scholarly journals EFFECT OF RENAL DYSFUNCTION ON THE CARDIACVASCULAR SYSTEM. THE POSSIBILI TIES OF EARLY DIAGNOSIS OF THE RENAL DYSFUNCTION

2018 ◽  
Vol 8 (4) ◽  
pp. 260-265
Author(s):  
B. Zh. Imanov ◽  
I. T. Murkamilov ◽  
I. S. Sabirov ◽  
A. Sh. Sarybaev
Keyword(s):  
Arterial Hypertension ◽  
Renal Dysfunction ◽  
Cardiovascular Events ◽  
Myocardial Dysfunction ◽  
Arterial Compliance ◽  
Pressure Overload ◽  
Cardiovascular Disorders ◽  
Increased Risk ◽  
Definition Of

The review is devoted to the discussion of modern concepts of the role of renal dysfunction in the development of chronic myocardial dysfunction in the context of cardio-renal syndrome (RVC) type 4. At the beginning of the review, the definition of cattle is given, general questions of pathogenesis and diagnosis of the disease are addressed. It is indicated that in patients with the initial stage of CKD, cardiovascular disorders are already registered which in the late stages of development of renal dysfunction are the leading causes of death and the true severity of the disease in patients with renal dysfunction is associated with an increased risk of cardiovascular events, rather than an achievement terminal renal failure and requiring renal replacement therapy. The progression of renal pathology leads to damage to the heart through various mechanisms and factors, both traditional and non-traditional, some of which, at the culmination of the renal continuum, are the result of the dialysis procedure itself in patients with terminal renal dysfunction. Mechanisms for the development of congestive heart failure in type 4 cattle include pressure overload (arterial hypertension) and volume (anemia, edematous syndrome), which increase in proportion to the decrease in renal function. Increase in blood pressure, changes in intracardial hemodynamics, deterioration of arterial compliance contribute to the acceleration of cardiovascular events. The role of laboratory predictors of renal dysfunction in the progression of cardiovascular disorders is discussed. The general approaches of echocardiographic visualization of the heart cavities and its importance in the diagnosis of cardiovascular diseases are discussed. Special attention is paid to the development of pulmonary arterial hypertension, changes in the left and right ventricle of the myocardium with renal dysfunction.

Primary prevention of cardiovascular disease in patients with systemic lupus erythematosus: case series and literature review

Lupus ◽  
2017 ◽  
Vol 26 (14) ◽  
pp. 1463-1472 ◽  
Author(s):  
S Fasano ◽  
D P Margiotta ◽  
L Navarini ◽  
L Pierro ◽  
I Pantano ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Cardiovascular Disease ◽  
Cardiovascular Event ◽  
Lupus Erythematosus ◽  
Cardiovascular Events ◽  
Hazard Ratio ◽  
Systemic Lupus ◽  
Increased Risk

Background Systemic lupus erythematosus is associated with an increased risk of cardiovascular disease. Low-dose aspirin, hydroxychloroquine and statins have been suggested to play a prophylactic role of cardiovascular events. This study is devoted to reviewing the literature on the topic and assessing the effects of these drugs in preventing a first cardiovascular event in a two-centre Italian series. Methods A PubMed search on cardiovascular prevention in systemic lupus erythematosus was performed. Moreover, systemic lupus erythematosus patients admitted to two centres from 2000–2015, who at admission had not experienced any cardiovascular event, were investigated. Aspirin, hydroxychloroquine and statin use, and the occurrence of any cardiovascular event, were recorded at each visit. Kaplan-Meier and Cox regression analyses were performed to evaluate the role of traditional, disease-related cardiovascular risk factors and of each of the three drugs in the occurrence of new cardiovascular events. Results The literature search produced conflicting results. Two hundred and ninety-one systemic lupus erythematosus patients were included in the study and followed for a median of eight years. During follow-up, 16 cardiovascular events occurred. At multivariate analysis, taking aspirin (hazard ratio: 0.24) and hydroxychloroquine for more than five years (hazard ratio: 0.27) reduced, while antiphospholipid antibody positivity (hazard ratio: 4.32) increased, the risk of a first cardiovascular event. No effect of statins emerged. Conclusion Our study confirms an additive role of aspirin and hydroxychloroquine in the primary prophylaxis of cardiovascular events in Italian patients with systemic lupus erythematosus. The lack of any detected effect in previous reports may depend on the design of studies and their short follow-up period.

