scholarly journals Association between Serum Magnesium Level with Acute Coronary Syndrome (ACS) in Diabetes Mellitus (DM) Patients

2019 ◽  
Vol 2 (2) ◽  
pp. 96
Author(s):  
Ratih Wulansari ◽  
Soebagijo Adi Soelistijo ◽  
Achmad Lefi
Keyword(s):  
Diabetes Mellitus ◽  
Acute Coronary Syndrome ◽  
Plaque Rupture ◽  
Serum Magnesium ◽  
Demographic Data ◽  
Cardiovascular Complications ◽  
Magnesium Level ◽  
Serum Magnesium Level ◽  
Coronary Syndrome ◽  
Normally Distributed

Introduction: Until now, cardiovascular complications are still the highest cause of death and disability in DM patients. Hypomagnesemia in DM accelerate atherosclerosis and can cause instability and plaque rupture which can lead to acute coronary syndrome.Methods: Design of this study was observational analytic using a "case control" study involved 76 samples of DM patients, consisting of 38 samples with SKA (+) and 38 samples with SKA (-). Subjects of this study were all DM patients in the period July-December 2018 in the Emergency Room (ER) and Outpatient Installation of Endocrine at the RSUD Dr. Soetomo Surabaya, which fulfills the criteria for inclusion and exclusion. Demographic data and clinical characteristics are presented descriptively. If data is normally distributed then an unpaired t test is carried out and if the data is not normally, distributed with Mann Whitney test is performed. The statistical test was stated to be significant if p <0.05. The association between hypomagnesemia and the incidence of ACS a multivariate logistic regression test was performed, the risk number was in the form of odds ratios (OR). Results: This study involved 76 subjects with diabetes mellitus with SKA and non SKA 38 subjects. The mean serum magnesium level in the ACS group was lower than non ACS (1.9 mg / dL vs. 2.1 mg / dL), hypomagnesemia cut-off of <2.08 mg / dL. In this study hypomagnesemia as a risk factor for the incidence of ACS in DM patients with OR 2.8 (CI 1.1-7.6; p = 0.039).Conclusion: Magnesium levels in the ACS group were lower than the non ACS group. Hypomagnesemia Increase The Incidence of Acute Coronary Syndrome in Diabetes Mellitus Patients.

scholarly journals Serum Magnesium Level in Gestational Diabetes Mellitus in a Tertiary Care Hospital of Bangladesh

2018 ◽  
Vol 9 (2) ◽  
pp. 59-62
Author(s):  
FA Mishu ◽  
MA Muttalib ◽  
S Naher ◽  
R Tabassum ◽  
R Ahmed ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Serum Magnesium ◽  
Magnesium Level ◽  
Control Group ◽  
Care Hospital ◽  
Serum Magnesium Level ◽  
Third Trimester ◽  
Group I

Gestational diabetes mellitus (GDM) is characterized by glucose intolerance during pregnancy. GDM is associated with an increased incidence of congenital abnormalities usually aggravated by maternal magnesium deficiency. Magnesium is one of the essential trace elements for normal embryogenesis and foetal growth and its deficiency increases mortality and morbidity rate of mothers, embryos and neonates. The present study was undertaken to evaluate the association of serum magnesium with GDM in second and third trimester of pregnancy. This case-control study was conducted in Mymensingh Medical College Hospital during the period from July 2013 to June 2014 to evaluate the association of serum magnesium with GDM in Bangladeshi women. A total of 172 subjects were recruited in this study; among them eighty six women with GDM were selected as case (Group-I) and eighty six healthy pregnant women were taken as control (Group- II). The cases again were subdivided as Group Ia and Ib at second and third trimester respectively. Controls also were subdivided as Group IIa and IIb at second and third trimester respectively. Student's unpaired 't' test was used to compare the data between groups. For analytical purpose 95% confidence limit (p<0.05) was taken as level of significance. Serum magnesium level was significantly decreased in cases compared to that of controls. It was significantly lowered (p<0.001) in cases Gr-Ia (1.3884±0.255 mg/dl) than controls Gr-IIa (1.6651±0.304 mg/dl) at second trimester. The result was also significantly (p<0.001) lowered when compared between cases Gr-Ib (0.9349±0.145 mg/dl) and controls Gr-IIb (1.6674±0.308 mg/dl) at third trimester. The study shows that serum magnesium level is decreased in pregnancy with GDM. So estimation of serum magnesium level may be done in every GDM cases to reduce the incidence of magnesium related complications by timely intervention.Bangladesh J Med Biochem 2016; 9(2): 59-62

scholarly journals Increased Atherothrombotic Burden in Patients with Diabetes Mellitus and Acute Coronary Syndrome: A Review of Antiplatelet Therapy

2012 ◽  
Vol 2012 ◽  
pp. 1-18 ◽  
Author(s):  
Karthik Balasubramaniam ◽  
Girish N. Viswanathan ◽  
Sally M. Marshall ◽  
Azfar G. Zaman
Keyword(s):  
Diabetes Mellitus ◽  
Acute Coronary Syndrome ◽  
Platelet Inhibition ◽  
Cardiovascular Complications ◽  
Diabetic Patients ◽  
Coronary Syndrome ◽  
Patients With Diabetes ◽  
Thrombotic Complications ◽  
Underlying Pathophysiology ◽  
Ischemic Events

