The Symbolic Use of Whetstones and Their Role in Displaying Authority over Metallurgical Processes and Trade

Whetstones of the Viking Age can have a conspicuous design, but not much is understood about the specific use of more unusual specimens, or their place in rituals. This article proposes a new interpretation of whetstones, based on novel studies of a well-known whetstone from Lejre, and miniature pendants from Tissø. Our examination of the prominent whetstone from the Lejre hoard with an x-ray fluorescence (XRF) scan, did not reveal any metal traces, which suggests that it was unused. At Tissø, the find distribution of so-called stafflike pendants – made of iron, bronze, or silver – links them to a metal-working area, and since their morphology resembles full-scale whetstones we suggest that they may be symbolic, miniature whetstones. Finally, we argue that the overarching meaning of the ritual use of whetstones is more related to the authority over – and control of – metallurgical processes, as well as the trade of metal goods, and only by proxy to the smith himself.

Why Females Do Better: The X Chromosomal TLR7 Gene-Dose Effect in COVID-19

A male sex bias has emerged in the COVID-19 pandemic, fitting to the sex-biased pattern in other viral infections. Males are 2.84 times more often admitted to the ICU and mortality is 1.39 times higher as a result of COVID-19. Various factors play a role in this, and novel studies suggest that the gene-dose of Toll-Like Receptor (TLR) 7 could contribute to the sex-skewed severity. TLR7 is one of the crucial pattern recognition receptors for SARS-CoV-2 ssRNA and the gene-dose effect is caused by X chromosome inactivation (XCI) escape. Female immune cells with TLR7 XCI escape have biallelic TLR7 expression and produce more type 1 interferon (IFN) upon TLR7 stimulation. In COVID-19, TLR7 in plasmacytoid dendritic cells is one of the pattern recognition receptors responsible for IFN production and a delayed IFN response has been associated with immunopathogenesis and mortality. Here, we provide a hypothesis that females may be protected to some extend against severe COVID-19, due to the biallelic TLR7 expression, allowing them to mount a stronger and more protective IFN response early after infection. Studies exploring COVID-19 treatment via the TLR7-mediated IFN pathway should consider this sex difference. Various factors such as age, sex hormones and escape modulation remain to be investigated concerning the TLR7 gene-dose effect.

Evaluation of Response to Treatment in Breast Cancer-related Lymphedema

ObjectiveThe aim of this study was to assess and compare the response to the BCRL treatment with CLUE scores, bioimpedence spectroscopy and the volume-assessments /measurements. A secondary aim of the study was to show whether CLUE has a place in the treatment response, and its correlation with the other measures of lymphedema.DesignThe design of our study is a retrospective study.SettingA rehabilitation center.ParticipantsA total of 40 patients were included in the study. Mean age and the body mass indices of the patients weres 57.8±12.46, and 30.99±4.69, respectively. Ninety-five percent of the patient were right handed, and the prevalence of the right arm lymphedema was 50%.InterventionsNot applicable.Main Outcome MeasuresAssessment of the upper-extremity volumes, CLUE (Breast Cancer-Related Lymphedema of the Upper Extremity) score, functional assessment of the upper extremities, bioimpedance Spectroscopy, hand-grip strength.ResultsCorrelation analyses showed that CLUE total score and BIS values were correlated with the reduction in the volumes (p=0.04 and p<0.001, respectively). Moreover, CLUE total score was also found to be positively correlated with the BIS values (p<0.001). Hand grip strength and QuickDASH scores were not found to be correlated with the changes in the volume (p=0.475 and p=0.210, respectively) and CLUE total scores (p=0.21 and p=0.57, respecively).ConclusionsIn conclusion, development of a structured clinical assessment like CLUE provides clinicians a standardized evaluation for BCRL. For the novel studies aiming to assess treatment responses to patients with BCRL, use of CLUE and BIS alongside with routinely used volumetric methods are encouraged.

Vascular Health Triad in Humans With Hypertension—Not the Usual Suspects

Hypertension (HTN) affects more than one-third of the US population and remains the top risk factor for the development of cardiovascular disease (CVD). Identifying the underlying mechanisms for developing HTN are of critical importance because the risk of developing CVD doubles with ∼20 mmHg increase in systolic blood pressure (BP). Endothelial dysfunction, especially in the resistance arteries, is the primary site for initiation of sub-clinical HTN. Furthermore, inflammation and reactive oxygen and nitrogen species (ROS/RNS) not only influence the endothelium independently, but also have a synergistic influence on each other. Together, the interplay between inflammation, ROS and vascular dysfunction is referred to as the vascular health triad, and affects BP regulation in humans. While the interplay of the vascular health triad is well established, new underlying mechanistic targets are under investigation, including: Inducible nitric oxide synthase, hydrogen peroxide, hydrogen sulfide, nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and nuclear factor activated T cells. This review outlines the role of these unusual suspects in vascular health and function in humans. This review connects the dots using these unusual suspects underlying inflammation, ROS and vascular dysfunction especially in individuals at risk of or with diagnosed HTN based on novel studies performed in humans.

