scholarly journals Effect of Manufacturing and Absorption Promotion of Lidocaine Hydrogel Using Ultrasonic Waves during Cosmetic Procedures

2021 ◽  
Vol 19 (4) ◽  
pp. 619-626
Author(s):  
Sol-Hui Song ◽  
Hoon Kim
Keyword(s):  
Ultrasonic Treatment ◽  
Hplc Analysis ◽  
Skin Penetration ◽  
Ultrasonic Waves ◽  
Viscosity Measurement ◽  
Ultrasound Treatment ◽  
Skin Permeability ◽  
Gelation Rate ◽  
Ultrasound Parameters ◽  
Permeability Experiment

Purpose: In this study, we study to more effectively use anesthesia products used in beauty procedures following the popularization of anti-aging. Hydrogel, which contains lidocaine, is believed to be more effective in relieving pain if used in cosmetic procedures with ultrasonic waves.Methods: The availability of manufactured hydrogels and commercial gels for ultrasonic treatment was compared, and the effect on skin penetration and skin penetration due to ultrasonic limitations was evaluated based on their applicability. Usability and optimal ultrasound parameters were identified during ultrasound treatment.Results: Viscosity measurement, gelation rate, swelling, skin permeability experiment, and HPLC analysis of manufactured hydrogels all revealed properties, with skin permeability being highest at frequency 1 MHz, cycle low 200, and high 50.Conclusions: Finally, hydrogels containing lidocaine increased skin permeability during ultrasound treatment, allowing for faster targeted transdermal transmission that was more effective depending on the ultrasound parameters. As a result, it is determined that it can be used in cosmetic procedures.

scholarly journals Dermal Delivery of the High-Molecular-Weight Drug Tacrolimus by Means of Polyglycerol-Based Nanogels

Pharmaceutics ◽  
2019 ◽  
Vol 11 (8) ◽  
pp. 394 ◽  
Author(s):  
Fiorenza Rancan ◽  
Hildburg Volkmann ◽  
Michael Giulbudagian ◽  
Fabian Schumacher ◽  
Jessica Isolde Stanko ◽  
...  
Keyword(s):  
Ex Vivo ◽  
Skin Barrier ◽  
Skin Penetration ◽  
Jurkat Cells ◽  
Skin Permeability ◽  
Enzyme Linked Immunosorbent Assay ◽  
Hydration Properties ◽  
Tacrolimus Ointment ◽  
Proliferative Effect ◽  
Inflammatory Conditions

Polyglycerol-based thermoresponsive nanogels (tNGs) have been shown to have excellent skin hydration properties and to be valuable delivery systems for sustained release of drugs into skin. In this study, we compared the skin penetration of tacrolimus formulated in tNGs with a commercial 0.1% tacrolimus ointment. The penetration of the drug was investigated in ex vivo abdominal and breast skin, while different methods for skin barrier disruption were investigated to improve skin permeability or simulate inflammatory conditions with compromised skin barrier. The amount of penetrated tacrolimus was measured in skin extracts by liquid chromatography tandem-mass spectrometry (LC-MS/MS), whereas the inflammatory markers IL-6 and IL-8 were detected by enzyme-linked immunosorbent assay (ELISA). Higher amounts of tacrolimus penetrated in breast as compared to abdominal skin or in barrier-disrupted as compared to intact skin, confirming that the stratum corneum is the main barrier for tacrolimus skin penetration. The anti-proliferative effect of the penetrated drug was measured in skin tissue/Jurkat cells co-cultures. Interestingly, tNGs exhibited similar anti-proliferative effects as the 0.1% tacrolimus ointment. We conclude that polyglycerol-based nanogels represent an interesting alternative to paraffin-based formulations for the treatment of inflammatory skin conditions.

scholarly journals Grape Cane Extracts as Multifunctional Rejuvenating Cosmetic Ingredient: Evaluation of Sirtuin Activity, Tyrosinase Inhibition and Bioavailability Potential

Molecules ◽  
2020 ◽  
Vol 25 (9) ◽  
pp. 2203
Author(s):  
Magdalena Anna Malinowska ◽  
Kévin Billet ◽  
Samantha Drouet ◽  
Thibaut Munsch ◽  
Marianne Unlubayir ◽  
...  
Keyword(s):  
Hplc Analysis ◽  
Major Constituent ◽  
Skin Permeability ◽  
Waste Biomass ◽  
Inhibition Assay ◽  
Tyrosinase Inhibition ◽  
Skin Whitening ◽  
Cosmetic Ingredients ◽  
Grape Varieties ◽  
Activation Capacity

