Correlational Study between Serum Vitamin-D Levels and Microvascular Complications in Diabetic Patients: A Tertiary Care Centre Experience from Western Uttar Pradesh

Background: Exclusive breast-feeding is recommended up to 6 months of age with all its beneficial effects on child survival. Several studies have concluded that adequate intake of vitamin D cannot be met with human milk as the sole source of vitamin D. So this study was undertaken to study the serum vitamin D levels in exclusively breastfed babies and their mothers in a tertiary care hospital.Methods: It was a prospective observational study. A minimum of 100 healthy infants born at term (38-42 weeks) and weighed >2.5kgs at birth and who were exclusively breast fed from age group 3-6 months attending the hospitals attached to J J M M C were selected for study. Approval from the ethical committee of the institution was obtained.Results: In this study there were totally 43% of males and 57% of females. Among them 14 (14%) of the infants were vitamin D deficient and 19 (19%) infants were vitamin D insufficient. And in 100 mothers studied 25 (25%) mothers were vitamin D deficient and 24 (24%) mothers were insufficient of vitamin D. The mean vitamin D level in infants was 25.72 ng/ml (±11.31ng/ml) and in mothers’ it was 22.09ng/ml (±9.17ng/ml).Conclusions: Breastfeeding might be one the contributing factors if the infant is not adequately exposed to sunlight for endogenous synthesis of vitamin D and if the mother is deplete in vitamin D levels transferring lower amount of vitamin D to infant through breast milk.

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Histopathological examination and evaluation of serum vitamin D levels in alopecia-is it necessary?

Our Dermatology Online ◽

10.7241/ourd.2020e.153 ◽

2020 ◽

Vol 11 (e) ◽

pp. e153.1-e153.3

Author(s):

Romita Bachaspatimayum ◽

N.A Bishurul Hafi ◽

Bipin Thingujam

Keyword(s):

Vitamin D ◽

Skin Biopsy ◽

Clinical Diagnosis ◽

Histopathological Examination ◽

Tertiary Care ◽

Serum Vitamin ◽

P Value ◽

Tertiary Care Centre ◽

Serum Vitamin D ◽

Vitamin D Levels

Background: Alopecia or hair loss may be of several types depending upon various etiological factors. Clinical and histopathological lapses have been encountered. Vitamin D has been found to have a role in the etiopathogenesis of alopecia. With this background, the study was undertaken to corroborate the histopathological and the clinical diagnosis and to find out the association between vitamin D levels and alopecia. Material and Methods: All patients of alopecia, attending out-patient Department of Dermatology in a tertiary care centre who were willing to participate were included while those due to infective causes or with incomplete reports were excluded from the prospective study of two years (January 2015-December 2016). Histopathological examination of skin biopsy was done and corroborated with the clinical diagnosis along with measurement of serum vitamin D levels by electrochemiluminescense immunoassay (ECLIA). Data was analyzed by spss20v; Fischer’s Exact test was used and a p value of 0.05 was taken as significant. Results: Out of total 50 patients, 20 (male:female=1.5:1) patients had both HPE and serum vitamin D reports and their results were analyzed. HPE and clinical diagnosis matched in only 10 patients (50%) with a significant p-value (p=0.007; p<0.05). Sufficient levels (>/= 30 ng/ml ) of serum vitamin D were found in only three (15%) with p value >0.05 (0.421) which was not significant. Conclusion: H.P.E. finding was significantly variable compared to clinical diagnosis. Hence, we should opt for a confirmatory skin biopsy wherever feasible. Evaluation of vitamin D is suggested with studies on a larger scale.

