scholarly journals Detection of antibodies against agents of human granulocytic anaplasmosis and human monocytic ehrlichiosis serum from patients from Novosibirsk Region

2008 ◽  
Vol 7 ◽  
pp. 73-77
Author(s):  
V. A. Rar ◽  
N. V. Fomenko ◽  
O. V. Mel’nikova ◽  
N. Ya. Chernousova
Keyword(s):  
Febrile Illness ◽  
Tick Bites ◽  
Serum Samples ◽  
Human Granulocytic Anaplasmosis ◽  
Specific Antibodies ◽  
Granulocytic Anaplasmosis ◽  
Novosibirsk Region ◽  
Tick Borne Encephalitis ◽  
Tick Borne Encephalitis Virus ◽  
Human Monocytic Ehrlichiosis

Serum samples from patients hospitalized with febrile illnesses occurring after tick bites were investigated for antibodies against agents of human granulocytic anaplasmosis (HGA) and human monocytic ehrlichiosis (HME). Ten from 205 patients were shown to contain HGA-specific antibodies, one patient — HME-specific antibodies, and one patient — both antibodies against agents of HGA and HME. Diagnosis of HGA was serologically and clinically confirmed for four patients. All patients with serologically confirmed HGA were shown to contain also antibodies against Borrelia burgdorferi sensu lato or HME-specific antibodies. Moreover, one patient was shown to be infected with tick-borne encephalitis virus. Thus, it seems reasonable to analyze patients with confirmed tick-borne encephalitis as well as with febrile illness after tick bites on the infection with HGA and HME.

scholarly journals Assessment of Epizootiological-Epidemiological Situation on Natural Focal Infections in Aleksandrovsk-Sakhalin Territory of the Sakhalin Region

2014 ◽  
pp. 11-15
Author(s):  
E. I. Andaev ◽  
M. V. Chesnokova ◽  
T. I. Borisova ◽  
E. A. Vershinin ◽  
S. A. Tatarnikov ◽  
...  
Keyword(s):  
Molecular Genetic ◽  
Genetic Material ◽  
West Nile Fever ◽  
Granulocytic Anaplasmosis ◽  
Current State ◽  
Tick Borne Encephalitis ◽  
Natural Foci ◽  
Tick Borne Encephalitis Virus ◽  
Human Monocytic Ehrlichiosis ◽  
Epidemiological Significance

Objective of the work was to carry out complex assessment of the current state of epizootic activity and epidemiological significance of the infectious disease natural foci in the Aleksandrovsk-Sakhalin territory of the Sakhalin Region. Trapped were 56 samples of small mammals in July, 2010; collected were 180 specimens of taiga tick imago, caught were 1000 specimens of mosquitoes. 223 samples of blood sera were taken from residents of the region. All the field data were tested to detect specific antibodies, antigens and genetic material of agents. Based on the results of epizootiological investigations, serological and molecular-genetic assays, demonstrated was the occurence of natural foci of leptospirosis, tularemia, tick-borne encephalitis, borreliosis, rickettsiosis, human granulocytic anaplasmosis, human monocytic ehrlichiosis, West Nile fever, Inco fever, Batai and Geto fevers, as well as HFRS with varying degree of activity manifestation in the territory of the region. Isolated was tick-borne encephalitis virus from mosquitoes.

scholarly journals First identification of tick-borne encephalitis in Denmark outside of Bornholm, August 2009

2009 ◽  
Vol 14 (36) ◽  
Author(s):  
A Fomsgaard ◽  
C B Christiansen ◽  
R Bødker
Keyword(s):  
Ixodes Ricinus ◽  
Encephalitis Virus ◽  
Igg Antibodies ◽  
Rt Pcr ◽  
Tick Bites ◽  
Serum Samples ◽  
First Report ◽  
Tick Borne Encephalitis ◽  
Tick Borne Encephalitis Virus ◽  
Clinical Cases

The incidence of tick-borne encephalitis (TBE) in Scandinavia is increasing and spreading geographically. Following two clinical cases of TBE hospitalised after tick bites in northern Zealand, Denmark, specific IgM and IgG antibodies against tick-borne encephalitis virus (TBEV) were demonstrated in acute serum samples of these patients. TBEV was identified by RT-PCR in ticks collected from the same location. This is the first report of TBEV in Ixodes ricinus leading to clinical cases in Denmark outside of Bornholm island.

