scholarly journals Serum vitamin D content in children with SARS-CoV-2 infection

2021 ◽  
Vol 6 ◽  
pp. 79-82
Author(s):  
V.N. Peregoedova ◽  
◽  
I.K. Bogomolova ◽  
Keyword(s):  
Vitamin D ◽  
Serum Level ◽  
Clinical Symptoms ◽  
Serum Vitamin ◽  
Serum Levels ◽  
Control Group ◽  
Immunochemical Method ◽  
Hydroxyvitamin D ◽  
Serum Vitamin D ◽  
25 Hydroxyvitamin D

Aim of study. To study the total level of 25-hydroxyvitamin D in children with SARS-CoV-2 infection (COVID-19). Material and мethods. A total of 82 children aged 0-17 diagnosed with SARS-CoV-2 infection were enrolled. Depending on the severity of clinical symptoms, all children were divided into three groups according to the COVID-19 severity: asymptomatic, mild and moderate. The serum level of vitamin D in all patients was tested via the immunochemical method. Results. It was found that children with SARS-CoV-2 infection had lower serum level of vitamin D (29.92 [22.22; 28.07] ng/ml) as compared with the control group (36.43 [32.05; 44.08] ng/ml; p<0.001). A total of 90% of the children with SARS-CoV-2 infection were diagnosed with insufficiency or deficiency of vitamin D (<30 ng/ml). Only 10 % of the patients had normal levels of vitamin D. The insufficiency of vitamin D was found more often amongst children aged 0-11 and deficiency of total 25-hydroxyvitamin D was more common for children aged 12-17. The difference in serum levels of vitamin D depending on the severity of SARS-CoV-2 infection was not found. Male children with SARS-CoV-2 infection showed lower levels of vitamin D (p=0.013). Conclusion. A total of 90 % of the children with SARS-CoV-2 infection had insufficiency or deficiency of vitamin D regardless of the severity of clinical symptoms.

scholarly journals Association of 25-hydroxyvitamin D, Cyclooxygenase-2 and Prostaglandin E2 Serum Levels in Breast Cancer Patients

2021 ◽  
Vol 13 (4) ◽  
pp. 426-32
Author(s):  
Theresia Ilyan ◽  
Dwi Retnoningrum ◽  
Meita Hendrianingtyas ◽  
Dian Widyaningrum ◽  
Banundari Rachmawati
Keyword(s):  
Breast Cancer ◽  
Vitamin D ◽  
Serum Level ◽  
Prostaglandin E2 ◽  
Serum Vitamin ◽  
Serum Levels ◽  
Cyclooxygenase 2 ◽  
Hydroxyvitamin D ◽  
Serum Vitamin D ◽  
25 Hydroxyvitamin D

BACKGROUND: Serum levels of 25-hydroxyvitamin D (25(OH)D), prostaglandin E2 (PGE2), and cyclooxygenase 2 (COX2) expression differ between breast cancer stages. Since, previous studies showed mixed results, in this study, we aimed to analyze vitamin D levels related to breast cancer stages and serum levels of COX2 and PGE2 in Indonesia.METHODS: This was a cross sectional study involving 75 breast cancer patients. Subjects were divided into 3 groups, namely operable early stage (K1), locally advanced stage (K2), and advanced stage (K3). Venous blood samples were taken from each subject, then were analyzed for the 25(OH)D, COX2, and PGE2 serum levels by enzyme-linked immunosorbent assay (ELISA) method.RESULTS: There were significant differences in 25(OH)D among groups (p=0.012); between K1 and K2 (p=0.009) and between K1 and K3 (p=0.023). However, there was no significant difference in serum COX2 level (p=0.328). There were significant differences of PGE2 among groups (p=0.002); between K1 and K2 (p=0.036) and between K1 and K3 (p=0.001). Correlation test showed that there were differences between 25(OH)D serum levels and PGE2 serum level (r=0.306, p=0.008) and also between 25(OH)D serum level and breast cancer stage (r=-0.229; p=0.048).CONCLUSION: There were differences in serum Vitamin D and PGE2 levels at various stages of breast cancer. Serum 25(OH)D levels had weak correlation with breast cancer stage and PGE2 serum level. Serum vitamin D level in advanced breast cancer were lower than early stage breast cancer and indicate a poor prognosis.KEYWORDS: breast cancer, 25-hydroxyvitamin D, cyclooxygenase 2, prostaglandin E2

scholarly journals Maternal Serum 25-Hydroxy Vitamin D Concentrations and Calcium Levels in Preeclamptic Women, Sindh, Pakistan