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Effect of Maternal Vitamin D Status on Vitamin D Levels in Early Infancy, in a Tertiary Care Centre in Sri Lanka

SSRN Electronic Journal ◽

10.2139/ssrn.3314427 ◽

2019 ◽

Author(s):

Anusha Kaneshapillai ◽

Usha Hettiaratchi ◽

Dulanie Gunaseker ◽

Shamini Rathapan ◽

Guwani Liyanage

Keyword(s):

Vitamin D ◽

Sri Lanka ◽

Tertiary Care ◽

Early Infancy ◽

Vitamin D Status ◽

Care Centre ◽

Tertiary Care Centre ◽

Maternal Vitamin ◽

Vitamin D Levels ◽

Maternal Vitamin D Status

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Serum Vitamin D Level in Patients with Coronary Artery Disease and Association with Sun Exposure: Experience from a Tertiary Care, Teaching Hospital in India

Advances in Medicine ◽

10.1155/2019/6823417 ◽

2019 ◽

Vol 2019 ◽

pp. 1-4 ◽

Cited By ~ 2

Author(s):

Tauseef Akhtar ◽

Ramesh Aggarwal ◽

Sachin Kumar Jain

Keyword(s):

Coronary Artery Disease ◽

Vitamin D ◽

Coronary Artery ◽

Vitamin D Deficiency ◽

Tertiary Care ◽

Serum Vitamin ◽

Sun Exposure ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

Artery Disease

Background. Vitamin D, a fat-soluble vitamin, has various extraskeletal effects, and several human and animal studies have suggested that vitamin D deficiency may be a contributory factor in the pathogenesis of coronary artery disease (CAD). However, such studies in the Indian subcontinent are either lacking or have shown conflicting results. Methods. This was a descriptive cross-sectional study involving 121 patients with CAD from a tertiary care center and their 80 age-matched healthy controls. Serum vitamin D levels along with serum and urine chemistries were measured in both the groups. The average duration of sun exposure/day and use of sunscreen were also considered in the study cohort using a questionnaire. Serum vitamin D levels were categorized into deficient (<30 nmol/lit), insufficient (30–75 nmol/lit), and sufficient (>75 nmol/lit) groups. Results. Among the cases, 51.2% of the patients were vitamin D deficient and 44.6% patients had insufficient vitamin D levels, whereas among controls, 40% and 31% of the population had deficient and insufficient levels of vitamin D, respectively. However, the mean value of the serum vitamin D level was not statistically different in the cases as compared to that of the controls (34.06 vs 40.19 nmol/lit) (P=0.08). Corrected serum calcium (9.26 vs 9.59 mg%) (P≤0.0001) and serum albumin levels (4.21 vs 4.75 gm%) (P≤0.0001) were lower in the cases than those of the controls. The average sun exposure/day was higher among the cases than that among the controls (2.93 vs 1.85 hours) (P=0.001). Conclusion. Vitamin D deficiency is widely prevalent in Indian population despite abundant sunshine, and the duration of sun exposure is not correlated with serum vitamin D levels. Vitamin D deficiency is not associated with CAD. However, serum calcium is deficient in CAD patients as compared to the controls. Large-scale studies are required to explore the association further to evaluate the benefits of screening and correction of vitamin D deficiency in patients with CAD.

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25-Hydroxy vitamin D levels in chronic urticaria and its correlation with disease severity from a tertiary care centre in South India

Clinical Chemistry and Laboratory Medicine (CCLM) ◽

10.1515/cclm-2013-1014 ◽

2014 ◽

Vol 52 (6) ◽

Cited By ~ 13

Author(s):

Laxmisha Chandrashekar ◽

Medha Rajappa ◽

Malathi Munisamy ◽

Palghat Hariharan Ananthanarayanan ◽

Devinder Mohan Thappa ◽

...

Keyword(s):

Vitamin D ◽

Disease Severity ◽

Chronic Urticaria ◽

South India ◽

Tertiary Care ◽

Care Centre ◽

Tertiary Care Centre ◽

Vitamin D Levels ◽

25 Hydroxy Vitamin D

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Glycated Haemoglobin Is Inversely Related to Serum Vitamin D Levels in Type 2 Diabetic Patients

PLoS ONE ◽

10.1371/journal.pone.0082733 ◽

2013 ◽

Vol 8 (12) ◽

pp. e82733 ◽

Cited By ~ 23

Author(s):

Giacomo Zoppini ◽

Anna Galletti ◽

Giovanni Targher ◽

Corinna Brangani ◽

Isabella Pichiri ◽

...

