scholarly journals Discovering correlates of age-related decline in a healthy late-midlife male birth cohort

Aging ◽  
2020 ◽  
Vol 12 (17) ◽  
pp. 16709-16743
Author(s):  
Kiyana Zarnani ◽  
Stephen M. Smith ◽  
Fidel Alfaro-Almagro ◽  
Birgitte Fagerlund ◽  
Martin Lauritzen ◽  
...  
Keyword(s):  
Birth Cohort ◽  
Male Birth ◽  
Age Related ◽  
Late Midlife

Revitalising the Metropolit 1953 Danish male birth cohort: background, aims and design

2004 ◽  
Vol 18 (5) ◽  
pp. 385-394 ◽  
Author(s):  
Merete Osler ◽  
Anne-Marie Nybo Andersen ◽  
Rikke Lund ◽  
G. David Batty ◽  
Charlotte Orsted Hougaard ◽  
...  
Keyword(s):  
Birth Cohort ◽  
Male Birth

scholarly journals Changes in testosterone related to body composition in late midlife: Findings from the 1946 British birth cohort study

Obesity ◽  
2015 ◽  
Vol 23 (7) ◽  
pp. 1486-1492 ◽  
Author(s):  
David Bann ◽  
Frederick C. W. Wu ◽  
Brian Keevil ◽  
Hany Lashen ◽  
Judith Adams ◽  
...  
Keyword(s):  
Body Composition ◽  
Cohort Study ◽  
Birth Cohort ◽  
Birth Cohort Study ◽  
Late Midlife

Fathers of children conceived using ART have higher cognitive ability scores than fathers of naturally conceived children

2020 ◽  
Vol 35 (6) ◽  
pp. 1461-1468
Author(s):  
Bernt Bratsberg ◽  
Ole Rogeberg ◽  
Vegard Skirbekk
Keyword(s):  
Cognitive Ability ◽  
Birth Cohort ◽  
Research Council ◽  
Cognitive Outcomes ◽  
Paternal Age ◽  
Sensitivity Analyses ◽  
Birth Cohorts ◽  
Male Birth ◽  
Ability Test ◽  
Military Conscription

Abstract STUDY QUESTION Does paternal cognitive ability differ for children conceived with and without assisted reproductive technology (ART)? SUMMARY ANSWER Young fathers of ART conceived children tend to score cognitively below their same-age natural conception (NC) counterparts and older (above 35) fathers of ART conceived children tend to score above. WHAT IS KNOWN ALREADY Cognitive ability is a genetically and socially transmitted trait, and If ART and NC children have parents with different levels of this trait, then this would in itself predict systematic differences in child cognitive outcomes. Research comparing cognitive outcomes of children with different modes of conception finds conflicting results, and studies may be influenced by selection and confounding. STUDY DESIGN, SIZE, DURATION This is a population-based study based on Norwegian data, combining information from the Medical Birth Registry (births through 2012), military conscription tests (birth cohorts 1955–1977) and the population registry. These data allow us to compare the cognitive ability scores of men registered as the father of an ART-conceived child to the cognitive abilities of other fathers and to average scores in the paternal birth cohorts. PARTICIPANTS/MATERIALS, SETTINGS, METHODS The population level study included 18 566 births after ART (5810 after ICSI, 12 756 after IVF), and 1 048 138 NC births. It included all Norwegian men who received a cognitive ability score after attending military conscription between 1973 and 1995. This constituted 614 827 men (89.4% of the male birth cohorts involved). An additional 77 650 unscored males were included in sensitivity analyses. MAIN RESULTS AND THE ROLE OF CHANCE Paternal cognitive level was assessed using intelligence quotients (IQ) converted from stanine scores on a three-part cognitive ability test with items measuring numeracy, vocabulary and abstract thought (Raven-like matrices). ART fathers averaged 1.95 IQ points above the average of their own birth cohort (P-value < 0.0005) and 1.83 IQ points above NC fathers in their own birth cohort (P < 0.0005). Comparisons of the IQ of ART fathers to those of NC fathers of similar age and whose children were born in the same year, however, found average scores to be more similar (point estimate 0.24, P = 0.023). These low average differences were found to differ substantially by age of fatherhood, with young ART fathers scoring below their NC counterparts and older ART fathers scoring above their NC counterparts. LIMITATIONS, REASONS FOR CAUTION We do not have information on maternal cognition. We also lack information on unsuccessful infertility treatments that did not result in a live birth. WIDER IMPLICATIONS OF THE FINDINGS Paternal cognitive ability of ART children differs from that of NC children, and this difference varies systematically with paternal age at child birth. Selection effects into ART may help explain differences between ART and NC children and need to be adequately controlled for when assessing causal effects of ART treatment on child outcomes. STUDY FUNDING/COMPETING INTEREST(S) This research has also been supported by the Research Council of Norway through its Centres of Excellence funding scheme, project number 262700 (Centre for Fertility and Health). It has also been supported by the Research Council of Norway’s Project 236992 (Egalitarianism under pressure? New perspectives on inequality and social cohesion). There are no competing interests. TRIAL REGISTRATION NUMBER N/A

Age-Related Differences in Intentional Forgetting of Prospective Memory

2020 ◽  
pp. 009141501990016
Author(s):  
Meral Bozdemir ◽  
Sevtap Cinan
Keyword(s):  
Prospective Memory ◽  
Cognitive Aging ◽  
Intentional Forgetting ◽  
Age Related ◽  
The Future ◽  
Midlife Adults ◽  
Late Midlife

This study investigated age-related differences in intentional forgetting (IF) of prospective memory (memory for actions to be performed in the future) in young (19–30 years) and late-midlife adults (LMA; 57–75 years). Prospective memory (PM) performance was examined by using the Virtual Week (VW) Task. An IF procedure was embedded into the VW task and the participants were instructed to forget some of the PM tasks that they were to remember and execute later on a virtual day. The study compared performances of the young and the LMA participants in the context of event- or time-based regular and irregular tasks. The results confirmed previous findings in showing that LMA participants exhibited worse PM than younger participants in lab-based tasks. In addition, although PM and IF performances separately have been shown to be affected by cognitive aging, larger age-related differences were not found in PM performance under IF conditions.