Grape canes are waste biomass of viticulture containing bioactive polyphenols valuable in cosmetics. Whereas several studies reported the cosmetic activities of E-resveratrol, only few described the potential of E-ε-viniferin, the second major constituent of grape cane extracts (GCE), and none of them investigated GCE as a natural blend of polyphenols for cosmetic applications. In this study, we considered the potential of GCE from polyphenol-rich grape varieties as multifunctional cosmetic ingredients. HPLC analysis was performed to quantify major polyphenols in GCE i.e., catechin, epicatechin, E-resveratrol, E-piceatannol, ampelopsin A, E-ε-viniferin, hopeaphenol, isohopeaphenol, E-miyabenol C and E-vitisin B from selected cultivars. Skin whitening potential through tyrosinase inhibition assay and the activation capacity of cell longevity protein (SIRT1) of GCE were compared to pure E-resveratrol and E-ε-viniferin. Drug-likeness of GCE polyphenols were calculated, allowing the prediction of skin permeability and bioavailability. Finally, the present data enabled the consideration of GCE from polyphenol-rich varieties as multifunctional cosmetic ingredients in accordance with green chemistry practices.

Changes of Mechanical and Thermal Properties of Cranberries Subjected to Ultrasound Treatment

2017 ◽  
Vol 13 (6) ◽  
Author(s):  
Malgorzata Nowacka ◽  
Aleksandra Fijalkowska ◽  
Artur Wiktor ◽  
Katarzyna Rybak ◽  
Magdalena Dadan ◽  
...  
Keyword(s):  
Thermal Properties ◽  
Ultrasonic Treatment ◽  
Dry Matter ◽  
Sucrose Solution ◽  
Matter Content ◽  
Ultrasound Treatment ◽  
Steviol Glycosides ◽  
Mechanical And Thermal Properties ◽  
Dry Matter Content ◽  
Osmotic Solution

Abstract The aim of the study was to investigate the effect of ultrasound treatment in osmotic solution, carried out at different time and solutions, on mechanical and thermal properties of cranberries. Ultrasound treatment was applied for 30 and 60 min in liquid mediums such as 61.5 % sucrose solution and 30 % sucrose solution with 0.1 % steviol glycosides addition. Before the ultrasound treatment samples were subjected to traditional operations (cutting, blanching). The traditional operations and ultrasonic treatment of whole fruits did not influence or slightly influenced dry matter content and mechanical properties. The cutting had impact on thermal properties to the highest extent due to the exposition of fruits’ flesh. The combination of cutting and sonication decreased thermal conductivity which suggests that mass transfer was more pronounced. The sonication had greater influence when compared to only ultrasonic treatment. Combined both cutting and blanching with ultrasonic treatment led to greater changes in cranberries properties.

Vehicle effects on human stratum corneum absorption and skin penetration

2016 ◽  
Vol 33 (5) ◽  
pp. 416-425 ◽  
Author(s):  
Alissa Zhang ◽  
Eui-Chang Jung ◽  
Hanjiang Zhu ◽  
Ying Zou ◽  
Xiaoying Hui ◽  
...  
Keyword(s):  
Benzoic Acid ◽  
Stratum Corneum ◽  
Skin Penetration ◽  
Chemical Exposure ◽  
Lipid Absorption ◽  
Percutaneous Penetration ◽  
Skin Permeability ◽  
Isopropyl Myristate ◽  
Skin Absorption ◽  
Lipid Film

This study evaluated the effects of three vehicles—ethanol (EtOH), isopropyl alcohol (IPA), and isopropyl myristate (IPM)—on stratum corneum (SC) absorption and diffusion of the [14C]-model compounds benzoic acid and butenafine hydrochloride to better understand the transport pathways of chemicals passing through and resident in SC. Following application of topical formulations to human dermatomed skin for 30 min, penetration flux was observed for 24 h post dosing, using an in vitro flow-through skin diffusion system. Skin absorption and penetration was compared to the chemical-SC (intact, delipidized, or SC lipid film) binding levels. A significant vehicle effect was observed for chemical skin penetration and SC absorption. IPA resulted in the greatest levels of intact SC/SC lipid absorption, skin penetration, and total skin absorption/penetration of benzoic acid, followed by IPM and EtOH, respectively. For intact SC absorption and total skin absorption/penetration of butenafine, the vehicle that demonstrated the highest level of sorption/penetration was EtOH, followed by IPA and IPM, respectively. The percent doses of butenafine that were absorbed in SC lipid film and penetrated through skin in 24 h were greatest for IPA, followed by EtOH and IPM, respectively. The vehicle effect was consistent between intact SC absorption and total chemical skin absorption and penetration, as well as SC lipid absorption and chemical penetration through skin, suggesting intercellular transport as a main pathway of skin penetration for model chemicals. These results suggest the potential to predict vehicle effects on skin permeability with simple SC absorption assays. As decontamination was applied 30 min after chemical exposure, significant vehicle effects on chemical SC partitioning and percutaneous penetration also suggest that skin decontamination efficiency is vehicle dependent, and an effective decontamination method should act on chemical solutes in the lipid domain.

