scholarly journals Histopathological examination and evaluation of serum vitamin D levels in alopecia-is it necessary?

2020 ◽  
Vol 11 (e) ◽  
pp. e153.1-e153.3
Author(s):  
Romita Bachaspatimayum ◽  
N.A Bishurul Hafi ◽  
Bipin Thingujam
Keyword(s):  
Vitamin D ◽  
Skin Biopsy ◽  
Clinical Diagnosis ◽  
Histopathological Examination ◽  
Tertiary Care ◽  
Serum Vitamin ◽  
P Value ◽  
Tertiary Care Centre ◽  
Serum Vitamin D ◽  
Vitamin D Levels

Background: Alopecia or hair loss may be of several types depending upon various etiological factors. Clinical and histopathological lapses have been encountered. Vitamin D has been found to have a role in the etiopathogenesis of alopecia. With this background, the study was undertaken to corroborate the histopathological and the clinical diagnosis and to find out the association between vitamin D levels and alopecia. Material and Methods: All patients of alopecia, attending out-patient Department of Dermatology in a tertiary care centre who were willing to participate were included while those due to infective causes or with incomplete reports were excluded from the prospective study of two years (January 2015-December 2016). Histopathological examination of skin biopsy was done and corroborated with the clinical diagnosis along with measurement of serum vitamin D levels by electrochemiluminescense immunoassay (ECLIA). Data was analyzed by spss20v; Fischer’s Exact test was used and a p value of 0.05 was taken as significant. Results: Out of total 50 patients, 20 (male:female=1.5:1) patients had both HPE and serum vitamin D reports and their results were analyzed. HPE and clinical diagnosis matched in only 10 patients (50%) with a significant p-value (p=0.007; p<0.05). Sufficient levels (>/= 30 ng/ml ) of serum vitamin D were found in only three (15%) with p value >0.05 (0.421) which was not significant. Conclusion: H.P.E. finding was significantly variable compared to clinical diagnosis. Hence, we should opt for a confirmatory skin biopsy wherever feasible. Evaluation of vitamin D is suggested with studies on a larger scale.

scholarly journals Correlation between Asthma Severity and Serum Vitamin D Levels: Experience from a Tertiary Care Centre in North India

2018 ◽  
Vol 07 (03) ◽  
Author(s):  
Haider Guru ◽  
Sonaullah Shah ◽  
Roohi Rasool ◽  
Qurteeba Qadri ◽  
Faisal R Guru ◽  
...  
Keyword(s):  
Vitamin D ◽  
Tertiary Care ◽  
Serum Vitamin ◽  
Asthma Severity ◽  
North India ◽  
Care Centre ◽  
Tertiary Care Centre ◽  
Serum Vitamin D ◽  
Vitamin D Levels

scholarly journals Study of vitamin D levels in exclusively breastfed term infants in a tertiary care centre

2017 ◽  
Vol 5 (1) ◽  
pp. 71
Author(s):  
Soumya M.
Keyword(s):  
Vitamin D ◽  
Tertiary Care ◽  
Child Survival ◽  
Serum Vitamin ◽  
Lower Amount ◽  
Contributing Factors ◽  
Tertiary Care Centre ◽  
Term Infants ◽  
Serum Vitamin D ◽  
Vitamin D Levels

Background: Exclusive breast-feeding is recommended up to 6 months of age with all its beneficial effects on child survival. Several studies have concluded that adequate intake of vitamin D cannot be met with human milk as the sole source of vitamin D. So this study was undertaken to study the serum vitamin D levels in exclusively breastfed babies and their mothers in a tertiary care hospital.Methods: It was a prospective observational study. A minimum of 100 healthy infants born at term (38-42 weeks) and weighed >2.5kgs at birth and who were exclusively breast fed from age group 3-6 months attending the hospitals attached to J J M M C were selected for study. Approval from the ethical committee of the institution was obtained.Results: In this study there were totally 43% of males and 57% of females. Among them 14 (14%) of the infants were vitamin D deficient and 19 (19%) infants were vitamin D insufficient. And in 100 mothers studied 25 (25%) mothers were vitamin D deficient and 24 (24%) mothers were insufficient of vitamin D. The mean vitamin D level in infants was 25.72 ng/ml (±11.31ng/ml) and in mothers’ it was 22.09ng/ml (±9.17ng/ml).Conclusions: Breastfeeding might be one the contributing factors if the infant is not adequately exposed to sunlight for endogenous synthesis of vitamin D and if the mother is deplete in vitamin D levels transferring lower amount of vitamin D to infant through breast milk. 

scholarly journals STUDY OF SERUM VITAMIN D LEVELS IN PREECLAMPTIC WOMEN BELOW 35 YEARS IN A TERTIARY CARE CENTRE IN SOUTHERN ASSAM, INDIA.

