MAGNETIC RESONANCE IMAGING IN THE DIAGNOSIS OF JUVENILE IDIOPATHIC ARTHRITIS

Juvenile idiopathic arthritis (JIA) are a group of socially significant diseases of childhood because of the high prevalence of a chronic nature, as well as a large percentage of early disability. JIA is a collection of diseases that have different start, course and outcome, as well as various etiologies, which emphasizes the difficulties in the diagnosis process in children. When this disease is progressive in nature, leads to loss of function of the musculoskeletal system, severe disability at an early age and, therefore, needs early diagnosis and adequate therapy appointment.Significant role in identifying pathology osteoarticular system belongs radiological methods and routine radiography remains the most widely used technique included in the classification criteria of the majority of rheumatic diseases. However, it is well known that secondary structural changes in the bones precedes roentgen period, and therefore the X-rays can not be regarded as a method of early diagnosis with articular syndrome. Widely introduced in recent years, magnetic resonance imaging (MRI) has more say in the assessment of capabilities of the joints, as in addition to assessment of bone allows quantitatively and qualitatively assess changes in the synovial membrane, articular cartilage, the presence and severity of inflammatory changes in the periarticular soft tissue and bone tissue. The data obtained using MRI may be used for diagnosis, prognosis, and monitoring response to treatment, including early stage disease.Nevertheless, despite the obvious opportunities MRI, this technique is not widely used, including the lack of clear diagnostic criteria for the disease, the lack of centralized research validated, standardized protocols for conducting MRI studies of children with articular syndrome. Thus, research is warranted to address a number of clinical and diagnostic aspects in JIA, in particular the development of the scoring system assessing the severity and progression of the disease.

Download Full-text

FRI0456 Performance of magnetic resonance imaging for the detection of chronic structural changes in the sacroiliac joints as compared to conventional x-rays in axial spondyloarthritis

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2013-eular.1583 ◽

2013 ◽

Vol 72 (Suppl 3) ◽

pp. A529.2-A529

Author(s):

I. Gaydukova ◽

K.-G. Hermann ◽

I.-H. Song ◽

H. Haibel ◽

J. Braun ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Structural Changes ◽

Axial Spondyloarthritis ◽

X Rays ◽

Resonance Imaging ◽

Sacroiliac Joints

Download Full-text

Sialic acid-engineered mesoporous polydopamine dual loaded with ferritin gene and SPIO for achieving endogenous and exogenous synergistic T2-weighted magnetic resonance imaging of HCC

Journal of Nanobiotechnology ◽

10.1186/s12951-021-00821-8 ◽

2021 ◽

Vol 19 (1) ◽

Author(s):

Kai Fan ◽

Chengying Lu ◽

Gaofeng Shu ◽

Xiu-Ling Lv ◽

Enqi Qiao ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Sialic Acid ◽

Magnetic Resonance ◽

Early Diagnosis ◽

Early Stage ◽

In Vivo Studies ◽

Resonance Imaging ◽

Ferritin Gene ◽

T2 Weighted Images

Abstract Background Hepatocellular carcinoma (HCC) is a common malignant tumor with poor prognosis. Magnetic resonance imaging (MRI) is one of the most effective imaging methods for the early diagnosis of HCC. However, the current MR contrast agents are still facing challenges in the early diagnosis of HCC due to their relatively low sensitivity and biosafety. Thus, the development of effective MR agents is highly needed for the early diagnosis of HCC. Results Herein, we fabricated an HCC-targeted nanocomplexes containing SPIO-loaded mesoporous polydopamine (MPDA@SPIO), sialic acid (SA)-modified polyethyleneimine (SA-PEI), and alpha-fetoprotein regulated ferritin gene (AFP-Fth) which was developed for the early diagnosis of HCC. It was found that the prepared nanocomplexes (MPDA@SPIO/SA-PEI/AFP-Fth) has an excellent biocompatibility towards the liver cells. In vivo and in vivo studies revealed that the transfection of AFP-Fth gene in hepatic cells significantly upregulated the expression level of ferritin, thereby resulting in an enhanced contrast on T2-weighted images via the formed endogenous MR contrast. Conclusions The results suggested that MPDA@SPIO/SA-PEI/AFP-Fth had a superior ability to enhance the MR contrast of T2-weighted images of tumor region than the other preparations, which was due to its HCC-targeted ability and the combined T2 contrast effect of endogenous ferritin and exogenous SPIO. Our study proved that MPDA@SPIO/SA-PEI/AFP-Fth nanocomplexes could be used as an effective MR contrast agent to detect HCC in the early stage.

