Blood and peritoneal fluid effector and regulatory subpopulations of innate immunity cells in women with endometriosis

Health becomes an important topic today. One current problem was how to treat the effects of metabolic diseases, such as diabetes mellitus (DM). Thus, this study used an ethanolic extract of propolis (EEP), to test their ability as the supplement in the diabetes treatment to reduce inflammation, through proinflammatory factor response, especially nuclear factor κB (NF-κB). The streptozotocin- induced diabetes mellitus (SID) mice model was used, and expression of an proinflammatory factor was analyzed in their innate immunity cells with 3 doses of EEP, i.e. 50 mg/kg body weight, 100 mg/kg body weight, and 200 mg/kg body weight. Treatment of EEP in SID with three doses treatment decrease the number of macrophages with NF-κB expression significantly with DM control group. The results of B cells with NF-κB expression showed that EEP treatment in SID could decrease in dose 1 and dose 3, but not in dose 2. Proinflammatory cytokines expression of macrophage, especially Tumor Necrosis Factor-α and Interferon-γ, with EEP treatment in SID could decrease in three doses. This study suggests that EEP could reduce inflammation by inhibiting the development of NF-κB in innate immunity cells.

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Effects of Immunomodulators on Functional Activity of Innate Immunity Cells Infected with Streptococcus pneumoniae

Bulletin of Experimental Biology and Medicine ◽

10.1007/s10517-015-2785-0 ◽

2015 ◽

Vol 158 (4) ◽

pp. 461-464

Author(s):

N. G. Plekhova ◽

N. M. Kondrashova ◽

L. M. Somova ◽

E. I. Drobot ◽

I. N. Lyapun

Keyword(s):

Innate Immunity ◽

Streptococcus Pneumoniae ◽

Functional Activity ◽

Innate Immunity Cells

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Interleukin-2 immunotherapy action on innate immunity cells in peripheral blood and tumoral tissue of pancreatic adenocarcinoma patients

Langenbeck s Archives of Surgery ◽

10.1007/s00423-008-0393-4 ◽

2008 ◽

Vol 394 (1) ◽

pp. 115-121 ◽

Cited By ~ 14

Author(s):

Luca Degrate ◽

Cinzia Nobili ◽

Claudio Franciosi ◽

Roberto Caprotti ◽

Fernando Brivio ◽

...

Keyword(s):

Innate Immunity ◽

Pancreatic Adenocarcinoma ◽

Peripheral Blood ◽

Interleukin 2 ◽

Innate Immunity Cells

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Innate Immunity Cells and the Neurovascular Unit

International Journal of Molecular Sciences ◽

10.3390/ijms19123856 ◽

2018 ◽

Vol 19 (12) ◽

pp. 3856 ◽

Cited By ~ 15

Author(s):

Ivan Presta ◽

Marco Vismara ◽

Fabiana Novellino ◽

Annalidia Donato ◽

Paolo Zaffino ◽

...

Keyword(s):

Central Nervous System ◽

Innate Immunity ◽

Nervous System ◽

Immune System ◽

Infectious Diseases ◽

Blood Brain Barrier ◽

Brain Barrier ◽

Secondary Neoplasms ◽

Blood Brain ◽

Innate Immunity Cells

Recent studies have clarified many still unknown aspects related to innate immunity and the blood-brain barrier relationship. They have also confirmed the close links between effector immune system cells, such as granulocytes, macrophages, microglia, natural killer cells and mast cells, and barrier functionality. The latter, in turn, is able to influence not only the entry of the cells of the immune system into the nervous tissue, but also their own activation. Interestingly, these two components and their interactions play a role of great importance not only in infectious diseases, but in almost all the pathologies of the central nervous system. In this paper, we review the main aspects in the field of vascular diseases (cerebral ischemia), of primitive and secondary neoplasms of Central Nervous System CNS, of CNS infectious diseases, of most common neurodegenerative diseases, in epilepsy and in demyelinating diseases (multiple sclerosis). Neuroinflammation phenomena are constantly present in all diseases; in every different pathological state, a variety of innate immunity cells responds to specific stimuli, differentiating their action, which can influence the blood-brain barrier permeability. This, in turn, undergoes anatomical and functional modifications, allowing the stabilization or the progression of the pathological processes.

