Gingival Crevicular Fluid Levels of Neopterin in Healthy Subjects and in Patients With Different Periodontal Diseases

2007 ◽  
Vol 78 (10) ◽  
pp. 1962-1967 ◽  
Author(s):  
A.R. Pradeep ◽  
Magesh S. Kumar ◽  
M.V. Ramachandraprasad ◽  
Chowdhry Shikha
Keyword(s):  
Healthy Subjects ◽  
Gingival Crevicular Fluid ◽  
Periodontal Diseases ◽  
Crevicular Fluid ◽  
Fluid Levels

scholarly journals Gingival Crevicular Fluid Calprotectin, Osteocalcin and Cross-Linked N-Terminal Telopeptid Levels in Health and Different Periodontal Diseases

2011 ◽  
Vol 31 (6) ◽  
pp. 343-352 ◽  
Author(s):  
Sema Becerik ◽  
Beral Afacan ◽  
Veli Özgen Öztürk ◽  
Harika Atmaca ◽  
Gülnur Emingil
Keyword(s):  
Healthy Subjects ◽  
Gingival Crevicular Fluid ◽  
Periodontal Diseases ◽  
Inflammatory Marker ◽  
Aggressive Periodontitis ◽  
Enzyme Linked Immunosorbent Assay ◽  
Probing Depth ◽  
Crevicular Fluid ◽  
First Time

Aim:The aim of the present study was to investigate gingival crevicular fluid (GCF) calprotectin, osteocalcin and cross-linked N-terminal telopeptide (NTx) levels in health along with different periodontal diseases.Material and methods:Twenty chronic periodontitis (CP), 20 generalized aggressive periodontitis (G-AgP), 20 gingivitis and 20 healthy subjects were included. Probing depth, clinical attachment level, plaque index and papillary bleeding index was recorded. GCF calprotectin, osteocalcin and NTx levels were analyzed by enzyme-linked immunosorbent assay (ELISA).Results:CP, G-AgP and gingivitis groups had higher GCF calprotectin total amount compared to healthy subjects (p< 0.008). CP and G-AgP groups had similar, but higher levels compared to gingivitis groups (p< 0.008). CP and G-AgP groups had lower GCF osteocalcin total amount compared to gingivitis and healthy groups (p< 0.008). CP group had higher GCF NTx but lower osteocalcin total amount and osteocalcin/NTx ratio than the G-AgP group (p< 0.008)Conclusions:Our results suggest that elevated GCF calprotectin levels play a role as a reliable inflammatory marker in the pathogenesis of periodontal disease. Fluctuating GCF levels of osteocalcin and NTx might point out to the abnormal bone turnover in periodontitis. Our data document for the first time the role of NTx in the pathogenesis of different periodontal diseases.

Gingival crevicular fluid levels of RANKL and OPG in periodontal diseases: implications of their relative ratio

2007 ◽  
Vol 34 (5) ◽  
pp. 370-376 ◽  
Author(s):  
Nagihan Bostanci ◽  
Tunc İlgenli ◽  
Gülnur Emingil ◽  
Beral Afacan ◽  
Buket Han ◽  
...  
Keyword(s):  
Gingival Crevicular Fluid ◽  
Periodontal Diseases ◽  
Relative Ratio ◽  
Crevicular Fluid ◽  
Fluid Levels

scholarly journals Are Proteinase 3 and Cathepsin C Enzymes Related to Pathogenesis of Periodontitis?

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Oya Türkoğlu ◽  
Elif Azarsız ◽  
Gülnur Emingil ◽  
Necil Kütükçüler ◽  
Gül Atilla
Keyword(s):  
Gingival Crevicular Fluid ◽  
Periodontal Diseases ◽  
Study Groups ◽  
Aggressive Periodontitis ◽  
Control Group ◽  
Proteinase 3 ◽  
Cathepsin C ◽  
Probing Depth ◽  
Inflammatory Processes ◽  
Crevicular Fluid

Aim. Cathepsin C is the activator of the polymorphonuclear leukocyte-derived proteinase 3, which contributes to inflammatory processes. The aim of the present study was to investigate gingival crevicular fluid (GCF) proteinase 3 and cathepsin C levels in periodontal diseases.Design. Eighteen patients with chronic periodontitis (CP), 20 patients with generalized aggressive periodontitis (G-AgP), 20 patients with gingivitis, and 18 healthy subjects were included in the study. Periodontal parameters including probing depth, clinical attachment level, papilla bleeding index, and plaque index were assessed in all study subjects. GCF proteinase 3 and cathepsin C levels were analyzed by ELISA.Results. GCF proteinase 3 total amount was significantly higher in diseased groups compared to control group, after adjusting ageP<0.05. No differences were found in GCF cathepsin C levels among the study groupsP>0.05. Periodontal parameters of sampling sites were positively correlated with GCF proteinase 3 total amountsP<0.01but not with cathepsin C total amountsP>0.05.Conclusions. Elevated levels of GCF proteinase 3 in CP, G-AgP, and gingivitis might suggest that proteinase 3 plays a role during inflammatory periodontal events in host response. However, cathepsin C in GCF does not seem to have an effect on the pathogenesis of periodontal diseases.

Gingival crevicular fluid levels of MMP-8, MMP-9, TIMP-2, and MPO decrease after periodontal therapy

2010 ◽  
Vol 37 (2) ◽  
pp. 180-190 ◽  
Author(s):  
Andrea M. Marcaccini ◽  
Cesar A. Meschiari ◽  
Leonardo R. Zuardi ◽  
Tiago Sampaio de Sousa ◽  
Mario Taba ◽  
...  
Keyword(s):  
Gingival Crevicular Fluid ◽  
Periodontal Therapy ◽  
Crevicular Fluid ◽  
Fluid Levels
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