Ocular Pharmacokinetics of Brimonidine Drug Delivery System in Monkeys and Translational Modeling for Selection of Dose and Frequency in Clinical Trials

Many drugs are available in the market for several diseases, disorder or even for a condition, but it is difficult to select a suitable carrier to attain maximum bioavailability and potential for a potent drug. Attaining a controlled and sustained release of a drug is purely focused on the selection of a carrier (natural, synthetic and hybrid) like nanosomes. Nanosomes have become a prominent tool in the field of pharmacy. Nanosomes are small uniform structures which deliver the drug to the specific targeted site, which mainly depends upon the presence of ligands, shape, size and surface chemistry. Nanosomes are available in various types which include Niosomes, Liposomes, Electrosomes, Aquasomes, Transfersomes, Phytosomes, Enzymosomes, Ethosomes, Invasome and Sphingosomes. In general, all these nanosomes are quite similar in nature with minute differences in their vesicular characteristics and composition. This review traces various ‘somes’ composition and their role in the formulation, applications, advantages, disadvantages, common formulation procedures and evaluation parameters.

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AN OVERVIEW OF CLINICAL TRIALS ON VACCINE OF COVID-19 UNDER NOVEL DRUG DELIVERY SYSTEM

PLANT ARCHIVES ◽

10.51470/plantarchives.2021.v21.no1.171 ◽

2021 ◽

Vol 21 (No 1) ◽

Author(s):

Mayuri. P. Pol ◽

Gayatri. C. Mahajan ◽

Suhas. K. Khairnar ◽

Dhananjay. M. Patil ◽

Vinod. A. Bairagi

Keyword(s):

Drug Delivery ◽

Clinical Trials ◽

Drug Delivery System ◽

Delivery System ◽

Virus Disease ◽

Viral Disease ◽

World Health ◽

Ongoing Research ◽

Novel Drug Delivery System ◽

Novel Drug

The Corona virus disease 2019 (COVID-19) has discovered its underlying foundations from Wuhan (China). Coronavirus is brought about by a novel COVID SARS-CoV2, recently named as 2019-nCoV. Coronavirus has spread across the globe and pronounced as pandemic by World Health Organization (WHO) 0n the 11th March, 2020 as of now, there is no standard medication or vaccine accessible for the treatment, so repurposing of existing medication is the solitary arrangement. vaccine are the arrangements given to patients to summon invulnerable reactions prompting the creation of antibodies (humoral) or cell-interceded reactions that will battle irresistible specialists or non-irresistible conditions, for example, malignancies. Disturbing safety profile of live vaccines, weak immunogenicity of sub-unit vaccines and immunization, failure due to poor patient compliance to booster doses which should potentiate prime doses are rarestoutexplanations, which required the progress of novelgroup of preventive and therapeutic vaccines to encourage effective vaccination. Endeavors are being made to convey immunizations through transporters as they control the spatial and worldly introduction of antigens to invulnerable framework consequently prompting their supported delivery and focusing on. Henceforth, lower dosages of frail immunogens can be successfully coordinated to invigorate safe reactions and kill the requirement for the organization of prime and supporter portions as a section vaccine regimen. Novel Drug Delivery System (NDDS) will be soon for resting of medications. The part of different NDDS in resting of existing medications for treatment of different viral disease, and their importance in COVID-19 has talked about in this paper. It focuses on the currently ongoing research in the implementation and clinical trials on vaccine in the usage of NDDS in COVID-19. In addition, it portrays the part of Liposomes, Virosomes and DNA based vaccine drug delivery advancement for COVID-19

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Effect of Vegetable Oil on Self-Nanoemulsifying Drug Delivery System of Dayak Onion [Eleutherine palmifolia (L.) Merr.] Extract using Hydrophilic-lipophilic Balance Approach: Formulation, Characterization

International Journal of Drug Delivery Technology ◽

10.25258/ijddt.10.2.4 ◽

2020 ◽

Vol 10 (02) ◽

pp. 210-216

Author(s):

Esti Hendradi ◽

Rahmi Annisa ◽

Mochammad Yuwono

Keyword(s):

