scholarly journals POLYSACCHARIDE AS GELATIN SUBTITUTE MATERIAL IN HALAL DRUG DELIVERY SYSTEM

2018 ◽  
Vol 1 (2) ◽  
pp. 15
Author(s):  
Hayyun Durrotul Faridah ◽  
Tri Susanti
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Xanthomonas Campestris ◽  
Islamic Law ◽  
Base Material ◽  
Brown Seaweed ◽  
Pharmaceutical Products ◽  
Alternative Material ◽  
Selection Of

Drug delivery system describe the journey of a drug to get the target of action. The material used in drug delivery is very diverse and according to the therapymethod. So far, the use of gelatin in the pharmaceutical is very extensive, such as material in the drug delivery system. Gelatin can be produced from the extraction of animal collagen like from skin, bone and connective tissue. They are usually taken from the products of animal slaughterhouse products such as pigs and cattles. To produce a halal material, starting from the selection of basic materials until production of a material must be appropiate with Islamic rules. Like the selection of basic materials that getting from halal animals, the slaughter process is according to Islamic law and does not contain alcohol or other non-halal ingredients. However, today the use of pig skin as a gelatin base material is preferred because of its abundant availability and ease of processing. But actually pigs are animals that should not be consumed in Islam. The large number of pharmaceutical products derivating from pigs is a problem for a Muslim because it can be non-halal product. Therefore it is necessary to look for alternative gelatin as drug delivery system. One of the alternative material that can be used is a polysaccharide which is a natural polymer with very abundant availability in nature. For example carrageenan which is a polysaccharide extracted from the red seaweed, alginate extracted from brown seaweed, and xanthan gum which is the excretion of Xanthomonas campestris bacteria. The polysaccharide can be used as a halal drug delivery system and has the potential to be developed further so that it has better quality than gelatin.

SOMES: A REVIEW ON COMPOSITION, FORMULATION METHODS AND EVALUATIONS OF DIFFERENT TYPES OF “SOMES” DRUG DELIVERY SYSTEM

2020 ◽  
pp. 7-18
Author(s):  
KUSUMA PRIYA M. D. ◽  
VINOD KUMAR ◽  
DAMINI V. K. ◽  
ESWAR K. ◽  
KADIRI RAJESH REDDY ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Sustained Release ◽  
Surface Chemistry ◽  
Drug Delivery System ◽  
Delivery System ◽  
Different Types ◽  
Potent Drug ◽  
Evaluation Parameters ◽  
Selection Of

Many drugs are available in the market for several diseases, disorder or even for a condition, but it is difficult to select a suitable carrier to attain maximum bioavailability and potential for a potent drug. Attaining a controlled and sustained release of a drug is purely focused on the selection of a carrier (natural, synthetic and hybrid) like nanosomes. Nanosomes have become a prominent tool in the field of pharmacy. Nanosomes are small uniform structures which deliver the drug to the specific targeted site, which mainly depends upon the presence of ligands, shape, size and surface chemistry. Nanosomes are available in various types which include Niosomes, Liposomes, Electrosomes, Aquasomes, Transfersomes, Phytosomes, Enzymosomes, Ethosomes, Invasome and Sphingosomes. In general, all these nanosomes are quite similar in nature with minute differences in their vesicular characteristics and composition. This review traces various ‘somes’ composition and their role in the formulation, applications, advantages, disadvantages, common formulation procedures and evaluation parameters.

scholarly journals Sustained drug delivery system in fish and the potential for use of PLGA microparticles: a review

2019 ◽  
Vol 64 (No. 7) ◽  
pp. 287-293
Author(s):  
J Matejkova ◽  
P Podhorec
Keyword(s):  
Drug Delivery ◽  
Sustained Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Hormonal Treatment ◽  
The United States ◽  
Pharmaceutical Products ◽  
European Medicines Agency ◽  
Sustained Drug Delivery ◽  
Plga Microparticles

Many fish species display some form of reproductive disorder in captivity. Captive fish reared in conditions outside the natural spawning environment show a failure of the pituitary to release the maturational gonadotropin luteinizing hormone thus necessitating administration of the hormone to induce spawning. A controlled sustained-release delivery system can conquer the issue of short half-life of gonadotropin releasing hormone (GnRH) in blood and avoid the necessity of using re-injections. Sustained release of GnRHa can induce long-term enhancement in semen production and multiple spawning in species with asynchronous or multiple batch group synchronous ovarian physiology. The most recent development is the incorporation of GnRHa into microparticles of biodegradable polymers that release the drug during a certain period of time ranging from days to weeks. The most attractive polymeric candidate used as a carrier for administering a pharmaceutical products is poly(lactic-co-glycolic acid); (PLGA). PLGA has excellent biodegradability and biocompatibility and is generally recognised as safe by international regulatory agencies including the European Medicines Agency and the United States Food and Drug Administration. This review describes methods of hormonal treatment in fish, highlights the advantage of sustained drug delivery system and discusses the potential of PLGA microparticles as a tool for achieving successful reproduction.