The Utah Population Database. The Legacy of Four Decades of Demographic Research

This paper summarizes the unique characteristics of the Utah Population Database (UPDB) and how it has catalyzed demographic, social and medical research since the mid-1970s. The UPDB is one of the world’s richest sources of linked population-based information for demographic, genetic, and epidemiological studies at the Individual-level. UPDB has supported hundreds of demographic and biomedical investigations, with heavy emphasis on families, in large part because of its size, representativeness, inclusion of multi-generational pedigrees, and linkages to numerous data sources. The UPDB contains data on over 11 million individuals from the late 18th century to the present. UPDB data represent Utah’s population that appear in administrative records and many of these data are updated due to longstanding efforts to add records as they become available including statewide birth and death certificates, hospitalizations, ambulatory surgeries, and driver licenses. The depth of information within UPDB has been used to support a wide range of family, medical and historical demographic studies which are described here arranged into four broad categories: fertility, mortality, life course analyses and some selected special topics. The paper concludes with a discussion of the future areas of innovation within the UPDB and the types of novel studies that they are likely to facilitate.

Cohort profile of Acutelines: a large data/biobank of acute and emergency medicine

PurposeResearch in acute care faces many challenges, including enrolment challenges, legal limitations in data sharing, limited funding and lack of singular ownership of the domain of acute care. To overcome these challenges, the Center of Acute Care of the University Medical Center Groningen in the Netherlands, has established a de novo data, image and biobank named ‘Acutelines’.ParticipantsClinical data, imaging data and biomaterials (ie, blood, urine, faeces, hair) are collected from patients presenting to the emergency department (ED) with a broad range of acute disease presentations. A deferred consent procedure (by proxy) is in place to allow collecting data and biomaterials prior to obtaining written consent. The digital infrastructure used ensures automated capturing of all bed-side monitoring data (ie, vital parameters, electrophysiological waveforms) and securely importing data from other sources, such as the electronic health records of the hospital, ambulance and general practitioner, municipal registration and pharmacy. Data are collected from all included participants during the first 72 hours of their hospitalisation, while follow-up data are collected at 3 months, 1 year, 2 years and 5 years after their ED visit.Findings to dateEnrolment of the first participant occurred on 1 September 2020. During the first month, 653 participants were screened for eligibility, of which 180 were approached as potential participants. In total, 151 (84%) provided consent for participation of which 89 participants fulfilled criteria for collection of biomaterials.Future plansThe main aim of Acutelines is to facilitate research in acute medicine by providing the framework for novel studies and issuing data, images and biomaterials for future research. The protocol will be extended by connecting with central registries to obtain long-term follow-up data, for which we already request permission from the participant.Trial registration numberNCT04615065.

The Orchestration of Corporate Performance Management and Business Process Management and Its Effect on Perceived Organizational Performance

Various management approaches have been proposed to maintain good organizational performance on a continuous basis, with corporate performance management (CPM) and business process management (BPM) being two major groups. While the conceptual connection between CPM and BPM might see obvious, their actual empirical connection with performance remains poorly understood. In this article, we address this gap and develop a theoretical model that explicates the causal paths from CPM via BPM toward organizational performance in terms of a set of hypotheses. Based on a survey, we find that the effect of CPM on organizational performance is largely mediated by CPM-BPM orchestration and process performance. With this study, we respond to recent calls for novel studies in this area and highlight the impact of well-orchestrated CPM and BPM initiatives on organizational performance.

Specialized Metabolites and Valuable Molecules in Crop and Medicinal Plants: The Evolution of Their Use and Strategies for Their Production

Plants naturally produce a terrific diversity of molecules, which we exploit for promoting our overall well-being. Plants are also green factories. Indeed, they may be exploited to biosynthesize bioactive molecules, proteins, carbohydrates and biopolymers for sustainable and large-scale production. These molecules are easily converted into commodities such as pharmaceuticals, antioxidants, food, feed and biofuels for multiple industrial processes. Novel plant biotechnological, genetics and metabolic insights ensure and increase the applicability of plant-derived compounds in several industrial sectors. In particular, synergy between disciplines, including apparently distant ones such as plant physiology, pharmacology, ‘omics sciences, bioinformatics and nanotechnology paves the path to novel applications of the so-called molecular farming. We present an overview of the novel studies recently published regarding these issues in the hope to have brought out all the interesting aspects of these published studies.

The Uncomfortable Ordinary

Despite extensive dialogue among Robinson scholars about the role of the ordinary in her fiction, critical attention limits itself almost exclusively to the transformation of the everyday. This chapter focuses instead on the way that, for Robinson’s protagonists, loss settles uneasily into the everyday; the aesthetic defamiliarization of a taken-for-granted world often translates into the intimate experience of estrangement. The power of representation that critics associate with Robinson’s rendering of ordinary things emerges from an intensity of perception that marks her characters’ expulsion from the taken for granted. Scarred by grief, illness, aging, and trauma, Robinson’s characters inhabit a world of transcendent beauty suffused with the terrifying threat of loss. This chapter introduces the concept of the “uncomfortable ordinary” within the frameworks of everyday life theory, Robinson criticism, contemporary novel studies, and recent dialogues on the lyrical novel to argue for the complexity, relevance, and contemporaneity of Robinson’s fiction.