TBE in Sweden

2020 ◽  
Keyword(s):  
Genetic Characterization ◽  
Immunoglobulin M ◽  
Enzyme Linked Immunosorbent Assay ◽  
Second Phase ◽  
Serum Samples ◽  
Tick Borne Encephalitis ◽  
Specific Immunoglobulin ◽  
Tick Borne Encephalitis Virus ◽  
First Time

Tick-borne encephalitis virus (TBEV) was isolated for the first time in Sweden in 1958 (from ticks and from 1 tick-borne encephalitis [TBE] patient).1 In 2003, Haglund and colleagues reported the isolation and antigenic and genetic characterization of 14 TBEV strains from Swedish patients (samples collected 1991–1994).2 The first serum sample, from which TBEV was isolated, was obtained 2–10 days after onset of disease and found to be negative for anti-TBEV immunoglobulin M (IgM) by enzyme-linked immunosorbent assay (ELISA), whereas TBEV-specific IgM (and TBEV-specific immunoglobulin G/cerebrospinal fluid [IgG/CSF] activity) was demonstrated in later serum samples taken during the second phase of the disease.

MONITORING STUDIES OF ARBOVIRUS INFECTIONS TRANSMITTED BY MOSQUITOES ON THE TERRITORY OF THE VOLGOGRAD REGION

2019 ◽  
pp. 60-66
Author(s):  
E.V. Molchanova ◽  
D.N. Luchinin ◽  
A.O. Negodenko ◽  
D.R. Prilepskaya ◽  
N.V. Boroday ◽  
...  
Keyword(s):  
Virus Antigen ◽  
Elisa Test ◽  
Serum Samples ◽  
Blood Sucking ◽  
Tick Borne Encephalitis ◽  
Volgograd Region ◽  
Two Samples ◽  
Probable Presence ◽  
California Serogroup ◽  
Tick Borne Encephalitis Virus

The paper presents data from the monitoring studies’ results of arbovirus infections transmitted by mosquitoes in the Volgograd region. West Nile virus antigen (WNV) in 9 samples, Tahyna virus in one sample, Batai virus in two samples were detected in the study of 110 samples of field material (blood-sucking mosquitoes) by ELISA test. Antibodies to WNV in 16.58 percent of the samples, to tick-borne encephalitis virus in 1.08 percent, to viruses of the California serogroup and Ukuniemi in 1.09 percent, to the virus Sindbis in 2.17 percent were detected as a result of the study of blood serum samples from donors in the Volgograd region. Thus, we obtained data on the probable presence of the Batai, Sindbis, Ukuniemi and Californian serogroup viruses along with the circulation of WNV on the territory of the Volgograd region.

scholarly journals THE IDENTIFICATION OF «NEW» PATHOGENS FOR FOCAL INFECTIONS IN IXODES TICKS ON THE TERRITORY OF TULA REGION

2018 ◽  
Vol 23 (4) ◽  
pp. 172-177
Author(s):  
T. V. Kozlova ◽  
T. I. Khomyakova ◽  
V. G. Dedkov ◽  
M. V. Safonova ◽  
L. S. Karan ◽  
...  
Keyword(s):  
Lyme Disease ◽  
Ixodes Ricinus ◽  
Mixed Infection ◽  
Dermacentor Reticulatus ◽  
Encephalitis Virus ◽  
Tick Borne Encephalitis ◽  
Ixodes Ticks ◽  
Pcr Method ◽  
Tick Borne Encephalitis Virus ◽  
Human Monocytic Ehrlichiosis

The most of ixodes ticks in Tula region belongs to the group of pasture mites. It is generally accepted to estimate the tick’s contamination by the tick-borne encephalitis virus and raoueti inducing Lyme Borellia. The aim of the present work was to educe the aetiologic agents of the set of potentially-enable infections out of ticks Dermacentor reticulatus, Ixodes ricinus and Ixodes сrenulatus collected at the different terrains of Tula Region by PCR method. The results: a considerable number of pathogenic rickettsiae R. raoultii was educes from the ticks D. reticulatus, which including them as the component of mixed infection together with the human monocytic ehrlichiosis agent. R. raoultii was determined in more than a half of the cases in ticks I. ricinus including the mixed infection together with ticks’ borreliosis virus and Kemerovo fever agent. Conclusion. The reasons, induced the quantity changes of the ticks’ distribution at Tula Region terrains, apparently promote the rise in frequency of the ticks contamination with the agents of herd tick-transmissive infection. It demand an infectiologist’s attention rise and dictate the necessity of the above mentioned diseases monitoring as well as Fr. tularensis, the tick-borne encephalitis virus and Lyme disease.

scholarly journals Tick-Borne Encephalitis Virus Vaccines Contain Non-Structural Protein 1 Antigen and May Elicit NS1-Specific Antibody Responses in Vaccinated Individuals

Vaccines ◽  
2020 ◽  
Vol 8 (1) ◽  
pp. 81 ◽  
Author(s):  
Jiri Salat ◽  
Kamil Mikulasek ◽  
Osmany Larralde ◽  
Petra Pokorna Formanova ◽  
Ales Chrdle ◽  
...  
Keyword(s):  
Viral Envelope ◽  
Structural Protein ◽  
Specific Antibodies ◽  
Virus Challenge ◽  
Ms Analysis ◽  
Tick Borne Encephalitis ◽  
Ns1 Antigen ◽  
The Mean ◽  
Tick Borne Encephalitis Virus ◽  
Viral Surface