scholarly journals The hardness of the vessel wall in patients with arterial hypertension

2015 ◽  
Vol 12 (2) ◽  
pp. 43-48
Author(s):  
O D Ostroumova ◽  
A I Kochetkov ◽  
I I Kopchenov ◽  
T F Guseva ◽  
O V Bondarec
Keyword(s):  
Arterial Hypertension ◽  
Vessel Wall ◽  
Antihypertensive Drugs ◽  
Blood Pressure Level ◽  
Vascular Wall ◽  
Cardiovascular Complications ◽  
Increased Risk ◽  
The Status ◽  
The Difference

The article deals with the role of the hardness of the vessel wall in the pathogenesis of arterial hypertension and its complications and cardiovascular mortality. We discussed the factors increasing the hardness of the vessel wall, such as age, blood pressure level, atherosclerosis, smoking and diabetes mellitus. We showed the indicators reflecting the status of the vascular wall and which could play a role of markers of increased risk of cardiovascular complications. We reviewed the data concerning the improvement of the parameters of the hardness of the vessel wall under the influence of antihypertensive therapy using the angiotensin II type 1 receptor blocker - candesartan. We discussed the possible mechanisms of the candesartan influence on the elastic properties of the vessels. We stressed that the effect on the hardness of the arteries on using antihypertensive drugs, even within the same class, was different, which, apparently, was associated with the difference in the pharmacokinetic properties.

scholarly journals The role of metabolic disorders in the progression of renal dysfunction in patients with metabolic syndrome and arterial hypertension

2019 ◽  
pp. 170-175
Author(s):  
E. I. Polozova ◽  
N. N. Sorokina ◽  
E. V. Puzanova ◽  
A. A. Seskina
Keyword(s):  
Metabolic Syndrome ◽  
Glomerular Filtration Rate ◽  
Arterial Hypertension ◽  
Renal Dysfunction ◽  
Cystatin C ◽  
Filtration Rate ◽  
Metabolic Disorders ◽  
Functional Changes ◽  
Group I

The clinical study enrolled 120 patients, who were hospitalized to the Therapeutic Department of Republican Clinical Hospital No.  5 of Saransk. The patients were divided into 2 groups: Group I (n = 60) included patients with metabolic syndrome; Group II (n = 60)  included patients with arterial hypertension. The paper presents data on the assessment of the functional state of kidneys in the  analysed groups, defines the role of metabolic disorders in the progression of renal dysfunction in patients with metabolic syndrome  and arterial hypertension. It is noted that more pronounced functional changes in the kidneys (microalbuminuria, increased cystatin  C levels, decreased glomerular filtration rate) are detected in patients with arterial hypertension and metabolic syndrome, as compared with patients without metabolic disorders. Cystatin C and microalbuminuria have been shown to be one of the earliest markers of kidney damage in hypertension, especially in combination with metabolic disorders. Cystatin C and microalbuminuria level is  significantly higher in patients with arterial hypertension and metabolic syndrome, as compared with patients with arterial hypertension, who have no metabolic disorders. Significant correlations were found between cystatin C, microalbuminuria levels and lipid  and carbohydrate metabolism in patients with arterial hypertension in combination with metabolic disorders. 