P201: Late midlife sleep pattern and sleep structure and the association to age-related changes in cognition

2014 ◽  
Vol 125 ◽  
pp. S101
Author(s):  
K.L.W. Waller ◽  
B. Fagerlund ◽  
K. Avlund ◽  
M. Osler ◽  
E. Lykke Mortensen ◽  
...  
Keyword(s):  
Sleep Pattern ◽  
Sleep Structure ◽  
Age Related ◽  
Late Midlife ◽  
Age Related Changes

scholarly journals Grip strength from midlife as an indicator of later-life brain health and cognition: evidence from a British birth cohort

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Quentin Dercon ◽  
Jennifer M. Nicholas ◽  
Sarah-Naomi James ◽  
Jonathan M. Schott ◽  
Marcus Richards
Keyword(s):  
Grip Strength ◽  
Birth Cohort ◽  
Later Life ◽  
Cognitive Test ◽  
White Matter Hyperintensity ◽  
Brain Health ◽  
Time Points ◽  
Age Related ◽  
Maximum Grip Strength ◽  
Maximum Grip

Abstract Background Grip strength is an indicator of physical function with potential predictive value for health in ageing populations. We assessed whether trends in grip strength from midlife predicted later-life brain health and cognition. Methods 446 participants in an ongoing British birth cohort study, the National Survey of Health and Development (NSHD), had their maximum grip strength measured at ages 53, 60–64, and 69, and subsequently underwent neuroimaging as part of a neuroscience sub-study, referred to as “Insight 46”, at age 69–71. A group-based trajectory model identified latent groups of individuals in the whole NSHD cohort with below- or above-average grip strength over time, plus a reference group. Group assignment, plus standardised grip strength levels and change from midlife were each related to measures of whole-brain volume (WBV) and white matter hyperintensity volume (WMHV), plus several cognitive tests. Models were adjusted for sex, body size, head size (where appropriate), sociodemographics, and behavioural and vascular risk factors. Results Lower grip strength from midlife was associated with smaller WBV and lower matrix reasoning scores at age 69–71, with findings consistent between analysis of individual time points and analysis of trajectory groups. There was little evidence of an association between grip strength and other cognitive test scores. Although greater declines in grip strength showed a weak association with higher WMHV at age 69–71, trends in the opposite direction were seen at individual time points with higher grip strength at ages 60–64, and 69 associated with higher WMHV. Conclusions This study provides preliminary evidence that maximum grip strength may have value in predicting brain health. Future work should assess to what extent age-related declines in grip strength from midlife reflect concurrent changes in brain structure.

scholarly journals Discovering markers of healthy aging: a prospective study in a Danish male birth cohort

Aging ◽  
2019 ◽  
Vol 11 (16) ◽  
pp. 5943-5974 ◽  
Author(s):  
Kiyana Zarnani ◽  
Thomas E. Nichols ◽  
Fidel Alfaro-Almagro ◽  
Birgitte Fagerlund ◽  
Martin Lauritzen ◽  
...  
Keyword(s):  
Prospective Study ◽  
Birth Cohort ◽  
Healthy Aging ◽  
Male Birth ◽  
A Prospective Study

scholarly journals Diet quality in late midlife is associated with faster walking speed in later life in women, but not men: findings from a prospective British birth cohort

2019 ◽  
Vol 123 (8) ◽  
pp. 913-921 ◽  
Author(s):  
Thanasis G. Tektonidis ◽  
Shelly Coe ◽  
Patrick Esser ◽  
Jane Maddock ◽  
Sarah Buchanan ◽  
...  
Keyword(s):  
Sex Differences ◽  
Diet Quality ◽  
Walking Speed ◽  
Later Life ◽  
Healthy Eating Index ◽  
Healthy Diet ◽  
Linear Regression Models ◽  
Physical Capability ◽  
Age Related ◽  
Late Midlife

AbstractHealthy diet has been linked to better age-related functioning, but evidence on the relationship of diet quality in late midlife and measures of physical capability in later life is limited. Research on potential sex differences in this relationship is scarce. The aim was to investigate the prospective association between overall diet quality, as assessed by the Healthy Eating Index-2015 (HEI-2015) at 60–64 years and measures of walking speed 7 years later, among men and women from the Insight 46, a neuroscience sub-study of the Medical Research Council National Survey of Health and Development. Diet was assessed at 60–64 years using 5-d food diaries, from which total HEI-2015 was calculated. At 69–71 years, walking speed was estimated during four 10-m walks at self-selected pace, using inertial measurement units. Multivariable linear regression models with sex as a modifier, controlling for age, follow-up, lifestyle, health/social variables and physical performance, were used. The final sample consists of 164 women and 167 men (n 331). Women had higher HEI-2015 and slower walking speed than men. A 10-point increase in HEI-2015 was associated with faster walking speed among women (B 0·024, 95 % CI 0·006, 0·043), but not men. The association remained significant in the multivariable model (B 0·021, 95 % CI 0·003, 0·040). In women, higher diet quality in late midlife is associated with faster walking speed. A healthy diet in late midlife is likely to contribute towards better age-related physical capability, and sex differences are likely to affect this relationship.

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