Vaccination against tick-borne encephalitis (TBE) is based on the use of formalin-inactivated, culture-derived whole-virus vaccines. Immune response following vaccination is primarily directed to the viral envelope (E) protein, the major viral surface antigen. In Europe, two TBE vaccines are available in adult and pediatric formulations, namely FSME-IMMUN® (Pfizer) and Encepur® (GlaxoSmithKline). Herein, we analyzed the content of these vaccines using mass spectrometry (MS). The MS analysis revealed that the Encepur vaccine contains not only proteins of the whole virus particle, but also viral non-structural protein 1 (NS1). MS analysis of the FSME-IMMUN vaccine failed due to the high content of human serum albumin used as a stabilizer in the vaccine. However, the presence of NS1 in FSME-IMMUN was confirmed by immunization of mice with six doses of this vaccine, which led to a robust anti-NS1 antibody response. NS1-specific Western blot analysis also detected anti-NS1 antibodies in sera of humans who received multiple doses of either of these two vaccines; however, most vaccinees who received ≤3 doses were negative for NS1-specific antibodies. The contribution of NS1-specific antibodies to protection against TBE was demonstrated by immunization of mice with purified NS1 antigen, which led to a significant (p < 0.01) prolongation of the mean survival time after lethal virus challenge. This indicates that stimulation of anti-NS1 immunity by the TBE vaccines may increase their protective effect.

Serological evidence for tick-borne encephalitis, borreliosis, and human granulocytic anaplasmosis in Mongolia

2006 ◽  
Vol 296 ◽  
pp. 69-75 ◽  
Author(s):  
Gernot Walder ◽  
Erdenechimeg Lkhamsuren ◽  
Abmed Shagdar ◽  
Jantsandoo Bataa ◽  
Tsetsegsaikhan Batmunkh ◽  
...  
Keyword(s):  
Serological Evidence ◽  
Human Granulocytic Anaplasmosis ◽  
Granulocytic Anaplasmosis ◽  
Tick Borne Encephalitis

scholarly journals Human Herpesvirus 6 Infection Presenting as an Acute Febrile Illness Associated with Thrombocytopenia and Leukopenia

2016 ◽  
Vol 2016 ◽  
pp. 1-3 ◽  
Author(s):  
Maja Arnež ◽  
Tatjana Avšič-Županc ◽  
Tina Uršič ◽  
Miroslav Petrovec
Keyword(s):  
Human Herpesvirus ◽  
Febrile Illness ◽  
Hantavirus Infection ◽  
Human Herpesvirus 6 ◽  
Endemic Region ◽  
Course Of Illness ◽  
Granulocytic Anaplasmosis ◽  
Tick Borne Encephalitis ◽  
Exanthema Subitum ◽  
Herpesvirus 6

We present an infant with acute fever, thrombocytopenia, and leukopenia, coming from an endemic region for tick-borne encephalitis, human granulocytic anaplasmosis, and hantavirus infection. The primary human herpesvirus 6 infection was diagnosed by seroconversion of specific IgM and IgG and by identification of viral DNA in the acute patient’s serum. The patient did not show skin rash suggestive of exanthema subitum during the course of illness.

Bacterial tick-associated infections in Australia: current studies and future directions

2018 ◽  
Vol 39 (4) ◽  
pp. 200
Author(s):  
Peter Irwin ◽  
Siobhon Egan ◽  
Telleasha Greay ◽  
Charlotte Oskam
Keyword(s):  
Northern Hemisphere ◽  
Lyme Borreliosis ◽  
High Throughput ◽  
Diagnostic Methods ◽  
Future Directions ◽  
Human Granulocytic Anaplasmosis ◽  
Boutonneuse Fever ◽  
Granulocytic Anaplasmosis ◽  
Tick Borne Encephalitis ◽  
Shed Light

It may seem perplexing that there is any uncertainty in Australia about the existence of zoonotic tick-associated infections1–3. Outside this country, particularly in the northern hemisphere, tick-borne diseases such as human granulocytic anaplasmosis, babesiosis, Boutonneuse fever, ehrlichiosis, Lyme borreliosis, and tick-borne encephalitis, have well documented aetiologies, epidemiology, diagnostic methods, and treatments. Why is Australia different and what research is being conducted to address this issue? This article briefly addresses these questions and explains how high-throughput metagenomic analysis has started to shed light on bacterial microbiomes in Australian ticks, providing new data on the presence and distribution of potentially zoonotic microbial taxa.

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