  
Vinod Prabhu ◽  
James Johnston ◽  
Duncan Ingrams ◽  
Carl Passant

The authors report the case to understand this unusual presentation and prognosis of mucoepidermoid carcinoma following treatment. We present a case of mucoepidermoid carcinoma in a 67-year-old man. The cancer was diagnosed in the right side of his neck but the primary tumor remained unknown despite attempts at staging. The neck was treated successfully and followed up for 2 years. Metastasis of the primary lesion to the left triceps was diagnosed following a swelling noticed by the patient during the 2-year follow up period. Mucoepidermoid carcinoma can be a low, intermediate or high-grade malignancy and can metastasize to different parts of the body. However, this is the first case report of a metastasis to the triceps muscle.


Sign in / Sign up

Export Citation Format

Share Document