Keyword(s):

Vitamin D ◽

Serum Vitamin ◽

Glycated Haemoglobin ◽

Diabetic Patients ◽

Type 2 Diabetic Patients ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

Type 2 Diabetic

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Status of Vitamin D among Patients Visiting a Tertiary Care Centre in Rupandehi, Nepal

International Journal of Applied Sciences and Biotechnology ◽

10.3126/ijasbt.v9i4.40425 ◽

2021 ◽

Vol 9 (4) ◽

pp. 256-260

Author(s):

Tirtha Narayan Shah ◽

Amar Kumar Sinha ◽

Krishna Kumar Jha ◽

Ram Jiban Prasad

Keyword(s):

Vitamin D ◽

Tertiary Care ◽

Age Groups ◽

Serum Vitamin ◽

Hypovitaminosis D ◽

Target Population ◽

Tertiary Care Centre ◽

Medical College ◽

Serum Vitamin D ◽

High Level

Serum vitamin D is one of the fat-soluble vitamin which has the role in maintenance of calcium and phosphorus levels and ultimately proper bone health and various physiological processes. Although many studies prevail hypovitaminosis D, we focused to find out the pattern of elevated or decreased serum vitamin D level as its deficiency and surplus have adverse effects to our health.. For this, a retrospective study was done from the records present in a hospital laboratory of Devdaha Medical College and Research Institute (DMCRI), Rupandehi, Nepal from January 2018 to December 2020 where 201 participants with 70.1% male and 29.9% female with different age groups were present. From total participants, 14.9% had deficient, 42.8% had insufficient, 35.3% had sufficient and 7% had high level of serum vitamin D. Male had 2.9% deficient and 14,9% insufficient vitamin D whereas female had 11.9% deficient, 27.8% insufficient and 7.0% surplus vitamin D. The greater prevalence of hypovitaminosis D in the females than the males could be overcome by the necessary strategies in the form of further studies and judicious supplementation vitamin D in the target population by monitoring the level of serum vitamin D. Int. J. Appl. Sci. Biotechnol. Vol 9(4): 256-260.

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Does Vitamin D Have a Role in the Inception of Childhood Asthma? - A Comparative Cross-Sectional Study

Journal of Evidence Based Medicine and Healthcare ◽

10.18410/jebmh/2021/223 ◽

2021 ◽

Vol 8 (17) ◽

pp. 1157-1162

Author(s):

Mohan Jayabal ◽

Rashmi Ramanathan ◽

Arun Kumar ◽

Pavithra Vyshnavi Yogisparan ◽

Manishankar Subramaniyam ◽

...

Keyword(s):

Vitamin D ◽

Pulmonary Function ◽

Tertiary Care ◽

Serum Vitamin ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Asthmatic Children ◽

Serum Vitamin D ◽

Vitamin D Levels

BACKGROUND Global prevalence of paediatric asthma has shown a sharp increase in last three decades. Recently vitamin D has been linked with lung function and vitamin D supplementation can lessen the acute exacerbations in asthmatic children. The purpose of the study was to compare lung parameters and vitamin D levels in asthmatic and non-asthmatic children and assess the correlation between vitamin D levels and pulmonary function parameters in children. METHODS A cross-sectional study was conducted among 40 asthmatic children and 42 healthy volunteers between the age group of 5 and 18 years attending the paediatric outpatient department (OPD) in a tertiary care centre in Coimbatore. Pulmonary functions were assessed using computerized spirometer and the serum 25-hydroxy vitamin D levels were estimated by Diazyme EZ vitamin D assay latex enhanced immunoturbidimetric method. The results were compared between asthmatics and non-asthmatics to find out the association. RESULTS The average age of the study participants was 10.5 ± 2.5 years. Lung parameters and mean vitamin D levels are reduced in asthmatics. There is a positive significant correlation between serum vitamin D levels and forced expiratory volume FEV1 / forced vital capacity (FVC) (P < 0.05, r = 0.781), and also between vitamin D and FEV1 (P < 0.05, r = 0.28). Lung parameters like FEV1, FEV1 / FVC ratio and peak expiratory flow rate (PEFR) are significantly decreased in asthmatic children. CONCLUSIONS Majority of the asthmatics have insufficient vitamin D levels than the normal peers with no asthma. Our study confirms the positive association between vitamin D and FEV1 and FEV1 / FVC ratio. KEYWORDS Vitamin D, Asthma, Pulmonary Function, Lung Parameters

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