2021 ◽  
pp. 216-221
Author(s):  
Khalil Ahmed Memon ◽  
Hazoora Shaikh ◽  
Rukhsana Soomoro ◽  
Yasmeen Joyo ◽  
Saira Parveen ◽  
...  
Keyword(s):  
Vitamin D ◽  
Pregnant Women ◽  
Multinomial Logistic Regression ◽  
Serum Vitamin ◽  
Maternal Serum ◽  
Control Group ◽  
Case Group ◽  
Hydroxyvitamin D ◽  
Serum Vitamin D ◽  
25 Hydroxyvitamin D

Objectives: To analyse the levels of serum 25-hydroxyvitamin D 25(OH) Dand calcium concentrations in patients with pre-eclampsia, Hyderabad, Sindh, Pakistan. Methodology: Cross sectional study was conducted at the Gynaecology and Obstetrics Department, LUHS, Hyderabad during the period of January 2020 to June 2020. Total 150 pregnant women were selected according to predesign Proforma and divided into two groups. 50 females were normal normotensive pregnant women as a control group, 100 were pre-eclamptic patients as case group. Obstetric history, clinical data was gathered and then 5ml of blood sample was collected from each patient. The blood samples were taken for the analysis of 25-hydroxyvitamin D or 25(OH)D and calcium levels. 25(OH)D were performed on chemiluminescence, While calcium concentration of Microlab 300. Data was analysed by using SPSS version 23. Student t-test was used for analysed of continuous variables. Results: The maternal serum vitamin D and calcium levels were significantly decreased as compared to patient with preeclampsia and normotensive healthy pregnant ladies. The blood pressure also declined in case group with P<0.001.Multinomial logistic regression showed significant odd ratio of Vitamin-D and Calcium deficiency in preeclampsia. Conclusion: The present study reveals that 25-hydroxyvitamin D, and Calcium levels declined significantly in preeclamptic women, and mighty be biomarker of this life threating disease.

scholarly journals Serum Vitamin D as a Biomarker in Autoimmune, Psychiatric and Neurodegenerative Diseases

Diagnostics ◽  
2022 ◽  
Vol 12 (1) ◽  
pp. 130
Author(s):  
Giulia Bivona ◽  
Caterina Maria Gambino ◽  
Bruna Lo Sasso ◽  
Concetta Scazzone ◽  
Rosaria Vincenza Giglio ◽  
...  
Keyword(s):  
Vitamin D ◽  
Autoimmune Diseases ◽  
Serum Vitamin ◽  
Serum Levels ◽  
Hydroxyvitamin D ◽  
Serum Vitamin D ◽  
Immune Mediated ◽  
Calcium Phosphorus ◽  
25 Hydroxyvitamin D ◽  
Meta Analyses

Vitamin D is a steroid hormone regulating calcium-phosphorus homeostasis, immune response and brain function. In the past thirty years, an increasing number of cohort studies, meta-analyses and randomized controlled trials (RTCs) evaluated the serum levels of 25-hydroxyvitamin D [25(OH)D], which is considered the Vitamin D status biomarker, in patients affected by neurological, psychiatric and autoimmune diseases. Although an association between low 25(OH)D serum levels and the prevalence of these diseases has been found, it is still unclear whether the serum 25(OH)D measurement can be clinically useful as a biomarker for diagnosis, prognosis and predicting treatment response in neurodegeneration, mental illness and immune-mediated disorders. The lack of standardized data, as well as discrepancies among the studies (in the analytical methods, cut-offs, endpoints and study sets), weakened the findings achieved, hindered pooling data, and, consequently, hampered drawing conclusions. This narrative review summarizes the main findings from the studies performed on serum 25(OH)D in neurological, psychiatric and autoimmune diseases, and clarifies whether or not serum 25(OH)D can be used as a reliable biomarker in these diseases.