scholarly journals Lanolin-Based Synthetic Membranes for Transdermal Permeation and Penetration Drug Delivery Assays

Membranes ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 444
Author(s):  
Cristina Alonso ◽  
Ilaria Collini ◽  
Meritxell Martí ◽  
Clara Barba ◽  
Luisa Coderch
Keyword(s):  
Ph Value ◽  
Skin Permeation ◽  
Diclofenac Sodium ◽  
Skin Penetration ◽  
Skin Surface ◽  
Skin Permeability ◽  
Active Compounds ◽  
Synthetic Membranes ◽  
Composition And Structure ◽  
Permeability Studies

Due to the high similarity in composition and structure between lanolin and human SC lipids, we will work with two models from wool wax. Two types of lanolin were evaluated: one extracted with water and surfactants (WEL) and the other extracted with organic solvents (SEL). Skin permeation and skin penetration studies were performed with two active compounds to study the feasibility of the use of lanolin-based synthetic membranes as models of mammalian skin. Diclofenac sodium and lidocaine were selected as the active compounds considering that they have different chemical natures and different lipophilicities. In the permeation assay with SEL, a better correlation was obtained with the less permeable compound diclofenac sodium. This assay suggests the feasibility of using artificial membranes with SEL as a model for percutaneous absorption studies, even though the lipophilic barrier should be improved. Penetration profiles of the APIs through the SEL and WEL membranes indicated that the two membranes diminish penetration and can be considered good membrane surrogates for skin permeability studies. However, the WEL membranes, with a pH value similar to that of the skin surface, promoted a higher degree of diminution of the permeability of the two drugs, similar to those found for the skin.

scholarly journals Characterization of Soluplus/ASC-DP Nanoparticles Encapsulated with Minoxidil for Skin Targeting

2021 ◽  
Vol 5 (3) ◽  
pp. 44
Author(s):  
Rina Takayama ◽  
Moe Ishizawa ◽  
Miyuki Yamada ◽  
Yutaka Inoue ◽  
Ikuo Kanamoto
Keyword(s):  
Hydrophobic Interactions ◽  
Skin Penetration ◽  
Drug Carriers ◽  
Skin Permeability ◽  
Particle Structure ◽  
Spherical Micelle ◽  
Transmission Electron ◽  
Skin Targeting ◽  
1H Nuclear Magnetic Resonance ◽  
Poorly Soluble

Soluplus (Sol) is an amphiphilic graft copolymer capable of forming self-assembled micelles and L-ascorbyl 2,6-dipalmitate (ASC-DP) aggregates spontaneously to form micelles. Micelles are used as drug carriers and can nanoparticulate drugs that are poorly soluble in water, such as minoxidil. The study aimed to prepare minoxidil-encapsulated nanoparticles using Sol/ASC-DP and evaluate their potential for targeted skin application. Sol/ASC-DP nanoparticles or Sol/ASC-DP with minoxidil were prepared using the hydration method, and physical evaluations were carried out, including assessments of particle size and zeta potential. Particle structure was evaluated by transmission electron microscopy (TEM) and 1H-nuclear magnetic resonance spectra to assess particle stability and perform functional evaluations in skin penetration tests. TEM images showed spherical micelle-like particles of approximately 100 nm for Sol/ASC-DP at a 9:1 ratio and of approximately 80 nm for Sol/ASC-DP with incorporated minoxidil at a 9:1:0.5 ratio. Changes were also observed in the solid state, suggesting a hydrophobic interaction between Sol and ASC-DP. In addition, evaporated microparticles (Sol/ASC-DP/minoxidil = 9/1/0.5) improved the skin permeability of minoxidil. These results suggest that Sol/ASC-DP nanoparticles form a stable new nanoparticle due to hydrophobic interactions, which would improve the skin permeability of minoxidil.

The factors determining the skin penetration and cellular uptake of nanocarriers: New hope for clinical development

2021 ◽  
Vol 27 ◽  
Author(s):  
Afsaneh Farjami ◽  
Sara Salatin ◽  
Samira Jafari ◽  
Mohammad Mahmoudian ◽  
Mitra Jelvehgari
Keyword(s):  
Drug Delivery ◽  
Skin Permeation ◽  
Direct Interaction ◽  
Skin Barrier ◽  
Skin Penetration ◽  
Physicochemical Characteristics ◽  
Skin Permeability ◽  
Topical Drug Delivery ◽  
Major Barrier ◽  
Composition And Structure

