Chemical Composition and Antimicrobial Efficiency of Swietenia macrophylla Seed Extract on Clinical Wound Pathogens

Background: Citrullus colocynthis L. (C. colocynthis) is commonly known as colocynth. It belongs to the family Cucurbitaceae that is frequently used in alternative medicine in the north of Africa. The aim of the study: the present research was undertaken to investigate the chemical composition, antioxidant, antiproliferative, and antibacterial potentials of C. colocynthis seed extract. Material and methods: the chemical composition of C. colocynthis seed organic extract was characterized using gas chromatography/mass spectrometry (GC-MS). The antioxidant property was carried out using both β-carotene bleaching and DPPH assays. The antibacterial effect was effectuated using the agar disc diffusion method. The antiproliferative activity vs. human colorectal adenocarcinoma cell line (HT-29) and human breast adenocarcinoma cell line (MDA MB 231) were carried by WST-1 test. The chemical analysis showed the presence of interesting potentially bioactive compounds. The studied plant extract exhibited antioxidant potential with IC50 value of 2. 22 mg/mL (β-carotene bleaching) and 8.98 ± 0.619 mg/mL (DPPH). Concerning the antiproliferative activity, the seed extract was effective in MDA-MB-231 and HT-29 cancer cells with IC50 values 86.89 ± 3.395 and 242.1 ± 17.9 μg/mL, respectively, whilst the extract of Citrullus colocynthis seeds was non-toxic in healthy human dermal fibroblasts. Regarding the antibacterial test, the extract was effective in Gram-positive bacteria only. Conclusion: The outcome of this research indicated that the extracts from C. colocynthis seeds may compose a promising source with interesting compounds that can be used to fight cancer, free radicals damage, and bacterial infections.

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Chemical composition of white currant seed extract

Journal of the Serbian Chemical Society ◽

10.2298/jsc110617132g ◽

2011 ◽

Vol 76 (11) ◽

pp. 1465-1470 ◽

Cited By ~ 2

Author(s):

Dejan Godjevac ◽

Vlatka Vajs ◽

Slobodan Milosavljevic ◽

Boban Djordjevic ◽

Gordana Zdunic ◽

...

Keyword(s):

Chemical Composition ◽

Seed Extract ◽

Spectral Studies ◽

Dihydrophaseic Acid

From the seeds of white currant (Ribes rubrum, cv. White Champagne), a new sesquiterpenoid glucoside (1) was isolated, along with two known compounds: dihydrophaseic acid 3?-O-?-Dglucopyranoside (2), and 3-carboxymethyl-indole-1-N-?-Dglucopyranoside (3). The structure of the new compound was identified as dihydrophaseic acid 3?-O-?-D-glucopyranosyl-1,6-?-D-glucopyranoside, based on extensive NMR and MS spectral studies.

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Antioxidative and hypolipidemic efficacy of alcoholic seed extract of Swietenia macrophylla in streptozotocin diabetic rats

Journal of Basic and Clinical Physiology and Pharmacology ◽

10.1515/jbcpp.2011.001 ◽

2011 ◽

Vol 22 (1-2) ◽

Cited By ~ 7

Author(s):

Kalaivanan Kalpana ◽

Kodukkur Viswanathan Pugalendi

Keyword(s):

Diabetic Rats ◽

Seed Extract ◽

Swietenia Macrophylla ◽

Streptozotocin Diabetic Rats

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Near infrared hyperspectral imaging and MCR-ALS applied for mapping chemical composition of the wood specie Swietenia Macrophylla King (Mahogany) at microscopic level

Microchemical Journal ◽

10.1016/j.microc.2015.09.022 ◽

2016 ◽

Vol 124 ◽

pp. 356-363 ◽

Cited By ~ 13

Author(s):

Carla J.G. Colares ◽

Tereza C.M. Pastore ◽

Vera T.R. Coradin ◽

Luiz F. Marques ◽

Alessandro C.O. Moreira ◽

...