scholarly journals Study on Serum Vitamin D in Alopecia Areata Patients

2019 ◽  
Vol 17 (01) ◽  
pp. 21-25
Author(s):  
Suchana Marahatta ◽  
Sudha Agrawal ◽  
Seraj Khan
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Alopecia Areata ◽  
Serum Vitamin ◽  
Control Group ◽  
Healthy Controls ◽  
Hydroxyvitamin D ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
25 Hydroxyvitamin D

Background: Alopecia areata is the commonest cause of non-scarring alopecia. Few previous studies have found correlation between AA and vitamin D deficiency, suggesting that vitamin D deficiency can be a risk factor for Alopecia areata. To compare serum vitamin D level between Alopecia areata patients and healthy controls; and to assess the relation between serum vitamin D levels and AA disease severity.Methods: This case control study included 30 newly diagnosed Alopecia areata patients. Thorough history was taken, detail examination was done and relevant findings were recorded in the standardized pro-forma. Their serum vitamin D (25-hydroxyvitamin D) levels were determined by competitive chemiluminescence methods; and were compared with that of age and sex matched healthy controls. Chi square test and Spearman’s rho correlation test were used for the inferential statistics using SPSS version 11.5. Results: There were 30 AA patients with mean age 28.37+10.07 years. Mean Severity of Alopecia Tool score was 3.56+3.50. Prevalence of 25-hydroxyvitamin D [25(OH)D] deficiency was significantly higher in AA group (83.3%) compared to the control group (53.3%) (P=0.01). Similarly, serum 25(OH)D level was reduced more in Alopecia areata group (12.84, IQR=8.87-20.47) than the control group (29.5, IQR=19.85-41.27) (P=0.06). There was inverse co-relation between serum 25(OH)D level and SALT score.Conclusions: Prevalence of serum 25(OH)D deficiency was significantly higher in Alopecia areata group compared to the control, with inverse co-relation between its level and Alopecia areata disease severity. Keywords: Alopecia areata; Nepal; SALT Score; Vitamin D.

Effect of Narrowband Ultraviolet B Therapy on Serum Vitamin D and Cathelicidin (LL-37) in Patients with Chronic Plaque Psoriasis

2014 ◽  
Vol 18 (1) ◽  
pp. 43-48 ◽  
Author(s):  
Nawaf Al-Mutairi ◽  
Dalia Shaaban
Keyword(s):  
Vitamin D ◽  
Critical Role ◽  
Serum Vitamin ◽  
Serum Levels ◽  
Ultraviolet B ◽  
Chronic Plaque Psoriasis ◽  
Hydroxyvitamin D ◽  
Serum Vitamin D ◽  
Before And After ◽  
25 Hydroxyvitamin D

Background: Narrowband ultraviolet B (NB-UVB) has been widely used in the treatment of psoriasis. It has been shown that vitamin D is a major regulator of the expression of human antimicrobial peptide cathelicidin LL-37, which has a critical role in inflammatory cascade in psoriasis. Objective: To evaluate the effect of NB-UVB therapy on serum levels of cathelicidin LL-37 and 25-hydroxyvitamin D [25(OH)D] in psoriasis patients. Methods: Ninety-three psoriasis patients and 50 controls were included in the study. For psoriasis patients, serum levels of 25(OH)D and cathelicidin LL-37 were estimated before and after NB-UVB therapy. Results: Before treatment, serum 25(OH)D levels were significantly lower in psoriasis patients (31.5 ± 14.41 nmol/L) compared to controls (53.5 ± 19.6 nmol/L), p = .015. In contrast, serum LL-37 was significantly higher in psoriasis patients (13.24 ± 3.2 ng/mL) than in controls (7.92 ± 5.33 ng/mL), p < .001. After NB-UVB treatment, there was a highly significant elevation of serum 25(OH)D to reach 56.85 ± 5.2 nmol/L ( p < .001) and further elevation of serum LL-37 to reach 29.4 ± 4.2 ( p = .02). Conclusions: The elevation of serum 25(OH)D and cathelicidin LL-37 could be an additional possible mechanism of action of NB-UVB therapy in the treatment of psoriasis.