The role of physical factors of the working environment in the formation of arterial hypertension

2020 ◽  
pp. 692-693
Author(s):  
A. V. Melentev ◽  
P. V. Serebryakov
Keyword(s):  
Arterial Hypertension ◽  
Working Conditions ◽  
Significant Contribution ◽  
Cardiovascular Complications ◽  
Working Environment ◽  
Physical Factors ◽  
Noise And Vibration ◽  
Increased Risk ◽  
Influence Of Noise

The influence of noise and vibration on the development of arterial hypertension in workers employed in adverse working conditions was studied. It is shown that these physical factors of the working environment make a significant contribution to the formation of an increased risk of cardiovascular complications

Influence of Arterial Hypertension on the Pregnancy in Women with RH-Negative Blood

2015 ◽  
Vol 22 (3) ◽  
pp. 56-62
Author(s):  
Тамазаева ◽  
Kh. Tamazaeva ◽  
Омаров ◽  
N.S. Omarov
Keyword(s):  
Arterial Hypertension ◽  
Pregnant Women ◽  
High Titer ◽  
Perinatal Outcomes ◽  
Control Group ◽  
Threatened Premature Birth ◽  
Definition Of ◽  
D Antigen ◽  
Work Up

The purpose of the study was to assess the role of arterial hypertension (AH) in the development of immunization in women with Rh-negative blood to optimize perinatal outcomes. Subject and methods. A prospective comparatively study was conducted in 3 groups of pregnant women with Rh-negative blood. The 1-st group (n=148) was with hypertensive disease (HD), the 2-nd group (n=144) - with gestational arterial hypertension (GAH); the 3-rd group (n=110) - without somatic pathology. The immune-hematological studies included a definition of the partial D antigen using gel method. Results. It was definited that the pregnancy of these patients accompanied by the high frequency of early gestational toxicosis, threatened premature birth, preeclampsia, placental insufficiency as well as expressed changes immu-nological properties of blood, which are pathogenetic basis of fetal and neonatal rhesus hemolytic disease. Antibodies (AB) in the blood serum of patients with hypertension were detected in the first half of pregnancy (up to 20 weeks) in 1.2-1.4 times more often than in healthy women, high titer of AB rate in patients with HD was significantly higher compared to other groups. Disadvantageous combination of immunoglobulins subclasses Gl and G3 was found in the group of pregnant women with HD (11.4%) and GAH (10,8%), significantly less frequently (6,45%) in the control group. Conclusion. To improve maternal, fetal and neonatal gestation outcomes the authors justified the necessity of prenatal work-up and delivery of these women.

scholarly journals Noninvasive Assessment of Coronary Arteries in Patients with Hematologic Disorders

2017 ◽  
Vol 2 (1) ◽  
pp. 12-16
Author(s):  
Erzsébet Lázár ◽  
Péter Balázs Oltean ◽  
Laura Jáni ◽  
István Kovács ◽  
Tiberiu Nyulas ◽  
...  
Keyword(s):  
Cardiovascular Events ◽  
Present Knowledge ◽  
Hematologic Disorders ◽  
Hematological Disorders ◽  
Hematological Diseases ◽  
Cardiovascular Screening ◽  
Non Hodgkin Lymphoma ◽  
Increased Risk ◽  
Noninvasive Assessment

AbstractHematological conditions and their treatments have an increased risk of cardiovascular events, and invasive interventions have a higher risk of periprocedural complications in this group of patients. The aim of this review was to evaluate the risk of invasive interventions in patients with hematologic disorders and to underline the role of noninvasive cardiovascular screening in patients with hematological disorders such as Hodgkin and non-Hodgkin lymphoma, anemia, hemophilia, thrombocythemia, polycythemia vera, and leukemia. Based on present knowledge in the field, our opinion is that the screening of patients with hematological diseases is very important to reduce the morbidity and mortality due to cardiovascular events. Noninvasive assessments are suitable for this purpose with a significantly lower risk compared to invasive interventions.

scholarly journals Newly Detected Atrial Fibrillation after Acute Stroke: A Narrative Review of Causes and Implications

Cardiology ◽  
2019 ◽  
Vol 144 (3-4) ◽  
pp. 112-121 ◽  
Author(s):  
Youcheng Wang ◽  
Yongsheng Qian ◽  
Daniel Smerin ◽  
Shujuan Zhang ◽  
Qingyan Zhao ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Ischemic Stroke ◽  
Acute Stroke ◽  
Adverse Outcomes ◽  
Stroke Recurrence ◽  
Stroke Patients ◽  
Increased Risk ◽  
Definition Of ◽  
Humoral Regulation