Drug Delivery ◽

Particle Size ◽

Olive Oil ◽

Drug Delivery System ◽

Delivery System ◽

Palm Oil ◽

Tween 20 ◽

Hydrophilic Lipophilic Balance ◽

Selection Of ◽

Optimal Formula

Eleutherine palmifolia is a typical plant of Kalimantan that has been empirically used by the Dayak people as a cure for various types of diseases. Self-nanoemulsifying drug delivery system (SNEDDS) is a drug delivery system that can be developed for onion Dayak to improve its absorption profile. Selection of oil phase, surfactant, and cosurfactant have an essential role in SNEDDS of Dayak onion. The aims of this study to determine the effect of the use of vegetable oils on SNEDDS using the HLB approach. Several 40 formulations in each oil phase with HLB ranging between 11 and 15 were screened to acquire stable SNEDDS composition without the presence of phase separation. Formulas optimal obtained F33 (HLB 14) using olive oil at a ratio formula of 1:7:2. F29 (HLB 14), using VCO at a formula ratio of 1:7:2. F14 (HLB 14) uses palm oil at a ratio formula of 2:7:1. The result showed that the optimal formula F33 (olive oil) with 58 nm of the particle size, 84.32 ± 0.00 of the transmittance percentage, 22.00 ± 0,18 of the emulsification time. Formula F29 (VCO) with 19.48 nm of the particle size, 91.78 ± 0.02 of the transmittance percentage, 43.00 ± 0.16 of the emulsification time. Formula F14 (palm oil) with 102 nm of the particle size, 90.93 ± 0.02 of the transmittance percentage, 110 ± 0.34 of the emulsification time. The optimal formula that has good characteristics and stability is the F29 (VCO) formula using tween 20/transcutol as the surfactant, PEG 400, as co-surfactant at a ratio formula of 1:7:2.

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POLYSACCHARIDE AS GELATIN SUBTITUTE MATERIAL IN HALAL DRUG DELIVERY SYSTEM

Journal of Halal Product and Research ◽

10.20473/jhpr.vol.1-issue.2.15-21 ◽

2018 ◽

Vol 1 (2) ◽

pp. 15

Author(s):

Hayyun Durrotul Faridah ◽

Tri Susanti

Keyword(s):

Drug Delivery ◽

Drug Delivery System ◽

Delivery System ◽

Xanthomonas Campestris ◽

Islamic Law ◽

Base Material ◽

Brown Seaweed ◽

Pharmaceutical Products ◽

Alternative Material ◽

Selection Of

Drug delivery system describe the journey of a drug to get the target of action. The material used in drug delivery is very diverse and according to the therapymethod. So far, the use of gelatin in the pharmaceutical is very extensive, such as material in the drug delivery system. Gelatin can be produced from the extraction of animal collagen like from skin, bone and connective tissue. They are usually taken from the products of animal slaughterhouse products such as pigs and cattles. To produce a halal material, starting from the selection of basic materials until production of a material must be appropiate with Islamic rules. Like the selection of basic materials that getting from halal animals, the slaughter process is according to Islamic law and does not contain alcohol or other non-halal ingredients. However, today the use of pig skin as a gelatin base material is preferred because of its abundant availability and ease of processing. But actually pigs are animals that should not be consumed in Islam. The large number of pharmaceutical products derivating from pigs is a problem for a Muslim because it can be non-halal product. Therefore it is necessary to look for alternative gelatin as drug delivery system. One of the alternative material that can be used is a polysaccharide which is a natural polymer with very abundant availability in nature. For example carrageenan which is a polysaccharide extracted from the red seaweed, alginate extracted from brown seaweed, and xanthan gum which is the excretion of Xanthomonas campestris bacteria. The polysaccharide can be used as a halal drug delivery system and has the potential to be developed further so that it has better quality than gelatin.

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The Physiology of the Liposome

Physiology ◽

10.1152/physiologyonline.1989.4.4.146 ◽

1989 ◽

Vol 4 (4) ◽

pp. 146-151 ◽

Cited By ~ 1

Author(s):

G Gregoriadis

Keyword(s):

Drug Delivery ◽

Clinical Trials ◽

Drug Delivery System ◽

Delivery System ◽

Wide Spectrum ◽

Experimental Animals ◽

And Control

Understanding of the behavior and control of liposomes in vivo has led to their successful use as a drug delivery system in the treatment or prevention of a wide spectrum of diseases in experimental animals and, more recently, in clinical trials.

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Optimisation and feature selection of poly-beta-amino-ester as a drug delivery system for cartilage

Journal of Materials Chemistry B ◽

10.1039/c9tb02778e ◽

2020 ◽

Vol 8 (23) ◽

pp. 5096-5108 ◽

Cited By ~ 3

Author(s):

Stefano Perni ◽

Polina Prokopovich

Keyword(s):

Drug Delivery ◽

Feature Selection ◽

Drug Delivery System ◽

Delivery System ◽

Polymer Structure ◽

Full Potential ◽

Amino Ester ◽

Amino Esters ◽

Drug Conjugates ◽

Selection Of

Drug localisation is one of the main challenges in treating cartilage; poly-beta-amino-esters (PBAEs) drug conjugates are a possible solution; their efficacy depends on the polymer structure hence the full potential of this system is still unknown.