Download Full-text

Applicability of Magnetic Resonance Imaging for Early Diagnosis of Common Peroneal Neuropathy

The Nerve ◽

10.21129/nerve.2021.7.2.36 ◽

2021 ◽

Vol 7 (2) ◽

pp. 36-40

Author(s):

Gwang Yoon Choi ◽

Jinseo Yang ◽

Yongjun Cho ◽

Hyukjai Choi ◽

Jinpyeong Jeon ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Early Diagnosis ◽

Muscle Atrophy ◽

Early Stage ◽

Acute Onset ◽

Resonance Imaging ◽

Diagnostic Modality ◽

Peroneal Neuropathy ◽

Onset Group

Objective: This study aimed to assess the clinical applicability of magnetic resonance imaging (MRI) for the early diagnosis of common peroneal neuropathy (CPNe).Methods: Over three years, the authors have treated 58 patients with CPNe. All patients had clinical or neurophysiological confirmation of CPNe. Among them, 35 (60%) patients underwent axial knee MRI with a 1.5-Tesla scanner. These 35 patients were selected for study and were classified into three groups according to the time of examination after the occurrence of dropped foot―acute, subacute, and chronic onset groups. According to muscle appearances (normal, edematous change, and atrophy), we diagnosed them with CPNe, except for those with normal morphology. We evaluated the applicability of MRI in the diagnosis of CPNe compared to that of electromyography (EMG).Results: The 18, 11, and six cases were included in the acute, subacute, and chronic onset groups, respectively. In the acute onset group, three cases had normal muscle appearance, while 15 cases had edematous changes in the affected muscles. In the subacute onset group, eight cases had edematous changes, while three cases showed muscle atrophy. In the chronic onset group, six cases had muscle atrophy. CPNe could be diagnosed using MRI in about 91% (32/35) of all the cases. Excluding the chronologically chronic stage, diagnosis rate was approximately 89%(26/29) of all the cases. However, only in 27 cases (77%) denervation potentials were presented on EMG.Conclusion: According to our results, MRI is a helpful diagnostic modality, especially in the early stage of CPNe, and may lead to proper management.

Download Full-text

Early diagnosis of temporomandibular joint involvement in juvenile idiopathic arthritis: a pilot study comparing clinical examination and ultrasound to magnetic resonance imaging

Rheumatology ◽

10.1093/rheumatology/kep068 ◽

2009 ◽

Vol 48 (6) ◽

pp. 680-685 ◽

Cited By ~ 140

Author(s):

L. Muller ◽

C. J. Kellenberger ◽

E. Cannizzaro ◽

D. Ettlin ◽

T. Schraner ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Juvenile Idiopathic Arthritis ◽

Pilot Study ◽

Magnetic Resonance ◽

Early Diagnosis ◽

Temporomandibular Joint ◽

Clinical Examination ◽

Joint Involvement ◽

Resonance Imaging

Download Full-text

Multifunctional targeted nanoprobe with high NIR-II PAI/MRI performance for precise theranostics of orthotopic early-stage hepatocellular carcinoma

Journal of Materials Chemistry B ◽

10.1039/d1tb01729b ◽

2021 ◽

Author(s):

Linyun He ◽

Yachao Zhang ◽

Jiangbo Chen ◽

Gongyuan Liu ◽

Jingyi Zhu ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Hepatocellular Carcinoma ◽

Magnetic Resonance ◽

Early Diagnosis ◽

Effective Treatment ◽

Near Infrared ◽

Photoacoustic Imaging ◽

Early Stage ◽

Resonance Imaging ◽

Infrared Window

Early diagnosis and effective treatment of hepatocellular carcinoma (HCC) is quite critical for improving patients’ prognosis. The combination of second near-infrared window photoacoustic imaging (NIR-II PAI) and T2-magnetic resonance imaging...