2017 ◽  
Vol 5 (8) ◽  
pp. 1186-1191
Author(s):  
Aparajeeta Bora ◽  
◽  
MauchumiSaikia Pathak ◽  
ArunPaul Choudhury ◽  
Biswadeep Choudhury ◽  
...  
Keyword(s):  
Vitamin D ◽  
Tertiary Care ◽  
Serum Vitamin ◽  
Care Centre ◽  
Tertiary Care Centre ◽  
Serum Vitamin D ◽  
Vitamin D Levels

Association of Vitamin D Levels and Other Risk Factors with Asthma Exacerbations in Children

2020 ◽  
Keyword(s):  
Risk Factors ◽  
Vitamin D ◽  
Serum Vitamin ◽  
Persistent Asthma ◽  
Food Allergies ◽  
P Value ◽  
Serum Vitamin D ◽  
Asthma Exacerbations ◽  
Vitamin D Levels ◽  
Animal Dander

Background: The risk factors for asthma exacerbations are well understood. However, the effect of vitamin D levels on number of asthma exacerbations per year is not clearly studied. The objective of the study was to find out the association of serum vitamin D levels and asthma risk factors on asthma exacerbations. Methods: In this study, ninety-nine subjects from 5 to 15 years of age were recruited at an episode of acute exacerbation. It was a cross sectional study and carried out from 2012 to 2015. Pulmonary function test was done by spirometry. Asthma exacerbation was labeled when forced expiratory volume/ forced vital capacity (FEV1/FVC) ratio was less than 80% (American Thoracic Society). Global Initiative for Asthma (GINA) guidelines were used to classify asthma into mild, moderate and severe persistent asthma. Serum vitamin D levels were measured by chemiluminescence method. Pearson Chi-square test was applied and p value (p<0.05) was considered as statistically significant. Results: Children who had exposure to animal dander had significantly lower asthma exacerbations per year (p-value <0.046). There was no significant association between vitamin D levels and number of exacerbations per years (p-value <0.099). Asthma was prevalent in girls of low socioeconomic status (SES) compared to males. However, there was no significant association between smoke, exercise, home environment, food allergies, weather, pollen and dust with asthma exacerbations. Conclusion: Low levels of vitamin D were not associated with increased number of asthma exacerbations per year. However, children exposed to animal dander had lesser number of exacerbations per year (p-value <0.046). Keywords: Asthma; Vitamin D; Children; Exacerbations, Risk factors.

Association between vitamin D deficiency and prostate cancer: Prospective case-control study

2021 ◽  
pp. 205141582199360
Author(s):  
Ghanshyam Kumawat ◽  
Vijay Chaudhary ◽  
Anurag Garg ◽  
Nishkarsh Mehta ◽  
Gagan Talwar ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Case Control Study ◽  
Serum Vitamin ◽  
P Value ◽  
Serum Vitamin D ◽  
Severe Vitamin ◽  
Vitamin D Levels ◽  
Control Study

Objective: We aimed to find out the association of low serum vitamin D levels with the incidence of prostate cancer through a prospective case-control study. Material and methods: This study was carried out in the tertiary care hospital (India). All newly diagnosed patients of prostate cancer and age-matched controls were included. Serum vitamin D levels were measured in all of them. Vitamin D status (ng/mL) was classified as severe deficiency <10, moderate deficiency 10–<30, normal 30–100, and toxicity >100. Normality of the data was tested by the Kolmogorov–Smirnov test, statistical analysis was done with Statistical Package for the Social Sciences version 26.0, p-value of <0.05 was considered significant. Results: In our study, 320 cases and 320 controls were included. The mean vitamin D levels in cases and controls were 15.71 ± 6.5 (ng/mL) and 17.63 ± 4.54 (ng/mL), respectively, ( p-Value <0.01). Patients with severe vitamin D deficiency (73.58%) had a Gleason score ⩾8 on biopsy and 79.24% of them had a serum prostate specific antigen (PSA) level >20 ng/mL. Conclusion: We had concluded that there was no significant association between vitamin D deficiency and increased risk of prostate cancer, although patients with higher-grade prostate cancer and with higher PSA level had severe vitamin D deficiency. Level of evidence: Not applicable for this multicentre audit.