scholarly journals Relationship between serum 25-hydroxyvitamin D, total antioxidant capacity and pneumonia incidence, severity and outcome in Nigerian children

2020 ◽  
Vol 14 (1) ◽  
Author(s):  
Bankole Peter Kuti ◽  
Alex Ifeoluwa Akinwumi ◽  
Demilade Kehinde Kuti ◽  
Kazeem Olanrewaju Amoo
Keyword(s):  
Vitamin D ◽  
Total Antioxidant Capacity ◽  
Serum Vitamin ◽  
Severe Pneumonia ◽  
Lower Serum ◽  
Hydroxyvitamin D ◽  
Serum Vitamin D ◽  
Nigerian Children ◽  
Total Antioxidant ◽  
25 Hydroxyvitamin D

Abstract Background The pathologic basis of childhood community-acquired pneumonia (CAP) involves the generation of reactive oxygen species by immune cells leading to cellular damage and lung congestion. Serum antioxidants and vitamin D with immunomodulatory properties therefore hold prospects in the prevention and management of pneumonia in children. This case–control study set out to compare the serum 25-hydroxyvitamin D (25-OHD) and total antioxidant capacity (TAC) in Nigerian children with CAP and age- and sex-matched controls and to relate these parameters with pneumonia severity and outcome—length of hospital stay (LOH). Results A total of 160 children (80 each for CAP and controls) were recruited. The median (IQR) age was 1.8 (0.6–4.0) years, male:female 1.7:1, 63 (78.8%) and 11 (13.8%) of CAP group had severe pneumonia and parapneumonic effusions, respectively. Serum 25-OHD (33.8 (18.3) ng/ml vs. 41.9 (12.3) ng/ml; p = 0.010) and TAC (6.1 (4.4–8.1) ng/dl vs. 7.2 (4.7–17.5) ng/dl; p = 0.023) were lower in children with CAP than controls. Lower serum 25-OHD was observed in severe than non-severe pneumonia (30.5(17.1) ng/ml vs. 46.3 (17.6) ng/ml; p = 0.001) but LOH did not correlate with serum 25-OHD and TAC. Conclusion Children with CAP had lower serum vitamin D and antioxidants than controls, and severe pneumonia was significantly associated with suboptimal serum vitamin D. They however were not related to pneumonia outcome. Optimal serum vitamin D and antioxidants may play a role in reducing the incidence of childhood CAP in Nigerian children.

Variation of circulating 25-Hydroxyvitamin D levels with life style in a cohort group in Sri Lanka

2019 ◽  
Vol 49 (4) ◽  
pp. 506-516 ◽  
Author(s):  
Shirani Ranasinghe ◽  
Thilak Jayalath ◽  
Sampath Thennakoon ◽  
Ranjith Jayasekara ◽  
Ran Shiva ◽  
...  
Keyword(s):  
Vitamin D ◽  
Sri Lanka ◽  
Feeding Habits ◽  
Serum Vitamin ◽  
Healthy Adults ◽  
Vitamin D Status ◽  
Content Type ◽  
Hydroxyvitamin D ◽  
Serum Vitamin D ◽  
25 Hydroxyvitamin D