Download Full-text

Bilateral Ischial Tuberculosis

Journal of Postgraduate Medicine Education and Research ◽

10.5005/jpmer-50-4-197 ◽

2016 ◽

Vol 50 (4) ◽

pp. 197-198

Author(s):

Sarvdeep S Dhatt

Keyword(s):

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Early Diagnosis ◽

High Index ◽

Response To Treatment ◽

Resonance Imaging ◽

Unique Case ◽

Magnetic Resonance Imaging Mri ◽

High Index Of Suspicion

ABSTRACT A unique case of bilateral ischial tuberculosis is presented with discussion of mode of spread of the case. Early diagnosis is mandatory for good results, and with a worldwide resurgence of the disease, a high index of suspicion is necessary. Magnetic resonance imaging (MRI) is helpful for defining the exact extent of the disease and response to treatment. How to cite this article Dhillon MS, Virk MS, Dhatt SS. Bilateral Ischial Tuberculosis. J Postgrad Med Edu Res 2016;50(4):197-198.

Download Full-text

AB1023 Bone Erosions Visualized by Magnetic Resonance Imaging in Juvenile Idiopathic Arthritis (JIA) are True Cortical Breaks Visible in High-Resolution Computed Tomography: Table 1

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2015-eular.6105 ◽

2015 ◽

Vol 74 (Suppl 2) ◽

pp. 1240.3-1240

Author(s):

S. Finzel ◽

G. Schett ◽

N. Tzaribachev

Keyword(s):

Magnetic Resonance Imaging ◽

Computed Tomography ◽

Juvenile Idiopathic Arthritis ◽

Magnetic Resonance ◽

High Resolution ◽

Resonance Imaging ◽

High Resolution Computed Tomography ◽

Bone Erosions

Download Full-text

The value of contrast-enhanced FLAIR magnetic resonance imaging in detecting meningeal abnormalities in suspected cases of meningitis compared to conventional contrast-enhanced T1WI sequences

Egyptian Journal of Radiology and Nuclear Medicine ◽

10.1186/s43055-020-00348-2 ◽

2020 ◽

Vol 51 (1) ◽

Author(s):

Wael Hamza Kamr ◽

Mohamed Gaber Eissawy ◽

Amr Saadawy

Keyword(s):

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Early Diagnosis ◽

Diagnosis And Treatment ◽

Effective Management ◽

Resonance Imaging ◽

Flair Sequence ◽

Csf Analysis ◽

Contrast Enhanced ◽

Magnetic Resonance Imaging Mri

Abstract Background Early diagnosis of meningitis with magnetic resonance imaging (MRI) would be useful for appropriate and effective management, decrease morbidity and mortality, and provide better diagnosis and treatment. The objective of the current study is to compare the accuracy of contrast-enhanced FLAIR (CE-FLAIR) and contrast-enhanced T1WI (CE-T1WI) in the detection of meningeal abnormalities in suspected cases of meningitis. Results Out of 45 patients, 37 patients were confirmed to have meningitis on CSF analysis. Out of the 37 patients, 34 patients were positive on CE-FLAIR sequence and 27 were positive on CE-T1WI. The sensitivity of CE-FLAIR sequence was 91.9% and specificity 100%, while the sensitivity of CE-T1WI sequence was 73% and specificity 100%. Conclusion CE-FLAIR is more sensitive than CE-T1WI in diagnosis of meningitis. It is recommended to be used in any cases with clinically suspected meningitis.

Download Full-text