scholarly journals Correlation of psoriasis and serum vitamin D

2021 ◽  
Vol 7 (4) ◽  
pp. 320-323
Author(s):  
Ritika Gujrati ◽  
Krishnendra Varma ◽  
Ujjwal Kumar
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Psoriasis Vulgaris ◽  
Systemic Disease ◽  
Serum Vitamin ◽  
Psoriatic Skin ◽  
Control Group ◽  
P Value ◽  
Serum Vitamin D ◽  
Vitamin D Levels

Psoriasis is an immuno-mediated chronic systemic disease involving cytokines of helper Th1 pathway. Vitamin D has an effect on keratinocyte proliferation, differentiation and immune modulation of immune system especially Th1 pathway, which is altered in psoriatic skin suggesting that Vitamin D may have a role in pathogenesis of psoriasis. To study correlation between psoriasis vulgaris and serum vitamin D. To evaluate serum vitamin D level in psoriasis cases and in control group and correlating vitamin D level with severity and duration of the psoriasis. 57 cases (&#62;15years of age) with psoriasis and 57 healthy subjects were recruited. Psoriasis was clinically diagnosed and severity evaluated by PASI scale. Vitamin D was analysed by enhanced chemilumine scence on vitrus Eci autoanalyzer of Orth clinical diagnostic. Vitamin D deficiency defined as &#60;20ng/ml, insufficiency 20-30ng/ml and sufficient 30-100ng/ml. Vitamin D deficiency in the study was 22.8% in patients and 14% in control group. Vitamin D insufficiency was found in 42.1% of cases and 19.3% of control. According to chi-square the p-value is 0.003 showing significant association. There was a tendency towards decrease in vitamin D level with increase in disease duration. There was negative correlation between vitamin D and PASI score. The study found a significant relationship between vitamin D and psoriasis. Further metanalysis involving larger study population will be required to establish whether vitamin D levels benefits patient with psoriasis vulgaris.

scholarly journals A clinical study to determine the relationship between serum vitamin D levels and severity of asthma

2017 ◽  
Vol 4 (4) ◽  
pp. 1397
Author(s):  
Pragalatha Kumar ◽  
Aruna Gowdra ◽  
Arathi Arathi ◽  
Ananya Sampath
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Serum Vitamin ◽  
Asthma Severity ◽  
Severe Form ◽  
P Value ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Children With Asthma ◽  
Age And Sex

Background: Vitamin D deficiency has been rediscovered as a public health problem worldwide. Few studies have shown that vitamin D deficiency is associated with asthma severity. The objective of present work was to study the serum vitamin D levels and its relationship with asthma severity in children.Methods: A prospective cohort study of 100 children with asthma between the age group of 5 to 15 years and age and sex matched 40 healthy controls who had come to Indira Gandhi Institute of Child Health, Bengaluru was done. These children’s serum vitamin D levels were estimated and correlated with asthma severity.Results: A total of 100 children with asthma and 40 healthy age and sex matched controls were evaluated. The study group had lower vitamin D (34.95 ng/ml) levels as compared to the control group (57.94 ng/ml) which was statistically significant (p<0.05). 68.4% children had significantly low vitamin D levels and severe form of asthma (p value <0.001). There was also a marked rise in absolute eosinophil count in those who had low vitamin D levels (56.6%) (p-value <0.0001).Conclusions: Vitamin D deficiency is an important risk factor for asthma severity. It modifies the immune system and reduces the inflammation. In the present study, low serum vitamin D levels were significantly correlated with severe form of asthma. There was a significant rise in the absolute eosinophil count in those who exhibited deficiency of vitamin D.  