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Inhibitory CD200R and proapoptotic CD95/CD95L molecules on innate immunity cells are modulated by cardiac surgery

Perfusion ◽

10.1177/0267659114558286 ◽

2014 ◽

Vol 30 (7) ◽

pp. 543-555 ◽

Cited By ~ 1

Author(s):

D Holmannova ◽

M Kolackova ◽

J Mandak ◽

P Kunes ◽

Z Holubcova ◽

...

Keyword(s):

Innate Immunity ◽

Cardiac Surgery ◽

Innate Immunity Cells

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Exploring the LPS/TLR4 signal pathway with small molecules

Biochemical Society Transactions ◽

10.1042/bst0381390 ◽

2010 ◽

Vol 38 (5) ◽

pp. 1390-1395 ◽

Cited By ~ 64

Author(s):

Francesco Peri ◽

Matteo Piazza ◽

Valentina Calabrese ◽

Gaetana Damore ◽

Roberto Cighetti

Keyword(s):

Innate Immunity ◽

Small Molecules ◽

Innate Immune ◽

Toll Like Receptor 4 ◽

Innate Immunity Cells ◽

Specific Receptors ◽

Extracellular Side ◽

Tlr4 Activation ◽

Lps Binding

The identification of the bacterial endotoxin receptors for innate immunity, most notably TLR4 (Toll-like receptor 4), has sparked great interest in therapeutic manipulation of the innate immune system. In the present mini-review, several natural and synthetic molecules that modulate the TLR4-mediated LPS (lipopolysaccharide) signalling in animals and humans are considered, and their mechanisms of action are discussed. The process of LPS sensing and signal amplification in humans is based on the sequential action of specific receptors situated in the extracellular side of the innate immunity cells, which bind and transfer LPS to TLR4: LBP (LPS-binding protein), CD14, MD-2 (myeloid differentiation protein 2). We classified the compounds active on TLR4 pathway depending on the specific molecular targets (LPS, LBP, CD14, MD-2 or TLR4). Small molecules developed by our group are described that inhibit LPS-stimulated TLR4 activation by selectively targeting the LPS–CD14 interaction. These compounds have an interesting antiseptic shock, anti-inflammatory and anti-neuropathic pain activity in vivo.

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PSEUDOTUBERCULOSIS: PATHOGENETIC VALUE OF INNATE IMMUNITY CELLS

Journal of microbiology epidemiology immunobiology ◽

10.36233/0372-9311-2017-5-78-90 ◽

2017 ◽

pp. 78-90

Author(s):

L. M. Somova ◽

N. G. Plekhova ◽

E. I. Drobot ◽

I. N. Lyapun

Keyword(s):

Immune Deficiency ◽

Innate Immunity ◽

Neutrophil Extracellular Traps ◽

Primary Immune Response ◽

Protective Function ◽

Extracellular Traps ◽

Unique Pair ◽

Causative Agents ◽

Innate Immunity Cells ◽

Far Eastern

Novel data on mechanisms of innate immunity during infections with pathogenic Yersiniae are summarized in the review, that was mostly determined by complex developments regarding a unique pair of genetically related causative agents Y. pseudotuberculosis/Y. pestis. Our previous studies have revealed a morphological substrate of relative granulocyte immune deficiency that determines characteristic pathomorphologic features of pseudotuberculosis. To date, evidence has been obtained, that pathogenic for human Yersinia predominately activate protective function of innate immunity cells that is an important strategy to avoid elimination and cause the disease for the bacteria. Neutrophils (PMNs) play a fundamental role in response to infection by pathogenic Yersiniae in primary immune response and limit of primary spread of bacteria that use several mechanisms of eradication ofbacteria, e.g.: phagocytosis, oxidative stress, secretory degranulation, formation of neutrophil extracellular traps, efferocytosis. Infected PMNs can act as an intermediate host for consequent non-inflammatory infection of macrophages. Further elaboration of questions relating to primary anti-infection protection during Yersinia infections gives a key to understanding of immune pathogenesis of epidemic pseudotuberculosis (far Eastern scarlet-like fever) and yersiniosis in general.

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