: The skin provides a protective barrier against toxic environments and also offers a valuable route for topical drug delivery. The stratum corneum (SC) is the outermost layer of the skin and serves as the major barrier to chemical transfer through the skin. The human skin barrier is particularly diffcult to overcome because of the complex composition and structure of the SC. Nanoparticulate carriers have gained widespread attention in topical drug delivery due to their tunable and versatile properties. The present review summarizes the main factors involved in the skin penetration of nanocarriers containing drug. Employment of nanotechnology in topical delivery has grown progressively during recent years; however, it is important to monitor the skin penetration of nanocarriers prior to their use due to avoid possible toxic effects. Nanocarriers can act as a means to increase the skin permeation of drugs by supporting a direct interaction with the SC and increasing the period of permanence on the skin. The skin penetration is influenced by the physicochemical characteristics of nanocarriers such as composition, size, shape, surface chemistry as well as skin features. Considering that the target of topical systems based on nanocarriers is the penetration of therapeutic agents in the skin layers, so a detailed understanding of the factors influencing skin permeability of nanocarriers is essential for safe and efficient therapeutic applications.

Improvement of Active Biological Sludge Quality for Anaerobic Digestion Phase in the Wastewater Treatment Plant by Ultrasonic Pretreatment

2018 ◽  
Vol 69 (1) ◽  
pp. 31-33
Author(s):  
Mihai Stefanescu ◽  
Gheorghe Nechifor ◽  
Costel Bumbac ◽  
Ioana Ionescu ◽  
Olga Tiron
Keyword(s):  
Reaction Time ◽  
Ultrasonic Treatment ◽  
Organic Matter Content ◽  
Treatment Plant ◽  
Cooling Water ◽  
Matter Content ◽  
Ultrasonic Waves ◽  
Operating Conditions ◽  
Biological Sludge ◽  
Ultrasound Energy

This paper emphasized the influence of the main operating parameters of ultrasonic biological sludge pretreatment onto disintegration (DD-COD) and solubilizing degree of organic matter content. The optimal ultrasonic reaction time, energy and amplitude of ultrasonic waves and pH of the sludge (non-modified pH and pH 8.5) were established taking into account their influence on the solubility level of COD, an evolution of particles size. Correlations between disintegration degree and dimensional analysis were performed. Ultrasonic reactor operating to 20 kHz ultrasound frequency was a close system having cooling water jacket. Experimental tests in different operating conditions (reaction time 5 � 60 min., ultrasound energy 2000 � 9000 kJ, pH = 6.5/8.5) demonstrated that alkaline ultrasonic treatment (pH = 8.5, initial homogeneous COD = 72600 mg O2/L) at medium - high ultrasound energy levels led to highest disintegration degree � DD 12% (comparing with pH = 6.5 � DD ~ 5%). Still, the process should be managed carefully because of possibility to have important variation of DD during the ultrasonic treatment.

scholarly journals Structure and properties forming in ductile iron during isothermal hardening using ultrasound

2020 ◽  
pp. 118-124
Author(s):  
M. S. Kovalko ◽  
A. T. Volochko ◽  
A. V. Ziziko ◽  
V. V. Rubanik
Keyword(s):  
Ultrasonic Treatment ◽  
Isothermal Holding ◽  
External Source ◽  
Ultrasonic Waves ◽  
Metallographic Analysis ◽  
Isothermal Quenching ◽  
Structure And Properties ◽  
National Academy Of Sciences ◽  
Cast Irons ◽  
Cooling Medium

The paper considers the possibility of intensifying isothermal holding processes during quenching of high-strength cast irons by using an external source of physical impact in the form of ultrasonic waves. For experimental evaluation of this effect in the laboratory of MiAM of the Physical-Technical Institute of the National Academy of Sciences of Belarus, prototypes of highstrength cast irons were cast in an ISV 0.004 crucible induction furnace. A mixture of NaNO2 and KNO3 salts in a 1:1 ratio was used as a liquid cooling medium during quenching. Ultrasonic treatment of the salt melt during the cooling of the samples was carried out using an UZG-20–15 generator in cooperation with the ITA of NAS of Belarus. The mechanical properties and structure of the treated cast irons were determined both in the cast state and after isothermal quenching.To study the effect of ultrasonic treatment of the quenching bath on the formation of the structure and properties of highstrength cast irons during isothermal quenching, a number of comparative experiments were carried out, consisting in cooling the samples from 910 °C to 350 °C with and without the use of dynamic waves to the bath. With the help of metallographic analysis, measurements of hardness and friction coefficient, the beneficial effect of ultrasonic treatment of the cooling medium on the structure and properties is shown, which is reflected in an increase in the uniformity of the distribution of hardness over the cross section of cast iron and in its wear resistance, as well as a reduction in the isothermal holding time by up to two times.

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