Purpose Purpose of this study is to measure the Vitamin D status of healthy adults and to correlate with their lifestyle and feeding habits. Plasma 25-Hydroxyvitamin D (25(OH)D) is the most common marker of vitamin D status of an individual. Deficiency of vitamin D is defined as the serum level less than 20 ng/mL and insufficiency as 30 ng/mL which can be prevented. Design/methodology/approach Vitamin D status of healthy adults (n = 82), both male and females between the age of 18 – 50 years who were attending to the National Transport Authority, Kandy, Sri Lanka from February to March 2016, was measured and correlated with their lifestyle, feeding habits, etc. Findings The mean total serum D (25(OH)D in this study was 40.15 ± 3.74 nmol/l with the mean value of 42.8 ± 28.8 and 37.5 ± 16.6 for women and men, respectively. The serum calcium levels of both female and male were around 8 mg/dl and the serum total protein was 6.5 and 7 g/dl in women and men, respectively. The serum Vitamin D, calcium and total protein were not statistically significantly different between the sexes. In this study, 84 per cent of the total subjects were normocalcemic, and there was no significant relationship between vitamin D levels and their calcium levels. Research limitations/implications This study demonstrates that there was no statistically significant correlation between the serum vitamin D with age, serum calcium or total proteins. The majority of participants who had exposure to the sunlight more than 30 mins/day had sufficient level of vitamin D and less than 30 min/day exposure had deficiency of vitamin D. Daily intake of multivitamin influenced vitamin D status of the study group. Practical implications These findings will implicate the importance of cultural, feed and social habits for the nutritional status of an individual.and there are no reported studies on vitamin D status with reference to the variation of life style. Social implications It is very important to investigate the factors affecting to the vitamin D status of a population as such, vitamin D insufficiency or deficiency can be prevented. In Sri Lanka, the population is consisting with many ethnic groups, different ethnic groups may find some nutritional problems according to their main cultural habits. Originality/value The objectives of this study are to evaluate the Vitamin D status in a group of healthy adults between 20 and 50 years in both men and women and to find out the correlation of their vitamin D status with their lifestyle and feeding habits, etc.

scholarly journals Seasonal variation of idiopathic benign paroxysmal positional vertigo correlates with serum 25-hydroxyvitamin D levels: a six-year registry study in Shanghai, China

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Liang Shu ◽  
Jing Wu ◽  
Chun-Yan Jiang ◽  
Xu-Hong Sun ◽  
Hui Pan ◽  
...  
Keyword(s):  
Vitamin D ◽  
Benign Paroxysmal Positional Vertigo ◽  
Serum Vitamin ◽  
Chinese Patients ◽  
Hydroxyvitamin D ◽  
Serum Vitamin D ◽  
Positional Vertigo ◽  
Vitamin D Levels ◽  
25 Hydroxyvitamin D ◽  
Paroxysmal Positional Vertigo

Abstract Seasonal variation of benign paroxysmal positional vertigo (BPPV) occurrence has been reported in recent years. Whether the seasonality of BPPV also exists in Chinese patients and whether it correlates with serum vitamin D levels is unexplored. We retrospectively analyzed the data of 1269 new-onset idiopathic BPPV patients registered in our vertigo outpatient clinic over a six-year period. Additionally, serum 25-hydroxyvitamin D levels during this period were measured in 877 patients by chemiluminescence immunoassay. We delineated the changing trend of the monthly BPPV patient numbers and serum 25-hydroxyvitamin D levels, and the correlation between them was explored. December to next March is the top 4 months with higher BPPV patient numbers. The median BPPV patient numbers in winter group were higher than those in summer group (20 vs. 16 patients, p < 0.05). Median 25-hydroxyvitamin D levels in winter group were much lower than those in summer group (16.3 vs. 20.8 ng/ml, p < 0.001) and autumn group (16.3 vs. 19.3 ng/ml, p < 0.05). A moderate negative correlation was observed between median serum 25-hydroxyvitamin D levels and BPPV patient numbers each month. The onset of BPPV also shows a seasonal fluctuation in Chinese patients. This phenomenon may be related to serum vitamin D levels.

scholarly journals Association between vitamin D concentrations and knee pain in patients with osteoarthritis

