Graphene Quantum Dots Potently Block Copper-Mediated Oxidative DNA Damage: Implications for Cancer Intervention

Electrochemiluminescence resonance energy transfer between graphene quantum dots (GQDs) and Au nanoparticles results in the electrochemiluminescence signal of the GQDs being quenched or recovering.

Download Full-text

Biocompatible nucleus-targeted graphene quantum dots for selective killing of cancer cells via DNA damage

Communications Biology ◽

10.1038/s42003-021-01713-1 ◽

2021 ◽

Vol 4 (1) ◽

Author(s):

Lei Qi ◽

Tonghe Pan ◽

Liling Ou ◽

Zhiqiang Ye ◽

Chunlei Yu ◽

...

Keyword(s):

Dna Damage ◽

Quantum Dots ◽

Cancer Cells ◽

Cancer Cell ◽

Electrostatic Interactions ◽

Rational Design ◽

Graphene Quantum Dots ◽

Cell Targeting ◽

Disulfide Linkage ◽

Cancer Cell Targeting

AbstractGraphene quantum dots (GQDs) are nano-sized graphene slices. With their small size, lamellar and aromatic-ring structure, GQDs tend to enter into the cell nucleus and interfere with DNA activity. Thus, GQD alone is expected to be an anticancer reagent. Herein, we developed GQDs that suppress the growth of tumor by selectively damaging the DNA of cancer cells. The amine-functionalized GQDs were modified with nucleus targeting TAT peptides (TAT-NGs) and further grafted with cancer-cell-targeting folic acid (FA) modified PEG via disulfide linkage (FAPEG-TNGs). The resulting FAPEG-TNGs exhibited good biocompatibility, nucleus uptake, and cancer cell targeting. They adsorb on DNA via the π–π and electrostatic interactions, which induce the DNA damage, the upregulation of the cell apoptosis related proteins, and the suppression of cancer cell growth, ultimately. This work presents a rational design of GQDs that induce the DNA damage to realize high therapeutic performance, leading to a distinct chemotherapy strategy for targeted tumor therapy.

Download Full-text

Preparation of Graphene Quantum Dots and Their Biological Applications

Journal of Inorganic Materials ◽

10.15541/jim20150424 ◽

2016 ◽

Vol 31 (4) ◽

pp. 337 ◽

Cited By ~ 7

Author(s):

SUN Xiao-Dan ◽

LIU Zhong-Qun ◽

YAN Hao

Keyword(s):

Quantum Dots ◽

Graphene Quantum Dots ◽

Biological Applications

Download Full-text

Acrylamide Exposure and Oxidative DNA Damage, Lipid Peroxidation and Fasting Plasma Glucose Alteration: Association and Mediation Analyses in Chinese Urban Adults

10.2337/figshare.12076134 ◽

2020 ◽

Author(s):

Bin Wang ◽

Weihong Qiu ◽

Shijie Yang ◽

Limin Cao ◽

Chunmei Zhu ◽

...

Keyword(s):

Lipid Peroxidation ◽

Dna Damage ◽

Plasma Glucose ◽

Fasting Plasma Glucose ◽

Oxidative Dna Damage ◽

Adult Population ◽

Prostaglandin F2α ◽

Mediation Analyses ◽

Mediating Role ◽

Fasting Plasma

<a>OBJECTIVE: </a>Acrylamide exposure from daily-consumed food has raised global concern. We aimed to assess the exposure-response relationships of internal acrylamide exposure with oxidative DNA damage, lipid peroxidation and fasting plasma glucose (FPG) alteration, and investigate the mediating role of oxidative DNA damage and lipid peroxidation in the association of internal acrylamide exposure with FPG. RESEARCH DESIGN AND METHODS: FPG and urinary biomarkers of oxidative DNA damage (8-hydroxy-deoxy-guanosine, 8-OHdG), lipid peroxidation (8-iso-prostaglandin-F2α, 8-iso-PGF2α) and acrylamide exposure (N-acetyl-S-(2-carbamoylethyl)-L-cysteine, AAMA; N-acetyl-S-(2-carbamoyl-2-hydroxyethyl)-L-cysteine, GAMA) were measured for 3,270 general adults from the Wuhan-Zhuhai cohort. The associations of urinary acrylamide metabolites with 8-OHdG, 8-iso-PGF2α and FPG were assessed by linear mixed models. The mediating roles of 8-OHdG and 8-iso-PGF2α were evaluated by mediation analysis. RESULTS: We found significant linear positive dose-response relationships of urinary acrylamide metabolites with 8-OHdG, 8-iso-PGF2α and FPG (except GAMA with FPG), and 8-iso-PGF2α with FPG. Each 1-unit increase in log-transformed level of AAMA, ΣUAAM (AAMA+GAMA) or 8-iso-PGF2α was associated with a 0.17-, 0.15- or 0.23-mmol/L increase in FPG, respectively (P or/and P trend<0.05). Each 1% increase in AAMA, GAMA or ΣUAAM was associated with a 0.19%, 0.27% or 0.22% increase in 8-OHdG, respectively, and a 0.40%, 0.48% or 0.44% increase in 8-iso-PGF2α, respectively (P and P trend<0.05). Increased 8-iso-PGF2α rather than 8-OHdG significantly mediated 64.29% and 76.92% of the AAMA and ΣUAAM associated-FPG increases, respectively. CONCLUSIONS: Exposure of general adult population to acrylamide was associated with FPG elevation, oxidative DNA damage and lipid peroxidation, which in turn partly mediated acrylamide-associated FPG elevation.

Download Full-text

Graphene quantum dots show protective effect on a model of experimental autoimmune encephalomyelitis

10.26226/morressier.5785edc5d462b80296c991bf ◽

2016 ◽

Author(s):

Jelena Tosic

Keyword(s):

Quantum Dots ◽

Experimental Autoimmune Encephalomyelitis ◽

Protective Effect ◽

Graphene Quantum Dots ◽

Autoimmune Encephalomyelitis ◽

Experimental Autoimmune

Download Full-text

Serum of 8-OHdG as a potential biomarker of oxidative DNA damage in workers exposed to harmful working environments

Russian Journal of Occupational Health and Industrial Ecology ◽

10.31089/1026-9428-2019-59-9-783-784 ◽

2020 ◽

pp. 783-783

Author(s):

I. A. Umnyagina ◽

L. A. Strakhova ◽

T. V. Blinova

Keyword(s):

Oxidative Stress ◽

Dna Damage ◽

Blood Serum ◽

Oxidative Dna Damage ◽

Working Environment ◽

Working Environments ◽

Potential Biomarker ◽

High Level ◽

Damage Marker

In the blood serum of 70% individuals exposed to harmful factors of the working environment, a high level of oxidative stress and the DNA damage marker 8-Hydroxy-2’-Deoxyguanosine (8-OHdG) were detected.

Download Full-text