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Formulation design and evaluation of a self-microemulsifying drug delivery system of lovastatin

Acta Pharmaceutica ◽

10.2478/v10007-012-0022-1 ◽

2012 ◽

Vol 62 (3) ◽

pp. 357-370 ◽

Cited By ~ 21

Author(s):

Urvash Goyal ◽

Ritika Arora ◽

Geeta Aggarwal

Keyword(s):

Drug Delivery ◽

Drug Delivery System ◽

Delivery System ◽

Ternary Phase Diagrams ◽

Transmission Electron ◽

Selection Of ◽

Saturated Solubility ◽

Drug Solution

Self-microemulsifying drug delivery system (SMEDDS) of lovastatin was aimed at overcoming the problems of poor solubility and bioavailability. The formulation strategy included selection of oil phase based on saturated solubility studies and surfactant and co-surfactant screening on the basis of their emulsification ability. Ternary phase diagrams were constructed to identify the self-emulsifying region. Capryol 90 (20 %) as oil, Cremophore RH40 (40 %) as surfactant and Transcutol P (40 %) as co-surfactant were concluded to be optimized components. The prepared SMEDDS was characterized through its droplet size, zeta potential, emulsification time, rheological determination and transmission electron microscopy. The optimized formulation exhibited 94 % in vitro drug release, which was significantly higher than that of the drug solution. In vivo studies using the Triton-induced hyperlipidemia model in Wistar rats revealed considerable reduction in lipid levels compared to pure lovastatin. The study confirmed the potential of lovastatin SMEDDS for oral administration.

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Company News

Asia-Pacific Biotech News ◽

10.1142/s0219030302000010 ◽

2002 ◽

Vol 06 (01) ◽

pp. 3-12 ◽

Cited By ~ 2

Keyword(s):

Drug Delivery ◽

Gene Therapy ◽

Clinical Trials ◽

Hong Kong ◽

Drug Delivery System ◽

Delivery System ◽

Bt Cotton ◽

Medical Systems ◽

Over The Counter ◽

Antibody Technology

India’s Nath Seeds Ties up with Chinese Biotech Firm for Bt Cotton. Japan’s Takara Grants Molmed Right to Use RetroNectin for Gene Therapy. Sumitomo to Access LifeSpan’s GPCR Expression and Localization Database. Wyeth Lederle Japan Transfers Over-the-counter Drugs to Takeda. Kyowa Hakko Develops New Antibody Technology. Australia’s BTF Completes Prototype for Precise Culture Based Microorganisms. Novogen to Start Phenoxodiol Clinical Trials in Australia. China Investigates Fault in US-made Tempo Pacemakers. Japan Drugmakers to Boost Sales in China. YuHan at Forefront of Pharmaceuticals in Korea. Eli Lilly Opens Asian Headquarters in Hong Kong. DSM Produces Semi-synthetic Penicillin in China. World Diagnostics to Sell Test Kits in India and Vietnam. AMDL Reports Disappointing Sales from Asian Distributor. Taiwan University and AbGenomics to Develop Proprietary Biomedical Platforms. Omeros Medical Systems and Singapore Institute to Develop New Drug Delivery System.

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Liposomes: Current Approaches for Development and Evaluation

International Journal of Drug Delivery Technology ◽

10.25258/ijddt.v7i04.10649 ◽

2017 ◽

Vol 7 (04) ◽

Author(s):

Ashutosh Gupta ◽

Malay Kumar Mandal ◽

Bhupendra Singh ◽

Yashwant Yashwant ◽

Bharat Jhanwar

Keyword(s):

Drug Delivery ◽

Drug Delivery System ◽

Delivery System ◽

Dosage Form ◽

Drug Loading ◽

Triggered Release ◽

Therapeutic Efficiency ◽

Antibiotic Drug ◽

Main Disadvantage ◽

Selection Of

Liposomes (50-1000nm) are the part of a specific type of drug delivery system which is non-toxic and biodegradable in nature. That having ability to reduce the toxicity also enhances the therapeutic efficiency and protects the drug which is encapsulated, from the degradation and immediate dilution. These can be prepared by using various techniques like lipid hydration method, sonication method and solvent injecting method etc. But the selection of technique is depended upon the size of liposome which we want. The main disadvantage of this dosage form is it is very much costly and also having time consuming process. But it has major applications in the form of extrusion for homogeneous size, long circulating liposomes, triggered release liposome, remote drug loading, ligand targeted liposomes and containing combination of drugs. These applications are helpful for advanced drug delivery of anticancer, antifungal and anti-inflammatory drug, the delivery of gene medicine, delivery of anaesthetic and antibiotic drug. The newer researches in this field include hybrid liposomes, phototrigerable liposomes which are fabricated to have the improved functionality. These serves as the upcoming novel nanomedicinal chemotherapy technique.

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