scholarly journals Effect of Vegetable Oil on Self-Nanoemulsifying Drug Delivery System of Dayak Onion [Eleutherine palmifolia (L.) Merr.] Extract using Hydrophilic-lipophilic Balance Approach: Formulation, Characterization

2020 ◽  
Vol 10 (02) ◽  
pp. 210-216
Author(s):  
Esti Hendradi ◽  
Rahmi Annisa ◽  
Mochammad Yuwono
Keyword(s):  
Drug Delivery ◽  
Particle Size ◽  
Olive Oil ◽  
Drug Delivery System ◽  
Delivery System ◽  
Palm Oil ◽  
Tween 20 ◽  
Hydrophilic Lipophilic Balance ◽  
Selection Of ◽  
Optimal Formula

Eleutherine palmifolia is a typical plant of Kalimantan that has been empirically used by the Dayak people as a cure for various types of diseases. Self-nanoemulsifying drug delivery system (SNEDDS) is a drug delivery system that can be developed for onion Dayak to improve its absorption profile. Selection of oil phase, surfactant, and cosurfactant have an essential role in SNEDDS of Dayak onion. The aims of this study to determine the effect of the use of vegetable oils on SNEDDS using the HLB approach. Several 40 formulations in each oil phase with HLB ranging between 11 and 15 were screened to acquire stable SNEDDS composition without the presence of phase separation. Formulas optimal obtained F33 (HLB 14) using olive oil at a ratio formula of 1:7:2. F29 (HLB 14), using VCO at a formula ratio of 1:7:2. F14 (HLB 14) uses palm oil at a ratio formula of 2:7:1. The result showed that the optimal formula F33 (olive oil) with 58 nm of the particle size, 84.32 ± 0.00 of the transmittance percentage, 22.00 ± 0,18 of the emulsification time. Formula F29 (VCO) with 19.48 nm of the particle size, 91.78 ± 0.02 of the transmittance percentage, 43.00 ± 0.16 of the emulsification time. Formula F14 (palm oil) with 102 nm of the particle size, 90.93 ± 0.02 of the transmittance percentage, 110 ± 0.34 of the emulsification time. The optimal formula that has good characteristics and stability is the F29 (VCO) formula using tween 20/transcutol as the surfactant, PEG 400, as co-surfactant at a ratio formula of 1:7:2.

scholarly journals Optimisation and feature selection of poly-beta-amino-ester as a drug delivery system for cartilage

2020 ◽  
Vol 8 (23) ◽  
pp. 5096-5108 ◽  
Author(s):  
Stefano Perni ◽  
Polina Prokopovich
Keyword(s):  
Drug Delivery ◽  
Feature Selection ◽  
Drug Delivery System ◽  
Delivery System ◽  
Polymer Structure ◽  
Full Potential ◽  
Amino Ester ◽  
Amino Esters ◽  
Drug Conjugates ◽  
Selection Of

Drug localisation is one of the main challenges in treating cartilage; poly-beta-amino-esters (PBAEs) drug conjugates are a possible solution; their efficacy depends on the polymer structure hence the full potential of this system is still unknown.

scholarly journals Formulation design and evaluation of a self-microemulsifying drug delivery system of lovastatin

2012 ◽  
Vol 62 (3) ◽  
pp. 357-370 ◽  
Author(s):  
Urvash Goyal ◽  
Ritika Arora ◽  
Geeta Aggarwal
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Ternary Phase Diagrams ◽  
Transmission Electron ◽  
Selection Of ◽  
Saturated Solubility ◽  
Drug Solution

Self-microemulsifying drug delivery system (SMEDDS) of lovastatin was aimed at overcoming the problems of poor solubility and bioavailability. The formulation strategy included selection of oil phase based on saturated solubility studies and surfactant and co-surfactant screening on the basis of their emulsification ability. Ternary phase diagrams were constructed to identify the self-emulsifying region. Capryol 90 (20 %) as oil, Cremophore RH40 (40 %) as surfactant and Transcutol P (40 %) as co-surfactant were concluded to be optimized components. The prepared SMEDDS was characterized through its droplet size, zeta potential, emulsification time, rheological determination and transmission electron microscopy. The optimized formulation exhibited 94 % in vitro drug release, which was significantly higher than that of the drug solution. In vivo studies using the Triton-induced hyperlipidemia model in Wistar rats revealed considerable reduction in lipid levels compared to pure lovastatin. The study confirmed the potential of lovastatin SMEDDS for oral administration.

Liposomes: Current Approaches for Development and Evaluation

2017 ◽  
Vol 7 (04) ◽  
Author(s):  
Ashutosh Gupta ◽  
Malay Kumar Mandal ◽  
Bhupendra Singh ◽  
Yashwant Yashwant ◽  
Bharat Jhanwar
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Dosage Form ◽  
Drug Loading ◽  
Triggered Release ◽  
Therapeutic Efficiency ◽  
Antibiotic Drug ◽  
Main Disadvantage ◽  
Selection Of