Keyword(s):

Chemical Composition ◽

Hyperspectral Imaging ◽

Near Infrared ◽

Microscopic Level ◽

Swietenia Macrophylla

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Phytotoxicity of Schiekia timida Seed Extracts, a Mixture of Phenylphenalenones

Molecules ◽

10.3390/molecules26144197 ◽

2021 ◽

Vol 26 (14) ◽

pp. 4197

Author(s):

Fernanda Maria Marins Ocampos ◽

Ana Julia Borim de Souza ◽

Guilherme Medeiros Antar ◽

Felipe Christoff Wouters ◽

Luiz Alberto Colnago

Keyword(s):

Chemical Composition ◽

Methanolic Extract ◽

Biological Activities ◽

Germination Rate ◽

Seed Extract ◽

Hypocotyl Growth ◽

Specialized Metabolites ◽

Phytotoxic Effect ◽

First Time ◽

Seed Extracts

Phenylphenalenones, metabolites found in Schiekia timida (Haemodoraceae), are a class of specialized metabolites with many biological activities, being phytoalexins in banana plants. In the constant search to solve the problem of glyphosate and to avoid resistance to commercial herbicides, this work aimed to investigate the phytotoxic effect of the methanolic extract of S. timida seeds. The chemical composition of the seed extract was directly investigated by NMR and UPLC-QToF MS and the pre- and post-emergence phytotoxic effect on a eudicotyledonous model (Lactuca sativa) and a monocotyledonous model (Allium cepa) was evaluated through germination and seedling growth tests. Three concentrations of the extract (0.25, 0.50, and 1.00 mg/mL) were prepared, and four replicates for each of them were analyzed. Three major phenylphenalenones were identified by NMR spectroscopy: 4-hydroxy-anigorufone, methoxyanigorufone, and anigorufone, two of those reported for the first time in S. timida. The presence of seven other phenylphenalenones was suggested by the LC-MS analyses. The phenylphenalenone mixture did not affect the germination rate, but impaired radicle and hypocotyl growth on both models. The effect in the monocotyledonous model was statistically similar to glyphosate in the lowest concentration (0.25 mg/mL). Therefore, although more research on this topic is required to probe this first report, this investigation suggests for the first time that phenylphenalenone compounds may be post-emergence herbicides.

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Preliminary Phytochemical Screening and Bioactive Compounds of Swietenia macrophylla Seed Support T1DM and T2DM

Journal of Natural Products and Resources ◽

10.30799/jnpr.099.21070102 ◽

2021 ◽

Vol 7 (1) ◽

pp. 267-271

Author(s):

M. Chandrabalan Kamaraj ◽

Ramakrishnan Akshaya ◽

Dandapani Sudhakaran Iyer

Keyword(s):

Antioxidant Activity ◽

Molecular Docking ◽

Free Radical ◽

Radical Scavenging ◽

Docking Studies ◽

Free Radical Scavenging ◽

Seed Extract ◽

Phytochemical Screening ◽

Swietenia Macrophylla ◽

Molecular Docking Studies

The purpose of this study was to investigate the antidiabetic effect of phytocompounds from Swietenia macrophylla seed using preliminary phytochemical screening, invitro antioxidant activity and molecular docking studies. The powdered seed extract of Swietenia macrophylla was to investigate the phytochemical screening exhibited the presence of alkaloid, phenols, tannins, flavonoids, terpenoids, steroids, carbohydrates, amino acids and proteins as major active constituents. The antioxidant activity of Swietenia macrophylla seed was evaluated by DPPH free radical scavenging assay. Rutin was used as a reference compound. The Swietenia macrophylla seed exhibited 56.0471% of free radical scavenging activity as compared with rutin. The molecular docking studies performed by using molecular docking server online respectively in which the antidiabetic target namely glutamine:fructose-6-phosphate amidotransferase (GFAT) (PDB id: 2ZJ3) have a potential interaction with swietenine, swietenolide, β-sitosterol, and fucosterol. In this study, the protein glutamine:fructose-6-phosphate amidotransferase (GFAT) was used from its structure perspectives. Its primary and secondary structures were evaluated using online tools. Its role in antidiabetic was assessed by molecular docking the compounds present in the seed extract of Swietenia macrophylla assayed by GC-MS analysis. This in-silico study demonstrates the interactions of active components of Swietenia macrophylla against Type I and Type II diabetes.

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