Cardiac arrhythmias occur frequently in patients with acute stroke, with atrial fibrillation (AF) being the most common. Newly detected AF may lead to increased risk of ischemic stroke, which in turn generates stroke recurrence and adverse outcomes. Currently, most studies are focusing on the role of AF in ischemic stroke and attributing cryptogenic ischemic stroke to previously undetected AF. However, in these studies, subjects used to have neither symptoms of palpitation nor evidence of AF. A better understanding of this association will contribute to the management and therapy for patients after clinical decisions regarding stroke patients. Currently, the definition of newly detected AF has not come to an agreement, and the pathophysiology remains incompletely understood, possibly involving complex alterations in both the autonomic network and humoral regulation. Therefore, this review aims to introduce the definition and epidemiology of newly detected AF after stroke with updated information and elucidate the potential pathophysi­ology, such as autonomic imbalance, catecholamine surge, poststroke systematic inflammation, and microvesicles and microRNAs.

scholarly journals Serum NT-pro-BNP Levels Predict Cardiovascular Events in Acromegaly Patients

2021 ◽  
Author(s):  
Marta Ragonese ◽  
Gianluca Di Bella ◽  
Federica Spagnolo ◽  
Loredana Grasso ◽  
Angela Alibrandi ◽  
...  
Keyword(s):  
Heart Failure ◽  
General Population ◽  
Brain Natriuretic Peptide ◽  
Roc Curve ◽  
Cardiovascular Events ◽  
Roc Analysis ◽  
Middle Term ◽  
Increased Risk

Abstract Background Acromegaly is associated with an increased risk of fatal and non-fatal cardiovascular (CV) events. Controlling acromegaly decreases, but does not normalize this risk. Brain natriuretic peptide (BNP) assessment is used in the general population for the diagnosis of heart failure and to predict ischemic recurrences and mortality. This is a retrospective, longitudinal, monocenter study that evaluates the role of serum N-terminal fragment of BNP (NT-pro-BNP) for predicting CV events in acromegaly patients. Methods Serum NT-pro-BNP levels were measured in 76 patients with acromegaly (23 males, 57.7±1.5 years), and compared with other predictors of CV events. NT-pro-BNP cut-off value discriminating the occurrence of CV events was determined by ROC analysis. CV events were recorded during a follow-up of 78.6±6.4 months. Results CV events occurred in 9.2% of patients. Mean log(NT-pro-BNP) concentration was higher in patients who experienced CV events than in those who did not (p<0.01) and in patients who died due to CV events than in those who died due to other causes (p<0.01). Based on the ROC curve, a cut-off value of 91.55 pg/mL could predict CV events (OR 19.06). Log(NT-pro-BNP) was lower in surgically treated patients by surgery (p<0.05), and in those cured by neurosurgery (p<0.02). Conclusions High NT-pro-BNP value is an independent middle-term predictor of fatal or non-fatal CV events in patients with acromegaly. According to this parameter, surgically treated patients show lower CV risk than those managed with medical therapy, especially if the disease is cured.

scholarly journals Features of comorbidity in patients with hypertensive crisis

2019 ◽  
Vol 2 (30) ◽  
pp. 41-43
Author(s):  
N. V. Orlova ◽  
A. Yu. Chuprakova
Keyword(s):  
Arterial Hypertension ◽  
Hypertensive Crisis ◽  
Gender Characteristics ◽  
Definition Of

The article presents the definition of comorbid pathology and the role of comorbidity in the prognosis of diseases. Comorbidity in patients with arterial hypertension and its effect on the course of the disease are considered. Based on the results of the study, an analysis was made of the prevalence of concomitant diseases in patients with hypertensive crisis, as well as the gender characteristics of the prevalence of concomitant diseases.

Sign in / Sign up

Export Citation Format

Share Document