scholarly journals Serum Vitamin D Level in Patients with Coronary Artery Disease and Association with Sun Exposure: Experience from a Tertiary Care, Teaching Hospital in India

2019 ◽  
Vol 2019 ◽  
pp. 1-4 ◽  
Author(s):  
Tauseef Akhtar ◽  
Ramesh Aggarwal ◽  
Sachin Kumar Jain
Keyword(s):  
Coronary Artery Disease ◽  
Vitamin D ◽  
Coronary Artery ◽  
Vitamin D Deficiency ◽  
Tertiary Care ◽  
Serum Vitamin ◽  
Sun Exposure ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Artery Disease

Background. Vitamin D, a fat-soluble vitamin, has various extraskeletal effects, and several human and animal studies have suggested that vitamin D deficiency may be a contributory factor in the pathogenesis of coronary artery disease (CAD). However, such studies in the Indian subcontinent are either lacking or have shown conflicting results. Methods. This was a descriptive cross-sectional study involving 121 patients with CAD from a tertiary care center and their 80 age-matched healthy controls. Serum vitamin D levels along with serum and urine chemistries were measured in both the groups. The average duration of sun exposure/day and use of sunscreen were also considered in the study cohort using a questionnaire. Serum vitamin D levels were categorized into deficient (<30 nmol/lit), insufficient (30–75 nmol/lit), and sufficient (>75 nmol/lit) groups. Results. Among the cases, 51.2% of the patients were vitamin D deficient and 44.6% patients had insufficient vitamin D levels, whereas among controls, 40% and 31% of the population had deficient and insufficient levels of vitamin D, respectively. However, the mean value of the serum vitamin D level was not statistically different in the cases as compared to that of the controls (34.06 vs 40.19 nmol/lit) (P=0.08). Corrected serum calcium (9.26 vs 9.59 mg%) (P≤0.0001) and serum albumin levels (4.21 vs 4.75 gm%) (P≤0.0001) were lower in the cases than those of the controls. The average sun exposure/day was higher among the cases than that among the controls (2.93 vs 1.85 hours) (P=0.001). Conclusion. Vitamin D deficiency is widely prevalent in Indian population despite abundant sunshine, and the duration of sun exposure is not correlated with serum vitamin D levels. Vitamin D deficiency is not associated with CAD. However, serum calcium is deficient in CAD patients as compared to the controls. Large-scale studies are required to explore the association further to evaluate the benefits of screening and correction of vitamin D deficiency in patients with CAD.

scholarly journals Status of Vitamin D among Patients Visiting a Tertiary Care Centre in Rupandehi, Nepal

2021 ◽  
Vol 9 (4) ◽  
pp. 256-260
Author(s):  
Tirtha Narayan Shah ◽  
Amar Kumar Sinha ◽  
Krishna Kumar Jha ◽  
Ram Jiban Prasad
Keyword(s):  
Vitamin D ◽  
Tertiary Care ◽  
Age Groups ◽  
Serum Vitamin ◽  
Hypovitaminosis D ◽  
Target Population ◽  
Tertiary Care Centre ◽  
Medical College ◽  
Serum Vitamin D ◽  
High Level

Serum vitamin D is one of the fat-soluble vitamin which has the role in maintenance of calcium and phosphorus levels  and ultimately proper bone health and various physiological processes.  Although many studies prevail hypovitaminosis D, we focused to find out the pattern of  elevated or decreased  serum vitamin D level as its deficiency and surplus have adverse effects to our health.. For this, a retrospective study was done from the records present in a hospital laboratory of Devdaha Medical College and Research Institute (DMCRI), Rupandehi, Nepal from January 2018 to December 2020 where 201 participants with 70.1% male and 29.9% female with different age groups were present. From total participants, 14.9% had deficient, 42.8% had insufficient, 35.3% had sufficient and 7%  had high level of serum vitamin D. Male had 2.9% deficient and 14,9% insufficient vitamin D whereas female had 11.9% deficient, 27.8% insufficient and 7.0% surplus vitamin D. The greater prevalence of hypovitaminosis D in the females than the males could be overcome by the necessary strategies in the form of further studies and judicious supplementation vitamin D in the target population by monitoring the level of serum vitamin D. Int. J. Appl. Sci. Biotechnol. Vol 9(4): 256-260.

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