PeerJ ◽  
2018 ◽  
Vol 6 ◽  
pp. e4670 ◽  
Author(s):  
Murat Cakar ◽  
Semih Ayanoglu ◽  
Haluk Cabuk ◽  
Metin Seyran ◽  
Suleyman Semih Dedeoglu ◽  
...  
Keyword(s):  
Vitamin D ◽  
Knee Pain ◽  
Clinical Symptoms ◽  
Serum Vitamin ◽  
Womac Score ◽  
Mean Values ◽  
Hydroxyvitamin D ◽  
Serum Vitamin D ◽  
Knee Oa ◽  
Grade 3

Objectives Osteoarthritis (OA) and vitamin D deficiency are common health conditions in older people. Whether vitamin D concentration is associated with knee OA is controversial. In this study, we aimed to determine the association between serum concentrations of vitamin D and osteoarthritic knee pain. Subjects and Methods Vitamin D concentrations were measured with the 25 hydroxyvitamin D test in patients presenting with clinical symptoms of primary knee osteoarthritis. Osteoarthritis was graded on the Kellgren-Lawrence grading scale from anteroposterior and lateral radiographs. Height, weight, and body mass index (BMI) were recorded. Patients completed a 10-cm visual analogue scale (VAS) for indicating pain and the Western Ontario and McMaster Universities Arthritis Index (WOMAC). Vitamin D concentration was defined as severely deficient (<10 ng/mL), insufficient (10 to 19 ng/mL), or normal (20 to 50 ng/mL). Results Of 149 patients (133 women), the mean age was 63.6 years. Mean vitamin D concentration was 11.53 ng/mL, and 90% patients were vitamin D deficient. Mean WOMAC score was 57.2, and VAS pain score was 7.5. Kellgren-Lawrence grade was 2 for 10 patients, grade 3 for 61, and grade 4 for 88. Mean BMI was 33.4. Mean values of VAS, WOMAC, and BMI did not differ by vitamin D status. Conclusion Serum vitamin D concentration is not associated with knee pain in patients with osteoarthritis.

scholarly journals Association between Vitamin D Concentrations and Knee Pain in Patients with Osteoarthritis

2017 ◽  
Vol 5 (2_suppl2) ◽  
pp. 2325967117S0008
Author(s):  
Murat Çakar ◽  
Semih Ayanoğlu ◽  
Haluk Çabuk ◽  
Metin Seyran ◽  
Süleyman Semih Dedeoğlu ◽  
...  
Keyword(s):  
Vitamin D ◽  
Knee Pain ◽  
Clinical Symptoms ◽  
Serum Vitamin ◽  
Womac Score ◽  
Mean Values ◽  
Hydroxyvitamin D ◽  
Serum Vitamin D ◽  
Knee Oa ◽  
Grade 3

Objectives: Osteoarthritis (OA) and vitamin D deficiency are common health conditions in older people. Whether vitamin D concentration is associated with knee OA is controversial. In this study, we aimed to determine the association between serum concentrations of vitamin D and osteoarthritic knee pain. Subjects and Methods: Vitamin D concentrations were measured with the 25 hydroxyvitamin D test in patients presenting with clinical symptoms of primary knee osteoarthritis. Osteoarthritis was graded on the Kellgren-Lawrence grading scale from anteroposterior and lateral radiographs. Height, weight, and body mass index (BMI) were recorded. Patients completed a 10-cm visual analogue scale (VAS) for indicating pain and the Western Ontario and McMaster Universities Arthritis Index (WOMAC). Vitamin D concentration was defined as severely deficient (<10 ng/mL), insufficient (10 to 19 ng/mL), or normal (20 to 50ng/mL). Results: Of 149 patients (133 women) the mean age was 63.6 years. Mean vitamin D concentration was 11.53 ng/mL, and 90% patients were Vitamin D deficient. Mean WOMAC score was 57.2, and VAS pain score was 7.5. Kellgren-Lawrence grade was 2 for 10 patients grade 3 for 61, and grade 4 for 88. Mean BMI was 33.4. Mean values of VAS, WOMAC, and BMI did not differ by vitamin D status. Conclusion: Serum vitamin D concentration is not associated with knee pain in patients with osteoarthritis.

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