Patients with diabetes mellitus presenting with acute coronary syndrome have a higher risk of cardiovascular complications and recurrent ischemic events when compared to nondiabetic counterparts. Different mechanisms including endothelial dysfunction, platelet hyperactivity, and abnormalities in coagulation and fibrinolysis have been implicated for this increased atherothrombotic risk. Platelets play an important role in atherogenesis and its thrombotic complications in diabetic patients with acute coronary syndrome. Hence, potent platelet inhibition is of paramount importance in order to optimise outcomes of diabetic patients with acute coronary syndrome. The aim of this paper is to provide an overview of the increased thrombotic burden in diabetes and acute coronary syndrome, the underlying pathophysiology focussing on endothelial and platelet abnormalities, currently available antiplatelet therapies, their benefits and limitations in diabetic patients, and to describe potential future therapeutic strategies to overcome these limitations.

scholarly journals Evaluation of Serum Magnesium Level along with Lipid Profile in a Gujarati Population diagnosed with Diabetes Mellitus

2017 ◽  
Vol 21 (2) ◽  
pp. 112-116
Author(s):  
Sandip S Sendhav ◽  
Amit Kakaiya ◽  
Bijoya Chatterjee
Keyword(s):  
Diabetes Mellitus ◽  
Lipid Profile ◽  
Serum Magnesium ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Magnesium Level ◽  
Lipoprotein Cholesterol ◽  
Low Density ◽  
Serum Magnesium Level ◽  
Low Density Lipoprotein Cholesterol

ABSTRACT Aims and objectives Diabetes is a common endocrinal disorder. Abnormal lipid and magnesium levels are observed in diabetes in many studies. The current study was done with an aim to find the relationship between lipid with magnesium and diabetes mellitus in Gujarati population. Materials and methods The cross-sectional study included 60 diabetics and 50 healthy subjects. Each subject was interviewed, examined, and investigated for serum lipid profile and magnesium. A 12-hour overnight fasting was recommended. The statistical analysis of data obtained was done by Student's t-test and calculation of Pearson correlation coefficient. Result Routine biochemical investigations showed a significant rise (p < 0.01) of fasting plasma glucose, triglycerides (TGs), total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C), and very low-density lipoprotein-cholesterol (VLDL-C) in diabetics, in comparison with controls (p < 0.01). Among diabetics, males have significantly higher (p < 0.01) TC, TG, and LDL-C while significantly lower high-density lipoprotein-cholesterol (HDL-C). Significant inverse correlation of magnesium with TC (r = −0.18), TGs (r = −0.14), LDL-C (r = −0.27), fasting blood sugar (FBS; r = −0.12) and direct correlation with HDL-C (r = 026) were observed in cases. Conclusion The major highlights of the current study are lower magnesium levels in cases compared with controls. In the current study, serum magnesium level has been found to be inversely related to cholesterol, TG, and LDL-C levels, while it is directly associated with HDL-C level. Hence, it could play a role in controlling the risk of coronary artery disease (CAD)-associated morbidities in future. How to cite this article Sendhav SS, Kakaiya A, Chatterjee B. Evaluation of Serum Magnesium Level along with Lipid Profile in a Gujarati Population diagnosed with Diabetes Mellitus. Indian J Med Biochem 2017;21(2):112-116.

Outcome of Patients Hospitalized with Acute Coronary Syndrome Fulfilling the Criteria of Metabolic Syndrome

2014 ◽  
Vol 15 (1) ◽  
pp. 31-35
Author(s):  
Mohammed Shahadat Hossain ◽  
Khan Abul Kalam Azad ◽  
Prodip Kumar Biswas ◽  
Md. Amir Hossain ◽  
Jayanta Kumar Saha ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Metabolic Syndrome ◽  
Acute Coronary Syndrome ◽  
Heart Block ◽  
Cardiovascular Complications ◽  
Coronary Syndrome ◽  
Group I ◽  
Significant Difference ◽  
Group Ii ◽  
The Impact

The aim of the study was to assess the association of metabolic syndrome in patients with acute coronary syndrome and the impact of metabolic syndrome on clinical outcome. Total 210 ACS patients were included in this study and divided in group I & II on the basis of presence or absence of MS respectively. Among the study patients mean age in group I and group II was 52.99 ± 11.49 years and 53.34 ± 12.54 years respectively. Among the risk factors, hypertension (70%vs 15%), dyslipidemia (100 vs. 97%), diabetes mellitus (36.4% vs. 6%) were significant between two groups. Mean waist circumference recorded was 103.12 ± 4.15 in group I and 96.50 ± 6.43 in group II which was significant. Present study showed, in hospital outcome was worse in group I in comparison to group II and was significant, like cardiogenic shock (11% vs. 1%), LVF (28.2% vs. 16%), and CVD (5.45 vs. 0%). But there were no significant difference in heart block, tachyarrhythmia, cardiac arrest, reinfarction and death. Complications were far more in group I than in group II (14.5% vs. 52.0%) which was also highly significant. So, we conclude that the presence of MS in patients suffered from ACS was associated with a greater incidence of in-hospital cardiovascular complications and mortality.DOI: http://dx.doi.org/10.3329/jom.v15i1.19857 J Medicine 2014; 15: 31-35

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