Liposomes (50-1000nm) are the part of a specific type of drug delivery system which is non-toxic and biodegradable in nature. That having ability to reduce the toxicity also enhances the therapeutic efficiency and protects the drug which is encapsulated, from the degradation and immediate dilution. These can be prepared by using various techniques like lipid hydration method, sonication method and solvent injecting method etc. But the selection of technique is depended upon the size of liposome which we want. The main disadvantage of this dosage form is it is very much costly and also having time consuming process. But it has major applications in the form of extrusion for homogeneous size, long circulating liposomes, triggered release liposome, remote drug loading, ligand targeted liposomes and containing combination of drugs. These applications are helpful for advanced drug delivery of anticancer, antifungal and anti-inflammatory drug, the delivery of gene medicine, delivery of anaesthetic and antibiotic drug. The newer researches in this field include hybrid liposomes, phototrigerable liposomes which are fabricated to have the improved functionality. These serves as the upcoming novel nanomedicinal chemotherapy technique.

scholarly journals Characterization, Disintegration, and Dissolution Analyses of Carrageenan-Based Hard-Shell Capsules Cross-Linked with Maltodextrin as a Potential Alternative Drug Delivery System

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Muhammad Al Rizqi Dharma Fauzi ◽  
Pratiwi Pudjiastuti ◽  
Esti Hendradi ◽  
Riyanto Teguh Widodo ◽  
Mohd. Cairul Iqbal Mohd. Amin
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Oral Drug Delivery ◽  
Pharmaceutical Products ◽  
Oral Drug ◽  
Potential Candidate ◽  
Dissolution Profile ◽  
Degree Of Swelling ◽  
Hard Shell

Hard-shell capsules commonly consist of gelatin which is not a universal material considering it is extracted from animal parts. Moreover, the mad cow disease triggered the scrutinization of the use of gelatin in pharmaceutical products. Hence, an alternative to conventional hard-shell capsules is needed. Carrageenan- (CRG-) based hard-shell capsules were successfully prepared by cross-linking CRG with maltodextrin (MD) and plasticizing with sorbitol (SOR). These CRG-MD/SOR hard-shell capsules were produced as an alternative to conventional hard-shell capsules in the oral drug delivery system (DDS). The physical properties of CRG-MD/SOR capsules were characterized using the degree of swelling, FTIR, and SEM analyses. The disintegration and dissolution profile release of paracetamol from CRG-MD/SOR hard-shell capsules was performed in an aqueous medium with three different pH levels. The degree of swelling of CRG-MD/SOR was 529.23±128.10%. The main peaks in the FTIR spectrum of CRG-MD/SOR were at 1248, 930, 847, and 805 cm−1 for ester sulfate groups, 3,6-anhydrogalactose, galactose-4-sulfate, and 3,6-anhydrogalactose-2-sulfate, respectively. The SEM analysis exhibited minuscule pores on the surface of CRG and CRG-MD/SOR at 5000 times of magnification. The CRG-MD/SOR capsules required 18.47±0.11 min on average to disintegrate. The CRG-MD/SOR dissolution was better in a weakly acidic medium (pH 4.5) than in a strongly acidic (pH 1.2) and neutral (pH 6.8) media. Based on the aforementioned results, CRG-MD/SOR capsules are the potential candidate to replace conventional hard-shell capsules.

3D Printing Technology in Customized Drug Delivery System: Current State of the Art, Prospective and the Challenges

2019 ◽  
Vol 24 (42) ◽  
pp. 5049-5061 ◽  
Author(s):  
Farooq A. Khan ◽  
Kaushik Narasimhan ◽  
C.S.V. Swathi ◽  
Sayyad Mustak ◽  
Gulam Mustafa ◽  
...  
Keyword(s):  
Drug Delivery ◽  
3D Printing ◽  
Drug Delivery System ◽  
Delivery System ◽  
Pharmaceutical Products ◽  
Drug Formulation ◽  
Formulation Development ◽  
Fused Deposition ◽  
Current State ◽  
3D Printed

Background: 3D printing/Additive Manufacturing seems a pragmatic approach to realize the quest for a truly customized and personalized drug delivery. 3DP technology, with innovations in pharmaceutical development and an interdisciplinary approach to finding newer Drug Delivery Systems can usher a new era of treatments to various diseases. The true potential of this is yet to be realized, and the US-FDA is focusing on the regulatory science of 3D printed medical devices to help patients access this technology safely and effectively. The approval of the first 3D printed prescription medicine by FDA is a promising step in the translation of more research in this area. Methods: A web-search on PubMed, ScienceDirect, and Nature was performed with the keywords Customized 3D printing and Drug delivery, publications dealing with the aspects of drug delivery using 3D printing for personalized or customized delivery were further considered and analyzed and discussed. Results: We present the advantages offered by 3DP over conventional methods of formulation development and discuss the current state of 3DP in pharmaceutics and how it can be used to develop a truly customized drug delivery system, various 3DP technologies including Stereolithography (SLA), Selective Laser Sintering (SLS), Fused Deposition Modelling (FDM), Pressure Assisted Microsyringe (PAM) that have been used to develop pharmaceutical products have been discussed along with their limitations and also the regulatory considerations to help formulation scientists envisaging research in this area with the necessary information. Conclusion: 3D printing has the potential to fabricate a customized drug delivery system. Presence of many drug formulation and the devices are already in the regulatory approval process indicating its success.

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